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Conserved domains on  [gi|4505529|ref|NP_000599|]
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alpha-1-acid glycoprotein 2 precursor [Homo sapiens]

Protein Classification

lipocalin/fatty-acid binding family protein( domain architecture ID 14443811)

lipocalin/fatty-acid binding family protein such as lipocalins, which are transporters for small hydrophobic molecules, including lipids, steroid hormones, bilins, and retinoids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lipocalin_AGP-like cd19451
alpha1-acid glycoprotein and similar proteins; Alpha1-acid glycoprotein (AGP), also known as ...
 21-193 1.91e-114

alpha1-acid glycoprotein and similar proteins; Alpha1-acid glycoprotein (AGP), also known as orosomucoid, has many important biological roles such as in the acute-phase reaction in response to inflammation, in immune regulation, in drug-binding and drug-transportation, in regulating sphingolipid synthesis and metabolism, and in maintaining the capillary barrier. This subgroup belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


:

Pssm-ID: 381226  Cd Length: 173  Bit Score: 323.15  E-value: 1.91e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529   21 PLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQ 100
Cdd:cd19451   1 PACANLTAAPITNATLDQLSGKWFYIGSAFRNPEYKKEVQEIQAAFFYLTPNKTEDTILLREYQTIGDQCVYNSSKLTVQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529  101 RENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK 180
Cdd:cd19451  81 RENGTLSKYEGGVEHVAHLLLLRDPGTFMLAFFPEDEKNVGLSFYADKPEATPEQLKEFYEALKCLGMDESEIMYTDWKK 160

                       170
                ....*....|...
gi 4505529  181 DKCEPLEKQHEKE 193
Cdd:cd19451 161 DKCEPLEKQHEEE 173
 
Name Accession Description Interval E-value
lipocalin_AGP-like cd19451
alpha1-acid glycoprotein and similar proteins; Alpha1-acid glycoprotein (AGP), also known as ...
 21-193 1.91e-114

alpha1-acid glycoprotein and similar proteins; Alpha1-acid glycoprotein (AGP), also known as orosomucoid, has many important biological roles such as in the acute-phase reaction in response to inflammation, in immune regulation, in drug-binding and drug-transportation, in regulating sphingolipid synthesis and metabolism, and in maintaining the capillary barrier. This subgroup belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381226  Cd Length: 173  Bit Score: 323.15  E-value: 1.91e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529   21 PLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQ 100
Cdd:cd19451   1 PACANLTAAPITNATLDQLSGKWFYIGSAFRNPEYKKEVQEIQAAFFYLTPNKTEDTILLREYQTIGDQCVYNSSKLTVQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529  101 RENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK 180
Cdd:cd19451  81 RENGTLSKYEGGVEHVAHLLLLRDPGTFMLAFFPEDEKNVGLSFYADKPEATPEQLKEFYEALKCLGMDESEIMYTDWKK 160

                       170
                ....*....|...
gi 4505529  181 DKCEPLEKQHEKE 193
Cdd:cd19451 161 DKCEPLEKQHEEE 173
Lipocalin pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small ...
 40-180 1.46e-12

Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.


Pssm-ID: 395015  Cd Length: 143  Bit Score: 62.46  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529     40 TGKWFYIASAFrNEEYNKSVQEIQATFFYFTPNkTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVS----RYEGGREH 115
Cdd:pfam00061   1 SGKWYLIASAN-FNELEEEMKALGVGFATIKVL-ENGNLPVTEITKEGGKCKTVSVTFKKTEEPGKLGvefdEYAGGRKV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4505529    116 vaHLLFLRDTKTLMF--GSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK 180
Cdd:pfam00061  79 --KVLTTDYDNYLIFyqKGDKDGKTTIVRELYGRDPELSPELLEKFKKFLKELGIDEENIVRLYQKD 143
 
Name Accession Description Interval E-value
lipocalin_AGP-like cd19451
alpha1-acid glycoprotein and similar proteins; Alpha1-acid glycoprotein (AGP), also known as ...
 21-193 1.91e-114

alpha1-acid glycoprotein and similar proteins; Alpha1-acid glycoprotein (AGP), also known as orosomucoid, has many important biological roles such as in the acute-phase reaction in response to inflammation, in immune regulation, in drug-binding and drug-transportation, in regulating sphingolipid synthesis and metabolism, and in maintaining the capillary barrier. This subgroup belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381226  Cd Length: 173  Bit Score: 323.15  E-value: 1.91e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529   21 PLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQ 100
Cdd:cd19451   1 PACANLTAAPITNATLDQLSGKWFYIGSAFRNPEYKKEVQEIQAAFFYLTPNKTEDTILLREYQTIGDQCVYNSSKLTVQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529  101 RENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK 180
Cdd:cd19451  81 RENGTLSKYEGGVEHVAHLLLLRDPGTFMLAFFPEDEKNVGLSFYADKPEATPEQLKEFYEALKCLGMDESEIMYTDWKK 160

