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Conserved domains on  [gi|319803058|ref|NP_001002460|]
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uncharacterized protein LOC436733 [Danio rerio]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PssE super family cl49515
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-159 5.72e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


The actual alignment was detected with superfamily member NF041548:

Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 119.17  E-value: 5.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   4 VFVTVGTTSFDDLIDTVtsDESVKALIQRGFTgvnLQVGRGSVvpDPESCPGlklqvFRFKDSIAEDMRHSDLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI--DELIEGLIDYEVT---FQIGDGKY--IPKNGEY-----FDFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 319803058  84 GSCLEALGANKPLLVVVNDKLMDNHQLELARQLQADSHLIYCT-CSTLPQTLREMDLTTLRPFAPgEPQNFAKFLDK 159
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPYEK-NPFFIADEIID 144
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-159 5.72e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 119.17  E-value: 5.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   4 VFVTVGTTSFDDLIDTVtsDESVKALIQRGFTgvnLQVGRGSVvpDPESCPGlklqvFRFKDSIAEDMRHSDLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI--DELIEGLIDYEVT---FQIGDGKY--IPKNGEY-----FDFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 319803058  84 GSCLEALGANKPLLVVVNDKLMDNHQLELARQLQADSHLIYCT-CSTLPQTLREMDLTTLRPFAPgEPQNFAKFLDK 159
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPYEK-NPFFIADEIID 144
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 3-158 4.11e-34

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 117.81  E-value: 4.11e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058    3 TVFVTVGTTSFDDLIDTVTSDESVKALiqRGFTGVNLQVGRGSVVPDPESCPGLKLQV--FRFKDSIAEDMRHSDLVISH 80
Cdd:pfam04101   1 TILVTGGSQGARALNELVLSVLPLLEL--KGELQVLHQTGKGDLEEVKIDYAELGINYevFPFIDNMAEYIKAADLVISR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   81 AGAGSCLEALGANKPLLVVVNDK----LMDNHQLELARQLQADSHLIYC-TCSTLPQTLREMDLTTLRPFAPGEPQNFAK 155
Cdd:pfam04101  79 AGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKElTPEKLIEALLKLLLNPLRLAEMAKASKASG 158


                  ...
gi 319803058  156 FLD 158
Cdd:pfam04101 159 FKD 161
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
4-162 2.44e-18

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 76.89  E-value: 2.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   4 VFVTVGTT--SFDDLIdtvtsdESVKALIQRGFTG--VNLQVGRGSVVPDpescpglKLQVFRF--KDSIAEDMRHSDLV 77
Cdd:COG5017    2 IFVTVGTHqlPFDRLV------RWVDELAAEGIIDeeVFVQTGHTTYVPR-------NAEAVPFlpPDEFQKLIAQARLV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058  78 ISHAGAGSCLEALGANKPLLVVVNDKL----MDNHQLELARQLqADSHLIYCTCST--LPQTLRE-MDLTTLRPFAPGEP 150
Cdd:COG5017   69 ISHAGMGSILTALKLGKPFILVPRLARygehVDDHQLETARAL-EKLGGIIVVEDPadLEAALDEaLALKSPEPFSVPSP 147

                        170
                 ....*....|....
gi 319803058 151 QN--FAKFLDKAVG 162
Cdd:COG5017  148 ARgaLVDFLRAFIT 161
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 24-116 4.95e-08

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 51.06  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058  24 ESVKALIQRGFTgVNLQVGRGSVVPDPESCPGL--KLQVFRFKDSIAEDMRHSDLVISHAGAGSCLEALGANKPLLVVVN 101
Cdd:cd03785  202 KALPKLLERGIQ-VIHQTGKGDYDEVKKLYEDLgiNVKVFPFIDDMAAAYAAADLVISRAGASTIAELTAAGKPAILIPY 280

                         90
                 ....*....|....*
gi 319803058 102 DKLMDNHQLELARQL 116
Cdd:cd03785  281 PYAADDHQEANARAL 295
murG PRK00726
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
 54-116 4.26e-03

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional


Pssm-ID: 234825 [Multi-domain]  Cd Length: 357  Bit Score: 36.65  E-value: 4.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 319803058  54 PGLKLQVFRFKDSIAEDMRHSDLVISHAGAGSCLE--ALGanKP-LLV---VVNdklmDNHQLELARQL 116
Cdd:PRK00726 233 AGINAEVVPFIDDMAAAYAAADLVICRAGASTVAElaAAG--LPaILVplpHAA----DDHQTANARAL 295
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 73-99 8.36e-03

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 35.82  E-value: 8.36e-03
                          10        20
                  ....*....|....*....|....*..
gi 319803058   73 HSDLVISHAGAGSCLEALGANKPLLVV 99
Cdd:TIGR01426 291 KADAFITHGGMNSTMEALFNGVPMVAV 317
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-159 5.72e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 119.17  E-value: 5.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   4 VFVTVGTTSFDDLIDTVtsDESVKALIQRGFTgvnLQVGRGSVvpDPESCPGlklqvFRFKDSIAEDMRHSDLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI--DELIEGLIDYEVT---FQIGDGKY--IPKNGEY-----FDFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 319803058  84 GSCLEALGANKPLLVVVNDKLMDNHQLELARQLQADSHLIYCT-CSTLPQTLREMDLTTLRPFAPgEPQNFAKFLDK 159
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPYEK-NPFFIADEIID 144
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 3-158 4.11e-34

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 117.81  E-value: 4.11e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058    3 TVFVTVGTTSFDDLIDTVTSDESVKALiqRGFTGVNLQVGRGSVVPDPESCPGLKLQV--FRFKDSIAEDMRHSDLVISH 80
Cdd:pfam04101   1 TILVTGGSQGARALNELVLSVLPLLEL--KGELQVLHQTGKGDLEEVKIDYAELGINYevFPFIDNMAEYIKAADLVISR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   81 AGAGSCLEALGANKPLLVVVNDK----LMDNHQLELARQLQADSHLIYC-TCSTLPQTLREMDLTTLRPFAPGEPQNFAK 155
Cdd:pfam04101  79 AGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKElTPEKLIEALLKLLLNPLRLAEMAKASKASG 158


                  ...
gi 319803058  156 FLD 158
Cdd:pfam04101 159 FKD 161
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
4-162 2.44e-18

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 76.89  E-value: 2.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   4 VFVTVGTT--SFDDLIdtvtsdESVKALIQRGFTG--VNLQVGRGSVVPDpescpglKLQVFRF--KDSIAEDMRHSDLV 77
Cdd:COG5017    2 IFVTVGTHqlPFDRLV------RWVDELAAEGIIDeeVFVQTGHTTYVPR-------NAEAVPFlpPDEFQKLIAQARLV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058  78 ISHAGAGSCLEALGANKPLLVVVNDKL----MDNHQLELARQLqADSHLIYCTCST--LPQTLRE-MDLTTLRPFAPGEP 150
Cdd:COG5017   69 ISHAGMGSILTALKLGKPFILVPRLARygehVDDHQLETARAL-EKLGGIIVVEDPadLEAALDEaLALKSPEPFSVPSP 147

                        170
                 ....*....|....
gi 319803058 151 QN--FAKFLDKAVG 162
Cdd:COG5017  148 ARgaLVDFLRAFIT 161
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
2-118 1.12e-09

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 55.25  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   2 KTVFVTVGTTSFD--DLIDTVtsdesVKALIQRGFTGVnLQVGR---GSVVPDPEScpglklqvFRFKDSI--AEDMRHS 74
Cdd:COG1819  121 PLVYVTLGTSANDraDLLRAV-----LEALADLGVRVV-VTTGGldpAELGPLPDN--------VRVVDYVpqDALLPRA 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 319803058  75 DLVISHAGAGSCLEALGANKPLLVV--VNDklmdnhQLELARQLQA 118
Cdd:COG1819  187 DAVVHHGGAGTTAEALRAGVPQVVVpfGGD------QPLNAARVER 226
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 24-116 4.95e-08

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 51.06  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058  24 ESVKALIQRGFTgVNLQVGRGSVVPDPESCPGL--KLQVFRFKDSIAEDMRHSDLVISHAGAGSCLEALGANKPLLVVVN 101
Cdd:cd03785  202 KALPKLLERGIQ-VIHQTGKGDYDEVKKLYEDLgiNVKVFPFIDDMAAAYAAADLVISRAGASTIAELTAAGKPAILIPY 280

                         90
                 ....*....|....*
gi 319803058 102 DKLMDNHQLELARQL 116
Cdd:cd03785  281 PYAADDHQEANARAL 295
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 59-118 1.52e-05

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 43.58  E-value: 1.52e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058  59 QVFRFKDSIAEDMRHSDLVISHAGAGSCLEALGANKPLLVVVNDKLMDNHQLELARQLQA 118
Cdd:COG0707  244 EVFPFIDDMADAYAAADLVISRAGASTVAELAALGKPAILVPLPHAADDHQTKNARALVE 303
COG4671 COG4671
Predicted glycosyl transferase [General function prediction only];
2-99 7.70e-04

Predicted glycosyl transferase [General function prediction only];


Pssm-ID: 443708 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 7.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803058   2 KTVFVTVGTTSF-DDLIDTV------TSDESVKALIqrgFTGVNLQVG-RGSVVPDPESCPGLklQVFRFKDSIAEDMRH 73
Cdd:COG4671  217 PLILVSAGGGGDgAELLEAAlaaaelLPPPDHRWLL---VTGPFMPAAdRAALRARAAALPNV--TVERFTPDFEALLAA 291

                         90       100
                 ....*....|....*....|....*.
gi 319803058  74 SDLVISHAGAGSCLEALGANKPLLVV 99
Cdd:COG4671  292 ADLSVSMGGYNTVCEILSTGKPALIV 317
murG PRK00726
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
 54-116 4.26e-03

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional


Pssm-ID: 234825 [Multi-domain]  Cd Length: 357  Bit Score: 36.65  E-value: 4.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 319803058  54 PGLKLQVFRFKDSIAEDMRHSDLVISHAGAGSCLE--ALGanKP-LLV---VVNdklmDNHQLELARQL 116
Cdd:PRK00726 233 AGINAEVVPFIDDMAAAYAAADLVICRAGASTVAElaAAG--LPaILVplpHAA----DDHQTANARAL 295
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 75-99 5.38e-03

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 36.38  E-value: 5.38e-03
                         10        20
                 ....*....|....*....|....*
gi 319803058  75 DLVISHAGAGSCLEALGANKPLLVV 99
Cdd:cd03784  309 GAFVTHGGWNSTLEALYAGVPMVVV 333
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 73-99 8.36e-03

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 35.82  E-value: 8.36e-03
                          10        20
                  ....*....|....*....|....*..
gi 319803058   73 HSDLVISHAGAGSCLEALGANKPLLVV 99
Cdd:TIGR01426 291 KADAFITHGGMNSTMEALFNGVPMVAV 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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