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Conserved domains on  [gi|67189007|ref|NP_001018016|]
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mucin-1 isoform 2 precursor [Homo sapiens]

Protein Classification

SEA domain-containing protein( domain architecture ID 10640846)

SEA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 45-161 1.79e-35

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


:

Pssm-ID: 214554  Cd Length: 121  Bit Score: 122.91  E-value: 1.79e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67189007     45 ETSATQRSSVPSST--EKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFRE 118
Cdd:smart00200   1 PTQSFGVSLSVLSVegENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 67189007    119 GTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 161
Cdd:smart00200  81 GVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 45-161 1.79e-35

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 122.91  E-value: 1.79e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67189007     45 ETSATQRSSVPSST--EKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFRE 118
Cdd:smart00200   1 PTQSFGVSLSVLSVegENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 67189007    119 GTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 161
Cdd:smart00200  81 GVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 63-117 1.84e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 39.53  E-value: 1.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67189007    63 FNSSLEDPSTDYYQELQRDISEMFLQIYKQ----GGFLGLSNIKFRP--GSVVVQLTLAFR 117
Cdd:pfam01390  14 YTPDLGNPSSQEFKSLSRRIESLLNELFRNsslrKQYIKSHVLRLRPdgGSVVVDVVLVFR 74
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 45-161 1.79e-35

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 122.91  E-value: 1.79e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67189007     45 ETSATQRSSVPSST--EKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFRE 118
Cdd:smart00200   1 PTQSFGVSLSVLSVegENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 67189007    119 GTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 161
Cdd:smart00200  81 GVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 63-117 1.84e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 39.53  E-value: 1.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67189007    63 FNSSLEDPSTDYYQELQRDISEMFLQIYKQ----GGFLGLSNIKFRP--GSVVVQLTLAFR 117
Cdd:pfam01390  14 YTPDLGNPSSQEFKSLSRRIESLLNELFRNsslrKQYIKSHVLRLRPdgGSVVVDVVLVFR 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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