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Conserved domains on  [gi|59710113|ref|NP_001010000|]
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rho GTPase-activating protein 28 isoform a [Homo sapiens]

Protein Classification

rho GTPase-activating protein( domain architecture ID 10138216)

rho GTPase-activating protein (GAP) acts by converting Rho-type GTPases to an inactive GDP-bound state, similar to human Rho GAP 18 that suppresses F-actin polymerization by inhibiting Rho

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-429 7.00e-118

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.80  E-value: 7.00e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAA 297
Cdd:cd04391   1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 298 VMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 377
Cdd:cd04391  81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 59710113 378 TVMAPNLFFSRSKHS-----DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVR 429
Cdd:cd04391 160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-429 7.00e-118

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.80  E-value: 7.00e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAA 297
Cdd:cd04391   1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 298 VMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 377
Cdd:cd04391  81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 59710113 378 TVMAPNLFFSRSKHS-----DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVR 429
Cdd:cd04391 160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 240-389 1.16e-42

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 149.62  E-value: 1.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113   240 PLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFkWDKMCHREAAVMLKAFFRELPTSLFPVEYIPA 319
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLD-LEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113   320 FISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS 389
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 239-395 1.29e-32

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 123.15  E-value: 1.29e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113    239 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELD--AKFNADKFKWDKMChreAAVMLKAFFRELPTSLFPVEY 316
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59710113    317 IPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE 395
Cdd:smart00324  80 YEEFIEAAKLEDETE-RLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASL 157
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-429 7.00e-118

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.80  E-value: 7.00e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAA 297
Cdd:cd04391   1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 298 VMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 377
Cdd:cd04391  81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 59710113 378 TVMAPNLFFSRSKHS-----DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVR 429
Cdd:cd04391 160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 240-389 1.16e-42

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 149.62  E-value: 1.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113   240 PLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFkWDKMCHREAAVMLKAFFRELPTSLFPVEYIPA 319
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLD-LEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113   320 FISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS 389
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 240-413 2.39e-37

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 135.89  E-value: 2.39e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 240 PLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDA-KFNADKFKWDkmCHrEAAVMLKAFFRELPTSLFPVEYIP 318
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRgEDIDDLEDYD--VH-DVASLLKLYLRELPEPLIPFELYD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 319 AFISLMERGPHvKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFfsRSKHSDYEELL 398
Cdd:cd00159  78 EFIELAKIEDE-EERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL--RPPDSDDELLE 154

                       170
                ....*....|....*
gi 59710113 399 LANTAAHIIRLMLKY 413
Cdd:cd00159 155 DIKKLNEIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 239-395 1.29e-32

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 123.15  E-value: 1.29e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113    239 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELD--AKFNADKFKWDKMChreAAVMLKAFFRELPTSLFPVEY 316
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59710113    317 IPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE 395
Cdd:smart00324  80 YEEFIEAAKLEDETE-RLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASL 157
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 219-385 1.53e-26

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 106.72  E-value: 1.53e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDrkkdpGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKF------NADKFKWDKMC 292
Cdd:cd04398   1 FGVPLEDLILRE-----GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPlnvlliSPEDYESDIHS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 293 hreAAVMLKAFFRELPTSLFPVEYIPAFI-SLMERGPHVKVQFqaLHLMVMALPDANRDAAQALMTFFNKVIANESKNRM 371
Cdd:cd04398  76 ---VASLLKLFFRELPEPLLTKALSREFIeAAKIEDESRRRDA--LHGLINDLPDANYATLRALMFHLARIKEHESVNRM 150

                       170
                ....*....|....
gi 59710113 372 SLWNISTVMAPNLF 385
Cdd:cd04398 151 SVNNLAIIWGPTLM 164
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 215-422 4.69e-25

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 103.27  E-value: 4.69e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 215 DNGIFGVPLTVLLdgdrkKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHR 294
Cdd:cd04375   1 DKNVFGVPLLVNL-----QRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIES--STDNVNYDGQQAY 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 295 EAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPhVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLW 374
Cdd:cd04375  74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVP-KEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTAT 152

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59710113 375 NISTVMAPNLFF-----------SRSKHSDY------EELLLANTAAHI-IRLMLKYQKILWKVPS 422
Cdd:cd04375 153 NLAVCLAPSLFHlntsrrensspARRMQRKKslgkpdQKELSENKAAHQcLAYMIEECNTLFMVPK 218
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 219-411 1.27e-23

