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Conserved domains on  [gi|27894330|ref|NP_000566|]
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interleukin-1 alpha precursor [Homo sapiens]

Protein Classification

IL1_propep and beta-trefoil_IL1B domain-containing protein( domain architecture ID 10493286)

IL1_propep and beta-trefoil_IL1B domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 123-267 5.70e-87

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466777  Cd Length: 145  Bit Score: 255.34  E-value: 5.70e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330 123 KYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPV 202
Cdd:cd23295   1 KYNFIRIIKQQFILNDALNQSIIRDPSQHLKAAALQNLDEEVKFDIGAYKSLDDDYKIPVTLRISNTQLFVSAQGEDEPV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27894330 203 LLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQIL 267
Cdd:cd23295  81 LLKEMPETPKTITGSETNLLFFWEEHGTKNFFSSAANPELFAATKQDELVHLARGLPSITDFQIL 145
IL1_propep pfam02394
Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. ...
 1-109 4.09e-52

Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.


:

Pssm-ID: 426754  Cd Length: 106  Bit Score: 165.57  E-value: 4.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330     1 MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNqKSFYHVSYGPLHEGCMDQSVSLSISETSKTSklTFKESMVVVATNgKV 80
Cdd:pfam02394   1 MAKVPELFEDLMACYSENEEFFEADGPLSLK-KSFQDLDLGPLHEDCMDKGIQLQISEQSKNS--SFKESVVVVVAV-EK 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 27894330    81 LKKRRLSLSQSITDDDLEAIANDS-EEEII 109
Cdd:pfam02394  77 LKKRRLSCSQFFQDDDLEAIFSDIfEEEPI 106
 
Name Accession Description Interval E-value
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 123-267 5.70e-87

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466777  Cd Length: 145  Bit Score: 255.34  E-value: 5.70e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330 123 KYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPV 202
Cdd:cd23295   1 KYNFIRIIKQQFILNDALNQSIIRDPSQHLKAAALQNLDEEVKFDIGAYKSLDDDYKIPVTLRISNTQLFVSAQGEDEPV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27894330 203 LLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQIL 267
Cdd:cd23295  81 LLKEMPETPKTITGSETNLLFFWEEHGTKNFFSSAANPELFAATKQDELVHLARGLPSITDFQIL 145
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 129-267 3.22e-63

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 195.29  E-value: 3.22e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330    129 IIKYEFILNDAlNQSIIR-ANDQYLTAAALH--NLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDE-DQPVLL 204
Cdd:smart00125   1 VISQECRLNDA-NQKSLVlSNPQYLKALHLNgqNLNQEVKFDMSFVQGEEDDSKIPVTLGISGTNLYLSCVKKgDEPTLQ 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27894330    205 KEMPEIPKTITgSETNLLFFWETH--GTKNYFTSVAHPNLFIATKQDYW--VCLAGGPPS--ITDFQIL 267
Cdd:smart00125  80 LEMVDPPKYPK-KEMEKRFVFEKHeiGNKVEFESAAHPNWFISTSQEEDkpVFLGNGPPSqdITDFQME 147
IL1_propep pfam02394
Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. ...
 1-109 4.09e-52

Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.


Pssm-ID: 426754  Cd Length: 106  Bit Score: 165.57  E-value: 4.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330     1 MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNqKSFYHVSYGPLHEGCMDQSVSLSISETSKTSklTFKESMVVVATNgKV 80
Cdd:pfam02394   1 MAKVPELFEDLMACYSENEEFFEADGPLSLK-KSFQDLDLGPLHEDCMDKGIQLQISEQSKNS--SFKESVVVVVAV-EK 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 27894330    81 LKKRRLSLSQSITDDDLEAIANDS-EEEII 109
Cdd:pfam02394  77 LKKRRLSCSQFFQDDDLEAIFSDIfEEEPI 106
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 155-266 1.96e-46

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 151.45  E-value: 1.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330   155 AALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNY- 233
Cdd:pfam00340   1 LQGQNLNLEVKFDMSFYKGDSDDSKIPVTLGIKGKKLYLSCVNKDEPVLQLEEVNIPKLIKNKESDKRFFFIRSESKNYv 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 27894330   234 -FTSVAHPNLFIATKQD-----YWVCLAGGPPSITDFQI 266
Cdd:pfam00340  81 eFESAAYPGWFIATKQEedlpvFLVNTAGGQDSITDFQI 119
 
Name Accession Description Interval E-value
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 123-267 5.70e-87

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466777  Cd Length: 145  Bit Score: 255.34  E-value: 5.70e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330 123 KYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPV 202
Cdd:cd23295   1 KYNFIRIIKQQFILNDALNQSIIRDPSQHLKAAALQNLDEEVKFDIGAYKSLDDDYKIPVTLRISNTQLFVSAQGEDEPV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27894330 203 LLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQIL 267
Cdd:cd23295  81 LLKEMPETPKTITGSETNLLFFWEEHGTKNFFSSAANPELFAATKQDELVHLARGLPSITDFQIL 145
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 129-267 3.22e-63

