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Conserved domains on  [gi|62955793|ref|NP_001017911|]
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ankyrin repeat domain-containing protein 31 [Danio rerio]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-97 4.43e-26

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.50  E-value: 4.43e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:COG0666  96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                        90
                ....*....|....*..
gi 62955793  81 GADPLLKCDRGKTPMDM 97
Cdd:COG0666 176 GADVNARDNDGETPLHL 192
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-97 4.43e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.50  E-value: 4.43e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:COG0666  96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                        90
                ....*....|....*..
gi 62955793  81 GADPLLKCDRGKTPMDM 97
Cdd:COG0666 176 GADVNARDNDGETPLHL 192
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-102 4.84e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.93  E-value: 4.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAD 83
Cdd:PHA02874 136 DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215

                         90       100
                 ....*....|....*....|.
gi 62955793   84 PLLKCDRGKTPMD--MITDRS 102
Cdd:PHA02874 216 IMNKCKNGFTPLHnaIIHNRS 236
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-87 6.07e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 6.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793     1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKaGAQANCKgDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLK-DNGRTALHYAARSGHLEIVKLLLEK 83


                  ....*..
gi 62955793    81 GADPLLK 87
Cdd:pfam12796  84 GADINVK 90
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 25-53 1.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.75e-04
                           10        20
                   ....*....|....*....|....*....
gi 62955793     25 GWTPLHEAVNRNNYDITEVLLKAGAQANC 53
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 23-86 3.57e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 3.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955793    23 YAGWTPLHEAVNRNNYDITEVLLKAGA--QANCKGDDGV-TPLLEAIQY-----QYYK------IVDLLLKYGADPLL 86
Cdd:TIGR00870 126 TPGITALHLAAHRQNYEIVKLLLERGAsvPARACGDFFVkSQGVDSFYHgesplNAAAclgspsIVALLSEDPADILT 203
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 14-93 5.53e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 5.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793  14 VGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKG----------DDGV----TPLLEAIQYQYYKIVDLLLK 79
Cdd:cd22194 130 INAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAkgvffnpkykHEGFyfgeTPLALAACTNQPEIVQLLME 209

                        90
                ....*....|....*
gi 62955793  80 YGADPLLKCD-RGKT 93
Cdd:cd22194 210 KESTDITSQDsRGNT 224
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-97 4.43e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.50  E-value: 4.43e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:COG0666  96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                        90
                ....*....|....*..
gi 62955793  81 GADPLLKCDRGKTPMDM 97
Cdd:COG0666 176 GADVNARDNDGETPLHL 192
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-113 4.66e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 4.66e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793  15 GASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLKCDRGKTP 94
Cdd:COG0666 143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTA 222

                        90
                ....*....|....*....
gi 62955793  95 MDMITDRSMCMVVEKYLQK 113
Cdd:COG0666 223 LDLAAENGNLEIVKLLLEA 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-95 1.06e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 1.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAD 83
Cdd:COG0666  66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145

                        90
                ....*....|..
gi 62955793  84 PLLKCDRGKTPM 95
Cdd:COG0666 146 VNAQDNDGNTPL 157
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-113 2.86e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 2.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   8 VRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLK 87
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                        90       100
                ....*....|....*....|....*.
gi 62955793  88 CDRGKTPMDMITDRSMCMVVEKYLQK 113
Cdd:COG0666 249 DKDGLTALLLAAAAGAALIVKLLLLA 274
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-102 4.84e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.93  E-value: 4.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAD 83
Cdd:PHA02874 136 DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215

                         90       100
                 ....*....|....*....|.
gi 62955793   84 PLLKCDRGKTPMD--MITDRS 102
Cdd:PHA02874 216 IMNKCKNGFTPLHnaIIHNRS 236
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-87 6.07e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 6.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793     1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKaGAQANCKgDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLK-DNGRTALHYAARSGHLEIVKLLLEK 83


                  ....*..
gi 62955793    81 GADPLLK 87
Cdd:pfam12796  84 GADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 12-83 3.62e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 3.62e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62955793   12 ISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAD 83
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
29-95 7.49e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.43  E-value: 7.49e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62955793    29 LHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAdpLLKCDRGKTPM 95
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTAL 65
PHA03095 PHA03095
ankyrin-like protein; Provisional
 4-94 2.84e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEV---LLKAGAQANCKGDDGVTPLLEAIQYQY-YKIVDLLLK 79
Cdd:PHA03095  26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIK 105

                         90
                 ....*....|....*
gi 62955793   80 YGADPLLKCDRGKTP 94
Cdd:PHA03095 106 AGADVNAKDKVGRTP 120
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-127 4.34e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.27  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    2 QEDLQDVRDMISVGASINVADYAGWTPLHEAV-NRNNYDITEVLLKAGAQANCKGDDGVTPLleaiqyQYY--------K 72
Cdd:PHA03095  60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIKAGADVNAKDKVGRTPL------HVYlsgfninpK 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 62955793   73 IVDLLLKYGADPllkCDR---GKTPMD-MITDRSMCMVVEKYLQKTKSDTFTADNSPRT 127
Cdd:PHA03095 134 VIRLLLRKGADV---NALdlyGMTPLAvLLKSRNANVELLRLLIDAGADVYAVDDRFRS 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-95 2.41e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 2.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793  12 ISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLKCDRG 91
Cdd:COG0666 206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285


                ....
gi 62955793  92 KTPM 95
Cdd:COG0666 286 LTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-95 2.48e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 2.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:COG0666  30 LLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA 109

                        90
                ....*....|....*
gi 62955793  81 GADPLLKCDRGKTPM 95
Cdd:COG0666 110 GADVNARDKDGETPL 124
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 8-116 9.72e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 9.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAV--NRNNYDITEVLLKAGAQANCK---------GDD-------GVTPLLEAIQYQ 69
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKnrvnyllsyGVPinikdvyGFTPLHYAVYNN 203

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 62955793   70 YYKIVDLLLKYGADPLLKCDRGKTPMDMITDRSMCMVVEKYLQKTKS 116
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 8-95 1.06e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    8 VRDMISVGASINVAD-YAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLL 86
Cdd:PHA02878 150 TKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229


                 ....*....
gi 62955793   87 KCDRGKTPM 95
Cdd:PHA02878 230 RDKCGNTPL 238
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 8-111 2.26e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 2.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAVNR-NNYDITEVLLKAGAQANCKGD-DGVTPLLEAIQYQyyKIVDLLLKYGADPl 85
Cdd:PHA02878 217 VHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSE--RKLKLLLEYGADI- 293

                         90       100
                 ....*....|....*....|....*.
gi 62955793   86 lkcdrgkTPMDMITDRSMCMVVEKYL 111
Cdd:PHA02878 294 -------NSLNSYKLTPLSSAVKQYL 312
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 11-83 2.46e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 2.46e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62955793   11 MISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQY-QYYKIVDLLLKYGAD 83
Cdd:PHA02878 187 LLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVD 260
PHA03095 PHA03095
ankyrin-like protein; Provisional
 7-79 7.21e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 7.21e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62955793    7 DVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLK 79
Cdd:PHA03095 239 LVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-95 7.89e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 7.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLK 87
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186


                 ....*...
gi 62955793   88 CDRGKTPM 95
Cdd:PHA02874 187 DNNGESPL 194
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 43-150 9.11e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.59  E-value: 9.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   43 VLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLKCDRGKTPMDMITDRSMCMVVEKYLQKTKSDTFTAD 122
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGA 179

                         90       100
                 ....*....|....*....|....*...
gi 62955793  123 NSPRTTDSGVNPSVDQSrnqnPIRDTRP 150
Cdd:PTZ00322 180 NAKPDSFTGKPPSLEDS----PISSHHP 203
Ank_4 pfam13637
Ankyrin repeats (many copies);
25-78 2.34e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 2.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62955793    25 GWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLL 78
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 15-94 2.47e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 2.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   15 GASINVADYAGWTPLHEAVN-----RNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQY--QYYKIVDLLLKYGADPLLK 87
Cdd:PHA03100  58 GADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIK 137


                 ....*..
gi 62955793   88 CDRGKTP 94
Cdd:PHA03100 138 NSDGENL 144
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1-83 2.86e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 2.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDG-VTPLLEAIQYQYYKIVDLLLK 79
Cdd:PHA02875 144 MMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIK 223


                 ....
gi 62955793   80 YGAD 83
Cdd:PHA02875 224 RGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 4-83 3.04e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNY-DITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGA 82
Cdd:PHA02876 320 DTENIRTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399


                 .
gi 62955793   83 D 83
Cdd:PHA02876 400 D 400
PHA03095 PHA03095
ankyrin-like protein; Provisional
 8-96 2.74e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    8 VRDMISVGASINVADYAGWTPLHE--AVNRNNYDITEVLLKAGAQANCKGDDGVTPLleAIqyqYYK-------IVDLLL 78
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPL--AV---LLKsrnanveLLRLLI 174

                         90
                 ....*....|....*...
gi 62955793   79 KYGADPLLKCDRGKTPMD 96
Cdd:PHA03095 175 DAGADVYAVDDRFRSLLH 192
Ank_5 pfam13857
Ankyrin repeats (many copies);
44-97 4.68e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 4.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 62955793    44 LLKAG-AQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLKCDRGKTPMDM 97
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
Ank_5 pfam13857
Ankyrin repeats (many copies);
16-65 9.45e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 9.45e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 62955793    16 ASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEA 65
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 8-80 9.49e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.43  E-value: 9.49e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKY 80
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 8-83 9.50e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 9.50e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAVNRN-NYDITEVLLKAGAQANCKGDDGVTPLLeaIQYQYYKIVDLLLKYGAD 83
Cdd:PHA02876 425 VKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLL--IALEYHGIVNILLHYGAE 499
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 3-84 1.07e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    3 EDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGA 82
Cdd:PHA02875 113 KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192


                 ..
gi 62955793   83 DP 84
Cdd:PHA02875 193 NI 194
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-96 2.44e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISV-GASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGA 82
Cdd:PHA02874  13 DIEAIEKIIKNkGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGV 92

                         90       100
                 ....*....|....*....|
gi 62955793   83 D------PLLKCDRGKTPMD 96
Cdd:PHA02874  93 DtsilpiPCIEKDMIKTILD 112
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 27-95 4.41e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 4.41e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62955793   27 TPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYY-----KIVDLLLKYGADPLLKCDRGKTPM 95
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPL 110
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 10-84 6.68e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 6.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62955793   10 DMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGA--DP 84
Cdd:PLN03192 543 ELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDP 619
Ank_4 pfam13637
Ankyrin repeats (many copies);
1-45 8.94e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 8.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 62955793     1 MQEDLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLL 45
Cdd:pfam13637  10 ASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 25-54 1.01e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 62955793    25 GWTPLHEAVNR-NNYDITEVLLKAGAQANCK 54
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNAR 32
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 25-53 1.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.75e-04
                           10        20
                   ....*....|....*....|....*....
gi 62955793     25 GWTPLHEAVNRNNYDITEVLLKAGAQANC 53
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 4-95 1.97e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYA-GWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGA 82
Cdd:PHA02875  80 DVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                         90
                 ....*....|...
gi 62955793   83 DPLLKCDRGKTPM 95
Cdd:PHA02875 160 CLDIEDCCGCTPL 172
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 4-128 2.40e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLL---KY 80
Cdd:PHA02875  14 ELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLdlgKF 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 62955793   81 GADPLLKcdRGKTPMDMITdRSMCMVVEKYLQKTKSDTfTADNSPRTT 128
Cdd:PHA02875  94 ADDVFYK--DGMTPLHLAT-ILKKLDIMKLLIARGADP-DIPNTDKFS 137
PHA03095 PHA03095
ankyrin-like protein; Provisional
 8-106 2.61e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAVNRNNYDITEV--LLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPL 85
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                         90       100
                 ....*....|....*....|..
gi 62955793   86 LKCDRGKTPMD-MITDRSMCMV 106
Cdd:PHA03095 285 AVSSDGNTPLSlMVRNNNGRAV 306
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 29-83 2.69e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.97  E-value: 2.69e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 62955793   29 LHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAD 83
Cdd:PHA02876 149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGAD 203
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 23-86 3.57e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 3.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955793    23 YAGWTPLHEAVNRNNYDITEVLLKAGA--QANCKGDDGV-TPLLEAIQY-----QYYK------IVDLLLKYGADPLL 86
Cdd:TIGR00870 126 TPGITALHLAAHRQNYEIVKLLLERGAsvPARACGDFFVkSQGVDSFYHgesplNAAAclgspsIVALLSEDPADILT 203
PHA02798 PHA02798
ankyrin-like protein; Provisional
 6-83 3.75e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.36  E-value: 3.75e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955793    6 QDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGAD 83
Cdd:PHA02798 239 KNILDFIFSYIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCLFTAFENESKFIFNSILNKKPN 316
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 25-53 5.11e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 5.11e-04
                          10        20
                  ....*....|....*....|....*....
gi 62955793    25 GWTPLHEAVNRNNYDITEVLLKAGAQANC 53
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 27-107 5.49e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.74  E-value: 5.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   27 TPLHEAVNRNNYDITEVLLKAGAQANCKGDDGV-TPLLEAIQYQYYKIVDLLLKYGADPLLKCDRGKTPMD---MITDRS 102
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIElalMICNNF 151


                 ....*
gi 62955793  103 MCMVV 107
Cdd:PHA02884 152 LAFMI 156
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 14-93 5.53e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 5.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793  14 VGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKG----------DDGV----TPLLEAIQYQYYKIVDLLLK 79
Cdd:cd22194 130 INAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAkgvffnpkykHEGFyfgeTPLALAACTNQPEIVQLLME 209

                        90
                ....*....|....*
gi 62955793  80 YGADPLLKCD-RGKT 93
Cdd:cd22194 210 KESTDITSQDsRGNT 224
PHA02946 PHA02946
ankyin-like protein; Provisional
 4-145 8.67e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.42  E-value: 8.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    4 DLQDVRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPL--LEAIQYQYYKIVDLLLKYG 81
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   82 AD-----------PLLKCdrgKTPMDMITDRSMCM-----VVEKYLQKTKSDTFTADNSPRTTDS-----GVNPSVDQSR 140
Cdd:PHA02946 131 AKinnsvdeegcgPLLAC---TDPSERVFKKIMSIgfearIVDKFGKNHIHRHLMSDNPKASTISwmmklGISPSKPDHD 207


                 ....*
gi 62955793  141 NQNPI 145
Cdd:PHA02946 208 GNTPL 212
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 23-162 1.13e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.24  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   23 YAGWTPLHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADpllkCDRGKTPMDM--ITD 100
Cdd:PLN03192 620 HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD----VDKANTDDDFspTEL 695

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62955793  101 RSMCMVVEKYLQKTKSDTFTADNSPRTTDSGVNPSVDQSRNQNPIRDTR------PPLQKTKRTADES 162
Cdd:PLN03192 696 RELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQGTSSDNQCRPRvsiykgHPLLRNERCCNEA 763
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 8-52 1.41e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 1.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 62955793    8 VRDMISVGASINVADYAGWTPLHEAVNRNNYDITEVLLKAGAQAN 52
Cdd:PHA03100 208 VKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 16-94 1.48e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.56  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   16 ASINVADYAGWTPLHEAVNRN-NYDITEVLLKAGAQANCKGDDGVTPLLEAIQY--QYYKIVDLLlkygADPLLKCDRGK 92
Cdd:PHA02874 245 ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYinKDPVIKDII----ANAVLIKEADK 320


                 ..
gi 62955793   93 TP 94
Cdd:PHA02874 321 LK 322
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 29-125 1.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.20  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793   29 LHEAVNRNNYDITEVLLKAGAQANCKGDDGVTPLLEAIQYQYYKIVDLLLKYGADPLLKCDRGKTPMDMITDRSMCMVVE 108
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100
                 ....*....|....*....|
gi 62955793  109 KYLQKTK--SDTFTAD-NSP 125
Cdd:PHA02875  86 ELLDLGKfaDDVFYKDgMTP 105
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-84 2.09e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*...
gi 62955793    57 DGVTPLLEAIQYQYYKIVDLLLKYGADP 84
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-87 2.19e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.19e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 62955793    57 DGVTPLLEAI-QYQYYKIVDLLLKYGADPLLK 87
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNAR 32
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 17-125 2.19e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62955793    17 SINVADYAGWTPLHEAVNRN-NYDITEVLLKagaqANCKGDDGVTpLLEAIQYQYYKIVDLLLKygadPLLKCDRGKTPM 95
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENeNLELTELLLN----LSCRGAVGDT-LLHAISLEYVDAVEAILL----HLLAAFRKSGPL 114

                          90       100       110
                  ....*....|....*....|....*....|
gi 62955793    96 DMITDRSmcmvvekylqktkSDTFTADNSP 125
Cdd:TIGR00870 115 ELANDQY-------------TSEFTPGITA 131
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-84 2.30e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.30e-03
                           10        20
                   ....*....|....*....|....*...
gi 62955793     57 DGVTPLLEAIQYQYYKIVDLLLKYGADP 84
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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