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 98.23  E-value: 1.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDgdRKKDpgvKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREEL--DAKFNADKFKWDKMCHREA 296
Cdd:cd04403   1 FGCHLEALCQ--RENS---TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVdhDEKLDLDDSKWEDIHVITG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 297 AvmLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNI 376
Cdd:cd04403  76 A--LKLFFRELPEPLFPYSLFNDFVAAIKL-SDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNL 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 59710113 377 STVMAPNLFfsrskHSDYEElllANTAAH------IIRLML 411
Cdd:cd04403 153 AIVFGPTLL-----RPEQET---GNIAVHmvyqnqIVELIL 185
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 219-382 2.87e-23

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 97.12  E-value: 2.87e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKkdpgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAV 298
Cdd:cd04377   1 FGVSLSSLTSEDRS------VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVNLEDYPIHVITS 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 MLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 378
Cdd:cd04377  73 VLKQWLRELPEPLMTFELYENFLRAMEL-EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAI 151


                ....
gi 59710113 379 VMAP 382
Cdd:cd04377 152 VFAP 155
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-407 5.83e-23

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 96.38  E-value: 5.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLldgDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMChrEAA 297
Cdd:cd04393   2 VFGVPLQEL---QQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVC--SAA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 298 VMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 377
Cdd:cd04393  77 SLLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLA 156

                       170       180       190
                ....*....|....*....|....*....|.
gi 59710113 378 TVMAPNLFFSRSKHSDYEELLLAN-TAAHII 407
Cdd:cd04393 157 AVFGPDVFHVYTDVEDMKEQEICSrIMAKLL 187
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 238-421 8.60e-23

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 96.36  E-value: 8.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 238 KVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYI 317
Cdd:cd04376   8 QVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELY 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 318 PAFISLMERGPhvKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANE-----------SKNRMSLWNISTVMAPNLfF 386
Cdd:cd04376  86 TAFIGTALLEP--DEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNL-L 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 59710113 387 SRSKHSDYEELLLANTAAH------IIRLMLKYQKILWKVP 421
Cdd:cd04376 163 HKQKSGEREFVQASLRIEEstaiinVVQTMIDNYEELFMVS 203
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 219-424 3.30e-21

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 92.04  E-value: 3.30e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLL-----DGDRKKDPGV-KVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMC 292
Cdd:cd04397   1 FGVPLEILVekfgaDSTLGVGPGKlRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 293 HREAAvMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKV-----IANES 367
Cdd:cd04397  81 VQLAA-LLKKFLRELPDPLLTFKLYRLWIS-SQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVssfshIDEET 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 59710113 368 KNRMSLWNISTVMAPNLFFSRSKHSDY-EELLLANTAAHiirLMLKYQKILWKVPSFL 424
Cdd:cd04397 159 GSKMDIHNLATVITPNILYSKTDNPNTgDEYFLAIEAVN---YLIENNEEFCEVPDEL 213
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 218-384 3.42e-21

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 91.27  E-value: 3.42e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLE-SEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREA 296
Cdd:cd04400   1 IFGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIyEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 297 -AVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 375
Cdd:cd04400  81 vAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                ....*....
gi 59710113 376 ISTVMAPNL 384
Cdd:cd04400 161 VCIVFSPTL 169
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 219-405 1.71e-20

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 89.60  E-value: 1.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRkkdpgVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAV 298
Cdd:cd04387   1 FGVKISTVTKRER-----SKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIAG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMvMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 378
Cdd:cd04387  76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLNLL-LSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLAT 154

                       170       180
                ....*....|....*....|....*..
gi 59710113 379 VMAPNLFFSRSKHSDYEELLLANTAAH 405
Cdd:cd04387 155 VFGPTLLRPSEKESKIPTNTMTDSWSL 181
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 219-415 1.81e-20

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 89.32  E-value: 1.81e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKKDPgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKqyreELDAKFNADK---FKWDKMCHRe 295
Cdd:cd04404   6 FGVSLQFLKEKNPEQEP---IPPVVRETVEYLQAHALTTEGIFRRSANTQVVK----EVQQKYNMGEpvdFDQYEDVHL- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 296 AAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQfqALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 375
Cdd:cd04404  78 PAVILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVE--RVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSN 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 59710113 376 ISTVMAPNLFFSRSKHSDYEELLLANTaahIIRLMLKYQK 415
Cdd:cd04404 156 LAVVFGPNLLWAKDASMSLSAINPINT---FTKFLLDHQD 192
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-412 2.01e-20

