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Conserved domains on  [gi|52138735|ref|NP_001004447|]
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spermatogenesis-associated protein 21 [Rattus norvegicus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 10040236)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 439-498 2.06e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


:

Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 54.09  E-value: 2.06e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52138735 439 FRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:cd00051   2 LREAFRLFdkDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 36-397 7.96e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735    36 AAVAAGQNGRADATERDSRKKPAAPrgPEKEPRHTASSQERSGEPQTQEQRPSARSkttqdgprelqtgqeqARPSGDFV 115
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAP--GRVSRPRRARRLGRAAQASSPPQRPRRRA----------------ARPTVGSL 2695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   116 ASEGRPQPAMQTKDQQKRWQSAEAKDVQSTESCQGNTDHDLGKPCTSDSRSHPQKTNSLSEGGRPQARLQEPMPAPSSGT 195
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   196 HKDNPQEAVPPKPKVTAEEKKAPPVlptvPRTHKDRGEAVESKASPRPPPPPPSPPPPPPPEERDVEKKelgQGQKQRQP 275
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPS----PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP---PPPGPPPP 2848

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   276 ALAAAGTQGPG-NFRRgfmkclleveeqeEATHRRTLKSRAlTARRSPKTVTSVPTSGPVNSSVPPLPPTLHEPSTSAPA 354
Cdd:PHA03247 2849 SLPLGGSVAPGgDVRR-------------RPPSRSPAAKPA-APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP 2914

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 52138735   355 TVPSWVKPPAPGQAPIPMGTPSSVLPTPAQDQSWRWPELLPQG 397
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 439-498 2.06e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 54.09  E-value: 2.06e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52138735 439 FRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:cd00051   2 LREAFRLFdkDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
PTZ00184 PTZ00184
calmodulin; Provisional
 436-498 1.21e-07

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 51.30  E-value: 1.21e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52138735  436 EEAFRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:PTZ00184  83 EEEIKEAFKVFdrDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMM 147
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
435-499 3.57e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 47.09  E-value: 3.57e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52138735 435 QEEAFRSYFDIF--NGPGEVDARSLKniLLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMTD 499
Cdd:COG5126  67 VEPFARAAFDLLdtDGDGKISADEFR--RLLTALGVSEEEADELFARLDTDGDGKISFEEFVAAVRD 131
EF-hand_7 pfam13499
EF-hand domain pair;
437-498 2.41e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 42.63  E-value: 2.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52138735   437 EAFRSYfDiFNGPGEVDARSLKNIL--LLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:pfam13499   6 EAFKLL-D-SDGDGYLDVEELKKLLrkLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-397 7.96e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735    36 AAVAAGQNGRADATERDSRKKPAAPrgPEKEPRHTASSQERSGEPQTQEQRPSARSkttqdgprelqtgqeqARPSGDFV 115
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAP--GRVSRPRRARRLGRAAQASSPPQRPRRRA----------------ARPTVGSL 2695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   116 ASEGRPQPAMQTKDQQKRWQSAEAKDVQSTESCQGNTDHDLGKPCTSDSRSHPQKTNSLSEGGRPQARLQEPMPAPSSGT 195
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   196 HKDNPQEAVPPKPKVTAEEKKAPPVlptvPRTHKDRGEAVESKASPRPPPPPPSPPPPPPPEERDVEKKelgQGQKQRQP 275
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPS----PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP---PPPGPPPP 2848

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   276 ALAAAGTQGPG-NFRRgfmkclleveeqeEATHRRTLKSRAlTARRSPKTVTSVPTSGPVNSSVPPLPPTLHEPSTSAPA 354
Cdd:PHA03247 2849 SLPLGGSVAPGgDVRR-------------RPPSRSPAAKPA-APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP 2914

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 52138735   355 TVPSWVKPPAPGQAPIPMGTPSSVLPTPAQDQSWRWPELLPQG 397
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957
EFh smart00054
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ...
 472-498 2.09e-03

EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.


