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Conserved domains on  [gi|51948382|ref|NP_001004205|]
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RILP-like protein 2 [Rattus norvegicus]

Protein Classification

RILP-like and RILP domain-containing protein( domain architecture ID 10199244)

RILP-like and RILP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RILP pfam11461
Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil ...
 123-189 4.08e-26

Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.


:

Pssm-ID: 463282 [Multi-domain]  Cd Length: 69  Bit Score: 95.35  E-value: 4.08e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51948382   123 TLQELRDVLQERNKLKSQLLLVQEELQCYRSGLLPPRETPGGRREKDAMVTMGNG--EKEERTIMKKLF 189
Cdd:pfam11461   1 TLQELRDVLQERNELKAQLFLLQEELAYYKSGLLNEEEIPSLRLESPSPRTKPQRskIKQEESGIKRLF 69
RILP-like cd14445
Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in ...
 18-95 8.50e-24

Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.


:

Pssm-ID: 271220 [Multi-domain]  Cd Length: 89  Bit Score: 89.96  E-value: 8.50e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51948382  18 ALAKSPLQLTTEDVYDISYVVGRELMALGS---DPRVTRLQFKIVRVMEMLEALVNEGS---LAVEELRMERDNLKQEVE 91
Cdd:cd14445   5 ALDKSPSELTVVDVYDIASAIGKEFERLIDrygPEAVAGLMPKVVRVLELLEALASRNErenLEIEELRLEVDRLELEKR 84


                ....
gi 51948382  92 GLRR 95
Cdd:cd14445  85 ERAQ 88
 
Name Accession Description Interval E-value
RILP pfam11461
Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil ...
 123-189 4.08e-26

Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.


Pssm-ID: 463282 [Multi-domain]  Cd Length: 69  Bit Score: 95.35  E-value: 4.08e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51948382   123 TLQELRDVLQERNKLKSQLLLVQEELQCYRSGLLPPRETPGGRREKDAMVTMGNG--EKEERTIMKKLF 189
Cdd:pfam11461   1 TLQELRDVLQERNELKAQLFLLQEELAYYKSGLLNEEEIPSLRLESPSPRTKPQRskIKQEESGIKRLF 69
RILP-like cd14445
Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in ...
 18-95 8.50e-24

Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.


Pssm-ID: 271220 [Multi-domain]  Cd Length: 89  Bit Score: 89.96  E-value: 8.50e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51948382  18 ALAKSPLQLTTEDVYDISYVVGRELMALGS---DPRVTRLQFKIVRVMEMLEALVNEGS---LAVEELRMERDNLKQEVE 91
Cdd:cd14445   5 ALDKSPSELTVVDVYDIASAIGKEFERLIDrygPEAVAGLMPKVVRVLELLEALASRNErenLEIEELRLEVDRLELEKR 84


                ....
gi 51948382  92 GLRR 95
Cdd:cd14445  85 ERAQ 88
 
Name Accession Description Interval E-value
RILP pfam11461
Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil ...
 123-189 4.08e-26

Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.


Pssm-ID: 463282 [Multi-domain]  Cd Length: 69  Bit Score: 95.35  E-value: 4.08e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51948382   123 TLQELRDVLQERNKLKSQLLLVQEELQCYRSGLLPPRETPGGRREKDAMVTMGNG--EKEERTIMKKLF 189
Cdd:pfam11461   1 TLQELRDVLQERNELKAQLFLLQEELAYYKSGLLNEEEIPSLRLESPSPRTKPQRskIKQEESGIKRLF 69
RILP-like cd14445
Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in ...
 18-95 8.50e-24

Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.


Pssm-ID: 271220 [Multi-domain]  Cd Length: 89  Bit Score: 89.96  E-value: 8.50e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51948382  18 ALAKSPLQLTTEDVYDISYVVGRELMALGS---DPRVTRLQFKIVRVMEMLEALVNEGS---LAVEELRMERDNLKQEVE 91
Cdd:cd14445   5 ALDKSPSELTVVDVYDIASAIGKEFERLIDrygPEAVAGLMPKVVRVLELLEALASRNErenLEIEELRLEVDRLELEKR 84


                ....
gi 51948382  92 GLRR 95
Cdd:cd14445  85 ERAQ 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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