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Conserved domains on  [gi|62821785|ref|NP_001017370|]
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NHL repeat-containing protein 3 isoform b [Homo sapiens]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 61-269 8.18e-25

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14958:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 300  Bit Score: 100.42  E-value: 8.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  61 GTTFC----VAVDSlNGLVYIG-----QRgdnipkILVFTEDGYFLRAWnytvdtphgifaastlyeqsvwitdvgsdfm 131
Cdd:cd14958 124 QTHFCkptdVAVAP-DGDIFVAdgycnSR------IVKFSPDGKLLKSW------------------------------- 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ilwlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEgPSSVRFTPDGKYLIV---A 208
Cdd:cd14958 166 -----GEPGSGPGQFNLPHSIALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpP 238

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 209 QLNLS------RLSVVAAPPVGSIGECsvisTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYV 269
Cdd:cd14958 239 RLNRSlpvrgfVIRIGKGLILGRFGPG----GKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 61-269 8.18e-25

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 100.42  E-value: 8.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  61 GTTFC----VAVDSlNGLVYIG-----QRgdnipkILVFTEDGYFLRAWnytvdtphgifaastlyeqsvwitdvgsdfm 131
Cdd:cd14958 124 QTHFCkptdVAVAP-DGDIFVAdgycnSR------IVKFSPDGKLLKSW------------------------------- 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ilwlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEgPSSVRFTPDGKYLIV---A 208
Cdd:cd14958 166 -----GEPGSGPGQFNLPHSIALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpP 238

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 209 QLNLS------RLSVVAAPPVGSIGECsvisTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYV 269
Cdd:cd14958 239 RLNRSlpvrgfVIRIGKGLILGRFGPG----GKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
107-270 2.08e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 65.81  E-value: 2.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 107 PHGIFAAStlyEQSVWITDVGSDfMILWLHGENG-----TGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEwL 181
Cdd:COG4257 104 PHGIAFDP---DGNLWFTDQGGN-RIGRLDPATGevtefPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGT-L 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 182 GAWNNCFTEEGPSSVRFTPDGKYLIVAQLNlSRLSVVAaPPVGSIGEcsvisTIQLADQVLPHLLEVDRKtGAVYVAEIG 261
Cdd:COG4257 179 TEYALPTPGAGPRGLAVDPDGNLWVADTGS-GRIGRFD-PKTGTVTE-----YPLPGGGARPYGVAVDGD-GRVWFAESG 250


                ....*....
gi 62821785 262 AKQVQKYVP 270
Cdd:COG4257 251 ANRIVRFDP 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 146-173 2.56e-06

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 43.16  E-value: 2.56e-06
                          10        20
                  ....*....|....*....|....*...
gi 62821785   146 FNIPHSVTLDSAGRVWVADRGNKRIQVF 173
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 61-269 8.18e-25

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 100.42  E-value: 8.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  61 GTTFC----VAVDSlNGLVYIG-----QRgdnipkILVFTEDGYFLRAWnytvdtphgifaastlyeqsvwitdvgsdfm 131
Cdd:cd14958 124 QTHFCkptdVAVAP-DGDIFVAdgycnSR------IVKFSPDGKLLKSW------------------------------- 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ilwlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEgPSSVRFTPDGKYLIV---A 208
Cdd:cd14958 166 -----GEPGSGPGQFNLPHSIALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpP 238

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 209 QLNLS------RLSVVAAPPVGSIGECsvisTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYV 269
Cdd:cd14958 239 RLNRSlpvrgfVIRIGKGLILGRFGPG----GKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-280 1.81e-22

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 93.54  E-value: 1.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAASTlyeQSVWITDVG----------SD 129
Cdd:cd05819  13 IAVDS-SGNIYVADTGNN--RIQVFDPDGNFITSFgsfgsgDGQFNEPAGVAVDSD---GNLYVADTGnhriqkfdpdGN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 130 FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAW------NNCFteEGPSSVRFTPDGk 203
Cdd:cd05819  87 FLASF--GGSGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPD-GEFLTTFgsggsgPGQF--NGPTGVAVDSDG- 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62821785 204 YLIVAQLNLSRLSVVAA--PPVGSIGEcSVISTIQLADqvlPHLLEVDRkTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd05819 161 NIYVADTGNHRIQVFDPdgNFLTTFGS-TGTGPGQFNY---PTGIAVDS-DGNIYVADSGNNRVQVFDPDGAGFGGNGN 234
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-208 3.30e-18

