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Conserved domains on  [gi|4557733|ref|NP_000419|]
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latent-transforming growth factor beta-binding protein 2 precursor [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 681-724 3.62e-14

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 68.07  E-value: 3.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 4557733     681 GTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC 724
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1423-1463 2.83e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.21  E-value: 2.83e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4557733    1423 CSSVLGRNTTQAECCC-TQGASWGDACDLCPSEDSAEFSEIC 1463
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1593-1636 5.45e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 4557733    1593 DVCSEPLrGHRTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1636
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
930-960 8.12e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.12e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 4557733      930 DINECEQPGVCS-GGQCTNTEGSYHCECDQGY 960
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1303-1335 2.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.40e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1218-1249 4.30e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.30e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1218 DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQ 1249
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1135-1175 6.43e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.43e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 4557733     1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQlaNGTVCE 1175
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1010-1041 9.80e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.80e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1010 DVNECLTPGVCAHG-KCTNLEGSFRCSCEQGYE 1041
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 31-165 2.22e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     31 GAGHAQRDPVGRYEPAGGDANRLRR-------------PGGSYPAAAAAKVYSLFREQDAPVAGLQPvERAQPGW--GSP 95
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRarrlgraaqasspPQRPRRRAARPTVGSLTSLADPPPPPPTP-EPAPHALvsATP 2720

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     96 RRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGqqqpaPRTRAAPALPrlgtpqrSGAAPPTPPRGRLTG 165
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTT-------AGPPAPAPPAAPAAG 2778
EGF_CA smart00179
Calcium-binding EGF-like domain;
1176-1217 5.57e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.57e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 4557733     1176 DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFvsaEGGTSCQ 1217
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
887-918 5.68e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.68e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733      887 DDNECL-RDPCKGKGRCINRVGSYSCFCYPGYT 918
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
622-651 1.39e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.39e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 4557733      622 DINECLTLGLCK-DAECVNTRGSYLCTCRPG 651
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1774-1808 2.18e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 4557733     1774 DVNECDDLNgpavLCVHGY-CENTEGSYRCHCSPGY 1808
Cdd:smart00179    1 DIDECASGN----PCQNGGtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 970-1005 2.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.95e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 4557733   970 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYRGQS 1005
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1485-1518 2.23e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.23e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 4557733     1485 DADECVIFGPglCPNG-RCLNTVPGYVCLCNPGFH 1518
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1051-1092 3.86e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 4557733     1051 DVDECASRASCPTG-LCLNTEGSFACSaCENGYwvnEDGTACE 1092
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1093-1123 4.29e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 4.29e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4557733    1093 DLDECAFPG-VCP-SGVCTNTAGSFSCKdCDGG 1123
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 845-879 8.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733   845 IDRCAAGatNVCGP-GTCVNLPDGYRCVCSPGYQLH 879
Cdd:cd00054    2 IDECASG--NPCQNgGTCVNTVGSYRCSCPPGYTGR 35
TB super family cl02926
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 561-595 8.83e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


The actual alignment was detected with superfamily member pfam00683:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 35.72  E-value: 8.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4557733     561 GQCANPLLELTT-QEDCCGSVGAFWGvTLCAPCPPR 595
Cdd:pfam00683    1 GRCSNPLPGNVTkSECCCTSVGRAWG-SPCELCPPP 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 681-724 3.62e-14

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 68.07  E-value: 3.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 4557733     681 GTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC 724
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1423-1463 2.83e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.21  E-value: 2.83e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4557733    1423 CSSVLGRNTTQAECCC-TQGASWGDACDLCPSEDSAEFSEIC 1463
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1593-1636 5.45e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 4557733    1593 DVCSEPLrGHRTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1636
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
930-960 8.12e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.12e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 4557733      930 DINECEQPGVCS-GGQCTNTEGSYHCECDQGY 960
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1303-1335 2.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.40e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1303-1335 2.71e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.71e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 930-961 3.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.58e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733   930 DINECEQPGVCS-GGQCTNTEGSYHCECDQGYI 961
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1218-1249 4.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.30e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1218 DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQ 1249
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1135-1175 6.43e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.43e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 4557733     1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQlaNGTVCE 1175
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1010-1041 9.80e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.80e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1010 DVNECLTPGVCAHG-KCTNLEGSFRCSCEQGYE 1041
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1135-1165 9.92e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 9.92e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1135 DVDECEDPQSSC-LGGECKNTVGSYQCLCPQG 1165
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-165 2.22e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     31 GAGHAQRDPVGRYEPAGGDANRLRR-------------PGGSYPAAAAAKVYSLFREQDAPVAGLQPvERAQPGW--GSP 95
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRarrlgraaqasspPQRPRRRAARPTVGSLTSLADPPPPPPTP-EPAPHALvsATP 2720

