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Conserved domains on  [gi|1465729075|ref|NP_000588|]
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insulin-like growth factor-binding protein 2 isoform a precursor [Homo sapiens]

Protein Classification

insulin-like growth factor-binding protein( domain architecture ID 11254546)

insulin-like growth factor-binding protein (IGFBP) controls the bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 40-132 8.63e-25

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 95.22  E-value: 8.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075   40 FRCPPCTPERLAACGPppvappaavaavaggarmPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSEL 119
Cdd:smart00121   1 ARCPPCDPARCPPCPP------------------GCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEER 62

                           90
                   ....*....|...
gi 1465729075  120 PLQALVMGEGTCE 132
Cdd:smart00121  63 PLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 227-306 1.80e-15

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.02  E-value: 1.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075 227 CQQELDQVLERISTMRLPDergplehlySLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 306
Cdd:pfam00086   1 CERERARALEQAASGRPAS---------GLYIPNCDEDGFYKPVQC----HGSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 40-132 8.63e-25

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 95.22  E-value: 8.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075   40 FRCPPCTPERLAACGPppvappaavaavaggarmPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSEL 119
Cdd:smart00121   1 ARCPPCDPARCPPCPP------------------GCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEER 62

                           90
                   ....*....|...
gi 1465729075  120 PLQALVMGEGTCE 132
Cdd:smart00121  63 PLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 227-306 1.80e-15

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.02  E-value: 1.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075 227 CQQELDQVLERISTMRLPDergplehlySLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 306
Cdd:pfam00086   1 CERERARALEQAASGRPAS---------GLYIPNCDEDGFYKPVQC----HGSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
74-111 4.25e-14

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 65.81  E-value: 4.25e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1465729075  74 PCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRC 111
Cdd:pfam00219  16 GCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 226-306 5.26e-14

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 65.95  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075 226 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 305
Cdd:cd00191     1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65


                  .
gi 1465729075 306 C 306
Cdd:cd00191    66 C 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 258-307 1.52e-10

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 55.85  E-value: 1.52e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1465729075  258 IPNCDKHGLYNLKQCkmslNGQRGECWCVNPnTGKLIQGAPTIRGDPECH 307
Cdd:smart00211   1 IPQCDEDGNYEPVQC----DGSSGQCWCVDA-TGREIPGTRTEGGDPDCP 45
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 40-132 8.63e-25

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 95.22  E-value: 8.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075   40 FRCPPCTPERLAACGPppvappaavaavaggarmPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSEL 119
Cdd:smart00121   1 ARCPPCDPARCPPCPP------------------GCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEER 62

                           90
                   ....*....|...
gi 1465729075  120 PLQALVMGEGTCE 132
Cdd:smart00121  63 PLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 227-306 1.80e-15

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 70.02  E-value: 1.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075 227 CQQELDQVLERISTMRLPDergplehlySLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 306
Cdd:pfam00086   1 CERERARALEQAASGRPAS---------GLYIPNCDEDGFYKPVQC----HGSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
74-111 4.25e-14

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 65.81  E-value: 4.25e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1465729075  74 PCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRC 111
Cdd:pfam00219  16 GCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 226-306 5.26e-14

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 65.95  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1465729075 226 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 305
Cdd:cd00191     1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65


                  .
gi 1465729075 306 C 306
Cdd:cd00191    66 C 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 258-307 1.52e-10

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 55.85  E-value: 1.52e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1465729075  258 IPNCDKHGLYNLKQCkmslNGQRGECWCVNPnTGKLIQGAPTIRGDPECH 307
Cdd:smart00211   1 IPQCDEDGNYEPVQC----DGSSGQCWCVDA-TGREIPGTRTEGGDPDCP 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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