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 81.98  E-value: 3.30e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYTV------DTPHGIFAAStlyEQSVWITDVG--------SDFM 131
Cdd:cd05819 107 IAVDS-SGNIYVADTGNH--RIQKFDPDGEFLTTFGSGGsgpgqfNGPTGVAVDS---DGNIYVADTGnhriqvfdPDGN 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTEEG---PSSVRFTPDGKyLIVA 208
Cdd:cd05819 181 FLTTFGSTGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQfnrPSGLAVDSDGN-LYVA 259
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-207 1.02e-15

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 75.28  E-value: 1.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYT------VDTPHGIfaaSTLYEQSVWITDVG--------SDFM 131
Cdd:cd14954 123 VAVDS-EGRIYVSDTRNH--RVQVFDSDGQFIRKFGFEgagpgqLDSPRGV---AVNPDGNIVVSDFNnhrlqvfdPDGQ 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWL---GAWNNCFTE-EGPSSVRFTPDGKYLIV 207
Cdd:cd14954 197 FLRFFGSEGSGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPD-GEFLcsfGTEGNGEGQfDRPSGVAVTPDGRIVVV 275
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 82-280 1.34e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 74.63  E-value: 1.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  82 DNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTL---YEQSVWITDVGSDFMI--------LWLHGENGTGPAKFNIPH 150
Cdd:cd14956  31 ARNGRIQVFDKDGTFLRRFGTTGDGPGQFGRPRGLavdKDGWLYVADYWGDRIQvftltgelQTIGGSSGSGPGQFNAPR 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 151 SVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEG----PSSVRFTPDGKyLIVAQLNLSRLSVVAAP--PVG 224
Cdd:cd14956 111 GVAVDADGNLYVADFGNQRIQKFDPD-GSFLRQWGGTGIEPGsfnyPRGVAVDPDGT-LYVADTYNDRIQVFDNDgaFLR 188

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62821785 225 SIGEcsviSTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd14956 189 KWGG----RGTGPGQFNYPYGIAIDPD-GNVFVADFGNNRIQKFTADGTFLTSWGS 239
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-193 1.46e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 74.63  E-value: 1.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW----------NYTVD---TPHGIFAASTLYEQSVWITDVGSDFMI 132
Cdd:cd14956 112 VAVDA-DGNLYVADFGNQ--RIQKFDPDGSFLRQWggtgiepgsfNYPRGvavDPDGTLYVADTYNDRIQVFDNDGAFLR 188

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62821785 133 LWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEGP 193
Cdd:cd14956 189 KW--GGRGTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTAD-GTFLTSWGSPGTGPGQ 246
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-280 1.48e-15

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 74.54  E-value: 1.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAAStlyEQSVWITDVGSD---------- 129
Cdd:cd14955  21 IAVDS-AGNVYVADTGNN--RIQKFDSTGTFLTKWgssgsgDGQFYSPTGIAVDS---DGNVYVADTGNHriqkfdstgt 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 130 FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEG----PSSV--------- 196
Cdd:cd14955  95 FLTKW--GSSGSGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSS-GTFITKWGSFGSGDGqfnsPTGIavdsagnvy 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 197 ----------RFTPDGKYLivAQLnlsrlsvvaappvGSIGEcsvistiqlADQVL--PHLLEVDRkTGAVYVAEIGAKQ 264
Cdd:cd14955 172 vadtgnnriqKFTSTGTFL--TKW-------------GSEGS---------GDGQFnaPYGIAVDS-AGNVYVADTGNNR 226