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 195.29  E-value: 3.22e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330    129 IIKYEFILNDAlNQSIIR-ANDQYLTAAALH--NLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDE-DQPVLL 204
Cdd:smart00125   1 VISQECRLNDA-NQKSLVlSNPQYLKALHLNgqNLNQEVKFDMSFVQGEEDDSKIPVTLGISGTNLYLSCVKKgDEPTLQ 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27894330    205 KEMPEIPKTITgSETNLLFFWETH--GTKNYFTSVAHPNLFIATKQDYW--VCLAGGPPS--ITDFQIL 267
Cdd:smart00125  80 LEMVDPPKYPK-KEMEKRFVFEKHeiGNKVEFESAAHPNWFISTSQEEDkpVFLGNGPPSqdITDFQME 147
IL1_propep pfam02394
Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. ...
 1-109 4.09e-52

Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.


Pssm-ID: 426754  Cd Length: 106  Bit Score: 165.57  E-value: 4.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330     1 MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNqKSFYHVSYGPLHEGCMDQSVSLSISETSKTSklTFKESMVVVATNgKV 80
Cdd:pfam02394   1 MAKVPELFEDLMACYSENEEFFEADGPLSLK-KSFQDLDLGPLHEDCMDKGIQLQISEQSKNS--SFKESVVVVVAV-EK 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 27894330    81 LKKRRLSLSQSITDDDLEAIANDS-EEEII 109
Cdd:pfam02394  77 LKKRRLSCSQFFQDDDLEAIFSDIfEEEPI 106
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 155-266 1.96e-46

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 151.45  E-value: 1.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330   155 AALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNY- 233
Cdd:pfam00340   1 LQGQNLNLEVKFDMSFYKGDSDDSKIPVTLGIKGKKLYLSCVNKDEPVLQLEEVNIPKLIKNKESDKRFFFIRSESKNYv 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 27894330   234 -FTSVAHPNLFIATKQD-----YWVCLAGGPPSITDFQI 266
Cdd:pfam00340  81 eFESAAYPGWFIATKQEedlpvFLVNTAGGQDSITDFQI 119
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 130-266 1.10e-32

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 117.04  E-value: 1.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330 130 IKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSS--KDDAKITVILRISKTQLYVTAQDE-DQPVL-LK 205
Cdd:cd00100   1 EKRNFVIRDSNDKSLYLRGNNELVAEDLSDVEKSAKITIYYYKSDsdEDFKGIPVVLNFTGTNCFLSCVKEgDKPSLqLE 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27894330 206 EMPEIP-KTITGSETNLLFFWET-HGTKNYFTSVAHPNLFIATKQDYWVCLAG--GPPSITDFQI 266
Cdd:cd00100  81 ECNKEElKNGDEEEWPFVFYMKAsHDNTCRFESAAHPGWFICTKKDQPVGLTKelGKTEDTDFYF 145
beta-trefoil_IL1B cd23296
beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, ...
 156-266 1.69e-10

beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, also called catabolin, is a potent inflammatory cytokine that activates the inflammatory process. It was initially discovered as the major endogenous pyrogen. It induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. IL-1 beta promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFN-gamma synthesis from T-helper 1 (Th1) cells. It plays a role in angiogenesis by inducing vascular endothelial growth factor (VEGF) production synergistically with tumor necrosis factor (TNF) and IL-6. IL-1 beta contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466778  Cd Length: 150  Bit Score: 58.01  E-value: 1.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330 156 ALH----NLDEAVKFDMGAYKSSK-DDAKITVILRISKTQLYVT-AQDEDQPVL-LKEMPEIPKTITGSETNLLFF-WET 227
Cdd:cd23296  27 ALHlqgpNSSQEVKLNMSFYRSPEsNGGKIPVALGIKGKNLYLScVKKGDKPTLqLEEVDPKNDSKSKDLKRFLFYkIES 106

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 27894330 228 HGTKNYFTSVAHPNLFIATKQDY----WVCLAGGPPSITDFQI 266
Cdd:cd23296 107 IGSTTTFESAAFPGWYISTSQAEnqpvFLGNQKGQQRITDFTL 149
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 142-249 2.14e-06

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 46.44  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27894330 142 QSIIRAND-QYLTA-----AALHNLDEA------VKFDMGAYKSSKDDAKITVILRISKT-QLYVTAQDEDQPVLLKEMp 208
Cdd:cd23298   4 TSIIRNKDnKFLVLdpdgqFVFEDLTDQelnapdCKFTIQIYKDTSPPRGLPVALYVKKDgKTYVLCCEENKEIRFKEM- 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 27894330 209 EIPKTITGSETNLLFFWE--THGTKNY-FTSVAHPNLFIATKQD 249
Cdd:cd23298  83 DLPDDIEGTKSDAIFYQKkfPGGTNKYkFESSLYPGYFLAFEPE 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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