NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|50657368|ref|NP_001002818|]
View 

FK506-binding protein-like [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
212-336 4.53e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 4.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLTLPPpgppertiLHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG0457  12 NNLGLAYRRLGRYEEAIEDYEKALELDPDDAE--------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQGKIQDA 336
Cdd:COG0457  84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEA 129
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
212-336 4.53e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 4.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLTLPPpgppertiLHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG0457  12 NNLGLAYRRLGRYEEAIEDYEKALELDPDDAE--------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQGKIQDA 336
Cdd:COG0457  84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEA 129
TPR_1 pfam00515
Tetratricopeptide repeat;
285-317 3.60e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 43.18  E-value: 3.60e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 50657368   285 KALYRRGVAQAALGDLDKATADLKKVLAVDPKN 317
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 260-321 2.57e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 45.31  E-value: 2.57e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50657368 260 QLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAK 321
Cdd:cd24142  10 LLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 285-317 5.20e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 5.20e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 50657368    285 KALYRRGVAQAALGDLDKATADLKKVLAVDPKN 317
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 252-330 3.08e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368   252 LHANLAACQLLLGHPQL--AAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVI 329
Cdd:TIGR02917 159 LYAKLGLAQLALAENRFdeARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILI 238


                  .
gi 50657368   330 Q 330
Cdd:TIGR02917 239 E 239
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
212-336 4.53e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 4.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLTLPPpgppertiLHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG0457  12 NNLGLAYRRLGRYEEAIEDYEKALELDPDDAE--------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQGKIQDA 336
Cdd:COG0457  84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEA 129
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 198-336 4.78e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 4.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 198 ELEAVEKEALAKEEHRRGTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVL 277
Cdd:COG3914  68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNP--------DNAEALFNLGNLLLALGRLEEALAALRRAL 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 278 EREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVI-QGKIQDA 336
Cdd:COG3914 140 ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQdLGRLEEA 199
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
212-336 1.06e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.87  E-value: 1.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG0457  46 YNLGLAYLRLGRYEEALADYEQALELDP--------DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLG 117

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVI-QGKIQDA 336
Cdd:COG0457 118 LALLELGRYDEAIEAYERALELDPDDADALYNLGIALEkLGRYEEA 163
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 215-320 6.26e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 6.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 215 GTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQ 294
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALALNP--------DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAL 190

                        90       100
                ....*....|....*....|....*.
gi 50657368 295 AALGDLDKATADLKKVLAVDPKNRAA 320
Cdd:COG3914 191 QDLGRLEEAIAAYRRALELDPDNADA 216
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
207-320 6.67e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 61.47  E-value: 6.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 207 LAKEEHRRGTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKA 286
Cdd:COG4785  72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDP--------DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143

                        90       100       110
                ....*....|....*....|....*....|....
gi 50657368 287 LYRRGVAQAALGDLDKATADLKKVLAVDPKNRAA 320
Cdd:COG4785 144 YLNRGIALYYLGRYELAIADLEKALELDPNDPER 177
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 218-320 1.17e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.48  E-value: 1.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 218 LFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAAL 297
Cdd:COG4235  27 YLRLGRYDEALAAYEKALRLDP--------DNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98

                        90       100
                ....*....|....*....|...
gi 50657368 298 GDLDKATADLKKVLAVDPKNRAA 320
Cdd:COG4235  99 GDYAEAIAAWQKLLALLPADAPA 121
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
253-336 3.42e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 3.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 253 HANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQG 331
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAlQALG 90


                ....*
gi 50657368 332 KIQDA 336
Cdd:COG0457  91 RYEEA 95
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 205-336 9.13e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.35  E-value: 9.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 205 EALAKEEHRRGTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHL 284
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDP--------DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 50657368 285 KALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVIQ-GKIQDA 336
Cdd:COG4783  73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRAlGRPDEA 125
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 253-336 4.16e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 4.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 253 HANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQG 331
Cdd:COG4235  20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99


                ....*
gi 50657368 332 KIQDA 336
Cdd:COG4235 100 DYAEA 104
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 182-315 2.66e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.66  E-value: 2.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 182 LAKLRLDSFTNGRDSWELEAVEKEALAKEEHRRGTELFRAGNPQGAARCYGRALRLLLTLPPpgppertiLHANLAACQL 261
Cdd:COG5010  28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE--------LYYNLALLYS 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 50657368 262 LLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDP 315
Cdd:COG5010 100 RSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
212-320 6.99e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 6.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG0457  80 NNLGLALQALGRYEEALEDYDKALELDP--------DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLG 151

                        90       100
                ....*....|....*....|....*....
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKNRAA 320
Cdd:COG0457 152 IALEKLGRYEEALELLEKLEAAALAALLA 180
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 217-336 8.93e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.11  E-value: 8.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 217 ELFRAGNPQGAARCYGRALRLLLTLPPPGPPERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAA 296
Cdd:COG5010  21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSR 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 50657368 297 LGDLDKATADLKKVLAVDPKNRAAKEELGKVVI-QGKIQDA 336
Cdd:COG5010 101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLsLGQDDEA 141
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 217-322 1.03e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.60  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 217 ELFRAGNPQGAARCYGRALRLLLTLPPPGPPertilHANLAACQLLLGHPQLAAQSCDRVLEREPGHLK---ALYRRGVA 293
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPDA-----LYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLS 76

                        90       100
                ....*....|....*....|....*....
gi 50657368 294 QAALGDLDKATADLKKVLAVDPKNRAAKE 322
Cdd:COG1729  77 YLELGDYDKARATLEELIKKYPDSEAAKE 105
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
181-320 1.24e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.84  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 181 PLAKLRLDSFTNGRDSWELEAVEKEALAKEEHRRGTELFRAGNPQGAARCYGRALRLLLTLPPPGPPERTILHANLAACQ 260
Cdd:COG4785   4 LALALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAY 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 261 LLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAA 320
Cdd:COG4785  84 DSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 212-317 3.81e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.65  E-value: 3.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG4783  42 ALLGEILLQLGDLDEAIVLLHEALELDP--------DEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLA 113

