|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
33-467 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 521.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 33 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVG 112
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 113 VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIE 272
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 273 WWAYEVGSFLSGIL-GMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCV 351
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 352 LLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISLMFVAK 431
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400
|
410 420 430
....*....|....*....|....*....|....*.
gi 62078965 432 LGVIGLWSGIIICSVCQTSCFLVFIARLNWKLACQQ 467
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
33-462 |
1.07e-70 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 233.55 E-value: 1.07e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 33 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVG 112
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 113 VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLFLHQL----HLGVMGSALANTISQFALAIFLFLYILWRKLHHA--TWGGWSWECLQDWASFLQLAIPSM 266
Cdd:cd13131 160 ALVLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRyrLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 267 LMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFA 346
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 347 VTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISL 426
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 62078965 427 MFVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWK 462
Cdd:cd13131 400 AFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
34-455 |
1.11e-67 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 225.41 E-value: 1.11e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 ILQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIE 272
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 273 WWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVL 352
Cdd:COG0534 246 SLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 353 LLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGIsLMFVAKL 432
Cdd:COG0534 326 LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY-LLAFLGL 404
|
410 420
....*....|....*....|...
gi 62078965 433 GVIGLWSGIIICSVCQTSCFLVF 455
Cdd:COG0534 405 GLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
43-382 |
1.58e-58 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 198.62 E-value: 1.58e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 43 PAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLIL 122
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 123 LLCCFPCWALFINTEQILLLFRQ-DPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALAN 201
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 202 YLFLHQLH--LGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIEWWAYEVG 279
Cdd:TIGR00797 160 YILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 280 SFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDL 359
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330 340
....*....|....*....|...
gi 62078965 360 VGYIFTTDWDIVALVAQVVPIYA 382
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
41-456 |
6.38e-50 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 177.90 E-value: 6.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 41 AGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINvTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTL 120
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 121 ILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNAL 199
Cdd:cd12082 80 LAILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 200 ANYLFLHQL---HLGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIEWWAY 276
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 277 EVGSFL-SGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLG 355
Cdd:cd12082 240 LIIVAIvAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 356 CKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGIsLMFVAKLGVI 435
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAY-VLAYLGLGLY 398
|
410 420
....*....|....*....|.
gi 62078965 436 GLWSGIIICSVCQTSCFLVFI 456
Cdd:cd12082 399 GIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-461 |
1.01e-49 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 177.72 E-value: 1.01e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 ILQRGTLILLLCCFPCWALFI-NTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLSAlAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLF----LHQLHLGVMGSALANTISQFALAIFLFLYILWRKLH--HATWGGWSWEcLQDWASFLQLAIPSM 266
Cdd:cd13133 163 MVVVNIVLDYALifgkLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrFGLRRAWRFD-RELLRRILRLGLPSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 267 LMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFA 346
Cdd:cd13133 242 LQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 347 VTFCVLLLGCKDLVGYIFTTDWD---IVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIG 423
Cdd:cd13133 322 LLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPA 401
|
410 420 430
....*....|....*....|....*....|....*...
gi 62078965 424 IsLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNW 461
Cdd:cd13133 402 Y-LLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-462 |
7.64e-49 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 175.01 E-value: 7.64e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVI 114
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 115 LQRGTLILLLCCFP-CWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAA 193
Cdd:cd13137 80 LGQSLLLALLLSLPlALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 194 NLVNALANYLF----LHQLHLGVMGSALANTISQFALAIFLFLYILWRKLH-HATWGGWSWEcLQDWASFLQLAIPSMLM 268
Cdd:cd13137 160 NVLNIVLDYVLifglWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPiKISFKGFRLD-RKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 269 LCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVT 348
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 349 FCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISLMF 428
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGF 398
|
410 420 430
....*....|....*....|....*....|....
gi 62078965 429 VAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWK 462
Cdd:cd13137 399 VLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
30-443 |
3.30e-41 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 154.59 E-value: 3.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 30 FQEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLK 109
Cdd:PRK01766 7 YKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIG-TSIWLPVILFGHGLLLALTPIVAQLNGAGRRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 110 HVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQ-DPDVSRLTQTYVMVFIPALPAAFLYtlQVKYLLNQGIVLPQV- 187
Cdd:PRK01766 86 RIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLY--QVLRSFIDGLGKTKPt 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 188 -ITGIAANLVNALANYLFLHQL----HLGVMGSALANTISQFALAIFLFLYILWRKL--HHATWGGWSWECLQDWASFLQ 260
Cdd:PRK01766 164 mVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 261 LAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLI 340
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 341 VTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGL 420
Cdd:PRK01766 324 VGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGL 403
|
410 420
....*....|....*....|...
gi 62078965 421 PIGISLMFVAKLGVIGLWSGIII 443
Cdd:PRK01766 404 PLGYILALTDPMGPFGFWIGLII 426
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-443 |
4.96e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 145.34 E-value: 4.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVtGISVGHGLSSACDTLISQTYGSQNLKHVGVI 114
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 115 LQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALpaaFLYTLQVKY---LLNQGIVLPQVITG 190
Cdd:cd13134 82 AGVALLFnLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSL---FLQALSLTLsaiLRSHGRTKIPMYVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 191 IAANLVNALANYLFLHQLH----LGVMGSALANTISQFA---LAIFLFLYILWRKLHHATWGGWSWECLQDwasFLQLAI 263
Cdd:cd13134 159 LIMNILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVglvLLFILLFRKLKIRFRLKDLRPFPKKLLKK---ILKIGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 264 PSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 343
Cdd:cd13134 236 PSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 344 LFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIG 423
Cdd:cd13134 316 LVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLA 395
|
410 420
....*....|....*....|
gi 62078965 424 ISLMFVAKLGVIGLWSGIII 443
Cdd:cd13134 396 YLLGIVLGLGLLGVWIAFAA 415
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
34-462 |
7.30e-34 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 133.35 E-value: 7.30e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGH-LGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVG 112
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 113 -VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLqVKYLLN-QGIVLPQVITG 190
Cdd:cd13138 81 kAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNA-YSAILRgLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 191 IAANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRKLH-HATWGGWSWEcLQDWASFLQLAIPSMLML 269
Cdd:cd13138 160 IIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPfKLSLKDFRFD-KEILKEILKIGLPSALQQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 270 CIewwayevgSFLSGIL--------GMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIV 341
Cdd:cd13138 239 SL--------VSISFLIinsivnsyGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 342 TELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLP 421
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIP 390
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 62078965 422 IGISLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWK 462
Cdd:cd13138 391 LAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-462 |
2.24e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 126.54 E-value: 2.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVInVTGISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 IL-QRGTLILLLCCFPCWALFINTEQILLLF-RQDPDVSRLTQTYVMVFIPALPAAFLY-TLQVkylLNQGI---VLPQV 187
Cdd:cd13142 89 VAgQTFSFVIILSLILAVLGYILSRPLLLLLiGAPEEVYPLALAYLRIIFLGLPFMFIFfVFNS---LLRGIgdtKTPMK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 188 ITGIAAnLVNALANYLFLHQL----HLGVMGSALANTISQFALAIFLfLYILWRKLHH------ATWGGWSWeclqdWAS 257
Cdd:cd13142 166 IMFGSV-LLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIG-LYLLFKGRVGlkislrDLKPDWEW-----LKK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 258 FLQLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAI 337
Cdd:cd13142 239 IFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 338 SLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYV 417
Cdd:cd13142 319 AALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWV 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 62078965 418 IGLPIGISLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWK 462
Cdd:cd13142 399 IRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWK 443
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-438 |
1.44e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 123.77 E-value: 1.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHL-GKLELDAVTLAIAVIN-VTGISVGHGLSSAcdTLISQTYGSQNLKHVG 112
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKAN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 113 VILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGI 191
Cdd:cd13143 82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 192 AANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRK-LHHATWGGWSWEcLQDWASFLQLAIPSMLMlc 270
Cdd:cd13143 162 IGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsLLKLSLLRFKLS-LKIIKEILALGFPSFLM-- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 271 iewwayEVGSFLSGIL---------GMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIV 341
Cdd:cd13143 239 ------QLSSSVVTIVlnltllgygGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 342 TELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLP 421
Cdd:cd13143 313 ALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIP 392
|
410
....*....|....*....
gi 62078965 422 igisLMFV--AKLGVIGLW 438
Cdd:cd13143 393 ----LLLIlpRLFGLDGIW 407
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
35-443 |
4.96e-28 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 116.51 E-value: 4.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKL-ELDAVTLAIAVINVtgISVGHG-LSSACDTLISQTYGSQNLKHVG 112
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNT--LFWLFGfLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 113 VILQRGTLILLLCcfpcwALFINTEQ------ILLLFRQDPDVSRLTQTYVMVFIPALPAAFL-YTLQVKYLLNQGIVLP 185
Cdd:cd13136 81 ALLVRALLLALAI-----GLLLILLQspllalALLLLGASAAVAALARQYLRIRILGAPAVLLnYVATGWFRGLQDTRTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 186 QVITgIAANLVNALANYLFLHQLHLGVMGSALANTISQFALAIfLFLYILWRKLHHATWGGWSweCLQDWASFLQLAIPS 265
Cdd:cd13136 156 LILQ-IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGAL-LGLWLLRRRVRLLGKSLSR--RLPSKAALKRLFKLN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 266 ------MLMLCIewwAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISL 339
Cdd:cd13136 232 rdifirTLALLA---AFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 340 IVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGA---IVNAIGYY 416
Cdd:cd13136 309 QWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRnsmLVSLAVFL 388
|
410 420
....*....|....*....|....*..
gi 62078965 417 ViglpigISLMFVAKLGVIGLWSGIII 443
Cdd:cd13136 389 P------LLFLLVPLWGNHGLWLALIL 409
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
33-480 |
6.92e-27 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 113.69 E-value: 6.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 33 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGhGLSSACDTLISQTYGSQNLKHVG 112
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCV-GVIAAVGTLVAIRHGAGDIEGAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 113 VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:PRK00187 87 RLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLFLHQL----HLGVMGSALANTISQFALAIFLFLYILWRKLHHA--TWGGWSWECLQDWASFLQLAIPSM 266
Cdd:PRK00187 167 GAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypLRKGLSRPSRAALRELWRLGLPIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 267 LMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFA 346
Cdd:PRK00187 247 GTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 347 VTFCVLLLGCKDLVGYIFTTDWD-----IVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLP 421
Cdd:PRK00187 327 LLFAGLFWLLPEAIIGLFLDRNDpafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAP 406
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 62078965 422 IGISLMFVAKLGVIGLWSGIIICSVCQTSCFLVfiaRLNWKLACQQAQVHANLKVNVAL 480
Cdd:PRK00187 407 LAWLLAFTLGWGAVGVWWGLALGLACAAVALTL---AFEWKTARLLRKARASEAVALSA 462
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
43-203 |
6.13e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 98.41 E-value: 6.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 43 PAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLIL 122
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 123 LLCCFP-CWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALAN 201
Cdd:pfam01554 80 LLLSLPiALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 62078965 202 YL 203
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-462 |
4.83e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 101.83 E-value: 4.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAV---------TLAIAVINVTGISVGhglssacdtlISQTYG 104
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVK----------VSQSIG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 105 SQNLKHVGVILQRGTLI-LLLCCFPCWALFINTEQILLLFR-QDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQG- 181
Cdd:cd13140 74 AKDEKEARKYARNALQLnLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGd 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 182 IVLPQVITGIAaNLVNALANYLFLHQL----HLGVMGSALANTISQfALAIFLFLYILwRKLHHATWGGWSWECL--QDW 255
Cdd:cd13140 154 SKTPFIINAIG-LVLNIILDPLLIFGFgpfpALGVAGAALATVLAQ-AIVFLLFLYAL-KKKKGLFLKIRILKRPdrKYI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 256 ASFLQLAIP----SMLMLCIEWWayeVGSFLSGiLGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQA 331
Cdd:cd13140 231 KEILKLGLPvalqSILFALISMI---LARIIAS-FGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 332 KKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVn 411
Cdd:cd13140 307 RKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAII- 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 62078965 412 AIGYYVIGLPIGISLMFvAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWK 462
Cdd:cd13140 386 SIVFNGLRIPLALLLSP-TGLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
264-423 |
1.59e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 94.17 E-value: 1.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 264 PSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 343
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 344 LFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGyYVIGLPIG 423
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-459 |
3.96e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 86.90 E-value: 3.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:cd13144 7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 ILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:cd13144 86 AANNGlLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLFLHQLH----LGVMGSALANTISQFALAIFLFLYILWR--------KLHHATWggwsweclQDWASFLQ 260
Cdd:cd13144 166 GAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKnkdvqpdlRLFRPSL--------RIIKEIYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 261 LAIPSMLMLCIewwayevGSFLSGILGMVELG-------AQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKK 333
Cdd:cd13144 238 VGLPSIIMQAI-------SSVMVFGLNKILAGfgptavaVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIRE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 334 SSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAI 413
Cdd:cd13144 311 AIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVA 390
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 62078965 414 GYYVIGLPigISLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIARL 459
Cdd:cd13144 391 RQLVVLLP--LAWLLAKMFGLNGVWWSFPIAEIVSFLLSLLFLKRL 434
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-462 |
5.00e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 83.82 E-value: 5.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVI 114
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 115 LQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYtlqvkyLLNQGIVLPQVITGIA- 192
Cdd:cd13139 93 AVQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLL------FLINGIFRGAGDAAIAm 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 -----ANLVNALANYLFLHQL----HLGVMGSALANTISQFALAIFLfLYILWRKLHHATWG----GWSWECLQdwaSFL 259
Cdd:cd13139 167 rslwlANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQ-LYHLFKGKGRIQIRrrhlKLDWAIIK---KII 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 260 QLAIPSMLMLCIEwwayeVGSFLSGILGMVELGAQSIT-YELAIIVYM---IPA-GFSVAANVRVGNALGAGNIDQAKKS 334
Cdd:cd13139 243 KIAVGGILQFLIA-----SSSWIFLVRIIAEFGSTALAgYTIAIRIIMfalLPAwGLSNAAATLVGQNLGAGQPDRAEKS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 335 saisLIVTELFAVTFC-----VLLLGCKDLVGyIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAI 409
Cdd:cd13139 318 ----VWRAGKYNMVFLgivslVFFLFAEPLVS-FFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTL 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 62078965 410 VNAIGYYVIGLPIGISLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWK 462
Cdd:cd13139 393 INLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWK 445
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-443 |
8.94e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 82.73 E-value: 8.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 37 LLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINvTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQ 116
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 117 ---RGTLILLLCCFPCWalFINTEQILLLFRQDPDVSRLTQTYVMVFIPALP-AAFLYTLQVkYLLNQGIVLPQVITGIA 192
Cdd:cd13135 82 ssiVYNSIIGVILFLLW--LFGARIIFVLFGVDGQILGYSINYVRIFSIYLLlLGILFTFSS-ILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLF----LHQLHLGVMGSALANTISQFALAIFLFLYIL-WRKLHHATWGGWS-WECLQDWASFLQLAIPSM 266
Cdd:cd13135 159 KNLLNVILDYVLifgnFGFPRLGIIGAAIATTIANVLNLIILVYLCRkIKKLTFKLSNTKVlKANIRPYKFTIKLGLPLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 267 LMLcIEWWAYE--VGSFLSGIlGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTEL 344
Cdd:cd13135 239 GEE-FLWNIGNlaVIRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 345 FAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGyYVIGLPIGI 424
Cdd:cd13135 317 IYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-TIIVVSVAL 395
|
410
....*....|....*....
gi 62078965 425 SLMFVAKLGVIGLWSGIII 443
Cdd:cd13135 396 LLIFVFKLGLAGVYITLFI 414
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
32-233 |
9.93e-14 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 73.25 E-value: 9.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 32 EELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHV 111
Cdd:COG0534 226 KILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDRA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 112 GVILQRGTLILLLCCFPCWALF-INTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITG 190
Cdd:COG0534 305 RRAARLALLLALGIGLLLALLLfLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIS 384
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 62078965 191 IAANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLY 233
Cdd:COG0534 385 LLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-421 |
1.74e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 72.72 E-value: 1.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGiSVGHGLSSACDTLISQTYGSQNLKHV-- 111
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAkr 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 112 ----GVILqrgTLILLLCCFPCWALFIntEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQG-IVLPQ 186
Cdd:cd13149 87 latdSLIL---SLLLSVIVSLLGLFTI--PPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGdTKRPS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 187 VITGIAAnLVNALANYLFLHQL----HLGVMGSALANTISQFALAIFLfLYILWRKLHHATWGGWSW-ECLQDWASFLQL 261
Cdd:cd13149 162 LVMLGAA-LVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAA-LYFLHYHHRLIDFSEPSLkALFRSWKDILSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 262 AIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIV 341
Cdd:cd13149 240 GIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 342 TELF-AVTFCVLLLGCKDLVGyIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGL 420
Cdd:cd13149 320 SLIYgAILGIVLALFAGWLAS-LFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYI 398
|
.
gi 62078965 421 P 421
Cdd:cd13149 399 P 399
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-446 |
1.80e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 72.43 E-value: 1.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 37 LLVLAGPAFLAQLMMFLISFISSVFCGHLGKlELDAVTLAIAVINVTG---ISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDP-SDPALVGGIGLVFPLGmifLALGNGIQVGVSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 ILQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIA 192
Cdd:cd13146 89 AADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 193 ANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRKLH---HATWGGWSWECLqdwASFLQLAIPSMLML 269
Cdd:cd13146 169 GTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNvtiHIKLSNISSSVI---VEILRVGLPQMLLQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 270 CIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTF 349
Cdd:cd13146 246 LISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 350 CVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISLMFV 429
Cdd:cd13146 326 VLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYV 405
|
410
....*....|....*..
gi 62078965 430 AKLGVIGLWSGIIICSV 446
Cdd:cd13146 406 FGKGITGVYFGIVSANF 422
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-458 |
8.58e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 61.18 E-value: 8.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 37 LLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQ 116
Cdd:cd13141 13 IISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKDQGEANAVFN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 117 RGTLILLLCCFPCWALFINTEQILLLF-RQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANL 195
Cdd:cd13141 92 QSLLLAAVLGLVVLVLGYLFGRLYLETlAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 196 VNALANYLFLHQL----HLGVMGSALANTISqFALAIFLFLYILWRKLHHATWGGWSWEC-LQDWASFLQLAIPS----M 266
Cdd:cd13141 172 LNIILAPILITGWgtgrALGVAGAGLASSIS-VAIAVVLLLYYFLRLEKYLRLDLALWRPdLPTWKRLLKIGLPSggefL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 267 LMLC----IEWWAYEVGSFLSGILGmveLGAQSITyelaiiVYMIPA-GFSVAANVRVGNALGAGNIDQAKKSSAISLIV 341
Cdd:cd13141 251 LTFVymavIYWALRPFGAAAQAGFG---IGSRIMQ------SLFLPAmAIAFAAPAIAGQNFGAGNYDRVRETFRITAIL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 342 TELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLP 421
Cdd:cd13141 322 TTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALP 401
|
410 420 430
....*....|....*....|....*....|....*..
gi 62078965 422 IgISLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIAR 458
Cdd:cd13141 402 V-IWLSAQPDFRIEQIWYLSVATTILQAALSLLLLRR 437
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
32-307 |
9.55e-10 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 60.93 E-value: 9.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 32 EELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGkleldavTLAIAVIN-----------VTGISVGhglsSACDTLIS 100
Cdd:COG0728 219 PGVRRVLKLMLPALLGVSVSQINLLVDTILASFLP-------EGSVSALYyadrlyqlplgLFGVAIG----TALLPRLS 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 101 QTYGSQNLKHVGVILQRGTLILLLCCFPCWALFI--NTEQILLLF---RQDPDVSRLTQTYVMVFIPALPAAFLYTLQVK 175
Cdd:COG0728 288 RAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIvlAEPIVRLLFergAFTAEDTALTALALAAYALGLPAFALVKVLAR 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 176 YLLNQGIVLPQVITGIAANLVNALANYLFLHqlHLGVMGSALANTISQFALAIFLFlYILWRKLHHATWGGWsweclqdW 255
Cdd:COG0728 368 AFYARQDTRTPVRIAVIAVVVNIVLNLLLVP--PLGHAGLALATSLSALVNALLLL-VLLRRRLGGLPLRGI-------L 437
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 62078965 256 ASFLQLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMI 307
Cdd:COG0728 438 RTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
259-463 |
1.52e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 54.05 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 259 LQLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAIS 338
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 339 LIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQK-------VGAIVN 411
Cdd:cd13137 84 LLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKtpmyimiIVNVLN 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 62078965 412 AIGYYVIGLPIGIslmfVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWKL 463
Cdd:cd13137 164 IVLDYVLIFGLWG----FPGLGVAGAALATVISRVVGALLLLFLLLRGRLPI 211
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
32-235 |
1.55e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 50.79 E-value: 1.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 32 EELRALLVLAGPAFLAQLMM-FLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGhGLSSACDTLISQTYGSQNLKH 110
Cdd:cd12082 216 ELLRRLLRIGLPSAIQNSLLsLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPAL-GLAQAALPVVGQNLGAGNFDR 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 111 VGVILQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPA-AFLYTLQvKYLLNQGIVLPQVI 188
Cdd:cd12082 295 ARRITWVALLIgLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFvGIGYVLQ-AGFQAAGRTLKSLI 373
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 62078965 189 TGIAANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYIL 235
Cdd:cd12082 374 VSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
85-458 |
3.06e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 49.90 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 85 ISVGHGLSSACDTLISQTYGSQNLKHVGVILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYvmvFIPA 163
Cdd:cd13145 58 IAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGlSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEY---MDVI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 164 LPAAFLYTLQvkYLLNqGIVLPQVITG------IAANLVNALANYLFLH----QLHLGVMGSALANTISQFALAIFLFLY 233
Cdd:cd13145 135 FAGSIFFLLN--FGLN-GILNAQGDTKsyrnflIIGFFLNIILDPLFIFggggIPAMGVSGIALATIISQFIGMFYLLYK 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 234 ILWRKLHHATWGGWSWECLQDWASFLQLAIPSML-MLCIEWWAYEVGSFLSGiLGMVELGAQSITYELAIIVYMIPAGFS 312
Cdd:cd13145 212 VRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLnMMTIGLGIFVITYFVGQ-FGDEAVAAYGIALRIEQILLLPTIGLN 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 313 VAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQ-------VVPIYAVsh 385
Cdd:cd13145 291 TAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGylridalIFYAYVV-- 368
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62078965 386 LFealacTCGGVLRGTGNQKVGAIVNaiGYYVIGLPIGIS--LMFVAKLGVIGLWSGIIIcSVCQTSCFLVFIAR 458
Cdd:cd13145 369 LF-----ISVSVLQGLKRPIFALWIG--LYRQLVGPALVFwlLVNVLGLGVTGIWWGIFT-IVWSAAIIALLYTR 435
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
32-235 |
4.57e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 49.05 E-value: 4.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 32 EELRALLVLAGPAFLAQLMMFLISFISS-VFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKH 110
Cdd:cd13143 223 KIIKEILALGFPSFLMQLSSSVVTIVLNlTLLGYGGDIGVAAFGIVTRILTFL-FLPLIGLSQGLQPIIGYNYGAGNYDR 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 111 VGVILQRGTLILLLCCFPCWA-LFINTEQILLLFRQDPDVSRLTQTYVMVFIPALP-AAFLYTLQVkYLLNQGIVLPQVI 188
Cdd:cd13143 302 VKQALKLALIVALIYGLVLFLiLLLFPEQIVSLFTDDPELIALAARILRIFLLAFPlAGINIVLSG-YFQAIGKAKRAAL 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 62078965 189 TGIAANLVNALANYLFLHQLhLGVMGSALANTISQFALAIFLFLYIL 235
Cdd:cd13143 381 LSLLRQGLFLIPLLLILPRL-FGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
43-446 |
9.35e-06 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 48.45 E-value: 9.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 43 PAFLAQLMMFLISFISSVFCGH-LGKLELDAVTLAIAVINVT---GISVGHGLSSacdtLISQTYGSQNLKHVGVILQRG 118
Cdd:PRK09575 20 PSIAAMLVNGLYQIVDGIFIGHyVGAEGLAGINMAWPVIGIIlgiGLMVGMGTGS----LLSIKRGEGDLEKAKRILTTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 119 -TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIvlPQVITG--IAANL 195
Cdd:PRK09575 96 lLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDES--PNLATGlmVIGAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 196 VNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRKlhhaTWGGWSWECLQ-DWAS---FLQLAIPSMLMlci 271
Cdd:PRK09575 174 INIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSR----ANIRLTLKELRfNWSLapkIVLLGSSSFFM--- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 272 ewwaYEVGSF---LSGILGM-----VELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 343
Cdd:PRK09575 247 ----YLYGSFvvaLHNRLFMeygsaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 344 LFAVTFCVLLLGCKDLVGYIFTTDwDIVALVAQVVPIYAvsHLFeALACTCGGVLRG----TGNQKVGAIVNAIGYYVIG 419
Cdd:PRK09575 323 LAGIAWVLLLNLFPETMIALFNSG-DSELIAETIVGIRL--HLF-AMFLDGFLVLASayfmAVNQGGKALFISIGNMLIQ 398
|
410 420 430
....*....|....*....|....*....|...
gi 62078965 420 LPIgisLMFVAK-LGVIGLW-----SGIIICSV 446
Cdd:PRK09575 399 LPF---LFILPKwLGVDGVWlamplSNIALSLV 428
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
45-436 |
5.38e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 45.61 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 45 FLAQLMMFLISFISSVFCG-HLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILL 123
Cdd:cd13128 9 FVGNIISKLLGFLVRVYLArYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEKIREIISTSLVLKLILGI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 124 LCcFPCWALFINteqilLLFRQDPdvsrLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALANYL 203
Cdd:cd13128 89 LA-LLLLFLFAF-----LIAFYDP----ELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 204 FLHqLHLGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWswecLQDWASFLQLAIPSMLMLCIEWWAYEVGSF-L 282
Cdd:cd13128 159 LVL-LGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFD----LKLAKELLRFSIPLALSGIFSLIYTRIDTImL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 283 SGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALgAGNIDQAKKSSAISLIVTELFAVTFCVLL-LGCKDLVG 361
Cdd:cd13128 234 GYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLfLFAEPIIT 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62078965 362 YIFTTDWDIVALVAQvvpIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGyyvIGLPIGISLMFVAKLGVIG 436
Cdd:cd13128 313 LLFGEEYLPAALVLQ---ILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIG---ALLNVILNLLLIPKYGIIG 381
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
35-456 |
5.94e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 45.61 E-value: 5.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVI 114
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 115 LQRGTLI-LLLCCFPCWALFINTEQILLLFrQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAA 193
Cdd:cd13147 88 AVHSILLgLIISIILTIVLLPFLEPILVLM-GAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 194 NLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRK-------LHHATwggWSWECLQDW------ASFLQ 260
Cdd:cd13147 167 SILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdtyvslsLKNFK---FDKKIVKDIlkvgipASLEQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 261 LAIpSMLMLCIEWWAYEVGSflsgilgmvelgaqsityELAIIVY----------MIPA-GFSVAANVRVGNALGAGNID 329
Cdd:cd13147 244 LIM-SVLMIILNLILVIVAG------------------TDGVAVYtagwrivsfaIIPLiGIATAVTSVTGAAYGARNYE 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 330 QAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVV---PIYAVSHLFEALACTCGGVLRGTGNQKV 406
Cdd:cd13147 305 KLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVaflRIMCLFLPFVPFGMMSSSMFQGIGKGLT 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 62078965 407 GAIVNAIGYYVIGLPIGISLMFVAKLGVIGLWSGIIICSVCqtSCFLVFI 456
Cdd:cd13147 385 SLIITILRELIFQVLFAYLFAIVLGLGLFGVWWGIVLGNAI--GSIVGYL 432
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-237 |
8.74e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 45.28 E-value: 8.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 35 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVgHGLSSACDTLISQTYGSQNLKHVGVI 114
Cdd:cd13145 234 KEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPT-IGLNTAVLSIAGQNFGAKKYDRVRET 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 115 LQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLlnQGIVLPQVIT--GI 191
Cdd:cd13145 313 YKKALKYgFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVL--QGLKRPIFALwiGL 390
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 62078965 192 AANLVN-ALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWR 237
Cdd:cd13145 391 YRQLVGpALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRRV 437
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
34-238 |
1.37e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 44.42 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDEARR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 ILQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPaaFLYTlqvkyllnqGIVLPQVITGIA 192
Cdd:cd13137 304 YGKRALRLgVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQP--FLAI---------SFVLSGALRGAG 372
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 62078965 193 ANLVNALAN------------YLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRK 238
Cdd:cd13137 373 DTRPPLIINlismwlvrlplaYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGK 430
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
32-238 |
1.40e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 44.37 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 32 EELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKlelDAVT----------LAIAVInvtGISVghglSSACDTLISQ 101
Cdd:cd13123 212 PGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPE---GSISalyyadrlyqLPLGIF---GVAI----ATALLPRLSR 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 102 TYGSQNLKHVGVILQRGTLILLLCCFPC--WALFINTEQILLLFRQ---DPDVSRLTQTYVMVFIPALPAAFLYTLQVKY 176
Cdd:cd13123 282 LAAAGDLDEFRRTLSRGLRLVLFLLLPAavGLIVLAEPIVRLLFERgafTAEDTLMTASALAAYALGLPAFALVKLLSRA 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62078965 177 LLNQGIVLPQVITGIAANLVNALANYLFLHqlHLGVMGSALANTISQFALAIFLFlYILWRK 238
Cdd:cd13123 362 FYALKDTKTPVKIAVIAVAVNILLNLLLIK--PLGHVGLALATSLSAWVNALLLL-VLLRRR 420
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
34-240 |
1.64e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 44.38 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 34 LRALLVLAGPAFLAQLMMFLISFISSVFCGHL----GKLELDAVTL-------AIAVINVtGISVGHGLSSACDTLISQT 102
Cdd:cd13124 223 LKELLSYAIPITLSSLILPLLQLIDSFTVPRRlqaaGLSESEATALygiltgrAQPLVQL-PTVIATALSTSLVPAISEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 103 YGSQNLKHVGVILQRGTLILLLCCFPC-WALFINTEQILLLFRQDPDVSRLTQTYVMVFIpalpaaFLYTLQVKYLLNQG 181
Cdd:cd13124 302 YAKGDKKELRRRINQALRLTLLIGLPAaVGLAVLAEPINTLLFGDSEGGLILQILAPSIL------FLSLQQVTAAILQG 375
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62078965 182 I---VLPQVITGIAAnLVNALANYLFLHqlHLGVMGSALANTISqFALAIFLFLYILWRKLH 240
Cdd:cd13124 376 LgkvKIPVINLLIGL-LVKIVLNYVLIP--IFGIYGAAIATVIG-FLVAALLNLRALKKLLG 433
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
119-437 |
3.15e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.21 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 119 TLILLLCCFPCWALfinTEQILLLF--RQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLV 196
Cdd:cd13123 82 LLVLLLLTLLGILF---APLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 197 NALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYiLWRKLHHATWGGWSWEclQDWASFLQLAIPSMLMLCIewwaY 276
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPA-LRRLGFRFRPRLDFRD--PGVRRVLKLMLPALLGVSV----S 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 277 EVGSFLSGILG-MVELGAQSITYeLAIIVYMIPAG-FSVAanvrVGNAL--------GAGNIDQAKK--SSAISLIVTEL 344
Cdd:cd13123 232 QINLLVDTILAsFLPEGSISALY-YADRLYQLPLGiFGVA----IATALlprlsrlaAAGDLDEFRRtlSRGLRLVLFLL 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 345 FAVTFCVLLLGcKDLVGYIF----TTDWDiVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGyyvIGL 420
Cdd:cd13123 307 LPAAVGLIVLA-EPIVRLLFergaFTAED-TLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIA---VAV 381
|
330
....*....|....*..
gi 62078965 421 PIGISLMFVAKLGVIGL 437
Cdd:cd13123 382 NILLNLLLIKPLGHVGL 398
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
278-425 |
1.45e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 41.43 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 278 VGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 357
Cdd:cd13145 31 VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 358 DLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQK-------VGAIVNAI-------GYYVIgLPIG 423
Cdd:cd13145 111 PPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKsyrnfliIGFFLNIIldplfifGGGGI-PAMG 189
|
..
gi 62078965 424 IS 425
Cdd:cd13145 190 VS 191
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
36-231 |
1.58e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 41.09 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 36 ALLVLAGPAFLAQLMMFLISFISSVFCGHLgkLELDAVTL--AIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGV 113
Cdd:COG2244 174 LVLKYSLPLLLSGLLGLLLTNLDRLLLGAL--LGPAAVGIysAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRR 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 114 ILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRlTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAA 193
Cdd:COG2244 252 LYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE-AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG 330
|
170 180 190
....*....|....*....|....*....|....*...
gi 62078965 194 NLVNALANYLFLHqlHLGVMGSALANTISQFALAIFLF 231
Cdd:COG2244 331 AVLNLVLNLLLIP--RYGLVGAAIATLLSYLVLLLLLL 366
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
278-438 |
1.88e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 40.69 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 278 VGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 357
Cdd:TIGR00797 15 VDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVGYFFI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078965 358 DLVGYIFTTDwDIVALVAQV--------VPIYAVSHLFEalactcgGVLRGTGNQKVGAIVNaigyyVIGLPIGISLMFV 429
Cdd:TIGR00797 95 DPLLSLMGAD-GEVAELAQDylrililgIPAYLLNFVLR-------GFLRGQGDTKTPMYIT-----LIGNVINIILNYI 161
|
....*....
gi 62078965 430 AKLGVIGLW 438
Cdd:TIGR00797 162 LIFGKFGFL 170
|
|
| |
