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Conserved domains on  [gi|4506607|ref|NP_000970|]
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large ribosomal subunit protein eL18 isoform 1 [Homo sapiens]

Protein Classification

eL18 family ribosomal protein( domain architecture ID 12181919)

eL18 family ribosomal protein is a component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Gene Ontology:  GO:0005840|GO:0006412|GO:0003735
PubMed:  24524803

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ribosomal_L18 pfam17135
Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from ...
2-176 2.11e-113

Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from eukaryotes and 50S L18e from Archaea.


:

Pssm-ID: 465358  Cd Length: 184  Bit Score: 320.29  E-value: 2.11e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607      2 GVDIRHnkdRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAV 81
Cdd:pfam17135   1 GIDITH---RKVHRKAPKSENPYLKLLVKLYRFLARRTDSKFNKVVLKRLFMSRINRPPLSLSRIARAMKKKGREGKIAV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607     82 VVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHS 161
Cdd:pfam17135  78 VVGTVTDDVRLLEVPKLSVCALRFTETARARILKAGGECLTFDQLALRAPTGKNTVLLRGPRNAREAVKHFGFAPGGPHS 157
                         170
                  ....*....|....*
gi 4506607    162 HTKPYVRSKGRKFER 176
Cdd:pfam17135 158 HTKPYVRSKGRKFER 172
 
Name Accession Description Interval E-value
Ribosomal_L18 pfam17135
Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from ...
2-176 2.11e-113

Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from eukaryotes and 50S L18e from Archaea.


Pssm-ID: 465358  Cd Length: 184  Bit Score: 320.29  E-value: 2.11e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607      2 GVDIRHnkdRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAV 81
Cdd:pfam17135   1 GIDITH---RKVHRKAPKSENPYLKLLVKLYRFLARRTDSKFNKVVLKRLFMSRINRPPLSLSRIARAMKKKGREGKIAV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607     82 VVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHS 161
Cdd:pfam17135  78 VVGTVTDDVRLLEVPKLSVCALRFTETARARILKAGGECLTFDQLALRAPTGKNTVLLRGPRNAREAVKHFGFAPGGPHS 157
                         170
                  ....*....|....*
gi 4506607    162 HTKPYVRSKGRKFER 176
Cdd:pfam17135 158 HTKPYVRSKGRKFER 172
PTZ00469 PTZ00469
60S ribosomal subunit protein L18; Provisional
1-187 1.29e-50

60S ribosomal subunit protein L18; Provisional


Pssm-ID: 185648  Cd Length: 187  Bit Score: 161.37  E-value: 1.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607     1 MGVDIRH-NKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpGRENKT 79
Cdd:PTZ00469   1 MGIALKNvGRIKKHGRKNLVSKNPYLRLLVKLYRFLARRTNANFNKIIAKRLIMPKRFRPPLSLSKLHRHMA--SYPDDV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607    80 AVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTP 159
Cdd:PTZ00469  79 AVVVGSITDDKRLYDCKKLKVCALRFTETARKRILDAGGECLTFDQLALKYPTGQKCILLRGPTKARTAEKHFGKAPGRP 158
                        170       180
                 ....*....|....*....|....*...
gi 4506607   160 HSHTKPYVRSKGRKFERARGRRASRGYK 187
Cdd:PTZ00469 159 KSKARPYVRSKGRKFEKARGRRKSRAYK 186
RPL18A COG1727
Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
22-139 3.29e-08

Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18E is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441333  Cd Length: 114  Bit Score: 49.42  E-value: 3.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607   22 DIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpgrENKTAVVVGTITDDVRVQEvpKLKVC 101
Cdd:COG1727   3 NPRLVSLIRDLKKASRENDAPIWRDVAERLEKPRRNRAEVNLSKINRYAK----EGDTVVVPGKVLGSGKLSK--KVTVA 76
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4506607  102 ALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLL 139
Cdd:COG1727  77 AFSFSETAAEKIEEAGGECLTIEELVKENPKGSGVRII 114
 
Name Accession Description Interval E-value
Ribosomal_L18 pfam17135
Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from ...
2-176 2.11e-113

Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from eukaryotes and 50S L18e from Archaea.