Pssm-ID: 197492 [Multi-domain]  Cd Length: 29  Bit Score: 35.82  E-value: 2.09e-03
                           10        20
                   ....*....|....*....|....*..
gi 52138735    472 QVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:smart00054   1 ELKEAFRLFDKDGDGKIDFEEFKDLLK 27
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 439-498 2.06e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 54.09  E-value: 2.06e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52138735 439 FRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:cd00051   2 LREAFRLFdkDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
PTZ00184 PTZ00184
calmodulin; Provisional
 436-498 1.21e-07

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 51.30  E-value: 1.21e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52138735  436 EEAFRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:PTZ00184  83 EEEIKEAFKVFdrDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMM 147
PTZ00183 PTZ00183
centrin; Provisional
 431-498 1.73e-07

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 51.23  E-value: 1.73e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735  431 LTLKQEEAFRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:PTZ00183  11 LTEDQKKEIREAFDLFdtDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDKDGSGKIDFEEFLDIMT 80
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
435-499 3.57e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 47.09  E-value: 3.57e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52138735 435 QEEAFRSYFDIF--NGPGEVDARSLKniLLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMTD 499
Cdd:COG5126  67 VEPFARAAFDLLdtDGDGKISADEFR--RLLTALGVSEEEADELFARLDTDGDGKISFEEFVAAVRD 131
EF-hand_7 pfam13499
EF-hand domain pair;
437-498 2.41e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 42.63  E-value: 2.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52138735   437 EAFRSYfDiFNGPGEVDARSLKNIL--LLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:pfam13499   6 EAFKLL-D-SDGDGYLDVEELKKLLrkLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00184 PTZ00184
calmodulin; Provisional
 429-497 1.07e-04

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 42.83  E-value: 1.07e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52138735  429 EHLTLKQEEAFRSYFDIF--NGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVM 497
Cdd:PTZ00184   3 DQLTEEQIAEFKEAFSLFdkDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTLM 73
Dockerin_1 pfam00404
Dockerin type I domain; The dockerin repeat is the binding partner of the cohesin domain ...
 447-497 1.39e-04

Dockerin type I domain; The dockerin repeat is the binding partner of the cohesin domain pfam00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome. The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium. This family contains two copies of the repeat.


Pssm-ID: 459805 [Multi-domain]  Cd Length: 56  Bit Score: 40.24  E-value: 1.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 52138735   447 NGPGEV---DARSLKNILLLIGFTftpaqVEEALMSADVNGDGHVDFKDFLAVM 497
Cdd:pfam00404   4 NGDGKVnalDALLLKNYLLGSGTG-----SSINKKAADVNGDGKVNALDALLLK 52
PTZ00183 PTZ00183
centrin; Provisional
 438-500 1.90e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 42.37  E-value: 1.90e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52138735  438 AFRSYFDifNGPGEVDARSLKNILLLIGFTFTPAQVEEALMSADVNGDGHVDFKDFLAVMTDT 500
Cdd:PTZ00183  95 AFRLFDD--DKTGKISLKNLKRVAKELGETITDEELQEMIDEADRNGDGEISEEEFYRIMKKT 155
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-397 7.96e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735    36 AAVAAGQNGRADATERDSRKKPAAPrgPEKEPRHTASSQERSGEPQTQEQRPSARSkttqdgprelqtgqeqARPSGDFV 115
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAP--GRVSRPRRARRLGRAAQASSPPQRPRRRA----------------ARPTVGSL 2695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   116 ASEGRPQPAMQTKDQQKRWQSAEAKDVQSTESCQGNTDHDLGKPCTSDSRSHPQKTNSLSEGGRPQARLQEPMPAPSSGT 195
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   196 HKDNPQEAVPPKPKVTAEEKKAPPVlptvPRTHKDRGEAVESKASPRPPPPPPSPPPPPPPEERDVEKKelgQGQKQRQP 275
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPS----PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP---PPPGPPPP 2848

