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Conserved domains on  [gi|52353302|ref|NP_001005209|]
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transmembrane protein 198 [Homo sapiens]

Protein Classification

TMEM198/TM7SF3 family protein( domain architecture ID 10620818)

TMEM198/TM7SF3 family protein similar to transmembrane protein 198, which promotes LRP6 phosphorylation thereby playing a role in Wnt signaling, and transmembrane 7 superfamily member 3, an orphan receptor that acts as an inhibitor of cytokine-induced death of pancreatic beta cells

Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4203 pfam13886
Domain of unknown function (DUF4203); This is the N-terminal region of 7tm proteins. The ...
 40-236 9.05e-27

Domain of unknown function (DUF4203); This is the N-terminal region of 7tm proteins. The function is not known.


:

Pssm-ID: 464018  Cd Length: 201  Bit Score: 104.97  E-value: 9.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353302    40 LVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLF 119
Cdd:pfam13886   1 VLGAILILTGLVYCFFGYRNFKATLFLSGFYLGSLIVFVLILYVMVLPSSAVQGAFLVAAVVAGLLGGLLAMLFWELGLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353302   120 LVGLLL-GLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLG 198
Cdd:pfam13886  81 LLGALGgFLLALWLLSLKEGGLIPSLPGKSIFGTIVGLGLVGAVLSLSWQKYLLIVSTSFVGATAVVLGIDCFVGAGLKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 52353302   199 RYVVERLRAA---PVPPLCWRSWALLALWPLLSLMGVLVQW 236
Cdd:pfam13886 161 FWLNLFPRATvalVTYPLTRGDWVELAAWPVLALVGVLVQF 201
 
Name Accession Description Interval E-value
DUF4203 pfam13886
Domain of unknown function (DUF4203); This is the N-terminal region of 7tm proteins. The ...
 40-236 9.05e-27

Domain of unknown function (DUF4203); This is the N-terminal region of 7tm proteins. The function is not known.


Pssm-ID: 464018  Cd Length: 201  Bit Score: 104.97  E-value: 9.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353302    40 LVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLF 119
Cdd:pfam13886   1 VLGAILILTGLVYCFFGYRNFKATLFLSGFYLGSLIVFVLILYVMVLPSSAVQGAFLVAAVVAGLLGGLLAMLFWELGLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353302   120 LVGLLL-GLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLG 198
Cdd:pfam13886  81 LLGALGgFLLALWLLSLKEGGLIPSLPGKSIFGTIVGLGLVGAVLSLSWQKYLLIVSTSFVGATAVVLGIDCFVGAGLKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 52353302   199 RYVVERLRAA---PVPPLCWRSWALLALWPLLSLMGVLVQW 236
Cdd:pfam13886 161 FWLNLFPRATvalVTYPLTRGDWVELAAWPVLALVGVLVQF 201
 
Name Accession Description Interval E-value
DUF4203 pfam13886
Domain of unknown function (DUF4203); This is the N-terminal region of 7tm proteins. The ...
 40-236 9.05e-27

Domain of unknown function (DUF4203); This is the N-terminal region of 7tm proteins. The function is not known.


Pssm-ID: 464018  Cd Length: 201  Bit Score: 104.97  E-value: 9.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353302    40 LVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLF 119
Cdd:pfam13886   1 VLGAILILTGLVYCFFGYRNFKATLFLSGFYLGSLIVFVLILYVMVLPSSAVQGAFLVAAVVAGLLGGLLAMLFWELGLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353302   120 LVGLLL-GLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLG 198
Cdd:pfam13886  81 LLGALGgFLLALWLLSLKEGGLIPSLPGKSIFGTIVGLGLVGAVLSLSWQKYLLIVSTSFVGATAVVLGIDCFVGAGLKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 52353302   199 RYVVERLRAA---PVPPLCWRSWALLALWPLLSLMGVLVQW 236
Cdd:pfam13886 161 FWLNLFPRATvalVTYPLTRGDWVELAAWPVLALVGVLVQF 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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