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     96 RRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGqqqpaPRTRAAPALPrlgtpqrSGAAPPTPPRGRLTG 165
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTT-------AGPPAPAPPAAPAAG 2778
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1218-1249 2.84e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.84e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1218 DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQ 1249
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1218-1247 3.19e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 3.19e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1218 DVDECAT-TDPC-VGGHCVNTEGSFNCLCETG 1247
Cdd:pfam07645    1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1135-1170 3.63e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.63e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733  1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLAN 1170
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1176-1217 5.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.57e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 4557733     1176 DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFvsaEGGTSCQ 1217
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
887-918 5.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.68e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733      887 DDNECL-RDPCKGKGRCINRVGSYSCFCYPGYT 918
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1010-1041 6.68e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.68e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1010 DVNECLTPGVC-AHGKCTNLEGSFRCSCEQGYE 1041
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 887-921 7.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.44e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733   887 DDNECL-RDPCKGKGRCINRVGSYSCFCYPGYTLAT 921
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
622-651 1.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.39e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 4557733      622 DINECLTLGLCK-DAECVNTRGSYLCTCRPG 651
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1176-1217 1.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 4557733  1176 DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVsaegGTSCQ 1217
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1303-1333 2.10e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1303 DIDECANDT-MCGSHGFCDNTDGSFRCLCDQG 1333
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1774-1808 2.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 4557733     1774 DVNECDDLNgpavLCVHGY-CENTEGSYRCHCSPGY 1808
Cdd:smart00179    1 DIDECASGN----PCQNGGtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 622-655 2.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.89e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 4557733   622 DINECLTLGLCK-DAECVNTRGSYLCTCRPGLMLD 655
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 970-1005 2.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.95e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 4557733   970 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYRGQS 1005
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1010-1039 7.45e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.45e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1010 DVNECLTPG-VC-AHGKCTNLEGSFRCSCEQG 1039
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
930-959 1.43e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733     930 DINECEQPG-VC-SGGQCTNTEGSYHCECDQG 959
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1774-1808 2.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733  1774 DVNECDDLNgpavLCV-HGYCENTEGSYRCHCSPGY 1808
Cdd:cd00054    1 DIDECASGN----PCQnGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1485-1518 2.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.23e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 4557733     1485 DADECVIFGPglCPNG-RCLNTVPGYVCLCNPGFH 1518
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
970-1002 2.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 4557733      970 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYR 1002
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
36-166 3.03e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 42.31  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733    36 QRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRV 115
Cdd:COG0515  248 AKDPEERYQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAA 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4557733   116 QPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGR 166
Cdd:COG0515  328 AAAAAAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAA 378
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 39-162 3.13e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 42.06  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     39 PVGRYEPAGGDAnrlrRPGGSYPAAAAAKVYSLfREQDAPVAGL--------QPVERAQPGWGSPRRPTEAEARRPSRAQ 110
Cdd:NF040712  201 TVPRLAREPADA----RPEEVEPAPAAEGAPAT-DSDPAEAGTPddlasarrRRAGVEQPEDEPVGPGAAPAAEPDEATR 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4557733    111 QSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGR 162
Cdd:NF040712  276 DAGEPPAPGAAETPEAAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRR 327
EGF_CA smart00179
Calcium-binding EGF-like domain;
1051-1092 3.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 4557733     1051 DVDECASRASCPTG-LCLNTEGSFACSaCENGYwvnEDGTACE 1092
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1093-1123 4.29e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 4.29e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4557733    1093 DLDECAFPG-VCP-SGVCTNTAGSFSCKdCDGG 1123
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1774-1807 5.94e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 4557733    1774 DVNECDDlnGPAVLCVHGYCENTEGSYRCHCSPG 1807
Cdd:pfam07645    1 DVDECAT--GTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1093-1134 7.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 4557733  1093 DLDECAFPGVC-PSGVCTNTAGSFSCkDCDGGYRpsplGDSCE 1134
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1093-1134 8.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.01e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 4557733     1093 DLDECAFPGVCPSG-VCTNTAGSFSCkDCDGGYRPsplGDSCE 1134
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRC-ECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 845-879 8.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733   845 IDRCAAGatNVCGP-GTCVNLPDGYRCVCSPGYQLH 879
Cdd:cd00054    2 IDECASG--NPCQNgGTCVNTVGSYRCSCPPGYTGR 35
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 561-595 8.83e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 35.72  E-value: 8.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4557733     561 GQCANPLLELTT-QEDCCGSVGAFWGvTLCAPCPPR 595
Cdd:pfam00683    1 GRCSNPLPGNVTkSECCCTSVGRAWG-SPCELCPPP 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 681-724 3.62e-14