Pssm-ID: 465358  Cd Length: 184  Bit Score: 320.29  E-value: 2.11e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607      2 GVDIRHnkdRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAV 81
Cdd:pfam17135   1 GIDITH---RKVHRKAPKSENPYLKLLVKLYRFLARRTDSKFNKVVLKRLFMSRINRPPLSLSRIARAMKKKGREGKIAV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607     82 VVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHS 161
Cdd:pfam17135  78 VVGTVTDDVRLLEVPKLSVCALRFTETARARILKAGGECLTFDQLALRAPTGKNTVLLRGPRNAREAVKHFGFAPGGPHS 157
                         170
                  ....*....|....*
gi 4506607    162 HTKPYVRSKGRKFER 176
Cdd:pfam17135 158 HTKPYVRSKGRKFER 172
PTZ00469 PTZ00469
60S ribosomal subunit protein L18; Provisional
1-187 1.29e-50

60S ribosomal subunit protein L18; Provisional


Pssm-ID: 185648  Cd Length: 187  Bit Score: 161.37  E-value: 1.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607     1 MGVDIRH-NKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpGRENKT 79
Cdd:PTZ00469   1 MGIALKNvGRIKKHGRKNLVSKNPYLRLLVKLYRFLARRTNANFNKIIAKRLIMPKRFRPPLSLSKLHRHMA--SYPDDV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607    80 AVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTP 159
Cdd:PTZ00469  79 AVVVGSITDDKRLYDCKKLKVCALRFTETARKRILDAGGECLTFDQLALKYPTGQKCILLRGPTKARTAEKHFGKAPGRP 158
                        170       180
                 ....*....|....*....|....*...
gi 4506607   160 HSHTKPYVRSKGRKFERARGRRASRGYK 187
Cdd:PTZ00469 159 KSKARPYVRSKGRKFEKARGRRKSRAYK 186
PTZ00195 PTZ00195
60S ribosomal protein L18; Provisional
1-173 2.10e-49

60S ribosomal protein L18; Provisional


Pssm-ID: 140222  Cd Length: 198  Bit Score: 158.66  E-value: 2.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607     1 MGVDIRH-NKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKL------P 73
Cdd:PTZ00195   1 MGVDLTGiSKKSRVVRHHTYSTNPYIKLLIKLYKFLAKRTSSGFNKVVYQRLIKSRSNRAPISLSRIAVVMKRkavftaK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607    74 GRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFG 153
Cdd:PTZ00195  81 GKKAPIAVVVGDVLDDVRMARIPAMRVCALRFSKSARQSIVAAGGECLTFDQLAMIAPTGKNTYLLRGRKSGRESVRHFG 160
                        170       180
                 ....*....|....*....|
gi 4506607   154 kAPGTPHSHTKPYVRSKGRK 173
Cdd:PTZ00195 161 -ASGVPGSHSKPYATNRGKE 179
RPL18A COG1727
Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
22-139 3.29e-08

Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18E is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441333  Cd Length: 114  Bit Score: 49.42  E-value: 3.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607   22 DIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpgrENKTAVVVGTITDDVRVQEvpKLKVC 101
Cdd:COG1727   3 NPRLVSLIRDLKKASRENDAPIWRDVAERLEKPRRNRAEVNLSKINRYAK----EGDTVVVPGKVLGSGKLSK--KVTVA 76
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4506607  102 ALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLL 139
Cdd:COG1727  77 AFSFSETAAEKIEEAGGECLTIEELVKENPKGSGVRII 114
PRK04005 PRK04005
50S ribosomal protein L18e; Provisional
28-139 3.77e-07

50S ribosomal protein L18e; Provisional


Pssm-ID: 235196  Cd Length: 111  Bit Score: 46.77  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506607    28 LVKLYRFL---ARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpgrENKTAVVVGTITDDVRVQEvpKLKVCALR 104
Cdd:PRK04005   2 LRKLIRDLkkaSRENGAPIWKDVAERLEKPRRRRAEVNLSKINRYAK----EGDTVVVPGKVLGSGKLDH--KVTVAALS 75
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 4506607   105 VTSRARSRILRAGGKILTFDQLALDSPKGCGTVLL 139
Cdd:PRK04005  76 FSETAKEKIEEAGGKALTIEELVEENPKGSNVRIM 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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