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   276 ALAAAGTQGPG-NFRRgfmkclleveeqeEATHRRTLKSRAlTARRSPKTVTSVPTSGPVNSSVPPLPPTLHEPSTSAPA 354
Cdd:PHA03247 2849 SLPLGGSVAPGgDVRR-------------RPPSRSPAAKPA-APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP 2914

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 52138735   355 TVPSWVKPPAPGQAPIPMGTPSSVLPTPAQDQSWRWPELLPQG 397
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 27-203 1.06e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 42.20  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735   27 STKKKTDLEAAVAAGQNGRAdaterdsrkKPAAPRGPEKEPRHTASSQERSGEPQTQEQRPSARSKTTQDGPRELQTGQE 106
Cdd:PRK12678  44 SGMRKGELIAAIKEARGGGA---------AAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735  107 QARPSGDFVASEGRPQPAMQTKDQQKRWQSAEAKDVQSTESCQGNTDHDLGKPCTSDSRSHPQKTNSLSEGGRPQARLQE 186
Cdd:PRK12678 115 AAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRRE 194

                        170
                 ....*....|....*..
gi 52138735  187 PMPAPSSGTHKDNPQEA 203
Cdd:PRK12678 195 ERGRDGDDRDRRDRREQ 211
EFh smart00054
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ...
 472-498 2.09e-03

EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.


Pssm-ID: 197492 [Multi-domain]  Cd Length: 29  Bit Score: 35.82  E-value: 2.09e-03
                           10        20
                   ....*....|....*....|....*..
gi 52138735    472 QVEEALMSADVNGDGHVDFKDFLAVMT 498
Cdd:smart00054   1 ELKEAFRLFDKDGDGKIDFEEFKDLLK 27
EF-hand_1 pfam00036
EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering ...
 473-500 2.30e-03

EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.


Pssm-ID: 425435 [Multi-domain]  Cd Length: 29  Bit Score: 35.84  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*...
gi 52138735   473 VEEALMSADVNGDGHVDFKDFLAVMTDT 500
Cdd:pfam00036   2 LKEIFRLFDKDGDGKIDFEEFKELLKKL 29
EFh_calglandulin_like cd16252
EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The ...
 410-498 5.63e-03

EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The family corresponds to a group of uncharacterized calglandulin-like proteins. Although their biological function remain unclear, they show high sequence similarity with human calglandulin-like protein GAGLP, which is an ortholog of calglandulin from the venom glands of Bothrops insularis snake. Both GAGLP and calglandulin are putative Ca2+-binding proteins with four EF-hand motifs. However, members in this family contain only three EF-hand motifs. In this point, they may belong to the parvalbumin-like EF-hand family, which is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix).


Pssm-ID: 319995 [Multi-domain]  Cd Length: 106  Bit Score: 37.12  E-value: 5.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138735 410 ESEEHGLFKLYQNWEERTEEHLTLKQEEAFRSYFDIFN--GPGEVDARSLKNILLLIGFT--FTPAQVEEA---LMSADV 482
Cdd:cd16252  10 EMRHHGSFNYSKFFEYMQKFQTSEQQEEAIRKAFQMLDkdKSGFIEWNEIKYILSTVPSSmpVAPLSDEEAeamIQAADT 89

                        90
                ....*....|....*.
gi 52138735 483 NGDGHVDFKDFLAVMT 498
Cdd:cd16252  90 DGDGRIDFQEFSDMVK 105
EF-hand_8 pfam13833
EF-hand domain pair;
450-499 6.73e-03

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 35.37  E-value: 6.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 52138735   450 GEVDARSLKNILLLIGF-TFTPAQVEEALMSADVNGDGHVDFKDFLAVMTD 499
Cdd:pfam13833   3 GVITREELKRALALLGLkDLSEDEVDILFREFDTDGDGYISFDEFCVLLER 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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