NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|56550081|ref|NP_001007794|]
View 

mitotic checkpoint protein BUB3 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-296 1.24e-33

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.24e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  11 QPPEDGISSVKFSPNtSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFyDP--THAWSGGLDHQLKMHDLNTD 87
Cdd:COG2319 117 TGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  88 QE--NLVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVW 162
Cdd:COG2319 195 KLlrTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSpdGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 163 DLRNmgyvqQRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVQkkkyAFKCHrlkennieqIYPVNA 239
Cdd:COG2319 274 DLAT-----GELLRTLTGHSGGVNsvAFsPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGH---------TGAVRS 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56550081 240 ISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-296 1.24e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.24e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  11 QPPEDGISSVKFSPNtSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFyDP--THAWSGGLDHQLKMHDLNTD 87
Cdd:COG2319 117 TGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  88 QE--NLVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVW 162
Cdd:COG2319 195 KLlrTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSpdGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 163 DLRNmgyvqQRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVQkkkyAFKCHrlkennieqIYPVNA 239
Cdd:COG2319 274 DLAT-----GELLRTLTGHSGGVNsvAFsPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGH---------TGAVRS 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56550081 240 ISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-296 2.54e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 2.54e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  14 EDGISSVKFSPNtSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFYDPTH-AWSGGLDHQLKMHDLNTDQEN- 90
Cdd:cd00200   9 TGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVr 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  91 -LVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVSGDRLIVGTAG--RRVLVWDLRN 166
Cdd:cd00200  88 tLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSqdGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 167 MGYVQQRR--ESSLkyqtRCIRAFPNKQGYVLSSIEGRVAVeyLDPSpeVQKKKYAFKCHRlkennieqiYPVNAISFHN 244
Cdd:cd00200 167 GKCVATLTghTGEV----NSVAFSPDGEKLLSSSSDGTIKL--WDLS--TGKCLGTLRGHE---------NGVNSVAFSP 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56550081 245 IHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-124 3.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.32e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 56550081     95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-124 8.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 8.49e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 56550081    95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-296 1.24e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.24e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  11 QPPEDGISSVKFSPNtSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFyDP--THAWSGGLDHQLKMHDLNTD 87
Cdd:COG2319 117 TGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  88 QE--NLVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVW 162
Cdd:COG2319 195 KLlrTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSpdGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 163 DLRNmgyvqQRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVQkkkyAFKCHrlkennieqIYPVNA 239
Cdd:COG2319 274 DLAT-----GELLRTLTGHSGGVNsvAFsPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGH---------TGAVRS 335

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56550081 240 ISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-296 2.54e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 2.54e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  14 EDGISSVKFSPNtSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFYDPTH-AWSGGLDHQLKMHDLNTDQEN- 90
Cdd:cd00200   9 TGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVr 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  91 -LVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVSGDRLIVGTAG--RRVLVWDLRN 166
Cdd:cd00200  88 tLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSqdGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 167 MGYVQQRR--ESSLkyqtRCIRAFPNKQGYVLSSIEGRVAVeyLDPSpeVQKKKYAFKCHRlkennieqiYPVNAISFHN 244
Cdd:cd00200 167 GKCVATLTghTGEV----NSVAFSPDGEKLLSSSSDGTIKL--WDLS--TGKCLGTLRGHE---------NGVNSVAFSP 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 56550081 245 IHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
11-296 1.24e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.24e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  11 QPPEDGISSVKFSPNTsQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFyDPTHAW--SGGLDHQLKMHDLNTD 87
Cdd:COG2319  75 LGHTAAVLSVAFSPDG-RLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAF-SPDGKTlaSGSADGTVRLWDLATG 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  88 QE--NLVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVS--GDRLIVGTAGRRVLVW 162
Cdd:COG2319 153 KLlrTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSpdGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 163 DLRNmgyvqQRRESSLKYQTRCIR--AF-PNKQGYVLSSIEGRVAVEYLDPSPEVqkkkyafkcHRLKENNieqiYPVNA 239
Cdd:COG2319 232 DLAT-----GKLLRTLTGHSGSVRsvAFsPDGRLLASGSADGTVRLWDLATGELL---------RTLTGHS----GGVNS 293

