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fibulin-2 isoform a precursor [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
ANATO | cd00017 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
430-490 | 1.63e-09 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins. : Pssm-ID: 237984 Cd Length: 70 Bit Score: 55.16 E-value: 1.63e-09
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
1072-1106 | 2.55e-07 | ||
Calcium-binding EGF domain; : Pssm-ID: 429571 Cd Length: 32 Bit Score: 48.00 E-value: 2.55e-07
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ANATO | cd00017 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
515-563 | 3.34e-07 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins. : Pssm-ID: 237984 Cd Length: 70 Bit Score: 48.61 E-value: 3.34e-07
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
616-644 | 9.98e-07 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 9.98e-07
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
905-947 | 1.37e-06 | ||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.09 E-value: 1.37e-06
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
811-846 | 1.67e-06 | ||
Calcium-binding EGF domain; : Pssm-ID: 429571 Cd Length: 32 Bit Score: 45.69 E-value: 1.67e-06
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
857-904 | 5.95e-06 | ||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 44.16 E-value: 5.95e-06
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
960-988 | 4.86e-05 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 41.46 E-value: 4.86e-05
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
1011-1032 | 7.18e-05 | ||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. : Pssm-ID: 463661 Cd Length: 22 Bit Score: 40.86 E-value: 7.18e-05
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
766-801 | 1.38e-04 | ||
Calcium-binding EGF domain; : Pssm-ID: 429571 Cd Length: 32 Bit Score: 40.30 E-value: 1.38e-04
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
685-717 | 1.41e-03 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 37.22 E-value: 1.41e-03
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
719-746 | 2.51e-03 | ||
Calcium-binding EGF domain; : Pssm-ID: 429571 Cd Length: 32 Bit Score: 36.45 E-value: 2.51e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1029-1071 | 2.72e-03 | ||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 36.84 E-value: 2.72e-03
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Name | Accession | Description | Interval | E-value | ||
ANATO | cd00017 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
430-490 | 1.63e-09 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins. Pssm-ID: 237984 Cd Length: 70 Bit Score: 55.16 E-value: 1.63e-09
|
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
1072-1106 | 2.55e-07 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 48.00 E-value: 2.55e-07
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ANATO | cd00017 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
515-563 | 3.34e-07 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins. Pssm-ID: 237984 Cd Length: 70 Bit Score: 48.61 E-value: 3.34e-07
|
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
616-644 | 9.98e-07 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 9.98e-07
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
905-947 | 1.37e-06 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.09 E-value: 1.37e-06
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
811-846 | 1.67e-06 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 45.69 E-value: 1.67e-06
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
905-938 | 5.92e-06 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.16 E-value: 5.92e-06
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
857-904 | 5.95e-06 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 44.16 E-value: 5.95e-06
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
960-988 | 4.86e-05 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 41.46 E-value: 4.86e-05
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
905-936 | 6.17e-05 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 41.07 E-value: 6.17e-05
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
948-989 | 6.47e-05 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 6.47e-05
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
1011-1032 | 7.18e-05 | ||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 40.86 E-value: 7.18e-05
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
766-801 | 1.38e-04 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 40.30 E-value: 1.38e-04
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
857-895 | 2.11e-04 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.93 E-value: 2.11e-04
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
766-802 | 2.54e-04 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 39.54 E-value: 2.54e-04
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ANATO | smart00104 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
445-480 | 3.41e-04 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. Pssm-ID: 197517 Cd Length: 35 Bit Score: 39.24 E-value: 3.41e-04
|
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
857-884 | 5.79e-04 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 38.37 E-value: 5.79e-04
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
948-989 | 1.00e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.00e-03
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
604-644 | 1.09e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 1.09e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
811-847 | 1.25e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 1.25e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1072-1107 | 1.34e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 1.34e-03
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
685-717 | 1.41e-03 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 37.22 E-value: 1.41e-03
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
766-805 | 2.22e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.85 E-value: 2.22e-03
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
719-746 | 2.51e-03 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 36.45 E-value: 2.51e-03
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
804-842 | 2.56e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 40.83 E-value: 2.56e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1029-1071 | 2.72e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 36.84 E-value: 2.72e-03
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ANATO | smart00104 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