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 68.07  E-value: 3.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 4557733     681 GTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC 724
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1423-1463 2.83e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.21  E-value: 2.83e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4557733    1423 CSSVLGRNTTQAECCC-TQGASWGDACDLCPSEDSAEFSEIC 1463
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1593-1636 5.45e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 4557733    1593 DVCSEPLrGHRTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1636
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
930-960 8.12e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.12e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 4557733      930 DINECEQPGVCS-GGQCTNTEGSYHCECDQGY 960
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1303-1335 2.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.40e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1303-1335 2.71e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.71e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 930-961 3.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.58e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733   930 DINECEQPGVCS-GGQCTNTEGSYHCECDQGYI 961
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1218-1249 4.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.30e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1218 DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQ 1249
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1135-1175 6.43e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.43e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 4557733     1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQlaNGTVCE 1175
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1010-1041 9.80e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.80e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733     1010 DVNECLTPGVCAHG-KCTNLEGSFRCSCEQGYE 1041
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1135-1165 9.92e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 9.92e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1135 DVDECEDPQSSC-LGGECKNTVGSYQCLCPQG 1165
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-165 2.22e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     31 GAGHAQRDPVGRYEPAGGDANRLRR-------------PGGSYPAAAAAKVYSLFREQDAPVAGLQPvERAQPGW--GSP 95
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRarrlgraaqasspPQRPRRRAARPTVGSLTSLADPPPPPPTP-EPAPHALvsATP 2720

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     96 RRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGqqqpaPRTRAAPALPrlgtpqrSGAAPPTPPRGRLTG 165
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTT-------AGPPAPAPPAAPAAG 2778
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1218-1249 2.84e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.84e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1218 DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQ 1249
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1218-1247 3.19e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 3.19e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1218 DVDECAT-TDPC-VGGHCVNTEGSFNCLCETG 1247
Cdd:pfam07645    1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1135-1170 3.63e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.63e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733  1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLAN 1170
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1176-1217 5.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.57e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 4557733     1176 DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFvsaEGGTSCQ 1217
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
887-918 5.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.68e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4557733      887 DDNECL-RDPCKGKGRCINRVGSYSCFCYPGYT 918
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
30-162 6.03e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.92  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     30 VGAGHAqrdpvgryePAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGlQPVERAQPGWGSPRRPTEAEA--RRPS 107
Cdd:PRK07003  362 VTGGGA---------PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTG-AAGAALAPKAAAAAAATRAEAppAAPA 431