                       250
                ....*....|....*.
gi 62821785 265 VQKYVPLNSYVPSFGS 280
Cdd:cd14955 227 IQKFDSSGTFITKWGS 242
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-268 9.30e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 72.32  E-value: 9.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYTVDTPHGIF-AASTLYEQSVWITDVGSDFMI--------LWLH 136
Cdd:cd14963  61 IAVDS-DGNIYVADLYNG--RIQVFDPDGKFLKYFPEKKDRVKLISpAGLAIDDGKLYVSDVKKHKVIvfdlegklLLEF 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWL----GAWNNCFTEEGPSSVRFTPDGKYLIVAqlNL 212
Cdd:cd14963 138 GKPGSEPGELSYPNGIAVDEDGNIYVADSGNGRIQVFDKN-GKFIkelnGSPDGKSGFVNPRGIAVDPDGNLYVVD--NL 214

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62821785 213 SRlSVVAAPPVGSIGECSVISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKY 268
Cdd:cd14963 215 SH-RVYVFDEQGKELFTFGGRGKDDGQFNLPNGLFID-DDGRLYVTDRENNRVAVY 268
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 140-280 1.68e-14

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 71.58  E-value: 1.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 140 GTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEG----PSSVRFTPDGkYLIVAQLNLSRL 215
Cdd:cd05819   1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPD-GNFITSFGSFGSGDGqfnePAGVAVDSDG-NLYVADTGNHRI 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62821785 216 SVVAapPVGSIGECSVISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd05819  79 QKFD--PDGNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFGS 140
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-268 2.19e-14

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 71.53  E-value: 2.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYT------VDTPHGIFAASTlyeQSVWITDVG--------SDFM 131
Cdd:cd14957  70 IAVDS-NGNIYVADTDNN--RIQVFNSSGVYQYSIGTGgsgdgqFNGPYGIAVDSN---GNIYVADTGnhriqvftSSGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtgewlGAWNNCFTEEGPSSVRF-TP-------DGK 203
Cdd:cd14957 144 FSYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQVFTSS-----GTFQYTFGSSGSGPGQFsDPygiavdsDGN 218

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 204 YLIVAQLNlSRLSVVAAPPV--GSIGecsvISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKY 268
Cdd:cd14957 219 IYVADTGN-HRIQVFTSSGAyqYSIG----TSGSGNGQFNYPYGIAVD-NDGKIYVADSNNNRIQVF 279
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-270 4.69e-13

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 67.60  E-value: 4.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAASTLYeqsVWITDVGS----------D 129
Cdd:cd14955 115 IAVDS-AGNVYVTDSGNN--RIQKFDSSGTFITKWgsfgsgDGQFNSPTGIAVDSAGN---VYVADTGNnriqkftstgT 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 130 FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAWNNCFTEEGPSSVrftpdgkylivaq 209
Cdd:cd14955 189 FLTKW--GSEGSGDGQFNAPYGIAVDSAGNVYVADTGNNRIQKFDS-SGTFITKWGSEGSGDGQFNS------------- 252

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62821785 210 lnlsrlsvvaapPVGsigecsvistiqladqvlphlLEVDRkTGAVYVAEIGAKQVQKYVP 270
Cdd:cd14955 253 ------------PSG---------------------IAVDS-AGNVYVADSGNNRIQKFAP 279
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-173 1.99e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 65.80  E-value: 1.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAWNYTVDT------PHGIFAAStlyEQSVWITD--------VGSDFM 131
Cdd:cd05819 154 VAVDS-DGNIYVADTGNH--RIQVFDPDGNFLTTFGSTGTGpgqfnyPTGIAVDS---DGNIYVADsgnnrvqvFDPDGA 227

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 62821785 132 ILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVF 173
Cdd:cd05819 228 GFGGNGNFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
107-270 2.08e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 65.81  E-value: 2.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 107 PHGIFAAStlyEQSVWITDVGSDfMILWLHGENG-----TGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEwL 181
Cdd:COG4257 104 PHGIAFDP---DGNLWFTDQGGN-RIGRLDPATGevtefPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGT-L 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 182 GAWNNCFTEEGPSSVRFTPDGKYLIVAQLNlSRLSVVAaPPVGSIGEcsvisTIQLADQVLPHLLEVDRKtGAVYVAEIG 261
Cdd:COG4257 179 TEYALPTPGAGPRGLAVDPDGNLWVADTGS-GRIGRFD-PKTGTVTE-----YPLPGGGARPYGVAVDGD-GRVWFAESG 250


                ....*....
gi 62821785 262 AKQVQKYVP 270
Cdd:COG4257 251 ANRIVRFDP 259
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-270 3.67e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 65.04  E-value: 3.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFT-EDGYFLRAWNYTVDTPHGIFAAStlyEQSVWITDVGSDfMILWLHGENGT--- 141
Cdd:COG4257  22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNGNN-RIGRIDPKTGEitt 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 142 --GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLgAWNNCFTEEGPSSVRFTPDGKyLIVAQLNLSRLSVVA 219
Cdd:COG4257  95 faLPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVT-EFPLPTGGAGPYGIAVDPDGN-LWVTDFGANAIGRID 172

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 62821785 220 AppvgsigECSVISTIQL-ADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVP 270
Cdd:COG4257 173 P-------DTGTLTEYALpTPGAGPRGLAVDPD-GNLWVADTGSGRIGRFDP 216
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 64-184 6.41e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 64.15  E-value: 6.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  64 FCVAVDSlNGLVYI--GQRGdnipKILVFTEDGYFLRAWNYTVDT--PHGI---------FAASTLYEQsVWITDVGSDF 130
Cdd:cd14962  60 IGVAIDA-NGNLYVsdAELG----KVFVFDRDGKFLRAIGAGALFkrPTGIavdpagkrlYVVDTLAHK-VKVFDLDGRL 133

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62821785 131 MILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAW 184
Cdd:cd14962 134 LFDI--GKRGSGPGEFNLPTDLAVDRDGNLYVTDTMNFRVQIFDAD-GKFLRSF 184
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 137-280 8.55e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 63.84  E-value: 8.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAW------NNCFTEegPSSVRFTPDGKyLIVAQL 210
Cdd:cd14956   3 GGRGSGPGQFKDPRGIAVDADDNVYVADARNGRIQVFDKD-GTFLRRFgttgdgPGQFGR--PRGLAVDKDGW-LYVADY 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62821785 211 NLSRLSV--VAAPPVGSIGECSViSTIQLADqvlPHLLEVDrKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd14956  79 WGDRIQVftLTGELQTIGGSSGS-GPGQFNA---PRGVAVD-ADGNLYVADFGNQRIQKFDPDGSFLRQWGG 145
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-280 1.13e-11

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 63.44  E-value: 1.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLrawnYTVdtphgifaastlyeqsvwitdvgsdfmilwlhGENGTGPAK 145
Cdd:cd14957  23 IAVDS-AGNIYVADTGNN--RIQVFTSSGVYS----YSI--------------------------------GSGGTGSGQ 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 146 FNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWL---GAWNNCFTEEGPSSVRFTPDGKyLIVAQLNLSRLSVVAAPP 222
Cdd:cd14957  64 FNSPYGIAVDSNGNIYVADTDNNRIQVFNSSGVYQYsigTGGSGDGQFNGPYGIAVDSNGN-IYVADTGNHRIQVFTSSG 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62821785 223 VGSIgecSVISTIQLADQV-LPHLLEVDRKtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd14957 143 TFSY---SIGSGGTGPGQFnGPQGIAVDSD-GNIYVADTGNHRIQVFTSSGTFQYTFGS 197
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
88-269 1.82e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.40  E-value: 1.82e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  88 LVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSVWITDVGSDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGN 167
Cdd:COG3391  10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 168 KRIQVFDKDTGEWLGAWNncfTEEGPSSVRFTPDGKYLIVAQLNLSRLSVVAAPpvgsigECSVISTIQLADQvlPHLLE 247
Cdd:COG3391  90 GRVSVIDLATGKVVATIP---VGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTA------TGKVVATIPVGAG--PHGIA 158

                       170       180
                ....*....|....*....|..
gi 62821785 248 VDRKTGAVYVAEIGAKQVQKYV 269
Cdd:COG3391 159 VDPDGKRLYVANSGSNTVSVIV 180
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
149-262 4.31e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 61.63  E-value: 4.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 149 PHSVTLDSAG-RVWVADRGNKRIQVFDKDTGEWLGAWNncfTEEGPSSVRFTPDGKYLIVAQLNLSRLSVVAAppVGSIG 227
Cdd:COG3391 112 PRGLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNTVSVIVS--VIDTA 186

