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Conserved domains on  [gi|4502179|ref|NP_000477|]
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aquaporin-2 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-219 1.40e-100

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 292.68  E-value: 1.40e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179      3 ELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPS-----VLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     78 GCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENP 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502179    158 GT-PALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLY 219
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-219 1.40e-100

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 292.68  E-value: 1.40e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179      3 ELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPS-----VLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     78 GCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENP 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502179    158 GT-PALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLY 219
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 11-222 1.78e-80

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 242.16  E-value: 1.78e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   11 RAVFAEFLATLLFVFFGLGSALNW---PQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAA 87
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNA---------LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRG-ENP 157
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGpPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502179  158 GTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTG---KFDDHWVFWIGPLVGAILGSLLYNYV 222
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-219 1.01e-67

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 209.08  E-value: 1.01e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     15 AEFLATLLFVFFGLGSAL-------NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAA 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNAL-SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPA-LSIG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFApLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502179    166 FSVALGHLLGIHYTGCSMNPARSLAPAVVTGK--FDDHWVFWIGPLVGAILGSLLY 219
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 11-223 5.66e-52

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 169.15  E-value: 5.66e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   11 RAVFAEFLATLLFVFFGLGSA--LNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAF 88
Cdd:COG0580   4 KRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   89 YVAAQLLGAVAGAALLHEI---TPADIRGDLAVNAL-----SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTP 160
Cdd:COG0580  84 YIIAQLLGAFLGAALVYLIyggHFDATEDGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLAP 163

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502179  161 aLSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFD------DHWVFWIGPLVGAILGSLLYNYVL 223
Cdd:COG0580 164 -LAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwgYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 6-223 5.49e-39

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 136.61  E-value: 5.49e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     6 SIAFSRAVFAEFLATLLFVFFGLGSALNW----------PQALPSVlQIAMAFGLGIGTLVQAlgHISGAHINPAVTVAC 75
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFakltsdaaldPAGLVAV-AVAHAFALFVGVSIAA--NISGGHLNPAVTLGL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    76 LVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADirgDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGE 155
Cdd:PLN00166  91 AIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGE---SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKG 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502179   156 NPGTPA-LSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVL 223
Cdd:PLN00166 168 SLGTIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-219 1.40e-100

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 292.68  E-value: 1.40e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179      3 ELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPS-----VLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     78 GCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENP 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502179    158 GT-PALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLY 219
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 11-222 1.78e-80

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 242.16  E-value: 1.78e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   11 RAVFAEFLATLLFVFFGLGSALNW---PQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAA 87
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNA---------LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRG-ENP 157
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGpPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502179  158 GTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTG---KFDDHWVFWIGPLVGAILGSLLYNYV 222
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-219 1.01e-67

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 209.08  E-value: 1.01e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     15 AEFLATLLFVFFGLGSAL-------NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAA 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNAL-SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPA-LSIG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFApLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502179    166 FSVALGHLLGIHYTGCSMNPARSLAPAVVTGK--FDDHWVFWIGPLVGAILGSLLY 219
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 11-223 5.66e-52

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 169.15  E-value: 5.66e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   11 RAVFAEFLATLLFVFFGLGSA--LNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAF 88
Cdd:COG0580   4 KRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   89 YVAAQLLGAVAGAALLHEI---TPADIRGDLAVNAL-----SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTP 160
Cdd:COG0580  84 YIIAQLLGAFLGAALVYLIyggHFDATEDGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLAP 163

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502179  161 aLSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFD------DHWVFWIGPLVGAILGSLLYNYVL 223
Cdd:COG0580 164 -LAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwgYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 6-223 5.49e-39

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 136.61  E-value: 5.49e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     6 SIAFSRAVFAEFLATLLFVFFGLGSALNW----------PQALPSVlQIAMAFGLGIGTLVQAlgHISGAHINPAVTVAC 75
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFakltsdaaldPAGLVAV-AVAHAFALFVGVSIAA--NISGGHLNPAVTLGL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    76 LVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADirgDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGE 155
Cdd:PLN00166  91 AIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGE---SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKG 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502179   156 NPGTPA-LSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVL 223
Cdd:PLN00166 168 SLGTIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-226 5.96e-38

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 133.76  E-value: 5.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    11 RAVFAEFLATLLFVFFGLGSALNWPQ------ALPSVL---QIAMAFGLGIGTLVQAlgHISGAHINPAVTVACLVGCHV 81
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKltdngsTTPAGLvaaALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    82 SVLRAAFYVAAQLLGAVAGAALLHEITpadirGDLAVNA--LSNSTTAGQAVTVELFLTLQLVLCIFAST-DERRGENPG 158
Cdd:PLN00027  99 TLLRGILYWIAQLLGSVVACLLLKFST-----GGLETSAfsLSSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGI 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502179   159 TPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPP 226
Cdd:PLN00027 174 IAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIGS 241
PRK05420 PRK05420
aquaporin Z; Provisional
 10-223 1.28e-35

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 127.01  E-value: 1.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    10 SRAVFAEFLATLLFVFFGLGSAL---NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRA 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAVlaaAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    87 AFYVAAQLLGAVAGAALLHEITPADIRGDLAVNAL-SN--------STTAGQAVTVELFLTLQLVLCIFASTDERrgENP 157
Cdd:PRK05420  82 VPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFaSNgygehspgGYSLLAALVCEVVLTAFFLLVILGATDKR--APA 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502179   158 GTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKF--DDHWVFWIGPLVGAILGSLLYNYVL 223
Cdd:PRK05420 160 GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 11-226 3.62e-35

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 126.56  E-value: 3.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    11 RAVFAEFLATLLFVFFGLGSALNWPQALP-------SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSV 83
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKLMPdaasdpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    84 LRAAFYVAAQLLGAVAGAALLHEITpadIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALS 163
Cdd:PLN00167 103 PTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGAIGPLA 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502179   164 IGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPP 226
Cdd:PLN00167 180 IGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFPT 242
PLN00184 PLN00184
aquaporin NIP1; Provisional
 6-238 1.60e-29

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 112.81  E-value: 1.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     6 SIAFSRAVFAEFLATLLFVFFGLGSALNWPQ-----ALPSvlqIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCH 80
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVVNMQndnvvTLPG---IAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    81 VSVLRAAFYVAAQLLGAVAGAALLHEITPADI-----RGDLAVNALSNSTTAgQAVTVELFLTLQLVLCIFA-STDERR- 153
Cdd:PLN00184 127 FPLKQVPAYVISQVIGSTLAAATLRLLFGLDHdvcsgKHDVFIGSSPVGSDL-QAFVMEFIVTFYLMFIISGvATDNRAi 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   154 GENPGtpaLSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLF--PPAKSLS 231
Cdd:PLN00184 206 GELAG---LAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYtdKPLREIT 282


                 ....*..
gi 4502179   232 ERLAVLK 238
Cdd:PLN00184 283 KSGSFLK 289
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-219 3.85e-28

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 108.79  E-value: 3.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    11 RAVFAEFLATLLFVF--FGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAF 88
Cdd:PLN00183  46 RMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    89 YVAAQLLGAVAgaALLHEITPADIRGDLAVNALSNSTTAgqAVTVELFLTLQLVLCIFASTDERRGENPGTpALSIGFSV 168
Cdd:PLN00183 126 YITAQTVGSVL--ATYVGVSVYGVKADLMTTKPAQGCSS--AFWVEFIATFIVMFLAASLTSQPQSLGHLS-GFVIGIAI 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4502179   169 ALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLY 219
Cdd:PLN00183 201 GLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMF 251
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 7-243 4.22e-28

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 108.84  E-value: 4.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     7 IAFSRAVFAEFLATLLFVFFGLGSAL--NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVL 84
Cdd:PLN00182  39 VCLTQKLIAEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    85 RAAFYVAAQLLGAVAGA---ALLHEITPADIRGDLAVNalsnstTAGQAVTVELFLTLQLVLCIFA-STDERR-GENPGt 159
Cdd:PLN00182 119 QVPLYIGAQLTGSLLASltlRLMFNVTPEAFFGTTPTD------SSGQALVAEIIISFLLMFVISGvATDSRAvGELAG- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   160 paLSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLF--PPAKSLSERLAVL 237
Cdd:PLN00182 192 --IAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFtdKPLRELTKSASFL 269


                 ....*.
gi 4502179   238 KGLEPD 243
Cdd:PLN00182 270 RSVSQK 275
PLN00026 PLN00026
aquaporin NIP; Provisional
 7-225 2.52e-26

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 104.56  E-value: 2.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     7 IAFSRAVFAEFLATLLFVFFGLGSAL--NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVL 84
Cdd:PLN00026  68 VSLTRKLGAEFVGTFILIFAATAGPIvnQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWK 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    85 RAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSnsttAGQAVTVELFLTLQLVLCIFA-STDERR-GENPGtpaL 162
Cdd:PLN00026 148 HVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSVS----TGQAFALEFIITFNLLFVVTAvATDTRAvGELAG---I 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502179   163 SIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFP 225
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLR 283
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 2-226 2.13e-22

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 93.65  E-value: 2.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179     2 WELRSIAFS-RAVFAEFLATLLFVFFGLGSALNW--PQALPSVLQIAMAFGLG--IGTLVQAlgHISGAHINPAVTVA-C 75
Cdd:PTZ00016  41 WAPREYRPNvREYVAEFLGTFVLLFFGEGVVATThtVGNNGDYLAITIGWGLGvtFGLLVSA--GISGGHLNPAVTLGnA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179    76 LVGChVSVLRAAFYVAAQLLGAVAGAALLHEITPADIR---GDLAVNALSNSTTAG-----------QAVTVELFLTLQL 141
Cdd:PTZ00016 119 VFGK-FPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKdhgIPELPWETMANGFAGvfatypregnfYAIFSELILTAIL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502179   142 VLCIFASTDERRGENPGTPALSIGFSV-ALGHLLGIHyTGCSMNPARSLAP----AVVTGK--FD-DHWVFWI---GPLV 210
Cdd:PTZ00016 198 LLVILAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevFTkDNYYFWVplvAPFV 276

                        250
                 ....*....|....*.
gi 4502179   211 GAILGSLLYNYVLFPP 226
Cdd:PTZ00016 277 GAVLGMFLYDKFIPPL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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