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Conserved domains on  [gi|51010919|ref|NP_001003418|]
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NADH:ubiquinone oxidoreductase subunit AB1a [Danio rerio]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein functions as the carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Ontology:  GO:0009245|GO:0000036|GO:0000035
PubMed:  20662770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 92-152 8.50e-24

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 88.30  E-value: 8.50e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51010919   92 INPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKKE 152
Cdd:PRK00982  18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 92-152 8.50e-24

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 88.30  E-value: 8.50e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51010919   92 INPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKKE 152
Cdd:PRK00982  18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 77-151 5.10e-22

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 83.60  E-value: 5.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51010919    77 TVHERVLYVLKLYDKINPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKK 151
Cdd:TIGR00517   3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 91-151 3.80e-19

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 76.43  E-value: 3.80e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51010919  91 KINPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKK 151
Cdd:COG0236  19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 91-142 2.20e-08

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.94  E-value: 2.20e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 51010919    91 KINPEKLQVTSHFMkDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQ 142
Cdd:pfam00550  12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 105-150 1.95e-03

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 35.30  E-value: 1.95e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 51010919    105 KDLGLDSLDQVEIIMAMEDEFGFEIPdedAEKLM---TPEQVVQYIAEK 150
Cdd:smart00823  40 RDLGLDSLMAVELRNRLEAATGLRLP---ATLVFdhpTPAALAEHLAAE 85
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 92-152 8.50e-24

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 88.30  E-value: 8.50e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51010919   92 INPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKKE 152
Cdd:PRK00982  18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 73-151 1.36e-22

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 87.06  E-value: 1.36e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51010919   73 LTLKTVHERVLYVLKLYDKINPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKK 151
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNN 144
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 77-151 5.10e-22

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 83.60  E-value: 5.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51010919    77 TVHERVLYVLKLYDKINPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKK 151
Cdd:TIGR00517   3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
acpP CHL00124
acyl carrier protein; Validated
 92-151 3.04e-21

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 81.99  E-value: 3.04e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 51010919   92 INPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKK 151
Cdd:CHL00124  20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKI 79
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 91-151 3.80e-19

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 76.43  E-value: 3.80e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51010919  91 KINPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEKK 151
Cdd:COG0236  19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PRK12449 PRK12449
acyl carrier protein; Provisional
 73-151 3.81e-12

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 58.18  E-value: 3.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51010919   73 LTLKTVHERVLYVLKlyDKINPEKLQVT--SHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQVVQYIAEK 150
Cdd:PRK12449   1 MTREEIFERLINLIQ--KQRSYLSLAITeqTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQR 78


                 .
gi 51010919  151 K 151
Cdd:PRK12449  79 L 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 91-142 2.20e-08

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.94  E-value: 2.20e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 51010919    91 KINPEKLQVTSHFMkDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMTPEQ 142
Cdd:pfam00550  12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK06508 PRK06508
acyl carrier protein; Provisional
 90-132 1.25e-07

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 46.73  E-value: 1.25e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 51010919   90 DKINPEklqvtSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDE 132
Cdd:PRK06508  21 DTITPE-----SHTIDDLGIDSLDFLDIVFAIDKAFGIKLPLE 58
PRK05828 PRK05828
acyl carrier protein; Validated
 104-153 3.11e-05

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 40.24  E-value: 3.11e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 51010919  104 MKDLGLDSLDQVEIIMAMEDEFGFEIPDedaEKLMTPEQVVQYIAEKKEV 153
Cdd:PRK05828  32 YRELKIDSLDMFSIIVSLESEFNIEFSD---EKLMKLKNLADLILEVKEL 78
PRK07081 PRK07081
acyl carrier protein; Provisional
 106-132 5.30e-05

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 39.56  E-value: 5.30e-05
                         10        20
                 ....*....|....*....|....*..
gi 51010919  106 DLGLDSLDQVEIIMAMEDEFGFEIPDE 132
Cdd:PRK07081  30 EAGLSSLATVQLMLAIEDAFDIEIPDE 56
PRK08172 PRK08172
acyl carrier protein;
78-139 1.38e-03

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 35.63  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51010919   78 VHERVLYVLKLYDKINPEKLQVTSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDEDAEKLMT 139
Cdd:PRK08172   5 IEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTT 66
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 105-150 1.95e-03

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 35.30  E-value: 1.95e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 51010919    105 KDLGLDSLDQVEIIMAMEDEFGFEIPdedAEKLM---TPEQVVQYIAEK 150
Cdd:smart00823  40 RDLGLDSLMAVELRNRLEAATGLRLP---ATLVFdhpTPAALAEHLAAE 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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