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62821785 228 ECSVISTIQLADQvlPHLLEVDRKTGAVYVAEIGA 262
Cdd:COG3391 187 TGKVVATIPVGGG--PVGVAVSPDGRRLYVANRGS 219
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-217 1.35e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 60.64  E-value: 1.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIfaaSTLYEQSVWITDVG--------SDFM 131
Cdd:cd14954  29 VAVDK-DGRIIVADRSNN--RVQVFDPDGKFLRKFgsygsrDGQFDRPAGV---AVNSRGRIIVADKDnhriqvfdLNGR 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 132 ILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtgewlGAWNNCFTEEG--------PSSVRFTPDGK 203
Cdd:cd14954 103 FLLKFGERGTKNGQFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSD-----GQFIRKFGFEGagpgqldsPRGVAVNPDGN 177

                       170
                ....*....|....
gi 62821785 204 yLIVAQLNLSRLSV 217
Cdd:cd14954 178 -IVVSDFNNHRLQV 190
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 64-174 1.58e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 60.28  E-value: 1.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  64 FCVAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGIFAAStlyEQSVWITDVGSD-------- 129
Cdd:cd14955 160 TGIAVDS-AGNVYVADTGNN--RIQKFTSTGTFLTKWgsegsgDGQFNAPYGIAVDS---AGNVYVADTGNNriqkfdss 233

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 62821785 130 --FMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFD 174
Cdd:cd14955 234 gtFITKW--GSEGSGDGQFNSPSGIAVDSAGNVYVADSGNNRIQKFA 278
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-173 1.91e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 59.99  E-value: 1.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGI-FAAStlyeQSVWITDVG--------SDF 130
Cdd:cd14956 159 VAVDP-DGTLYVADTYND--RIQVFDNDGAFLRKWggrgtgPGQFNYPYGIaIDPD----GNVFVADFGnnriqkftADG 231

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 62821785 131 MILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVF 173
Cdd:cd14956 232 TFLTSWGSPGTGPGQFKNPWGVVVDADGTVYVADSNNNRVQRF 274
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 137-280 3.18e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 59.20  E-value: 3.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEW--LGAWNNCFTE-EGPSSVRFTPDGKyLIVAQLNLS 213
Cdd:cd14957   8 GSNGSGNGQFNTPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSysIGSGGTGSGQfNSPYGIAVDSNGN-IYVADTDNN 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62821785 214 RLSVVAAPPVG--SIGecsvISTIQLADQVLPHLLEVDrKTGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd14957  87 RIQVFNSSGVYqySIG----TGGSGDGQFNGPYGIAVD-SNGNIYVADTGNHRIQVFTSSGTFSYSIGS 150
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
64-228 9.68e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.72  E-value: 9.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  64 FCVAVDSlNGLVYI-GQRGDNIPKILvfTEDGYFlRAWNYTVD--TPHGIFAAStlyEQSVWITDVGSDfMILWLHGENG 140
Cdd:COG4257 105 HGIAFDP-DGNLWFtDQGGNRIGRLD--PATGEV-TEFPLPTGgaGPYGIAVDP---DGNLWVTDFGAN-AIGRIDPDTG 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 141 T-----GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWlGAWNNCFTEEGPSSVRFTPDGKyLIVAQLNLSRL 215
Cdd:COG4257 177 TlteyaLPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGTV-TEYPLPGGGARPYGVAVDGDGR-VWFAESGANRI 254

                       170
                ....*....|...
gi 62821785 216 SVVAapPVGSIGE 228
Cdd:COG4257 255 VRFD--PDTELTE 265
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 91-217 2.42e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 56.53  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  91 TEDGYFLRAWNYTVDTPHgIFAASTLyEQSVWITDVGSDFMILWlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRI 170
Cdd:cd14963   4 PFGDPLNKPMGVAVSDGR-IYVADTN-NHRVQVFDYEGKFKKSF--GGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRI 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 62821785 171 QVFDKDtGEWLGAwnncFTEEGPSSVRFTP------DGKyLIVAQLNLSRLSV 217
Cdd:cd14963  80 QVFDPD-GKFLKY----FPEKKDRVKLISPaglaidDGK-LYVSDVKKHKVIV 126
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 137-207 2.79e-09

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 56.58  E-value: 2.79e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAWNNCF-TEEGPSSVRFTPDGKYLIV 207
Cdd:cd14960 190 GSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDS-SGSFLSYINTSAdPLYGPQGLALTSDGHVVVA 260
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-173 3.93e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 56.06  E-value: 3.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSLNGLVY---------------------IGQRGD-----NIP-------------------KILVFTEDGYFLRAW 100
Cdd:cd14962 105 IAVDPAGKRLYvvdtlahkvkvfdldgrllfdIGKRGSgpgefNLPtdlavdrdgnlyvtdtmnfRVQIFDADGKFLRSF 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 101 NYTVDT------PHGIFAAStlyEQSVWITDVGSD-FMI--------LWLhGENGTGPAKFNIPHSVTLDSAGRVWVADR 165
Cdd:cd14962 185 GERGDGpgsfarPKGIAVDS---EGNIYVVDAAFDnVQIfnpegellLTV-GGPGSGPGEFYLPSGIAIDKDDRIYVVDQ 260


                ....*...
gi 62821785 166 GNKRIQVF 173
Cdd:cd14962 261 FNRRIQVF 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 140-207 1.04e-08

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 54.97  E-value: 1.04e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62821785 140 GTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFD------KDTGEWLGAWNNCFTeegPSSVRFTPDGkYLIV 207
Cdd:cd14961   4 GGWPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDsdgnclQQFGPKGDAGQDIRY---PLDVAVTPDG-HIVV 73
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 137-280 1.16e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 54.89  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAWNNCFTEEG----PSSV---------------- 196
Cdd:cd14955   6 GSYGSGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDS-TGTFLTKWGSSGSGDGqfysPTGIavdsdgnvyvadtgnh 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 197 ---RFTPDGKYLivAQLnlsrlsvvaappvGSIGecsviSTIQLADQvlPHLLEVDRkTGAVYVAEIGAKQVQKYVPLNS 273
Cdd:cd14955  85 riqKFDSTGTFL--TKW-------------GSSG-----SGDGQFNS--PSGIAVDS-AGNVYVTDSGNNRIQKFDSSGT 141


                ....*..
gi 62821785 274 YVPSFGS 280
Cdd:cd14955 142 FITKWGS 148
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 142-280 1.24e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 54.52  E-value: 1.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 142 GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNNCFTEEGPSSVRFTPDGKYLIVAQLNLSRLSVVAA- 220
Cdd:cd14962  52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRD-GKFLRAIGAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLd 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 221 -------PPVGSIGEcsvistiQLAdqvLPHLLEVDRKtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:cd14962 131 grllfdiGKRGSGPG-------EFN---LPTDLAVDRD-GNLYVTDTMNFRVQIFDADGKFLRSFGE 186
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 64-174 4.14e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 53.04  E-value: 4.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  64 FCVAVDSlNGLVYIGQRGDNipKILVFTEDGYFLRAW------NYTVDTPHGI--------------------FAASTLY 117
Cdd:cd14957 162 QGIAVDS-DGNIYVADTGNH--RIQVFTSSGTFQYTFgssgsgPGQFSDPYGIavdsdgniyvadtgnhriqvFTSSGAY 238

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 118 EQSVwitdvgsdfmilwlhGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFD 174
Cdd:cd14957 239 QYSI---------------GTSGSGNGQFNYPYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 128-207 8.71e-08

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 52.27  E-value: 8.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 128 SDFMILWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKdTGEWLGAWNNCFTEEG----PSSVR-FTPDG 202
Cdd:cd14959   3 SKMIIHCKFGESGSGEGQFNSPSGFCLGEDEDILVADTNNHRIQVFDK-EGEFKFQFGIPGKRDGqlwyPNKVAvCRVTG 81


                ....*
gi 62821785 203 KYLIV 207
Cdd:cd14959  82 RYVVT 86
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
143-280 1.55e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.17  E-value: 1.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 143 PAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTeeGPSSVRFTPDGKyLIVAQLNLSRLSVVaAPP 222
Cdd:COG4257  13 PAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGS--GPHGIAVDPDGN-LWFTDNGNNRIGRI-DPK 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62821785 223 VGsigecsVISTIQL-ADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVPLNSYVPSFGS 280
Cdd:COG4257  89 TG------EITTFALpGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGEVTEFPL 140
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 137-176 1.91e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 48.31  E-value: 1.91e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKD 176
Cdd:cd14954  14 GKEGSKDGELCRPWGVAVDKDGRIIVADRSNNRVQVFDPD 53
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 146-173 2.56e-06

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 43.16  E-value: 2.56e-06
                          10        20
                  ....*....|....*....|....*...
gi 62821785   146 FNIPHSVTLDSAGRVWVADRGNKRIQVF 173
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 137-279 8.33e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 8.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAkFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGE---WLGAWNNCFTEegPSSVRFTPDGKyLIVAQLNLS 213
Cdd:cd14962   3 GEERPKEA-LTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKvfvIGNAGPNRFVS--PIGVAIDANGN-LYVSDAELG 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62821785 214 RLSVVAAP--PVGSIGEcsvistiqLADQVLPHLLEVDRKTGAVYVAEIGAKQVQKYVPLNSYVPSFG 279
Cdd:cd14962  79 KVFVFDRDgkFLRAIGA--------GALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIG 138
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 139-170 1.97e-05

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 45.21  E-value: 1.97e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 62821785 139 NGTGP-AKFNIPHSVTLDSAGRVWVADRGNKRI 170
Cdd:cd14953  68 DGGGAaAQFNTPSGVAVDAAGNLYVADTGNHRI 100
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-170 1.17e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 42.90  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIGQRGDN-IPKI--------------LVFTEDGYFLRAwnyTVDTPHGI--FAASTLYeqsvwITD--- 125
Cdd:cd14953 137 VAVDA-AGNLYVADTGNHrIRKItpdgvvttvagtggAGYAGDGPATAA---QFNNPTGVavDAAGNLY-----VADrgn 207

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62821785 126 -----VGSDFMI--------LWLHGENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRI 170
Cdd:cd14953 208 hrirkITPDGVVttvagtgtAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRI 265
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 137-176 2.89e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 41.75  E-value: 2.89e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKD 176
Cdd:cd14953 122 DDGGATAAQFNYPTGVAVDAAGNLYVADTGNHRIRKITPD 161
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
40-178 3.21e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 3.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  40 RTEKILYRLDVGwpKHPEYftgttfcVAVDSLNGLVYIGQRGDNipKILVF-TEDGYFLRAWNyTVDTPHGIfaASTLYE 118
Cdd:COG3391  98 ATGKVVATIPVG--GGPRG-------LAVDPDGGRLYVADSGNG--RVSVIdTATGKVVATIP-VGAGPHGI--AVDPDG 163

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62821785 119 QSVWITDVGSD---FMILWLHGENGTGPAKFNI---PHSVTLDSAGR-VWVADRGN-------KRIQVFDKDTG 178
Cdd:COG3391 164 KRLYVANSGSNtvsVIVSVIDTATGKVVATIPVgggPVGVAVSPDGRrLYVANRGSntsnggsNTVSVIDLATL 237
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 66-207 5.92e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.65  E-value: 5.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785  66 VAVDSlNGLVYIG--QRGDNIPKILVFTEDGyFLRAWNYTVDTPHGI-FAA--STLY-----EQSVWITDVGSDFMI--- 132
Cdd:COG3386  98 GVVDP-DGRLYFTdmGEYLPTGALYRVDPDG-SLRVLADGLTFPNGIaFSPdgRTLYvadtgAGRIYRFDLDADGTLgnr 175

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62821785 133 -LWLHGENGTGpakfnIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWLGAWNncFTEEGPSSVRF-TPDGKYLIV 207
Cdd:COG3386 176 rVFADLPDGPG-----GPDGLAVDADGNLWVALWGGGGVVRFDPD-GELLGRIE--LPERRPTNVAFgGPDLRTLYV 244
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 144-170 1.00e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 39.82  E-value: 1.00e-03
                        10        20
                ....*....|....*....|....*..
gi 62821785 144 AKFNIPHSVTLDSAGRVWVADRGNKRI 170
Cdd:cd14953  20 ARFNSPSGVAVDAAGNLYVADRGNHRI 46
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 142-209 1.20e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 39.49  E-value: 1.20e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62821785 142 GPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWlGAWnnCFTEEGPSSVRFTPDGKyLIVAQ 209
Cdd:COG3386   3 ADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAV-EVF--AEPSGRPNGLAFDPDGR-LLVAD 66
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
140-235 1.23e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 39.89  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 140 GTGPAKFNI----PHSVTLDSAGR-VWVADRGNKRIQVF--DKDTGEW-LGAWNNCFTEEGPSSVRFTPDGKYLIVAQ-L 210
Cdd:COG2706 139 GSGPNPERQegphAHSVVFDPDGRfLYVPDLGTDRIYVYrlDPATGKLpEPPEVSLPPGSGPRHLAFHPNGRFAYVINeL 218

                        90       100
                ....*....|....*....|....*.
gi 62821785 211 NlSRLSVVA-APPVGSIGECSVISTI 235
Cdd:COG2706 219 D-STVSVYAyDAATGTLTLIQTVSTL 243
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 145-270 1.29e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 39.49  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 145 KFNIPHSVTLDSAGRVWVAD----RGNKRIQVFDKDtGEwLGAWNNCFTeeGPSSVRFTPDGKYLIVAQLNLSRLSVVAA 220
Cdd:COG3386  91 PLNRPNDGVVDPDGRLYFTDmgeyLPTGALYRVDPD-GS-LRVLADGLT--FPNGIAFSPDGRTLYVADTGAGRIYRFDL 166

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62821785 221 PPVGSIGECSVISTIQlADQVLPHLLEVDRKtGAVYVAEIGAKQVQKYVP 270
Cdd:COG3386 167 DADGTLGNRRVFADLP-DGPGGPDGLAVDAD-GNLWVALWGGGGVVRFDP 214
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 137-170 1.57e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 39.44  E-value: 1.57e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 62821785 137 GENGTG-PAKFNIPHSVTLDSAGRVWVADRGNKRI 170
Cdd:cd14953 286 GDGGPAtSAQFNNPTGVAVDAAGNLYVADTGNNRI 320
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
149-268 2.65e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 38.73  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 149 PHSVTLDSAGR-VWVADRGNK-RIQVF--DKDTGEwLGAWNNCFTE-EGPSSVRFTPDGKYLIVAQLNLSRLSVVAAPPV 223
Cdd:COG2706  47 PSFLALSPDGRfLYAVNEVDDgGVSAFriDPADGT-LTLLNTVSSGgASPCHLSVDPDGRFLFVANYGGGSVSVFPIDAD 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62821785 224 GSIGEcsVISTIQLA-------DQVLPHL--LEVDRKTGAVYVAEIGAKQVQKY 268
Cdd:COG2706 126 GSLGE--PVQVIQHEgsgpnpeRQEGPHAhsVVFDPDGRFLYVPDLGTDRIYVY 177
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 137-217 3.28e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 38.09  E-value: 3.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 137 GENGTGPAKFNIPHSVTLDSAGRVWVADRGNKRIQVFDKDtGEWL------GAWNNCFTeeGPSSVRFTPDGKyLIVAQL 210
Cdd:cd14960 143 GSRGNGDRQFAGPHFAAVNNNNEIIVTDFHNHSVKVFNAE-GEFLfkfgsnGEGNGQFN--APTGVAVDSNGN-IIVADW 218


                ....*..
gi 62821785 211 NLSRLSV 217
Cdd:cd14960 219 GNSRIQV 225
WD40 COG2319
WD40 repeat [General function prediction only];
106-208 7.27e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.58  E-value: 7.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62821785 106 TPHGIFAASTLYEQSVWITDVGSDFMILWLHGENGTgpakfniPHSVTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWN 185
Cdd:COG2319 129 SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-------VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201

                        90       100
                ....*....|....*....|...
gi 62821785 186 NcfTEEGPSSVRFTPDGKYLIVA 208
Cdd:COG2319 202 G--HTGAVRSVAFSPDGKLLASG 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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