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Conserved domains on  [gi|152963637|ref|NP_001002836|]
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zinc finger protein 787 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
67-200 1.60e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963637  67 ICNECGKSFSHwSKLTRHQRTHTGER-----PNACADCGKTFSQSSHLVQHRR--IHTGE--KPYACLE--CGKRFSWSS 135
Cdd:COG5048  259 ESPRSSLPTAS-SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 152963637 136 NLMQHQRIHTGEKPYTCPDCGRSFTQSKSLAK-------HRRSHSGLKPFVC--PRCGRGFSQPKSLARHLRLH 200
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
67-200 1.60e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963637  67 ICNECGKSFSHwSKLTRHQRTHTGER-----PNACADCGKTFSQSSHLVQHRR--IHTGE--KPYACLE--CGKRFSWSS 135
Cdd:COG5048  259 ESPRSSLPTAS-SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 152963637 136 NLMQHQRIHTGEKPYTCPDCGRSFTQSKSLAK-------HRRSHSGLKPFVC--PRCGRGFSQPKSLARHLRLH 200
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-161 1.26e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.26e-06
                          10        20
                  ....*....|....*....|....*.
gi 152963637  136 NLMQHQRIHTGEKPYTCPDCGRSFTQ 161
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 149-197 5.10e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 5.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 152963637 149 PYTCPDCGRSFTQSKSLAKHRRSHSGLKpfVCPRCGRGFSQPKSLARHL 197
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
ZnF_C2H2 smart00355
zinc finger;
66-88 4.54e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 4.54e-03
                           10        20
                   ....*....|....*....|...
gi 152963637    66 YICNECGKSFSHWSKLTRHQRTH 88
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
67-200 1.60e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963637  67 ICNECGKSFSHwSKLTRHQRTHTGER-----PNACADCGKTFSQSSHLVQHRR--IHTGE--KPYACLE--CGKRFSWSS 135
Cdd:COG5048  259 ESPRSSLPTAS-SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 152963637 136 NLMQHQRIHTGEKPYTCPDCGRSFTQSKSLAK-------HRRSHSGLKPFVC--PRCGRGFSQPKSLARHLRLH 200
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-161 1.26e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.26e-06
                          10        20
                  ....*....|....*....|....*.
gi 152963637  136 NLMQHQRIHTGEKPYTCPDCGRSFTQ 161
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 66-88 1.44e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.52  E-value: 1.44e-05
                          10        20
                  ....*....|....*....|...
gi 152963637   66 YICNECGKSFSHWSKLTRHQRTH 88
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
66-173 2.40e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963637  66 YICNECGKSFSHWSKLTRHQRTHTGERPNACADCGktfsqsshlvqhrrihtgekpyacleCGKRFSWSSNLMQHQRIHT 145
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRTHH 87

                         90       100
                 ....*....|....*....|....*...
gi 152963637 146 GEKPYTCPDCGRSFTQSKSLAKHRRSHS 173
Cdd:COG5048   88 NNPSDLNSKSLPLSNSKASSSSLSSSSS 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
108-132 3.60e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.60e-05
                          10        20
                  ....*....|....*....|....*
gi 152963637  108 HLVQHRRIHTGEKPYACLECGKRFS 132
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-208 4.80e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963637 120 KPYACLECGKRFSWSSNLMQHQRIHTGEKPYTCPDCGR--SFTQSKSLAKHRRSHSGLKPFVCprcgrgfSQPKSLARHL 197
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLN-------SKSLPLSNSK 104

                         90
                 ....*....|.
gi 152963637 198 RLHPELSGPGV 208
Cdd:COG5048  105 ASSSSLSSSSS 115
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 150-172 1.51e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.51e-04
                          10        20
                  ....*....|....*....|...
gi 152963637  150 YTCPDCGRSFTQSKSLAKHRRSH 172
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 149-197 5.10e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 5.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 152963637 149 PYTCPDCGRSFTQSKSLAKHRRSHSGLKpfVCPRCGRGFSQPKSLARHL 197
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 96-116 1.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|.
gi 152963637   96 CADCGKTFSQSSHLVQHRRIH 116
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 121-168 1.80e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 1.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 152963637 121 PYACLECGKRFSWSSNLMQHQRIHTGEKpyTCPDCGRSFTQSKSLAKH 168
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
81-105 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 152963637   81 LTRHQRTHTGERPNACADCGKTFSQ 105
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 178-200 3.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|...
gi 152963637  178 FVCPRCGRGFSQPKSLARHLRLH 200
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
66-88 4.54e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 4.54e-03
                           10        20
                   ....*....|....*....|...
gi 152963637    66 YICNECGKSFSHWSKLTRHQRTH 88
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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