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4557733    108 RAQQSRRVQPPAQTRRSTPLGQQQPAP---RTRAAPALPRLGTPQRSGAAPPTPPRGR 162
Cdd:PRK07003  432 PPATADRGDDAADGDAPVPAKANARASadsRCDERDAQPPADSGSASAPASDAPPDAA 489
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1010-1041 6.68e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.68e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 4557733  1010 DVNECLTPGVC-AHGKCTNLEGSFRCSCEQGYE 1041
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 47-163 6.84e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 6.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     47 GGDANRlRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPT---EAEARRPSRAQQSRRVQPPAQTRr 123
Cdd:PHA03247 2859 GGDVRR-RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQpqaPPPPQPQPQPPPPPQPQPPPPPP- 2936

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557733    124 stPLGQQQPAPRTRAAPA--------LPRLGT-----------------PQRSGAAPPTPPRGRL 163
Cdd:PHA03247 2937 --PRPQPPLAPTTDPAGAgepsgavpQPWLGAlvpgrvavprfrvpqpaPSREAPASSTPPLTGH 2999
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2-159 7.22e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 7.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733      2 RPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSlfREQDAPVAG 81
Cdd:PRK12323  391 APAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPA--AAARPAAAG 468

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4557733     82 LQPVERAQPgwGSPRRPTEAEARRPSRAQQSRRVQPPAqTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPP 159
Cdd:PRK12323  469 PRPVAAAAA--AAPARAAPAAAPAPADDDPPPWEELPP-EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAP 543
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 887-921 7.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.44e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733   887 DDNECL-RDPCKGKGRCINRVGSYSCFCYPGYTLAT 921
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
622-651 1.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.39e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 4557733      622 DINECLTLGLCK-DAECVNTRGSYLCTCRPG 651
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-162 1.54e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733      2 RPRTKARSPGRALRnPWRGFLPLTLALFVGAGHAQRDPVGRYEPA--------GGDANRLRRPGGSYPAAAAA-KVYSLF 72
Cdd:PHA03247 2700 DPPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAvpagpatpGGPARPARPPTTAGPPAPAPpAAPAAG 2778

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     73 REQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRA--APALP------- 143
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGppPPSLPlggsvap 2858

                         170       180
                  ....*....|....*....|....
gi 4557733    144 -----RLGTPQRSGAAPPTPPRGR 162
Cdd:PHA03247 2859 ggdvrRRPPSRSPAAKPAAPARPP 2882
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1176-1217 1.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 4557733  1176 DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVsaegGTSCQ 1217
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1303-1333 2.10e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1303 DIDECANDT-MCGSHGFCDNTDGSFRCLCDQG 1333
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1774-1808 2.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 4557733     1774 DVNECDDLNgpavLCVHGY-CENTEGSYRCHCSPGY 1808
Cdd:smart00179    1 DIDECASGN----PCQNGGtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 622-655 2.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.89e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 4557733   622 DINECLTLGLCK-DAECVNTRGSYLCTCRPGLMLD 655
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 970-1005 2.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.95e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 4557733   970 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYRGQS 1005
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
PHA03378 PHA03378
EBNA-3B; Provisional
 45-161 3.26e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     45 PAGGDANRLRR--PGGSYPAAAAAKVYSlfREQDAPVAGLQPveRAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTR 122
Cdd:PHA03378  678 PTGANTMLPIQwaPGTMQPPPRAPTPMR--PPAAPPGRAQRP--AAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGR 753

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 4557733    123 RSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRG 161
Cdd:PHA03378  754 ARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRG 792
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 47-161 4.93e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     47 GGDANRLRRPGGSYPAAAAAKVyslfrEQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTP 126
Cdd:PRK07764  372 RGLLARLERLERRLGVAGGAGA-----PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAG 446

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 4557733    127 LGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRG 161
Cdd:PRK07764  447 NAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPA 481
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 9-175 5.58e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 5.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733      9 SPGRALRNPWRGflpltlalfVGAGHAQRDPvGRYEPAGGDANRLRRP-----GGSYPAAAAAKVYSLFREQDAPVAGLQ 83
Cdd:PHA03307  261 APITLPTRIWEA---------SGWNGPSSRP-GPASSSSSPRERSPSPspsspGSGPAPSSPRASSSSSSSRESSSSSTS 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     84 PVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAP-----RTRAAPALPRLGTPQ-RSGAAPPT 157
Cdd:PHA03307  331 SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASagrptRRRARAAVAGRARRRdATGRFPAG 410

