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Conserved domains on  [gi|55956770|ref|NP_001007234|]
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DNA excision repair protein ERCC-8 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-303 2.20e-33

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 2.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   2 LSGGSDGVIVLYDLENSSRQSyytckavcsigrdHPDVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 81
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLR-------------TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  82 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDV 158
Cdd:COG2319 160 gHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 159 RRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLK 238
Cdd:COG2319 234 ATGK-LLRTL---------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHS 288

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55956770 239 FTVSCgcsseFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:COG2319 289 GGVNS-----VAFSPDGKLLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-303 2.20e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 2.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   2 LSGGSDGVIVLYDLENSSRQSyytckavcsigrdHPDVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 81
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLR-------------TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  82 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDV 158
Cdd:COG2319 160 gHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 159 RRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLK 238
Cdd:COG2319 234 ATGK-LLRTL---------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHS 288

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55956770 239 FTVSCgcsseFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:COG2319 289 GGVNS-----VAFSPDGKLLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-303 2.07e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.07e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   1 MLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSSFDKTLKVWDTNTLQTADVF 80
Cdd:cd00200  24 LATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  81 N-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVR 159
Cdd:cd00200  90 TgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 160 RASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKvcNNSKKGLKF 239
Cdd:cd00200 166 TGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55956770 240 TVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:cd00200 228 SPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 117-157 6.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 55956770    117 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 114-224 9.93e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 9.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  114 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 169
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55956770  170 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 224
Cdd:PTZ00420 191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
WD40 pfam00400
WD domain, G-beta repeat;
118-157 1.18e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 55956770   118 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-303 2.20e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 2.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   2 LSGGSDGVIVLYDLENSSRQSyytckavcsigrdHPDVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 81
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLR-------------TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  82 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDV 158
Cdd:COG2319 160 gHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 159 RRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLK 238
Cdd:COG2319 234 ATGK-LLRTL---------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHS 288

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55956770 239 FTVSCgcsseFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:COG2319 289 GGVNS-----VAFSPDGKLLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-303 2.07e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.07e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   1 MLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSSFDKTLKVWDTNTLQTADVF 80
Cdd:cd00200  24 LATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  81 N-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVR 159
Cdd:cd00200  90 TgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 160 RASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKvcNNSKKGLKF 239
Cdd:cd00200 166 TGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55956770 240 TVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:cd00200 228 SPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
3-303 5.36e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 5.36e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   3 SGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 82
Cdd:COG2319 179 SGSDDGTVRLWDLATGKLLRTLT-------------GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  83 EE-TVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDVr 159
Cdd:COG2319 245 HSgSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKL---LASGSDDGTVRLWDL- 317

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 160 rASG-CLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNssngentlvnygkvcnnskkglk 238
Cdd:COG2319 318 -ATGkLLRTL---------------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD----------------------- 358

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55956770 239 ftvscgcssefvfvpygstiavytVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:COG2319 359 ------------------------LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
3-215 2.04e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 2.04e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   3 SGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRdhpdvHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN- 81
Cdd:COG2319 221 SGSADGTVRLWDLA--------TGKLLRTLTG-----HSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTg 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  82 FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRrA 161
Cdd:COG2319 287 HSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA-T 361

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 55956770 162 SGCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 215
Cdd:COG2319 362 GELLRTL---------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-215 1.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.57e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   2 LSGGSDGVIVLYDLENssrqsyYTCKAVCsigRDHPDvhrySVETVQWyPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 81
Cdd:cd00200 109 SSSSRDKTIKVWDVET------GKCLTTL---RGHTD----WVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  82 -FEETVYSHHMSPVSTKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRyDYILATASADSRVKLWDVRR 160
Cdd:cd00200 175 gHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRT 250

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 55956770 161 ASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 215
Cdd:cd00200 251 GE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-303 3.09e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 3.09e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  40 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGS 119
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 120 CSHILQGHRQEILAVSWSPryD-YILATASADSRVKLWDVrrASG-CLITLdqhngkksqavesanTAHNGKVNGLCFTS 197
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSP--DgKTLASGSADGTVRLWDL--ATGkLLRTL---------------TGHSGAVTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 198 DGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYSG 266
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKLLAsgsadgtvrLWDLATG 236

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 55956770 267 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
2-159 1.49e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   2 LSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN 81
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLT-------------GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55956770  82 -FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVR 159
Cdd:COG2319 328 gHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-303 1.83e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 1.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 100 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVrRASGCLITLdqhngkksqav 179
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL-ETGECVRTL----------- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 180 esanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK---VCNNSKKGLKFTVSCGCSSefvfvpygS 256
Cdd:cd00200  90 ----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHtdwVNSVAFSPDGTFVASSSQD--------G 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 55956770 257 TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:cd00200 158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-303 8.18e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 8.18e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 120 CSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVrrasgclitldqhngkKSQAVESANTAHNGKVNGLCFTSDG 199
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL----------------ETGELLRTLKGHTGPVRDVAASADG 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770 200 LHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS---------TIAVYTVYSGEQIT 270
Cdd:cd00200  64 TYLASGSSDKTIRLWDLETGE---------CVRTLTGHTSYVSS-----VAFSPDGRilssssrdkTIKVWDVETGKCLT 129

                       170       180       190
                ....*....|....*....|....*....|...
gi 55956770 271 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 117-157 6.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 55956770    117 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 114-224 9.93e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 9.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  114 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 169
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55956770  170 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 224
Cdd:PTZ00420 191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 24-217 1.00e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   24 YTCKAVCSIGRD--HPDVH---RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYSHHMSpvSTK 97
Cdd:PLN00181 510 FECESIIKDGRDihYPVVElasRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQlVTEMKEHEKRVWSIDYS--SAD 587

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   98 HCLVAVGTRGPKVQLCDLKSGSCSHILQGhRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLdqhngkksq 177
Cdd:PLN00181 588 PTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTM--------- 657

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 55956770  178 avesanTAHNGKVNGLCFTsDGLHLLTVGTDNRMRLWNSS 217
Cdd:PLN00181 658 ------IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 pfam00400
WD domain, G-beta repeat;
118-157 1.18e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 55956770   118 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 115-219 1.40e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770  115 LKSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRasgclitldqhnGKKSQAVESantaHNGKVNG 192
Cdd:PTZ00421 110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER------------GKAVEVIKC----HSDQITS 173

                         90       100
                 ....*....|....*....|....*..
gi 55956770  193 LCFTSDGLHLLTVGTDNRMRLWNSSNG 219
Cdd:PTZ00421 174 LEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-215 7.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 7.59e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55956770    184 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 215
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 134-220 1.89e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956770   134 VSWSPRYDyILATASADSRVklwDVRRASGclitldqhngkksQAVESANT-AHNGKVNGLCFTSDGlHLLTVGT-DNRM 211
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGEL---LLHRLNW-------------QRVWTLSPdKEDLEVTSLAWRPDG-KLLAVGYsDGTV 62


                  ....*....
gi 55956770   212 RLWNSSNGE 220
Cdd:pfam12894  63 RLLDAENGK 71
WD40 pfam00400
WD domain, G-beta repeat;
184-215 5.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.31e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 55956770   184 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 215
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 265-303 8.92e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.92e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55956770    265 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
266-303 9.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55956770   266 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 303
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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