NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|47716519|ref|NP_001001346|]
View 

claudin-20 precursor [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology:  GO:0016020
PubMed:  19706201

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PMP22_Claudin super family cl21598
PMP-22/EMP/MP20/Claudin family;
5-181 4.18e-21

PMP-22/EMP/MP20/Claudin family;


The actual alignment was detected with superfamily member pfam00822:

Pssm-ID: 473919  Cd Length: 162  Bit Score: 85.89  E-value: 4.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47716519     5 GLQLLAFILALSGVSGVLTATLLPN-WKVnvdvdSNIITAIVQLhGLWMDCTWYS-TGMFSCalkhSILSLPIHVQAARA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPDqWKV-----SRYVGAAASA-GLWRNCTTQScTGQISC----KVLELNDALQAVQA 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47716519    83 TMVLACVLSALGICTSTVGMKCTRLGGDretkshaSFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPEsNKHEPGG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGR-------FKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPN-RKYSFGY 143
                         170
                  ....*....|....*....
gi 47716519   163 AIYIGFISAMLLFISGMIF 181
Cdd:pfam00822 144 SFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-181 4.18e-21

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 85.89  E-value: 4.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47716519     5 GLQLLAFILALSGVSGVLTATLLPN-WKVnvdvdSNIITAIVQLhGLWMDCTWYS-TGMFSCalkhSILSLPIHVQAARA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPDqWKV-----SRYVGAAASA-GLWRNCTTQScTGQISC----KVLELNDALQAVQA 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47716519    83 TMVLACVLSALGICTSTVGMKCTRLGGDretkshaSFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPEsNKHEPGG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGR-------FKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPN-RKYSFGY 143
                         170
                  ....*....|....*....
gi 47716519   163 AIYIGFISAMLLFISGMIF 181
Cdd:pfam00822 144 SFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-181 4.18e-21

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 85.89  E-value: 4.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47716519     5 GLQLLAFILALSGVSGVLTATLLPN-WKVnvdvdSNIITAIVQLhGLWMDCTWYS-TGMFSCalkhSILSLPIHVQAARA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPDqWKV-----SRYVGAAASA-GLWRNCTTQScTGQISC----KVLELNDALQAVQA 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47716519    83 TMVLACVLSALGICTSTVGMKCTRLGGDretkshaSFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPEsNKHEPGG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGR-------FKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPN-RKYSFGY 143
                         170
                  ....*....|....*....
gi 47716519   163 AIYIGFISAMLLFISGMIF 181
Cdd:pfam00822 144 SFILGWVAFALAFIGGVLY 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH