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Conserved domains on  [gi|61098457|ref|NP_001012772|]
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NHL repeat-containing protein 3 isoform a precursor [Homo sapiens]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-336 4.49e-46

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14958:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 300  Bit Score: 158.58  E-value: 4.49e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVD-SLNGLVYI-GQRGDNIPkILVFTEDGYFLRAW--NYTVDtPHGIFAAStlyEQSVWITDVGSgffgHTVKKYSSF 141
Cdd:cd14958  35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgaGLFYM-PHGLTIDP---DGNIWVTDVGL----HQVFKFDPE 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 142 GDLVQ--VLGTPGKKGTSLNPlqFDNPAELYVEDTGDIYIVDGDGglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd14958 106 GKLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSI 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 220 TLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEgPSSVRFTPDGKYLIV---------AQLNLSRLSVVAAPPV 290
Cdd:cd14958 182 ALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpprlnrsLPVRGFVIRIGKGLIL 259

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 61098457 291 GSIGECsvisTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYV 336
Cdd:cd14958 260 GRFGPG----GKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 66-336 4.49e-46

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 158.58  E-value: 4.49e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVD-SLNGLVYI-GQRGDNIPkILVFTEDGYFLRAW--NYTVDtPHGIFAAStlyEQSVWITDVGSgffgHTVKKYSSF 141
Cdd:cd14958  35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgaGLFYM-PHGLTIDP---DGNIWVTDVGL----HQVFKFDPE 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 142 GDLVQ--VLGTPGKKGTSLNPlqFDNPAELYVEDTGDIYIVDGDGglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd14958 106 GKLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSI 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 220 TLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEgPSSVRFTPDGKYLIV---------AQLNLSRLSVVAAPPV 290
Cdd:cd14958 182 ALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpprlnrsLPVRGFVIRIGKGLIL 259

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 61098457 291 GSIGECsvisTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYV 336
Cdd:cd14958 260 GRFGPG----GKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-337 5.44e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 71.20  E-value: 5.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFT-EDGYFLRAWNYTVDTPHGIFAAStlyEQSVWITDVGsgffGHTVKKYSSFGDL 144
Cdd:COG4257  22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNG----NNRIGRIDPKTGE 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 145 VQVLGTPGKKgtslnplqfDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHgengTGPAKFNIPHSVTLDSA 224
Cdd:COG4257  92 ITTFALPGGG---------SNPHGIAFDPDGNLWFTDQG---GNRIGRLDPATGEVTEF----PLPTGGAGPYGIAVDPD 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 225 GRVWVADRGNKRIQVFDKDTGEwLGAWNNCFTEEGPSSVRFTPDGKYLIVAQLNlSRLSVVAaPPVGSIGEcsvisTIQL 304
Cdd:COG4257 156 GNLWVTDFGANAIGRIDPDTGT-LTEYALPTPGAGPRGLAVDPDGNLWVADTGS-GRIGRFD-PKTGTVTE-----YPLP 227

                       250       260       270
                ....*....|....*....|....*....|...
gi 61098457 305 ADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVP 337
Cdd:COG4257 228 GGGARPYGVAVDGD-GRVWFAESGANRIVRFDP 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 213-240 2.76e-06

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 43.16  E-value: 2.76e-06
                          10        20
                  ....*....|....*....|....*...
gi 61098457   213 FNIPHSVTLDSAGRVWVADRGNKRIQVF 240
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 66-336 4.49e-46

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 158.58  E-value: 4.49e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVD-SLNGLVYI-GQRGDNIPkILVFTEDGYFLRAW--NYTVDtPHGIFAAStlyEQSVWITDVGSgffgHTVKKYSSF 141
Cdd:cd14958  35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgaGLFYM-PHGLTIDP---DGNIWVTDVGL----HQVFKFDPE 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 142 GDLVQ--VLGTPGKKGTSLNPlqFDNPAELYVEDTGDIYIVDGDGglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd14958 106 GKLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSI 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 220 TLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEgPSSVRFTPDGKYLIV---------AQLNLSRLSVVAAPPV 290
Cdd:cd14958 182 ALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpprlnrsLPVRGFVIRIGKGLIL 259

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 61098457 291 GSIGECsvisTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYV 336
Cdd:cd14958 260 GRFGPG----GKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-275 8.70e-33

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 122.81  E-value: 8.70e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAAStlyEQSVWITDVGsgffGHTVKKYS 139
Cdd:cd05819  60 VAVDS-DGNLYVADTGNH--RIQKFDPDGNFLASFggsgdgDGEFNGPRGIAVDS---SGNIYVADTG----NHRIQKFD 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGDLVQVLGTPGKkgtslNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd05819 130 PDGEFLTTFGSGGS-----GPGQFNGPTGVAVDSDGNIYVADTG---NHRIQVFDPDGNFLTTFGSTGTGPGQFNYPTGI 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61098457 220 TLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTEEG---PSSVRFTPDGKyLIVA 275
Cdd:cd05819 202 AVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQfnrPSGLAVDSDGN-LYVA 259
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 105-347 2.28e-29

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 113.57  E-value: 2.28e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 105 DTPHGIFAAStlyEQSVWITDVGsgffGHTVKKYSSFGDLVQVLGTPGKkgtslNPLQFDNPAELYVEDTGDIYIVDGDg 184
Cdd:cd05819   8 NNPQGIAVDS---SGNIYVADTG----NNRIQVFDPDGNFITSFGSFGS-----GDGQFNEPAGVAVDSDGNLYVADTG- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 185 glNNRLIKLSQD--FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAW------NNCFt 256
Cdd:cd05819  75 --NHRIQKFDPDgnFLASF--GGSGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPD-GEFLTTFgsggsgPGQF- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 257 eEGPSSVRFTPDGkYLIVAQLNLSRLSVVAA--PPVGSIGEcSVISTIQLADqvlPHLLEVDRkTGAVYVAEIGAKQVQK 334
Cdd:cd05819 149 -NGPTGVAVDSDG-NIYVADTGNHRIQVFDPdgNFLTTFGS-TGTGPGQFNY---PTGIAVDS-DGNIYVADSGNNRVQV 221

                       250
                ....*....|...
gi 61098457 335 YVPLNSYVPSFGS 347
Cdd:cd05819 222 FDPDGAGFGGNGN 234
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 82-335 3.16e-25

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 102.75  E-value: 3.16e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  82 DNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTL---YEQSVWITDvgsgFFGHTVKKYSSFGDLVQVLGTPGKKgtsl 158
Cdd:cd14956  31 ARNGRIQVFDKDGTFLRRFGTTGDGPGQFGRPRGLavdKDGWLYVAD----YWGDRIQVFTLTGELQTIGGSSGSG---- 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 159 nPLQFDNPAELYVEDTGDIYIvdGDGGlNNRLIKLSQD--FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKR 236
Cdd:cd14956 103 -PGQFNAPRGVAVDADGNLYV--ADFG-NQRIQKFDPDgsFLRQW--GGTGIEPGSFNYPRGVAVDPDGTLYVADTYNDR 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 237 IQVFDKDtGEWLGAWNNCFTEEG----PSSVRFTPDGKyLIVAQLNLSRLSVVAAP-----PVGSIGEcsviSTIQLADq 307
Cdd:cd14956 177 IQVFDND-GAFLRKWGGRGTGPGqfnyPYGIAIDPDGN-VFVADFGNNRIQKFTADgtfltSWGSPGT----GPGQFKN- 249

                       250       260
                ....*....|....*....|....*...
gi 61098457 308 vlPHLLEVDRkTGAVYVAEIGAKQVQKY 335
Cdd:cd14956 250 --PWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-335 9.54e-24

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 98.88  E-value: 9.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAASTlyeQSVWITDVgsgfFGHTVKKYS 139
Cdd:cd14957  23 IAVDS-AGNIYVADTGNN--RIQVFTSSGVYSYSIgsggtgSGQFNSPYGIAVDSN---GNIYVADT----DNNRIQVFN 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGDLVQVLGTpgkkgTSLNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd14957  93 SSGVYQYSIGT-----GGSGDGQFNGPYGIAVDSNGNIYVADTG---NHRIQVFTSSGTFSYSIGSGGTGPGQFNGPQGI 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 220 TLDSAGRVWVADRGNKRIQVFDKDtgewlGAWNNCFTEEGPSSVRF-TP-------DGKYLIVAQLNlSRLSVVAAPPV- 290
Cdd:cd14957 165 AVDSDGNIYVADTGNHRIQVFTSS-----GTFQYTFGSSGSGPGQFsDPygiavdsDGNIYVADTGN-HRIQVFTSSGAy 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 61098457 291 -GSIGecsvISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKY 335
Cdd:cd14957 239 qYSIG----TSGSGNGQFNYPYGIAVD-NDGKIYVADSNNNRIQVF 279
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 162-347 1.98e-23

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 97.77  E-value: 1.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 162 QFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFD 241
Cdd:cd05819   6 ELNNPQGIAVDSSGNIYVADTG---NNRIQVFDPDGNFITSFGSFGSGDGQFNEPAGVAVDSDGNLYVADTGNHRIQKFD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 242 KDtGEWLGAW----NNCFTEEGPSSVRFTPDGKYLIVAQLNlSRLSVVAA--PPVGSIGeCSVISTIQLADqvlPHLLEV 315
Cdd:cd05819  83 PD-GNFLASFggsgDGDGEFNGPRGIAVDSSGNIYVADTGN-HRIQKFDPdgEFLTTFG-SGGSGPGQFNG---PTGVAV 156

                       170       180       190
                ....*....|....*....|....*....|..
gi 61098457 316 DRKtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Cdd:cd05819 157 DSD-GNIYVADTGNHRIQVFDPDGNFLTTFGS 187
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-240 1.03e-20

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 90.07  E-value: 1.03e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYTV------DTPHGIFAAStlyEQSVWITDvgsgFFGHTVKKYS 139
Cdd:cd05819 107 IAVDS-SGNIYVADTGNH--RIQKFDPDGEFLTTFGSGGsgpgqfNGPTGVAVDS---DGNIYVAD----TGNHRIQVFD 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGDLVQVLGTPGkkgtsLNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd05819 177 PDGNFLTTFGSTG-----TGPGQFNYPTGIAVDSDGNIYVADSG---NNRVQVFDPDGAGFGGNGNFLGSDGQFNRPSGL 248

                       170       180
                ....*....|....*....|.
gi 61098457 220 TLDSAGRVWVADRGNKRIQVF 240
Cdd:cd05819 249 AVDSDGNLYVADTGNNRIQVF 269
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-262 1.59e-19

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 86.86  E-value: 1.59e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAASTlyeQSVWITDVGsgffGHTVKKYS 139
Cdd:cd14955  68 IAVDS-DGNVYVADTGNH--RIQKFDSTGTFLTKWgssgsgDGQFNSPSGIAVDSA---GNVYVTDSG----NNRIQKFD 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGdlvQVLGTPGKKGTSLNplQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQD--FMILWlhGENGTGPAKFNIPH 217
Cdd:cd14955 138 SSG---TFITKWGSFGSGDG--QFNSPTGIAVDSAGNVYVADTG---NNRIQKFTSTgtFLTKW--GSEGSGDGQFNAPY 207

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 61098457 218 SVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAWNNCFTEEGPSS 262
Cdd:cd14955 208 GIAVDSAGNVYVADTGNNRIQKFDS-SGTFITKWGSEGSGDGQFN 251
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-240 3.85e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 85.80  E-value: 3.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYTvdtphGIFAASTLYEQSVWITDVGSGF----FGHTVKKYSSF 141
Cdd:cd14956 112 VAVDA-DGNLYVADFGNQ--RIQKFDPDGSFLRQWGGT-----GIEPGSFNYPRGVAVDPDGTLYvadtYNDRIQVFDND 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 142 GDLVQVLGTPGKKgtslnPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTL 221
Cdd:cd14956 184 GAFLRKWGGRGTG-----PGQFNYPYGIAIDPDGNVFVADFG---NNRIQKFTADGTFLTSWGSPGTGPGQFKNPWGVVV 255

                       170
                ....*....|....*....
gi 61098457 222 DSAGRVWVADRGNKRIQVF 240
Cdd:cd14956 256 DADGTVYVADSNNNRVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-241 1.64e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 84.17  E-value: 1.64e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAASTLYeqsVWITDVGSgffgHTVKKYS 139
Cdd:cd14955 115 IAVDS-AGNVYVTDSGNN--RIQKFDSSGTFITKWgsfgsgDGQFNSPTGIAVDSAGN---VYVADTGN----NRIQKFT 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGDLVQVLGTPGKkGTSlnplQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQD--FMILWlhGENGTGPAKFNIPH 217
Cdd:cd14955 185 STGTFLTKWGSEGS-GDG----QFNAPYGIAVDSAGNVYVADTG---NNRIQKFDSSgtFITKW--GSEGSGDGQFNSPS 254

                       170       180
                ....*....|....*....|....
gi 61098457 218 SVTLDSAGRVWVADRGNKRIQVFD 241
Cdd:cd14955 255 GIAVDSAGNVYVADSGNNRIQKFA 278
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 162-347 4.17e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 83.01  E-value: 4.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 162 QFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQD--FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQV 239
Cdd:cd14955  14 QFNSPSGIAVDSAGNVYVADTG---NNRIQKFDSTgtFLTKW--GSSGSGDGQFYSPTGIAVDSDGNVYVADTGNHRIQK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 240 FDKdTGEWLGAWNNCFTEEG----PSSV-------------------RFTPDGKYLivAQLnlsrlsvvaappvGSIGec 296
Cdd:cd14955  89 FDS-TGTFLTKWGSSGSGDGqfnsPSGIavdsagnvyvtdsgnnriqKFDSSGTFI--TKW-------------GSFG-- 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 61098457 297 svISTIQLADqvlPHLLEVDrKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Cdd:cd14955 151 --SGDGQFNS---PTGIAVD-SAGNVYVADTGNNRIQKFTSTGTFLTKWGS 195
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-274 2.93e-17

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 80.67  E-value: 2.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRA--------------WNYTVDTPHGIFaastlyeqsvwITDVGSgff 131
Cdd:cd14954  76 VAVNS-RGRIIVADKDNH--RIQVFDLNGRFLLKfgergtkngqfnypWGVAVDSEGRIY-----------VSDTRN--- 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 132 gHTVKKYSSFGDLVQVLGTPGKKgtslnPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPA 211
Cdd:cd14954 139 -HRVQVFDSDGQFIRKFGFEGAG-----PGQLDSPRGVAVNPDGNIVVSDFN---NHRLQVFDPDGQFLRFFGSEGSGNG 209

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61098457 212 KFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWL---GAWNNCFTE-EGPSSVRFTPDGKYLIV 274
Cdd:cd14954 210 QFKRPRGVAVDDEGNIIVADSGNHRVQVFSPD-GEFLcsfGTEGNGEGQfDRPSGVAVTPDGRIVVV 275
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 64-241 2.16e-16

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 78.08  E-value: 2.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  64 FCVAVDSlNGLVYIGQRGDNIpkILVFTEDGYFLRA------WNYTVDTPHGIF--AASTLYeqsvwITDVgsgfFGHTV 135
Cdd:cd14957 115 YGIAVDS-NGNIYVADTGNHR--IQVFTSSGTFSYSigsggtGPGQFNGPQGIAvdSDGNIY-----VADT----GNHRI 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 136 KKYSSFGDLVQVLGTPGKkgtslNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNI 215
Cdd:cd14957 183 QVFTSSGTFQYTFGSSGS-----GPGQFSDPYGIAVDSDGNIYVADTG---NHRIQVFTSSGAYQYSIGTSGSGNGQFNY 254

                       170       180
                ....*....|....*....|....*.
gi 61098457 216 PHSVTLDSAGRVWVADRGNKRIQVFD 241
Cdd:cd14957 255 PYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-240 1.02e-15

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 76.43  E-value: 1.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYT------VDTPHGIfaaSTLYEQSVWITDvgsgFFGHTVKKYS 139
Cdd:cd14954 123 VAVDS-EGRIYVSDTRNH--RVQVFDSDGQFIRKFGFEgagpgqLDSPRGV---AVNPDGNIVVSD----FNNHRLQVFD 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGDLVQVLGTPGKkgtslNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd14954 193 PDGQFLRFFGSEGS-----GNGQFKRPRGVAVDDEGNIIVADSG---NHRVQVFSPDGEFLCSFGTEGNGEGQFDRPSGV 264

                       170       180
                ....*....|....*....|.
gi 61098457 220 TLDSAGRVWVADRGNKRIQVF 240
Cdd:cd14954 265 AVTPDGRIVVVDRGNHRIQVF 285
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 162-347 5.51e-15

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 74.22  E-value: 5.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 162 QFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFD 241
Cdd:cd14957  16 QFNTPRGIAVDSAGNIYVADTG---NNRIQVFTSSGVYSYSIGSGGTGSGQFNSPYGIAVDSNGNIYVADTDNNRIQVFN 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 242 KDTGEWL---GAWNNCFTEEGPSSVRFTPDGKyLIVAQLNLSRLSVVAAPPVGSIgecSVISTIQLADQV-LPHLLEVDR 317
Cdd:cd14957  93 SSGVYQYsigTGGSGDGQFNGPYGIAVDSNGN-IYVADTGNHRIQVFTSSGTFSY---SIGSGGTGPGQFnGPQGIAVDS 168

                       170       180       190
                ....*....|....*....|....*....|
gi 61098457 318 KtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Cdd:cd14957 169 D-GNIYVADTGNHRIQVFTSSGTFQYTFGS 197
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 64-248 9.54e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 73.39  E-value: 9.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  64 FCVAVDSlNGLVYI--GQRGdnipKILVFTEDGYFLRAWNYTVDT--PHGIFAASTlyEQSVWITDVGsgffGHTVKKYS 139
Cdd:cd14962  60 IGVAIDA-NGNLYVsdAELG----KVFVFDRDGKFLRAIGAGALFkrPTGIAVDPA--GKRLYVVDTL----AHKVKVFD 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 140 SFGDLVQVLGTPGKKgtslnPLQFDNPAELYVEDTGDIYIVDGdggLNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSV 219
Cdd:cd14962 129 LDGRLLFDIGKRGSG-----PGEFNLPTDLAVDRDGNLYVTDT---MNFRVQIFDADGKFLRSFGERGDGPGSFARPKGI 200

                       170       180
                ....*....|....*....|....*....
gi 61098457 220 TLDSAGRVWVADRGNKRIQVFDKdTGEWL 248
Cdd:cd14962 201 AVDSEGNIYVVDAAFDNVQIFNP-EGELL 228
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-240 1.02e-14

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 73.00  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSLNGLVYIGQRGDNipKILVFTEDGYFLRAWNyTVDTPHGIFAAST----LYEQSVWITDVGSGffghTVKKYSSF 141
Cdd:cd14962 105 IAVDPAGKRLYVVDTLAH--KVKVFDLDGRLLFDIG-KRGSGPGEFNLPTdlavDRDGNLYVTDTMNF----RVQIFDAD 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 142 GDLVQVLGTPGkkgtsLNPLQFDNPAELYVEDTGDIYIVDGDGglnNRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTL 221
Cdd:cd14962 178 GKFLRSFGERG-----DGPGSFARPKGIAVDSEGNIYVVDAAF---DNVQIFNPEGELLLTVGGPGSGPGEFYLPSGIAI 249

                       170
                ....*....|....*....
gi 61098457 222 DSAGRVWVADRGNKRIQVF 240
Cdd:cd14962 250 DKDDRIYVVDQFNRRIQVF 268
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 152-347 1.28e-14

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 73.09  E-value: 1.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 152 GKKGTSlnPLQFDNPAELYVEDTGDIYIVD------------------------GDGGL--------------------N 187
Cdd:cd14956   3 GGRGSG--PGQFKDPRGIAVDADDNVYVADarngriqvfdkdgtflrrfgttgdGPGQFgrprglavdkdgwlyvadywG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 188 NRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEG----PSSV 263
Cdd:cd14956  81 DRIQVFTLTGELQTIGGSSGSGPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPD-GSFLRQWGGTGIEPGsfnyPRGV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 264 RFTPDGKyLIVAQLNLSRLSVVAAP--PVGSIGEcsviSTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVPLNSY 341
Cdd:cd14956 160 AVDPDGT-LYVADTYNDRIQVFDNDgaFLRKWGG----RGTGPGQFNYPYGIAIDPD-GNVFVADFGNNRIQKFTADGTF 233


                ....*.
gi 61098457 342 VPSFGS 347
Cdd:cd14956 234 LTSWGS 239
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-335 3.68e-14

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 71.55  E-value: 3.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDslNGLVYIGQRGDNipKILVFTEDGYFLRA----------WNYtvdtPHGIfaasTLYEQS-VWITDVGSGffghT 134
Cdd:cd14963  15 VAVS--DGRIYVADTNNH--RVQVFDYEGKFKKSfggpgtgpgeFKY----PYGI----AVDSDGnIYVADLYNG----R 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 135 VKKYSSFGDLVQVLGTPGKKgtslnpLQFDNPAELYVEDtGDIYIVDGDGglnNRLIKLSQDFMILWLHGENGTGPAKFN 214
Cdd:cd14963  79 IQVFDPDGKFLKYFPEKKDR------VKLISPAGLAIDD-GKLYVSDVKK---HKVIVFDLEGKLLLEFGKPGSEPGELS 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 215 IPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWL----GAWNNCFTEEGPSSVRFTPDGKYLIVAqlNLSRlSVVAAPPV 290
Cdd:cd14963 149 YPNGIAVDEDGNIYVADSGNGRIQVFDKN-GKFIkelnGSPDGKSGFVNPRGIAVDPDGNLYVVD--NLSH-RVYVFDEQ 224

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 61098457 291 GSIGECSVISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKY 335
Cdd:cd14963 225 GKELFTFGGRGKDDGQFNLPNGLFID-DDGRLYVTDRENNRVAVY 268
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-337 5.44e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 71.20  E-value: 5.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFT-EDGYFLRAWNYTVDTPHGIFAAStlyEQSVWITDVGsgffGHTVKKYSSFGDL 144
Cdd:COG4257  22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNG----NNRIGRIDPKTGE 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 145 VQVLGTPGKKgtslnplqfDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHgengTGPAKFNIPHSVTLDSA 224
Cdd:COG4257  92 ITTFALPGGG---------SNPHGIAFDPDGNLWFTDQG---GNRIGRLDPATGEVTEF----PLPTGGAGPYGIAVDPD 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 225 GRVWVADRGNKRIQVFDKDTGEwLGAWNNCFTEEGPSSVRFTPDGKYLIVAQLNlSRLSVVAaPPVGSIGEcsvisTIQL 304
Cdd:COG4257 156 GNLWVTDFGANAIGRIDPDTGT-LTEYALPTPGAGPRGLAVDPDGNLWVADTGS-GRIGRFD-PKTGTVTE-----YPLP 227

                       250       260       270
                ....*....|....*....|....*....|...
gi 61098457 305 ADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVP 337
Cdd:COG4257 228 GGGARPYGVAVDGD-GRVWFAESGANRIVRFDP 259
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 207-347 1.16e-13

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 70.04  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 207 GTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEG----PSSVRFTPDGkYLIVAQLNLSRL 282
Cdd:cd05819   1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPD-GNFITSFGSFGSGDGqfnePAGVAVDSDG-NLYVADTGNHRI 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61098457 283 SVVAapPVGSIGECSVISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Cdd:cd05819  79 QKFD--PDGNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFGS 140
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 121-251 1.62e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 63.76  E-value: 1.62e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 121 VWITDVGSGFfghtVKKYSSFGDLVQVLGTPGKK----GTSLNPLQfdnpAELYVEDTGD--IYIVDGDGglnnRLIKls 194
Cdd:cd14962  70 LYVSDAELGK----VFVFDRDGKFLRAIGAGALFkrptGIAVDPAG----KRLYVVDTLAhkVKVFDLDG----RLLF-- 135

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 61098457 195 qDFmilwlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAW 251
Cdd:cd14962 136 -DI------GKRGSGPGEFNLPTDLAVDRDGNLYVTDTMNFRVQIFDAD-GKFLRSF 184
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-237 2.98e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 63.70  E-value: 2.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDN-IPKI--------------LVFTEDGYFLRAwnyTVDTPHGI--FAASTLYeqsvwITDvgs 128
Cdd:cd14953 137 VAVDA-AGNLYVADTGNHrIRKItpdgvvttvagtggAGYAGDGPATAA---QFNNPTGVavDAAGNLY-----VAD--- 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 129 gFFGHTVKKYSSFGDLVQVLGTPGK---KGTSLNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLH-- 203
Cdd:cd14953 205 -RGNHRIRKITPDGVVTTVAGTGTAgfsGDGGATAAQLNNPTGVAVDAAGNLYVADSG---NHRIRKITPAGVVTTVAgg 280

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 61098457 204 -----GENGTG-PAKFNIPHSVTLDSAGRVWVADRGNKRI 237
Cdd:cd14953 281 gagfsGDGGPAtSAQFNNPTGVAVDAAGNLYVADTGNNRI 320
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
226-336 3.87e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.40  E-value: 3.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 226 RVWVADRGNKRIQVFDKDTGEWLGAWNncfTEEGPSSVRFTPDGKYLIVAQLNLSRLSVVAAPpvgsigECSVISTIQLA 305
Cdd:COG3391  81 RLYVANSGSGRVSVIDLATGKVVATIP---VGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTA------TGKVVATIPVG 151

                        90       100       110
                ....*....|....*....|....*....|.
gi 61098457 306 DQvlPHLLEVDRKTGAVYVAEIGAKQVQKYV 336
Cdd:COG3391 152 AG--PHGIAVDPDGKRLYVANSGSNTVSVIV 180
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
216-329 8.82e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 61.25  E-value: 8.82e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 216 PHSVTLDSAG-RVWVADRGNKRIQVFDKDTGEWLGAWNncfTEEGPSSVRFTPDGKYLIVAQLNLSRLSVVAAppVGSIG 294
Cdd:COG3391 112 PRGLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNTVSVIVS--VIDTA 186

                        90       100       110
                ....*....|....*....|....*....|....*
gi 61098457 295 ECSVISTIQLADQvlPHLLEVDRKTGAVYVAEIGA 329
Cdd:COG3391 187 TGKVVATIPVGGG--PVGVAVSPDGRRLYVANRGS 219
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
107-337 1.85e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 1.85e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 107 PHGIFAAStlyEQSVWITDVGSGFFGhtvkkyssfgdlvqVLGTPGKKGTSLNPLQFDNPAELYVEDTGDIYIVDGdggL 186
Cdd:COG4257  19 PRDVAVDP---DGAVWFTDQGGGRIG--------------RLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDN---G 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 187 NNRLIKLSQDfmilwlhgeNGT-----GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLgAWNNCFTEEGPS 261
Cdd:COG4257  79 NNRIGRIDPK---------TGEittfaLPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVT-EFPLPTGGAGPY 148

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61098457 262 SVRFTPDGKyLIVAQLNLSRLSVVAAppvgsigECSVISTIQL-ADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVP 337
Cdd:COG4257 149 GIAVDPDGN-LWVTDFGANAIGRIDP-------DTGTLTEYALpTPGAGPRGLAVDPD-GNLWVADTGSGRIGRFDP 216
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 152-274 2.53e-10

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 60.44  E-value: 2.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 152 GKKGTSLNplQFDNPAELYVEDTGDIYIVDgdggLNNRLIKL-SQDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVA 230
Cdd:cd14960 143 GSRGNGDR--QFAGPHFAAVNNNNEIIVTD----FHNHSVKVfNAEGEFLFKFGSNGEGNGQFNAPTGVAVDSNGNIIVA 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61098457 231 DRGNKRIQVFDKdTGEWLGAWNNCF-TEEGPSSVRFTPDGKYLIV 274
Cdd:cd14960 217 DWGNSRIQVFDS-SGSFLSYINTSAdPLYGPQGLALTSDGHVVVA 260
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
107-295 8.85e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 58.49  E-value: 8.85e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 107 PHGIFAAStlyEQSVWITDVGsgffGHTVKKYSSFGDLVQVLGTPGKKGtslnplqfdNPAELYVEDTGDIYIVDGDggl 186
Cdd:COG4257 104 PHGIAFDP---DGNLWFTDQG----GNRIGRLDPATGEVTEFPLPTGGA---------GPYGIAVDPDGNLWVTDFG--- 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 187 NNRLIKLSQDFMILWLHgengTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWlGAWNNCFTEEGPSSVRFT 266
Cdd:COG4257 165 ANAIGRIDPDTGTLTEY----ALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGTV-TEYPLPGGGARPYGVAVD 239

                       170       180
                ....*....|....*....|....*....
gi 61098457 267 PDGKyLIVAQLNLSRLSVVAapPVGSIGE 295
Cdd:COG4257 240 GDGR-VWFAESGANRIVRFD--PDTELTE 265
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-237 9.94e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 59.08  E-value: 9.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDN-IPKI----LVFTEDGYFLRAWNY-------TVDTPHGIF--AASTLYeqsvwITDVGsgff 131
Cdd:cd14953  82 VAVDA-AGNLYVADTGNHrIRKItpdgVVSTLAGTGTAGFSDdggataaQFNYPTGVAvdAAGNLY-----VADTG---- 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 132 GHTVKKYSSFGDLVQVLGTPGKKGTSLNPL---QFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMI--------L 200
Cdd:cd14953 152 NHRIRKITPDGVVTTVAGTGGAGYAGDGPAtaaQFNNPTGVAVDAAGNLYVADRG---NHRIRKITPDGVVttvagtgtA 228

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 61098457 201 WLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRI 237
Cdd:cd14953 229 GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRI 265
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 163-249 1.81e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 57.69  E-value: 1.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 163 FDNPAELYVEDtGDIYIVDGdggLNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDK 242
Cdd:cd14963   9 LNKPMGVAVSD-GRIYVADT---NNHRVQVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRIQVFDP 84


                ....*..
gi 61098457 243 DtGEWLG 249
Cdd:cd14963  85 D-GKFLK 90
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 204-347 1.89e-09

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 57.66  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 204 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEW--LGAWNNCFTE-EGPSSVRFTPDGKyLIVAQLNLS 280
Cdd:cd14957   8 GSNGSGNGQFNTPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSysIGSGGTGSGQfNSPYGIAVDSNGN-IYVADTDNN 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61098457 281 RLSVVAAPPV--GSIGecsvISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Cdd:cd14957  87 RIQVFNSSGVyqYSIG----TGGSGDGQFNGPYGIAVD-SNGNIYVADTGNHRIQVFTSSGTFSYSIGS 150
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 149-237 3.57e-09

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 57.15  E-value: 3.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 149 GTPGKKGTSLNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQD-----FMILWLHG-ENGTGP-AKFNIPHSVTL 221
Cdd:cd14953   8 GTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRG---NHRIRKITPDgvvttVAGTGTAGfADGGGAaAQFNTPSGVAV 84

                        90
                ....*....|....*.
gi 61098457 222 DSAGRVWVADRGNKRI 237
Cdd:cd14953  85 DAAGNLYVADTGNHRI 100
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 207-274 2.58e-08

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 54.20  E-value: 2.58e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61098457 207 GTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFD------KDTGEWLGAWNNCFTeegPSSVRFTPDGkYLIV 274
Cdd:cd14961   4 GGWPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDsdgnclQQFGPKGDAGQDIRY---PLDVAVTPDG-HIVV 73
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 204-251 3.34e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 54.12  E-value: 3.34e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 61098457 204 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAW 251
Cdd:cd14955   6 GSYGSGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDS-TGTFLTKW 52
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 133-243 3.46e-08

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 54.07  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 133 HTVKKYSSFGDlVQVLGTPGKKGTS---LNPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHG----- 204
Cdd:cd14953  44 HRIRKITPDGV-VTTVAGTGTAGFAdggGAAAQFNTPSGVAVDAAGNLYVADTG---NHRIRKITPDGVVSTLAGtgtag 119

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 61098457 205 -ENGTGP--AKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKD 243
Cdd:cd14953 120 fSDDGGAtaAQFNYPTGVAVDAAGNLYVADTGNHRIRKITPD 161
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 152-265 1.15e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 52.55  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 152 GKKGTSlnPLQFDNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVAD 231
Cdd:cd14954  14 GKEGSK--DGELCRPWGVAVDKDGRIIVADRS---NNRVQVFDPDGKFLRKFGSYGSRDGQFDRPAGVAVNSRGRIIVAD 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 61098457 232 RGNKRIQVFDKDtGEWLGawnnCFTEEGPSSVRF 265
Cdd:cd14954  89 KDNHRIQVFDLN-GRFLL----KFGERGTKNGQF 117
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 195-274 1.65e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 51.89  E-value: 1.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 195 QDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAWNNCFTEEG----PSSVR-FTPDG 269
Cdd:cd14959   3 SKMIIHCKFGESGSGEGQFNSPSGFCLGEDEDILVADTNNHRIQVFDK-EGEFKFQFGIPGKRDGqlwyPNKVAvCRVTG 81


                ....*
gi 61098457 270 KYLIV 274
Cdd:cd14959  82 RYVVT 86
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
210-347 2.19e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.56  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 210 PAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTeeGPSSVRFTPDGKyLIVAQLNLSRLSVVaAPP 289
Cdd:COG4257  13 PAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGS--GPHGIAVDPDGN-LWFTDNGNNRIGRI-DPK 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61098457 290 VGsigecsVISTIQL-ADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 347
Cdd:COG4257  89 TG------EITTFALpGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGEVTEFPL 140
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 213-240 2.76e-06

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 43.16  E-value: 2.76e-06
                          10        20
                  ....*....|....*....|....*...
gi 61098457   213 FNIPHSVTLDSAGRVWVADRGNKRIQVF 240
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 152-326 4.53e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 47.66  E-value: 4.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 152 GKKGTslNPLQFDNPAELYVEDTGDIYIVDgDGglNNRlIKL--SQDFMILWLhGENGTGPAKFNIPHSVTLDSAGRVWV 229
Cdd:cd14961   1 GSFGG--WPGTLNNPTGVAVTPTGRVVVAD-DG--NKR-IQVfdSDGNCLQQF-GPKGDAGQDIRYPLDVAVTPDGHIVV 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 230 ADRGNKRIQVFDKDtGEWLGAWNNCFTEegPSSVRFTPDGKYLiVAQLNLSRLSVV-AAPPVGSIGECSVISTiQLadqV 308
Cdd:cd14961  74 TDAGDRSVKVFSFD-GRLKLFVRKSFSL--PWGVAVNPSGEIL-VTDSEAGKLFVLtVDFKLGILKKGQKLCS-QL---C 145

                       170
                ....*....|....*...
gi 61098457 309 LPHLLEVDRKtGAVYVAE 326
Cdd:cd14961 146 RPRFVAVSRL-GAVAVTE 162
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 204-346 2.35e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 45.27  E-value: 2.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 204 GENGTGPAkFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGE---WLGAWNNCFTEegPSSVRFTPDGKyLIVAQLNLS 280
Cdd:cd14962   3 GEERPKEA-LTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKvfvIGNAGPNRFVS--PIGVAIDANGN-LYVSDAELG 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61098457 281 RLSVVAAP--PVGSIGEcsvistiqLADQVLPHLLEVDRKTGAVYVAEIGAKQVQKYVPLNSYVPSFG 346
Cdd:cd14962  79 KVFVFDRDgkFLRAIGA--------GALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIG 138
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 118-337 5.40e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 5.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 118 EQSVWITDVgsgfFGHTVKKYSSFGDLVQVLGTPGKKGTSLnplQFDNPAELYVEDTGD-IYIVDGDGGlnnrliklsqd 196
Cdd:COG3386  18 DGRLYWVDI----PGGRIHRYDPDGGAVEVFAEPSGRPNGL---AFDPDGRLLVADHGRgLVRFDPADG----------- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 197 fMILWLHGENGtgpAKFNIPHSVTLDSAGRVWVAD----RGNKRIQVFDKDtGEwLGAWNNCFTeeGPSSVRFTPDGKYL 272
Cdd:COG3386  80 -EVTVLADEYG---KPLNRPNDGVVDPDGRLYFTDmgeyLPTGALYRVDPD-GS-LRVLADGLT--FPNGIAFSPDGRTL 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61098457 273 IVAQLNLSRLSVVAAPPVGSIGECSVISTIQlADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVP 337
Cdd:COG3386 152 YVADTGAGRIYRFDLDADGTLGNRRVFADLP-DGPGGPDGLAVDAD-GNLWVALWGGGGVVRFDP 214
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 59-237 8.30e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 8.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  59 FTGTTFC--VAVDSlNGLVYIGQRGDN----------IPKILVFTEdgyflrawnytVDTPHGIFAASTlyeQSVWITDV 126
Cdd:cd14952   6 FTGLDGPggVAVDA-AGNVYVADSGNNrvlklaagstTQTVLPFTG-----------LYQPQGVAVDAA---GTVYVTDF 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 127 GSgffghtvkkyssfgDLVQVLgTPGkkGTSLNPLQF---DNPAELYVEDTGDIYIVDGDgglNNRLIKL---SQDFMIL 200
Cdd:cd14952  71 GN--------------NRVLKL-AAG--STTQTVLPFtglNDPTGVAVDAAGNVYVADTG---NNRVLKLaagSNTQTVL 130