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 89.44  E-value: 2.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTvlldgDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAK-FNADKFKWDKMCHREA 296
Cdd:cd04386   4 VFGTPLE-----EHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEFYSDPHAVA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 297 AVmLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNI 376
Cdd:cd04386  79 SA-LKSYLRELPDPLLTYNLYEDWVQAANKPDEDE-RLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNI 156

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 59710113 377 STVMAPNLFFSRSKHSDYEelLLANTAAH---IIRLMLK 412
Cdd:cd04386 157 AIVLAPNLLWAKNEGSLAE--MAAGTSVHvvaIVELIIS 193
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 219-411 2.58e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 82.89  E-value: 2.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKkdpgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHrEAAV 298
Cdd:cd04373   1 FGVPLANVVTSEKP------IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVN-AVAG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 378
Cdd:cd04373  74 ALKSFFSELPDPLIPYSMHLELVEAAKINDREQ-RLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSI 152

                       170       180       190
                ....*....|....*....|....*....|...
gi 59710113 379 VMAPNLFfsRSKHSDYEELLLANTAAHIIRLML 411
Cdd:cd04373 153 CFWPTLM--RPDFTSMEALSATRIYQTIIETFI 183
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 219-384 4.96e-18

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 82.45  E-value: 4.96e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKKdpgvKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKF---NADKFKWDKMchRE 295
Cdd:cd04395   2 FGVPLDDCPPSSENP----YVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfdiDLQDPRWRDV--NV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 296 AAVMLKAFFRELPTSLFPVEYIPAFISL--MErGPHVKVqfQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSL 373
Cdd:cd04395  76 VSSLLKSFFRKLPEPLFTNELYPDFIEAnrIE-DPVERL--KELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEP 152

                       170
                ....*....|.
gi 59710113 374 WNISTVMAPNL 384
Cdd:cd04395 153 RNLAIVFGPTL 163
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 252-425 9.94e-18

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 81.75  E-value: 9.94e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 252 ESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKwdKMChrEAAVMLKAFFRELPTSLFPVEYIPAFISLMERgPHVK 331
Cdd:cd04394  32 LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSA--LPC--DVAGLLKQFFRELPEPLLPYDLHEALLKAQEL-PTDE 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 332 VQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE---ELLLANTAAhIIR 408
Cdd:cd04394 107 ERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFQSEEGGEKMSsstEKRLRLQAA-VVQ 185

                       170
                ....*....|....*..
gi 59710113 409 LMLKYQKILWKVPSFLI 425
Cdd:cd04394 186 TLIDNASNIGIVPDFIL 202
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 219-387 1.72e-17

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 80.56  E-value: 1.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKKDpGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKmchREAAV 298
Cdd:cd04381   1 FGASLSLAVERSRCHD-GIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEP---PTVAS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 MLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 378
Cdd:cd04381  77 LLKQYLRELPEPLLTKELMPRFEEACGR-PTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISI 155


                ....*....
gi 59710113 379 VMAPNLFFS 387
Cdd:cd04381 156 VLSPTVQIS 164
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 239-385 2.76e-17

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 80.04  E-value: 2.76e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 239 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAV--MLKAFFRELPTSLFPVEY 316
Cdd:cd04385  15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRK--DARSVQLREGEYTVHDVadVLKRFLRDLPDPLLTSEL 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59710113 317 IPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLF 385
Cdd:cd04385  93 HAEWIEAAEL-ENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLF 160
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 219-385 4.74e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 79.27  E-value: 4.74e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDgdrKKDPgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKwDKMCHREAAV 298
Cdd:cd04407   1 FGVRVGSLTS---NKTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLE-NYPIHAITGL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 mLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 378
Cdd:cd04407  74 -LKQWLRELPEPLMTFAQYNDFLRAVEL-PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAI 151


                ....*..
gi 59710113 379 VMAPNLF 385
Cdd:cd04407 152 VFAPCLL 158
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 219-384 6.93e-17

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 79.10  E-value: 6.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLdgdrkKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVkqyrEELDAKFNADKFKWDKMCHREAAV 298
Cdd:cd04372   1 YGCDLTTLV-----KAHNTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEI----EDVKMAFDRDGEKADISATVYPDI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 -----MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSL 373
Cdd:cd04372  72 nvitgALKLYFRDLPIPVITYDTYPKFIDAAKISNPDE-RLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNA 150

                       170
                ....*....|.
gi 59710113 374 WNISTVMAPNL 384
Cdd:cd04372 151 ENLGIVFGPTL 161
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 219-394 1.38e-16

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 78.66  E-value: 1.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLdgdRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREA-A 297
Cdd:cd04379   1 FGVPLSRLV---EREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINViT 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 298 VMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVM--ALPDANRDAAQALMTFFNKVIANESKNRMSLWN 375
Cdd:cd04379  78 GVLKDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIidCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQN 157

                       170
                ....*....|....*....
gi 59710113 376 ISTVMAPNLFFSRSKHSDY 394
Cdd:cd04379 158 LAVCFGPVLMFCSQEFSRY 176
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 217-393 3.75e-15

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 74.40  E-value: 3.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 217 GIFGVPLTVLLDGDRKKDPGVkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKfNADKFKWDKMCHREA 296
Cdd:cd04390   1 GVFGQRLEDTVAYERKFGPRL-VPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAG-ERPSFDSDTDVHTVA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 297 AvMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQ-FQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 375
Cdd:cd04390  79 S-LLKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKgLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQN 157

                       170
                ....*....|....*...
gi 59710113 376 ISTVMAPNLFfsRSKHSD 393
Cdd:cd04390 158 LATVFGPNIL--RPKVED 173
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-406 5.45e-15

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 73.69  E-value: 5.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLLdgdrkKDPGVKVPLVLQKFFEKVEESGLeSEGIFRLSGCTAKVKQYREELDAKFNADKFKwDKMCHREAA 297
Cdd:cd04384   2 VFGCDLTEHL-----LNSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIPDLTK-DVYIQDIHS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 298 V--MLKAFFRELPTSLFPVEYIPAFISLMERGPhVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 375
Cdd:cd04384  75 VssLCKLYFRELPNPLLTYQLYEKFSEAVSAAS-DEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKN 153

                       170       180       190
                ....*....|....*....|....*....|.
gi 59710113 376 ISTVMAPNLFfsRSKHSdyEELLLANTAAHI 406
Cdd:cd04384 154 LAIVWAPNLL--RSKQI--ESACFSGTAAFM 180
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 218-417 1.47e-12

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 67.44  E-value: 1.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLT----------VLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKqyreELDAKFNA---- 283
Cdd:cd04396   1 VFGVSLEeslkyasvaiSIVDEDGEQYVYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIR----ELQLIFSTppdy 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 284 -DKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALH----------------LMVMALPD 346
Cdd:cd04396  77 gKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPLRKRPRILQYMKGRIneplntdidqaikeyrDLITRLPN 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59710113 347 ANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTaahIIRLMLKYQKIL 417
Cdd:cd04396 157 LNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSRL---VVEFLIEHQDKF 224
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 252-429 1.78e-12

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 66.72  E-value: 1.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 252 ESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHrEAAVMLKAFFRELPTSLFPVEYIPAFISLME------ 325
Cdd:cd04392  21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAH-DCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfde 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 326 -----RGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKH-SDYEEllL 399
Cdd:cd04392 100 kgnktSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTpEDLHE--N 177

                       170       180       190
                ....*....|....*....|....*....|
gi 59710113 400 ANTAAHIIRLMLKYQKILWKVPSFLITQVR 429
Cdd:cd04392 178 AQKLNSIVTFMIKHSQKLFKAPAYLREDAR 207
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-384 1.72e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 63.47  E-value: 1.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 218 IFGVPLTVLLDGDrkkdpgvKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADkfkwdkmCHREA- 296
Cdd:cd04402   1 LFGQPLSNICEDD-------NLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVD-------LKAEPv 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 297 ---AVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQfQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSL 373
Cdd:cd04402  67 lllASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKI-AELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDA 145

                       170
                ....*....|.
gi 59710113 374 WNISTVMAPNL 384
Cdd:cd04402 146 FNLAVCIAPSL 156
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 219-382 2.37e-11

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 62.71  E-value: 2.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKkdpgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAV 298
Cdd:cd04406   1 FGVELSRLTSEDRS------VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDT--DANSVNLDDYNIHVIAS 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 299 MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVqFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 378
Cdd:cd04406  73 VFKQWLRDLPNPLMTFELYEEFLRAMGLQERRET-VRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAI 151


                ....
gi 59710113 379 VMAP 382
Cdd:cd04406 152 VFAP 155
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 219-393 6.24e-11

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 61.64  E-value: 6.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 219 FGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEES-GLESEGIFRLSGCTAKVKQYREELD-AKFNADKFKwDKmchREA 296
Cdd:cd04389   1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALgGFQTEGIFRVPGDIDEVNELKLRVDqWDYPLSGLE-DP---HVP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 297 AVMLKAFFRELPTSLFPVEYIPAFISlmergpHVKVQFQALHLmVMALPDANRDAAQALMTFFNKVI--ANESKNRMSLW 374
Cdd:cd04389  77 ASLLKLWLRELEEPLIPDALYQQCIS------ASEDPDKAVEI-VQKLPIINRLVLCYLINFLQVFAqpENVAHTKMDVS 149

                       170
                ....*....|....*....
gi 59710113 375 NISTVMAPNlfFSRSKHSD 393
Cdd:cd04389 150 NLAMVFAPN--ILRCTSDD 166
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 250-398 2.84e-10

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 60.00  E-value: 2.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 250 VEESGLESEGIFRLSGCTAKVKQYREE-LDAKFNADKFKWD--KMCHreaavMLKAFFRELPTSLFPVEYIPAFISLMER 326
Cdd:cd04382  28 IEARGLTEEGLYRVSGSEREVKALKEKfLRGKTVPNLSKVDihVICG-----CLKDFLRSLKEPLITFALWKEFMEAAEI 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59710113 327 GPHVKVQfQALHLMVMALPDANRDAAQALMTFFNKViANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELL 398
Cdd:cd04382 103 LDEDNSR-AALYQAISELPQPNRDTLAFLILHLQRV-AQSPECKMDINNLARVFGPTIVGYSVPNPDPMTIL 172
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 243-416 3.75e-10

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 59.71  E-value: 3.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 243 LQKFFEKVEESGLESEGIFRLSGCTAKVKQY-------REELDAKFNADKFKWDKmchREAAVMLKAFFRELPTSLFPVE 315
Cdd:cd04374  32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldpKTSTPGDVDLDNSEWEI---KTITSALKTYLRNLPEPLMTYE 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 316 YIPAFISLMERG-PHVKVQfqALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFfsRSKhsdy 394
Cdd:cd04374 109 LHNDFINAAKSEnLESRVN--AIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLL--RPQ---- 180

                       170       180
                ....*....|....*....|..
gi 59710113 395 EElllanTAAHIirLMLKYQKI 416
Cdd:cd04374 181 EE-----TVAAI--MDIKFQNI 195
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 238-384 2.06e-09

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 57.52  E-value: 2.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 238 KVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVkqyrEELDAKFNADKFKWDKMCH--REAAVMLKAFFRELPTSLFPVE 315
Cdd:cd04408  15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARV----EKLCQAFENGRDLVDLSGHspHDITSVLKHFLKELPEPVLPFQ 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 316 YIPAFISL---MERGPHVKVQ--------FQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNL 384
Cdd:cd04408  91 LYDDFIALakeLQRDSEKAAEspsiveniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTL 170
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 231-384 3.60e-09

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 56.66  E-value: 3.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 231 RKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCH--REAAVMLKAFFRELP 308
Cdd:cd04383  10 YIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER--GEDPLADDQNDHdiNSVAGVLKLYFRGLE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 309 TSLFPVEYIPAFIS------LMERGPHVKvqfqalhLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAP 382
Cdd:cd04383  88 NPLFPKERFEDLMScvklenPTERVHQIR-------EILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGP 160


                ..
gi 59710113 383 NL 384
Cdd:cd04383 161 TL 162
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 239-413 4.56e-09

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 56.66  E-value: 4.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 239 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVkqyrEELDAKFNADKFKWDKMCHREAAV--MLKAFFRELPTSLFPVEY 316
Cdd:cd04378  16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARV----EKLCQAFENGKDLVELSELSPHDIssVLKLFLRQLPEPLILFRL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59710113 317 IPAFISLMERGPHVKVQFQALHL-------------MVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPN 383
Cdd:cd04378  92 YNDFIALAKEIQRDTEEDKAPNTpievnriirklkdLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPT 171

                       170       180       190
                ....*....|....*....|....*....|..
gi 59710113 384 LFFSRSKHSDYEELLLANTA--AHIIRLMLKY 413
Cdd:cd04378 172 LIRPRPGDADVSLSSLVDYGyqARLVEFLITN 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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