521-553 | 2.77e-03 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. Pssm-ID: 197517 Cd Length: 35 Bit Score: 36.54 E-value: 2.77e-03
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ANATO | pfam01821 | Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ... |
445-480 | 2.81e-03 | ||
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. Pssm-ID: 460347 Cd Length: 36 Bit Score: 36.48 E-value: 2.81e-03
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
604-644 | 6.37e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 35.69 E-value: 6.37e-03
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
717-759 | 7.06e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 39.68 E-value: 7.06e-03
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Name | Accession | Description | Interval | E-value | ||
ANATO | cd00017 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
430-490 | 1.63e-09 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins. Pssm-ID: 237984 Cd Length: 70 Bit Score: 55.16 E-value: 1.63e-09
|
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
1072-1106 | 2.55e-07 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 48.00 E-value: 2.55e-07
|
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ANATO | cd00017 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
515-563 | 3.34e-07 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins. Pssm-ID: 237984 Cd Length: 70 Bit Score: 48.61 E-value: 3.34e-07
|
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
616-644 | 9.98e-07 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 9.98e-07
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
905-947 | 1.37e-06 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.09 E-value: 1.37e-06
|
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
811-846 | 1.67e-06 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 45.69 E-value: 1.67e-06
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
905-938 | 5.92e-06 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.16 E-value: 5.92e-06
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
857-904 | 5.95e-06 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 44.16 E-value: 5.95e-06
|
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
960-988 | 4.86e-05 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 41.46 E-value: 4.86e-05
|
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
905-936 | 6.17e-05 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 41.07 E-value: 6.17e-05
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
948-989 | 6.47e-05 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 6.47e-05
|
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
1011-1032 | 7.18e-05 | ||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 40.86 E-value: 7.18e-05
|
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
999-1027 | 9.01e-05 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 40.69 E-value: 9.01e-05
|
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
766-801 | 1.38e-04 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 40.30 E-value: 1.38e-04
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
857-895 | 2.11e-04 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.93 E-value: 2.11e-04
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
766-802 | 2.54e-04 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 39.54 E-value: 2.54e-04
|
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ANATO | smart00104 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
445-480 | 3.41e-04 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. Pssm-ID: 197517 Cd Length: 35 Bit Score: 39.24 E-value: 3.41e-04
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
857-884 | 5.79e-04 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 38.37 E-value: 5.79e-04
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
948-989 | 1.00e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.00e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
604-644 | 1.09e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 1.09e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
811-847 | 1.25e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 1.25e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1072-1107 | 1.34e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 1.34e-03
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
685-717 | 1.41e-03 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 37.22 E-value: 1.41e-03
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
946-986 | 1.72e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 41.22 E-value: 1.72e-03
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
972-993 | 1.75e-03 | ||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 36.62 E-value: 1.75e-03
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
766-805 | 2.22e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.85 E-value: 2.22e-03
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
719-746 | 2.51e-03 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 36.45 E-value: 2.51e-03
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
804-842 | 2.56e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 40.83 E-value: 2.56e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1029-1071 | 2.72e-03 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 36.84 E-value: 2.72e-03
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ANATO | smart00104 | Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ... |
521-553 | 2.77e-03 | ||
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. Pssm-ID: 197517 Cd Length: 35 Bit Score: 36.54 E-value: 2.77e-03
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ANATO | pfam01821 | Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ... |
445-480 | 2.81e-03 | ||
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins. Pssm-ID: 460347 Cd Length: 36 Bit Score: 36.48 E-value: 2.81e-03
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
903-937 | 3.85e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 40.45 E-value: 3.85e-03
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
604-644 | 6.37e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 35.69 E-value: 6.37e-03
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
811-847 | 6.43e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 35.69 E-value: 6.43e-03
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
717-759 | 7.06e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 39.68 E-value: 7.06e-03
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Blast search parameters | ||||
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