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 61098457 201 WLHGENGtgpakfniPHSVTLDSAGRVWVADRGNKRI 237
Cdd:cd14952 131 PFTGLSN--------PDGVAVDGAGNVYVTDTGNNRV 159
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 169-274 4.03e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.42  E-value: 4.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 169 LYVEDTGD--IYI--VDGDGGLNNRliklsqdfmILWLHGENGTGpakfnIPHSVTLDSAGRVWVADRGNKRIQVFDKDt 244
Cdd:COG3386 151 LYVADTGAgrIYRfdLDADGTLGNR---------RVFADLPDGPG-----GPDGLAVDADGNLWVALWGGGGVVRFDPD- 215

                        90       100       110
                ....*....|....*....|....*....|.
gi 61098457 245 GEWLGAWNncFTEEGPSSVRF-TPDGKYLIV 274
Cdd:COG3386 216 GELLGRIE--LPERRPTNVAFgGPDLRTLYV 244
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 164-237 9.08e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.27  E-value: 9.08e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61098457 164 DNPAELYVEDTGDIYIVDGDgglNNRLIKLSQDfmilwlhgenGTGPAKF-----NIPHSVTLDSAGRVWVADRGNKRI 237
Cdd:cd14952 136 SNPDGVAVDGAGNVYVTDTG---NNRVLKLAAG----------STTQTVLpftglNSPSGVAVDTAGNVYVTDHGNNRV 201
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 66-275 1.29e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.95  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGY--------FLRAWNYTVDTPHGIFaastlyeqsvwITDVGSGFFGHTVkk 137
Cdd:cd14961  63 VAVTP-DGHIVVTDAGDR--SVKVFSFDGRlklfvrksFSLPWGVAVNPSGEIL-----------VTDSEAGKLFVLT-- 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 138 ySSFGdlVQVLGTPGKKGTSLNplqfdNPAELYVEDTGDIYIVDGDGGLNNRL----IKLSQDFMILWlhGE-----NGT 208
Cdd:cd14961 127 -VDFK--LGILKKGQKLCSQLC-----RPRFVAVSRLGAVAVTEHLFANGTRSsstrVKVFSSGGQLL--GQidsfgLNL 196

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61098457 209 GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWlgawnnCFTEE------GPSSVRFTPDGkYLIVA 275
Cdd:cd14961 197 VFPSLICASGVAFDSEGNVIVADTGSGAILCLGKPEGFP------ILKPIvtqglsRPVGLAVTPDG-SLVVL 262
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 209-276 1.66e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 39.49  E-value: 1.66e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61098457 209 GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWlGAWnnCFTEEGPSSVRFTPDGKyLIVAQ 276
Cdd:COG3386   3 ADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAV-EVF--AEPSGRPNGLAFDPDGR-LLVAD 66
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
207-302 2.13e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 39.50  E-value: 2.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 207 GTGPAKFNI----PHSVTLDSAGR-VWVADRGNKRIQVF--DKDTGEW-LGAWNNCFTEEGPSSVRFTPDGKYLIVAQ-L 277
Cdd:COG2706 139 GSGPNPERQegphAHSVVFDPDGRfLYVPDLGTDRIYVYrlDPATGKLpEPPEVSLPPGSGPRHLAFHPNGRFAYVINeL 218

                        90       100
                ....*....|....*....|....*.
gi 61098457 278 NlSRLSVVA-APPVGSIGECSVISTI 302
Cdd:COG2706 219 D-STVSVYAyDAATGTLTLIQTVSTL 243
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 166-237 2.42e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.11  E-value: 2.42e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61098457 166 PAELYVEDTGDIYIVDGDgglNNRLIKLSQdfmilwlhGENGTGPAKF---NIPHSVTLDSAGRVWVADRGNKRI 237
Cdd:cd14952 180 PSGVAVDTAGNVYVTDHG---NNRVLKLAA--------GSTTPTVLPFtglNGPLGVAVDAAGNVYVADRGNDRV 243
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
216-335 4.85e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 38.35  E-value: 4.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61098457 216 PHSVTLDSAGR-VWVADRGNK-RIQVF--DKDTGEwLGAWNNCFTE-EGPSSVRFTPDGKYLIVAQLNLSRLSVVAAPPV 290
Cdd:COG2706  47 PSFLALSPDGRfLYAVNEVDDgGVSAFriDPADGT-LTLLNTVSSGgASPCHLSVDPDGRFLFVANYGGGSVSVFPIDAD 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 61098457 291 GSIGEcsVISTIQLA-------DQVLPHL--LEVDRKTGAVYVAEIGAKQVQKY 335
Cdd:COG2706 126 GSLGE--PVQVIQHEgsgpnpeRQEGPHAhsVVFDPDGRFLYVPDLGTDRIYVY 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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