                        90       100
                ....*....|....*....|....*.
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKN 317
Cdd:COG4783 114 RAYRALGRPDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
218-319 4.54e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.47  E-value: 4.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 218 LFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQlAAQSCDRVLEREPGHLKALYRRGVAQAAL 297
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDP--------DNADALNNLGLLLLEQGRYD-EAIALEKALKLDPNNAEALLNLAELLLEL 72

                        90       100
                ....*....|....*....|..
gi 50657368 298 GDLDKATADLKKVLAVDPKNRA 319
Cdd:COG3063  73 GDYDEALAYLERALELDPSALR 94
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 218-336 5.58e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 5.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 218 LFRAGNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAAL 297
Cdd:COG2956 120 YEQEGDWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQ 191

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 50657368 298 GDLDKATADLKKVLAVDPKNRAAKEELGKVVIQ-GKIQDA 336
Cdd:COG2956 192 GDYEEAIAALERALEQDPDYLPALPRLAELYEKlGDPEEA 231
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
259-336 5.97e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.09  E-value: 5.97e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50657368 259 CQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKAtADLKKVLAVDPKNRAAKEELGKVVI-QGKIQDA 336
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLeLGDYDEA 78
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 212-339 2.49e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 2.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 212 HRRGTELFRAGNPQGAARCYGRALRLLLTLPPpgppertiLHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRG 291
Cdd:COG2956 148 CELAELYLEQGDYDEAIEALEKALKLDPDCAR--------ALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLA 219

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 50657368 292 VAQAALGDLDKATADLKKVLAVDPKNrAAKEELGKVVIQGKIQDAGLA 339
Cdd:COG2956 220 ELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALA 266
TPR_1 pfam00515
Tetratricopeptide repeat;
285-317 3.60e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 43.18  E-value: 3.60e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 50657368   285 KALYRRGVAQAALGDLDKATADLKKVLAVDPKN 317
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 252-336 4.66e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 4.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 252 LHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVIQ- 330
Cdd:COG2956  44 AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQe 123


                ....*.
gi 50657368 331 GKIQDA 336
Cdd:COG2956 124 GDWEKA 129
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 260-321 2.57e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 45.31  E-value: 2.57e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50657368 260 QLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAK 321
Cdd:cd24142  10 LLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 269-336 4.12e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 4.12e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50657368 269 AAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQGKIQDA 336
Cdd:COG4235   2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEAlLAAGDTEEA 70
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 217-336 4.65e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 4.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 217 ELFRA-GNPQGAARCYGRALRLLLtlpppgppERTILHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQA 295
Cdd:COG2956  50 NLYRRrGEYDRAIRIHQKLLERDP--------DRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYE 121

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 50657368 296 ALGDLDKATADLKKVLAVDPKNRAAKEELGKVVI-QGKIQDA 336
Cdd:COG2956 122 QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLeQGDYDEA 163
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 285-317 5.20e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 5.20e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 50657368    285 KALYRRGVAQAALGDLDKATADLKKVLAVDPKN 317
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
277-336 2.80e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 2.80e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50657368 277 LEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQGKIQDA 336
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAyLRLGRYEEA 61
TPR_19 pfam14559
Tetratricopeptide repeat;
264-327 4.58e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.95  E-value: 4.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50657368   264 GHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV 327
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLAKL 65
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
257-325 5.01e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 5.01e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50657368 257 AACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELG 325
Cdd:COG4785  46 LALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRG 114
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 285-316 1.59e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 1.59e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 50657368   285 KALYRRGVAQAALGDLDKATADLKKVLAVDPK 316
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
TPR_9 pfam13371
Tetratricopeptide repeat;
264-320 2.01e-03

Tetratricopeptide repeat;


Pssm-ID: 463860 [Multi-domain]  Cd Length: 73  Bit Score: 36.43  E-value: 2.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 50657368   264 GHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAA 320
Cdd:pfam13371   9 EDWERALAVVERLLLLAPDDPEERRDRGLLYAQLGCFQAALEDLEAYLELAPDAPDA 65
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 252-330 3.08e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368   252 LHANLAACQLLLGHPQL--AAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVI 329
Cdd:TIGR02917 159 LYAKLGLAQLALAENRFdeARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILI 238


                  .
gi 50657368   330 Q 330
Cdd:TIGR02917 239 E 239
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 261-340 3.99e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 3.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368 261 LLLGHPQLAAQSCDRVLEREPGHL---KALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELGKV-VIQGKIQDA 336
Cdd:COG1729   4 LKAGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLgLSYLELGDY 83


                ....
gi 50657368 337 GLAR 340
Cdd:COG1729  84 DKAR 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 256-325 5.97e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 5.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368   256 LAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGDLDKATADLKKVLAVDPKNRAAKEELG 325
Cdd:TIGR02917 335 LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLG 404
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 214-337 8.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50657368   214 RGTELFRAGNPQGAARCYGRALRLLLTLPPPgppertilHANLAACQLLLGHPQLAAQSCDRVLEREPGHLKALYRRGVA 293
Cdd:TIGR02917 199 KGDLLLSLGNIELALAAYRKAIALRPNNIAV--------LLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALV 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 50657368   294 QAALGDLDKATADLKKVLAVDPKNRAAKEELGKVVIQ-GKIQDAG 337
Cdd:TIGR02917 271 DFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQlGNLEQAY 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH