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Conserved domains on  [gi|62945284|ref|NP_001017464|]
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BTB/POZ domain-containing protein 16 [Rattus norvegicus]

Protein Classification

BTB/POZ domain-containing protein 16( domain architecture ID 13604765)

BTB/POZ domain-containing protein 16 (BTBD16) is a BTB-domain-containing Kelch-like protein

Gene Symbol:  BTBD16
Gene Ontology:  GO:0005515
PubMed:  17120193|15544948|8519696

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 74-214 1.22e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18291:

Pssm-ID: 453885  Cd Length: 114  Bit Score: 147.21  E-value: 1.22e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284  74 GTQSGEADVILDCLGFKWELHHPQIFQSETLAKLYltaliqntkssqrdlekilkvhstermkkrspvKKIIISLRINDP 153
Cdd:cd18291   7 VARSACPDVVLECLGSFWELHSPYLCKSETLAELL---------------------------------KPVTISLNINDP 53

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62945284 154 AVTRVAFALALKNLYMNEVEMTVDNVLGVLASAHILQFNRLFRKCVSTMLNRLTPCTIKNF 214
Cdd:cd18291  54 LVTKEAFAVALGNLYNSEVEVNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSSTVCKF 114
BACK_BTBD16 cd18492
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); ...
 206-302 2.17e-42

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB-domain-containing Kelch-like protein. Its function remains unclear. BTBD16 SNPs may be bipolar disorder (BD) genetic susceptibility variants exhibiting genetic background-dependent effects.


:

Pssm-ID: 350567  Cd Length: 97  Bit Score: 145.90  E-value: 2.17e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284 206 LTPCTIKNFYLAGCKYKEEQLTNACEKWLAMNLVPLVGTQIHLRHIPEPLLYKVLKSPRLFTFSEFHLLKTLLMWVYLQM 285
Cdd:cd18492   1 IKSSTVCKFHRAACKYKQESLATACERWLELNLVPQLSSQIYLRDLPLELLHKILKSPRLFTFNEYSLYKTLCYWVFLQL 80

                        90
                ....*....|....*..
gi 62945284 286 NGKVQTLPIHETMLAFF 302
Cdd:cd18492  81 NPKVQLMPSHSTILTYF 97
 
Name Accession Description Interval E-value
BTB_POZ_BTBD16 cd18291
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-214 1.22e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349600  Cd Length: 114  Bit Score: 147.21  E-value: 1.22e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284  74 GTQSGEADVILDCLGFKWELHHPQIFQSETLAKLYltaliqntkssqrdlekilkvhstermkkrspvKKIIISLRINDP 153
Cdd:cd18291   7 VARSACPDVVLECLGSFWELHSPYLCKSETLAELL---------------------------------KPVTISLNINDP 53

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62945284 154 AVTRVAFALALKNLYMNEVEMTVDNVLGVLASAHILQFNRLFRKCVSTMLNRLTPCTIKNF 214
Cdd:cd18291  54 LVTKEAFAVALGNLYNSEVEVNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSSTVCKF 114
BACK_BTBD16 cd18492
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); ...
 206-302 2.17e-42

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB-domain-containing Kelch-like protein. Its function remains unclear. BTBD16 SNPs may be bipolar disorder (BD) genetic susceptibility variants exhibiting genetic background-dependent effects.


Pssm-ID: 350567  Cd Length: 97  Bit Score: 145.90  E-value: 2.17e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284 206 LTPCTIKNFYLAGCKYKEEQLTNACEKWLAMNLVPLVGTQIHLRHIPEPLLYKVLKSPRLFTFSEFHLLKTLLMWVYLQM 285
Cdd:cd18492   1 IKSSTVCKFHRAACKYKQESLATACERWLELNLVPQLSSQIYLRDLPLELLHKILKSPRLFTFNEYSLYKTLCYWVFLQL 80

                        90
                ....*....|....*..
gi 62945284 286 NGKVQTLPIHETMLAFF 302
Cdd:cd18492  81 NPKVQLMPSHSTILTYF 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 221-293 1.27e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 38.48  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62945284    221 YKEEQLTNACEKWLAMNLVPLVGTQiHLRHIPEPLLYKVLKSPRLFTFSEFHLLKTLLMWVYLQMNGKVQTLP 293
Cdd:smart00875  11 HGLEELAEKALRFILQNFSEVSSSE-EFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLP 82
 
Name Accession Description Interval E-value
BTB_POZ_BTBD16 cd18291
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-214 1.22e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349600  Cd Length: 114  Bit Score: 147.21  E-value: 1.22e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284  74 GTQSGEADVILDCLGFKWELHHPQIFQSETLAKLYltaliqntkssqrdlekilkvhstermkkrspvKKIIISLRINDP 153
Cdd:cd18291   7 VARSACPDVVLECLGSFWELHSPYLCKSETLAELL---------------------------------KPVTISLNINDP 53

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62945284 154 AVTRVAFALALKNLYMNEVEMTVDNVLGVLASAHILQFNRLFRKCVSTMLNRLTPCTIKNF 214
Cdd:cd18291  54 LVTKEAFAVALGNLYNSEVEVNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSSTVCKF 114
BACK_BTBD16 cd18492
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); ...
 206-302 2.17e-42

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB-domain-containing Kelch-like protein. Its function remains unclear. BTBD16 SNPs may be bipolar disorder (BD) genetic susceptibility variants exhibiting genetic background-dependent effects.


Pssm-ID: 350567  Cd Length: 97  Bit Score: 145.90  E-value: 2.17e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284 206 LTPCTIKNFYLAGCKYKEEQLTNACEKWLAMNLVPLVGTQIHLRHIPEPLLYKVLKSPRLFTFSEFHLLKTLLMWVYLQM 285
Cdd:cd18492   1 IKSSTVCKFHRAACKYKQESLATACERWLELNLVPQLSSQIYLRDLPLELLHKILKSPRLFTFNEYSLYKTLCYWVFLQL 80

                        90
                ....*....|....*..
gi 62945284 286 NGKVQTLPIHETMLAFF 302
Cdd:cd18492  81 NPKVQLMPSHSTILTYF 97
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-203 2.30e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 54.98  E-value: 2.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62945284  62 FQKLFTEsimdsgtqsGE-ADVILDCLGFKWELHHPQIFQSEtlaklYLTALIQNT-KSSQRDlekilkvhstermkkrs 139
Cdd:cd18305   6 YQTLFLN---------GEnSDITICALGREWKLHKIYLCQSG-----YFASMFSGSwKESKET----------------- 54

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62945284 140 pvkkiIISLRINDPAVTRVAFALALKNLYMNEVEMTVDNVLGVLASAHILQFNRLFRKCVSTML 203
Cdd:cd18305  55 -----VINLEIPDDNITVEALNVVFGSLYRDEIEIKPSRVVSILAAATLLQLDGLIQQCSEVMK 113
BACK_GCL cd18495
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less ...
 214-283 1.26e-06

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; The GCL protein is a nuclear envelope protein highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in Drosophila embryos. Both human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L) may function in spermatogenesis. They may also be substrate-specific adaptors of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350570  Cd Length: 78  Bit Score: 46.09  E-value: 1.26e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62945284 214 FYLAGCKYKEEQLTNACEKWLAMNLVPLVGTQiHLRHIPEPLLYKVLKSPRLF-TFSEFHLLKTLLMWVYL 283
Cdd:cd18495   9 YYEAACMYGLTEVKKKCLEWLLRNLMTSQNVT-LLRELSIELMEQLIASPNLFvMQVEMDVYTLLKKWLFL 78
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 167-208 3.15e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 40.54  E-value: 3.15e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 62945284 167 LYMNEVEMTVDNVLGVLASAHILQFNRLFRKCVSTMLNRLTP 208
Cdd:cd18268  82 VYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTP 123
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 221-293 1.27e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 38.48  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62945284    221 YKEEQLTNACEKWLAMNLVPLVGTQiHLRHIPEPLLYKVLKSPRLFTFSEFHLLKTLLMWVYLQMNGKVQTLP 293
Cdd:smart00875  11 HGLEELAEKALRFILQNFSEVSSSE-EFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLP 82
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 155-209 1.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 38.21  E-value: 1.99e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62945284 155 VTRVAFALALKNLYMNEVEMTVDNVLGVLASAHILQFNRLFRKCVSTMLNRLTPC 209
Cdd:cd18265  70 VSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPC 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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