                         170
                  ....*....|....*...
gi 4557733    158 PPRGRLTGRNVCGGQCCP 175
Cdd:PHA03307  411 RPRPSPLDAGAASGAFYA 428
EGF_CA pfam07645
Calcium-binding EGF domain;
1010-1039 7.45e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.45e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733    1010 DVNECLTPG-VC-AHGKCTNLEGSFRCSCEQG 1039
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 30-160 8.13e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 8.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     30 VGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVerAQPGWGSPRRPTEAEARRPSRA 109
Cdd:PRK07764  647 VAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA--PAPAATPPAGQADDPAAQPPQA 724

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4557733    110 QQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPR 160
Cdd:PRK07764  725 AQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 35-164 1.21e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     35 AQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPgwgsPRRPTEAEARRPSRAQQSRR 114
Cdd:PRK14951  363 AFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPP----AAAPPAPVAAPAAAAPAAAP 438

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4557733    115 VQPPAqTRRSTPLGQQQPAPRTRAAPAL--PRLGTPQRSGAAPPTPPRGRLT 164
Cdd:PRK14951  439 AAAPA-AVALAPAPPAQAAPETVAIPVRvaPEPAVASAAPAPAAAPAAARLT 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-162 1.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733      3 PRTKARSPGRALRNPWRGFLPLTLAlfvgAGHAQRDPVGRYEPAGGDANRLrrPGGSYPAAAAAKVYSLFREQDAPVAGL 82
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRE----SLPSPWDPADPPAAVLAPAAAL--PPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     83 QPVERAQPGWGSP-----RR------------PTEAEARRPSRAQQSRRVQPPAQtrrsTPLGQQQPAPRTRAAPALPRL 145
Cdd:PHA03247 2846 PPPSLPLGGSVAPggdvrRRppsrspaakpaaPARPPVRRLARPAVSRSTESFAL----PPDQPERPPQPQAPPPPQPQP 2921

                         170
                  ....*....|....*..
gi 4557733    146 GTPQRSGAAPPTPPRGR 162
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPR 2938
EGF_CA pfam07645
Calcium-binding EGF domain;
930-959 1.43e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557733     930 DINECEQPG-VC-SGGQCTNTEGSYHCECDQG 959
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1774-1808 2.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733  1774 DVNECDDLNgpavLCV-HGYCENTEGSYRCHCSPGY 1808
Cdd:cd00054    1 DIDECASGN----PCQnGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1485-1518 2.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.23e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 4557733     1485 DADECVIFGPglCPNG-RCLNTVPGYVCLCNPGFH 1518
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
970-1002 2.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 4557733      970 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYR 1002
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
EGF smart00181
Epidermal growth factor-like domain;
933-964 2.34e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 2.34e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 4557733      933 ECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDK 32
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
36-166 3.03e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 42.31  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733    36 QRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRV 115
Cdd:COG0515  248 AKDPEERYQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAA 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4557733   116 QPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGR 166
Cdd:COG0515  328 AAAAAAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAA 378
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
39-159 3.11e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     39 PVGRYEPAGGDANRLRRPGGSYPAAAAAKvyslfreqdAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPP 118
Cdd:PRK12323  381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAA---------PAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4557733    119 AqTRRSTPLGQQQPA-----PRTRAAPALPRLGTPQR-SGAAPPTPP 159
Cdd:PRK12323  452 P-APAAAPAAAARPAaagprPVAAAAAAAPARAAPAAaPAPADDDPP 497
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 39-162 3.13e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 42.06  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     39 PVGRYEPAGGDAnrlrRPGGSYPAAAAAKVYSLfREQDAPVAGL--------QPVERAQPGWGSPRRPTEAEARRPSRAQ 110
Cdd:NF040712  201 TVPRLAREPADA----RPEEVEPAPAAEGAPAT-DSDPAEAGTPddlasarrRRAGVEQPEDEPVGPGAAPAAEPDEATR 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4557733    111 QSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGR 162
Cdd:NF040712  276 DAGEPPAPGAAETPEAAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRR 327
EGF_CA smart00179
Calcium-binding EGF-like domain;
1051-1092 3.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 4557733     1051 DVDECASRASCPTG-LCLNTEGSFACSaCENGYwvnEDGTACE 1092
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 35-161 3.93e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     35 AQRDPVGRYEPAGGDANRlrrPGGSYPAAAAAKVYSLFREQDAPVAGlqpvERAQPGWGSPRRPTEAEARRPSRAQQSrr 114
Cdd:PRK07764  617 APAAPAAPAAPAPAGAAA---APAEASAAPAPGVAAPEHHPKHVAVP----DASDGGDGWPAKAGGAAPAAPPPAPAP-- 687