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 56550081 240 ISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
13-166 2.20e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 2.20e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  13 PEDGISSVKFSPNtSQFLLVSSWDTSVRLYDVPANS-MRLKYQHTGAVLDCAF-YDPTHAWSGGLDHQLKMHDLNTDQE- 89
Cdd:COG2319 245 HSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLATGKLl 323

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  90 -NLVGtHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEK-VYTLSVS--GDRLIVGTAGRRVLVWDLR 165
Cdd:COG2319 324 rTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGaVTSVAFSpdGRTLASGSADGTVRLWDLA 402


                .
gi 56550081 166 N 166
Cdd:COG2319 403 T 403
WD40 COG2319
WD40 repeat [General function prediction only];
17-296 2.78e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 2.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAF-YDPTHAWSGGLDHQLKMHDLNTDQENLVGT- 94
Cdd:COG2319  39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGTVRLWDLATGLLLRTLTg 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvq 171
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLAT----- 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 172 qrresslkyqTRCIRAFPNKQGYVLSsiegrVAVeyldpSPEvqkkkyafkchrlkennieqiypvnaisfhniHNTFAT 251
Cdd:COG2319 194 ----------GKLLRTLTGHTGAVRS-----VAF-----SPD--------------------------------GKLLAS 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 56550081 252 GGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
WD40 COG2319
WD40 repeat [General function prediction only];
22-296 5.19e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 5.19e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  22 FSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDP--THAWSGGLDHQLKMHDLNTDQENLVGTHDAPI 99
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 100 RCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QPEKVYTLSVS--GDRLIVGTAGRRVLVWDLRNmgyvqqrres 176
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSpdGKTLASGSADGTVRLWDLAT---------- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 177 slkyqTRCIRAFPNKQGyvlssiegrvaveyldpspevqkkkyafkchrlkennieqiyPVNAISFHNIHNTFATGGSDG 256
Cdd:COG2319 152 -----GKLLRTLTGHSG------------------------------------------AVTSVAFSPDGKLLASGSDDG 184

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 56550081 257 FVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:COG2319 185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-124 1.43e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  14 EDGISSVKFSPNTSQFLLVSSwDTSVRLYDVpaNSMRLKYQ---HTGAVLDCAFyDPTHAW--SGGLDHQLKMHDLNTDQ 88
Cdd:cd00200 177 TGEVNSVAFSPDGEKLLSSSS-DGTIKLWDL--STGKCLGTlrgHENGVNSVAF-SPDGYLlaSGSEDGTIRVWDLRTGE 252

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56550081  89 ENLVGT-HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
Cdd:cd00200 253 CVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-296 1.56e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081  95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD------PRTPCNAgtfSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNmG 168
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDletgelLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDLET-G 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550081 169 YVQQRRESSLKYqTRCIRAFPNKQgYVLSSIE-GRVAVEYLDPSpevqKKKYAFKCHRlkennieqiYPVNAISFHnIHN 247
Cdd:cd00200  84 ECVRTLTGHTSY-VSSVAFSPDGR-ILSSSSRdKTIKVWDVETG----KCLTTLRGHT---------DWVNSVAFS-PDG 147

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 56550081 248 TFATGGS-DGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
Cdd:cd00200 148 TFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-124 3.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.32e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 56550081     95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-124 8.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 8.49e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 56550081    95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-262 3.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.11e-04
                           10        20
                   ....*....|....*....|....*..
gi 56550081    236 PVNAISFHNIHNTFATGGSDGFVNIWD 262
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
14-43 2.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.95e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 56550081    14 EDGISSVKFSPNtSQFLLVSSWDTSVRLYD 43
Cdd:pfam00400  11 TGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
236-262 3.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.07e-03
                          10        20
                  ....*....|....*....|....*..
gi 56550081   236 PVNAISFHNIHNTFATGGSDGFVNIWD 262
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-43 9.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.44  E-value: 9.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 56550081     14 EDGISSVKFSPNtSQFLLVSSWDTSVRLYD 43
Cdd:smart00320  12 TGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH