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Conserved domains on  [gi|9845524|ref|NP_000390|]
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E3 SUMO-protein ligase EGR2 isoform a [Homo sapiens]

Protein Classification

DUF3446 and COG5048 domain-containing protein( domain architecture ID 12112558)

protein containing domains DUF3446, zf-C2H2, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 94-188 3.80e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.77  E-value: 3.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9845524     94 GKFSIDPQYP-GASCYPEGIINIVSaGILQGVTSPASTTASSSVTSASPNplATGPLGVCTMSQTQPDLDHLYSPPPPPP 172
Cdd:pfam11928   1 GKFSIDPQYPgGGSLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSPN--SSGPLCTMSCSVQSSEMEHIYSAPPPYP 77

                          90
                  ....*....|....*.
gi 9845524    173 PySGCaGDLYQDPSAF 188
Cdd:pfam11928  78 S-SGC-GDLYQDPSAF 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
368-436 5.00e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.00e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9845524  368 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIHLRQKERKSSAPSASVP 436
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSN 102
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 340-364 2.95e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.95e-04
                          10        20
                  ....*....|....*....|....*
gi 9845524    340 YPCPaeGCDRRFSRSDELTRHIRIH 364
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 94-188 3.80e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.77  E-value: 3.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9845524     94 GKFSIDPQYP-GASCYPEGIINIVSaGILQGVTSPASTTASSSVTSASPNplATGPLGVCTMSQTQPDLDHLYSPPPPPP 172
Cdd:pfam11928   1 GKFSIDPQYPgGGSLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSPN--SSGPLCTMSCSVQSSEMEHIYSAPPPYP 77

                          90
                  ....*....|....*.
gi 9845524    173 PySGCaGDLYQDPSAF 188
Cdd:pfam11928  78 S-SGC-GDLYQDPSAF 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
368-436 5.00e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.00e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9845524  368 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIHLRQKERKSSAPSASVP 436
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSN 102
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-409 1.05e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 1.05e-06
                          10        20
                  ....*....|....*....|....*.
gi 9845524    384 HLTTHIRTHTGEKPFACDYCGRKFAR 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 340-364 2.95e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.95e-04
                          10        20
                  ....*....|....*....|....*
gi 9845524    340 YPCPaeGCDRRFSRSDELTRHIRIH 364
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 369-416 3.26e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 3.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 9845524   369 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDYCGRKFARSDERKRH 416
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-382 4.24e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.24e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9845524  325 KYPNRPSKTPVHE----RPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRS 382
Cdd:COG5048 303 SPLTRHLRSVNHSgeslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 94-188 3.80e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.77  E-value: 3.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9845524     94 GKFSIDPQYP-GASCYPEGIINIVSaGILQGVTSPASTTASSSVTSASPNplATGPLGVCTMSQTQPDLDHLYSPPPPPP 172
Cdd:pfam11928   1 GKFSIDPQYPgGGSLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSPN--SSGPLCTMSCSVQSSEMEHIYSAPPPYP 77

                          90
                  ....*....|....*.
gi 9845524    173 PySGCaGDLYQDPSAF 188
Cdd:pfam11928  78 S-SGC-GDLYQDPSAF 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
368-436 5.00e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.00e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9845524  368 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIHLRQKERKSSAPSASVP 436
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSN 102
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-409 1.05e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 1.05e-06
                          10        20
                  ....*....|....*....|....*.
gi 9845524    384 HLTTHIRTHTGEKPFACDYCGRKFAR 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-406 1.03e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.03e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9845524  336 HERPYPCPaeGCDRRFSRSDELTRHIRIHTGHKPFQCRICMR--NFSRSDHLTTHIRTHTGEKPFACDYCGRK 406
Cdd:COG5048  30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
340-436 2.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9845524  340 YPCPAEGCDRRFSRSDELTRHIR--IHTG--HKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDY--CGRKFARSD 411
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                        90       100
                ....*....|....*....|....*
gi 9845524  412 ERKRHTKIHLRQKERKSSAPSASVP 436
Cdd:COG5048 368 NNEPPQSLQQYKDLKNDKKSETLSN 392
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-418 2.33e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9845524  325 KYPNRPSKTpVHERPYPCPAEGCDRRFSRSDELTRHiRIHtGHK-----PFQCRICMRNFSRSDhltthirthtgeKPFA 399
Cdd:COG5189 336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                        90
                ....*....|....*....
gi 9845524  400 CDYCGRKFARSDERKRHTK 418
Cdd:COG5189 401 CEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-381 4.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.37e-05
                          10        20
                  ....*....|....*....|....*.
gi 9845524    356 ELTRHIRIHTGHKPFQCRICMRNFSR 381
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 340-364 2.95e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.95e-04
                          10        20
                  ....*....|....*....|....*
gi 9845524    340 YPCPaeGCDRRFSRSDELTRHIRIH 364
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 370-392 9.86e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.86e-04
                          10        20
                  ....*....|....*....|...
gi 9845524    370 FQCRICMRNFSRSDHLTTHIRTH 392
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 398-420 2.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|...
gi 9845524    398 FACDYCGRKFARSDERKRHTKIH 420
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 369-416 3.26e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 3.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 9845524   369 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDYCGRKFARSDERKRH 416
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 370-392 3.88e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|...
gi 9845524    370 FQCRICMRNFSRSDHLTTHIRTH 392
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
342-421 3.93e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 39.62  E-value: 3.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9845524  342 CPAEGCDRRFSRSDELTRHIRIHtgHKPFQCRICMRN---------FSRSDHLTTHIRTHTGEKPFA----CDYCGRKFA 408
Cdd:COG5236 154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGNkkdfwneirLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231

                        90
                ....*....|....*...
gi 9845524  409 RSDE-----RKRHTKIHL 421
Cdd:COG5236 232 DDDElrrhcRLRHEACHI 249
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-382 4.24e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.24e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9845524  325 KYPNRPSKTPVHE----RPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRS 382
Cdd:COG5048 303 SPLTRHLRSVNHSgeslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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