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4557733    115 VQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRG 161
Cdd:PRK07764  688 AAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPA 734
EGF_CA pfam07645
Calcium-binding EGF domain;
1093-1123 4.29e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 4.29e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4557733    1093 DLDECAFPG-VCP-SGVCTNTAGSFSCKdCDGG 1123
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1774-1807 5.94e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 4557733    1774 DVNECDDlnGPAVLCVHGYCENTEGSYRCHCSPG 1807
Cdd:pfam07645    1 DVDECAT--GTHNCPANTVCVNTIGSFECRCPDG 32
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 32-161 5.95e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     32 AGHAQR-DPVGRYEPAGGDA--NRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSR 108
Cdd:PRK07764  372 RGLLARlERLERRLGVAGGAgaPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAG 451

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4557733    109 AQQSRRvQPPAQTRRSTPLGQQQPAPRTRAAPALPrlgTPQRSGAAPPTPPRG 161
Cdd:PRK07764  452 GAPSPP-PAAAPSAQPAPAPAAAPEPTAAPAPAPP---AAPAPAAAPAAPAAP 500
EGF smart00181
Epidermal growth factor-like domain;
1013-1041 7.41e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 7.41e-03
                            10        20
                    ....*....|....*....|....*....
gi 4557733     1013 ECLTPGVCAHGKCTNLEGSFRCSCEQGYE 1041
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1093-1134 7.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 4557733  1093 DLDECAFPGVC-PSGVCTNTAGSFSCkDCDGGYRpsplGDSCE 1134
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1093-1134 8.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 8.01e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 4557733     1093 DLDECAFPGVCPSG-VCTNTAGSFSCkDCDGGYRPsplGDSCE 1134
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRC-ECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 845-879 8.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 4557733   845 IDRCAAGatNVCGP-GTCVNLPDGYRCVCSPGYQLH 879
Cdd:cd00054    2 IDECASG--NPCQNgGTCVNTVGSYRCSCPPGYTGR 35
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 54-166 8.51e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.04  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     54 RRPGGSYPAAAAAkvyslfrEQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTplgQQQPA 133
Cdd:PRK12678   58 ARGGGAAAAAATP-------AAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAP---EAAQA 127

                          90       100       110
                  ....*....|....*....|....*....|...
gi 4557733    134 PRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGR 166
Cdd:PRK12678  128 RERRERGEAARRGAARKAGEGGEQPATEARADA 160
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 561-595 8.83e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 35.72  E-value: 8.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4557733     561 GQCANPLLELTT-QEDCCGSVGAFWGvTLCAPCPPR 595
Cdd:pfam00683    1 GRCSNPLPGNVTkSECCCTSVGRAWG-SPCELCPPP 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 933-969 9.67e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 9.67e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 4557733   933 ECEQPGVCS-GGQCTNTEGSYHCECDQGYImvRKGHCQ 969
Cdd:cd00053    1 ECAASNPCSnGGTCVNTPGSYRCVCPPGYT--GDRSCE 36
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 19-168 9.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 9.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     19 RGFLPLTLALFVGAGHAQRDPVGryEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPvaglQPVERAQPGwgsPRRP 98
Cdd:PRK07764  372 RGLLARLERLERRLGVAGGAGAP--AAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAP----QPAPAPAPA---PAPP 442

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557733     99 TEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNV 168
Cdd:PRK07764  443 SPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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