                       170
                ....*....|...
gi 4505529  181 DKCEPLEKQHEKE 193
Cdd:cd19451 161 DKCEPLEKQHEEE 173
lipocalin_ApoM_AGP cd19415
apolipoprotein M and alpha1-acid glycoprotein family; Apolipoprotein M (ApoM) is mainly found ...
 23-176 3.46e-41

apolipoprotein M and alpha1-acid glycoprotein family; Apolipoprotein M (ApoM) is mainly found in high-density lipoproteins (HDL) and is expressed in the liver and in the kidney; it is associated to a lesser extend with low density lipids and triglyceride rich lipoproteins. ApoM is involved in lipid transport and can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. Alpha1-acid glycoprotein (AGP), also known as orosomucoid, has many important biological roles such as in the acute-phase reaction in response to inflammation, in immune regulation, in drug-binding and drug-transportation, in regulating sphingolipid synthesis and metabolism, and in maintaining the capillary barrier. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381190  Cd Length: 153  Bit Score: 136.70  E-value: 3.46e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529   23 CANLVPvPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVqRE 102
Cdd:cd19415   1 CEELVK-PLSLADPSQILGKWVFIAGASDSEEYLAILKLVDSSWVNLTASSDEDTIVLRQGNRLNGKCIYSTVNATL-EG 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4505529  103 NGTVSRYEGGREHVAHLLFLRDTKTLM--FGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPrSDVMYT 176
Cdd:cd19415  79 SGTTFTYTNASETSTGLLLTSCPDCLLlnFNSTSGEEKGRSLYLYSRTGTLEKSELEEFKKQAECLGFS-PPFIYD 153
Lipocalin pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small ...
 40-180 1.46e-12

Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.


Pssm-ID: 395015  Cd Length: 143  Bit Score: 62.46  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529     40 TGKWFYIASAFrNEEYNKSVQEIQATFFYFTPNkTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVS----RYEGGREH 115
Cdd:pfam00061   1 SGKWYLIASAN-FNELEEEMKALGVGFATIKVL-ENGNLPVTEITKEGGKCKTVSVTFKKTEEPGKLGvefdEYAGGRKV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4505529    116 vaHLLFLRDTKTLMF--GSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK 180
Cdd:pfam00061  79 --KVLTTDYDNYLIFyqKGDKDGKTTIVRELYGRDPELSPELLEKFKKFLKELGIDEENIVRLYQKD 143
lipocalin_ApoM cd19450
Apolipoprotein M; Apolipoprotein M (ApoM) is mainly found in high-density lipoproteins (HDL) ...
 23-184 6.46e-07

Apolipoprotein M; Apolipoprotein M (ApoM) is mainly found in high-density lipoproteins (HDL) and is expressed in the liver and the kidney; it is associated to a lesser extend with low density lipids and triglyceride rich lipoproteins. It is involved in lipid transport and can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. This subgroup belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381225  Cd Length: 161  Bit Score: 47.08  E-value: 6.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529   23 CANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNkTEDTIFLREYQTRQNQCFYNSSYLNVQRE 102
Cdd:cd19450   1 CPPPAPLSTSVLNPDQYLGRWYFVAAAAWDEDDLATFKPLDNIVFNMQKG-SNDTLQLTATIRIGGQCVPRKWTYRLTEH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529  103 NGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIprSDVMYTDWKKDK 182
Cdd:cd19450  80 TGSFELRTEGRPDMKWDGFSANCPGCIILQETDQEEYNRFLLYARSPHPPEECIEEFKSKTSCLGM--EDFLLTPLQQGY 157


                ..
gi 4505529  183 CE 184
Cdd:cd19450 158 CK 159
lipocalin_FABP cd00301
lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low ...
 38-146 5.08e-05

lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They have a large beta-barrel ligand-binding cavity. Members include retinol-binding protein, retinoic acid-binding protein, complement protein C8 gamma, Can f 2, apolipoprotein D, extracellular fatty acid-binding protein, beta-lactoglobulin, oderant-binding protein, and bacterial lipocalin Blc. Lipocalins are involved in many important processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty acid-binding proteins also bind hydrophobic ligands in a non-covalent, reversible manner, and are involved in protection and shuttling of fatty acids within the cell, and in acquisition and removal of fatty acids from intracellular sites.


Pssm-ID: 381182  Cd Length: 109  Bit Score: 40.99  E-value: 5.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505529   38 RITGKWFYIASAFRNEEynksVQEIQATFFYFTPNKtEDTIFLREYQTRQNQCFYNSSYLNVQRENG--TVSRYEGGREH 115
Cdd:cd00301   1 KFSGKWYEVASASNAPE----EDEGKCTTAEYTLEG-NGNLKVTNSFVRDGVCKSITGTLKKTDGPGkfTVTYPGYTGKN 75

                        90       100       110
                ....*....|....*....|....*....|.
gi 4505529  116 VAHLLFLRDTKTLMFgsYLDDEKNWGLSFYA 146
Cdd:cd00301  76 ELYVLSTDYDNYAIV--YSCKNLDGGHTVVA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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