|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
439-944 |
1.61e-132 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 414.62 E-value: 1.61e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 439 PKVLNSNLKlqAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLW 518
Cdd:COG0553 235 PAGLKATLR--PYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKF 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 519 CPSLKVLIYYGSVEdrkylRQDILTGLIDFNIIVSTYNLTignDHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTI 598
Cdd:COG0553 313 APGLRVLVLDGTRE-----RAKGANPFEDADLVITSYGLL---RRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRAL 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 599 NAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSqiskmFSTRSSEEESSFHKDRIAQARLIMKPFILRRVKSEVLK 678
Cdd:COG0553 385 KARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKA-----FRERFARPIEKGDEEALERLRRLLRPFLLRRTKEDVLK 459
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 679 ELPPKMEKIEMCPMSDAQHKLYDILFKRLKKTPNGDK--RELCNV---MMQLRKMANHPLLhrqyytsdklaamskaMLK 753
Cdd:COG0553 460 DLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAEgiRRRGLIlaaLTRLRQICSHPAL----------------LLE 523
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 754 EPTHYDAdpaliqedmevmsdfelhnlcreyssisgfqlekalilDSGKFALLTKTLAKLKEKGDRVVLFSQFTMMLDIV 833
Cdd:COG0553 524 EGAELSG--------------------------------------RSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLL 565
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 834 EILLKHLDHQYVRLDGSTPMAERIGLIDKYNTNPEIFVFLLSTRAGGQGINLASANTVILHDIDCNPFNDKQAEDRCHRM 913
Cdd:COG0553 566 EERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRI 645
|
490 500 510
....*....|....*....|....*....|.
gi 167860150 914 GQTRTVQVIKLISKDSIEDCMLRVGQEKLKL 944
Cdd:COG0553 646 GQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
448-630 |
2.15e-121 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 367.48 E-value: 2.15e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLIY 527
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRKYLRQDILTGLIDFNIIVSTYNLTIGNDHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLT 607
Cdd:cd17998 81 YGSQEERKHLRYDILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|...
gi 167860150 608 GTPLQNNLLELMSLLNFIMPSMF 630
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMPKPF 183
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
438-945 |
1.21e-116 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 382.61 E-value: 1.21e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 438 QPKVLNSnlKLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYE-KGIKGPHLITVPSSTLDNWVRELG 516
Cdd:PLN03142 162 QPSCIKG--KMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPKSTLGNWMNEIR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 517 LWCPSLKVLIYYGSVEDRKYLRQDILTGLiDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLM 596
Cdd:PLN03142 240 RFCPVLRAVKFHGNPEERAHQREELLVAG-KFDVCVTSFEMAI---KEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMR 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 597 TINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFSTRSSEEessfHKDRIAQARLIMKPFILRRVKSEV 676
Cdd:PLN03142 316 LFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQISGEND----QQEVVQQLHKVLRPFLLRRLKSDV 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 677 LKELPPKMEKIEMCPMSDAQHKLYDILFKRLKKTPN--GDKRELCNVMMQLRKMANHPLLHRQyytsdklaamskamlKE 754
Cdd:PLN03142 391 EKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNagGERKRLLNIAMQLRKCCNHPYLFQG---------------AE 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 755 PthydaDPALIQEDmevmsdfelHnlcreyssisgfqlekaLILDSGKFALLTKTLAKLKEKGDRVVLFSQFTMMLDIVE 834
Cdd:PLN03142 456 P-----GPPYTTGE---------H-----------------LVENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILE 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 835 ILLKHLDHQYVRLDGSTPMAERIGLIDKYNT-NPEIFVFLLSTRAGGQGINLASANTVILHDIDCNPFNDKQAEDRCHRM 913
Cdd:PLN03142 505 DYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRI 584
|
490 500 510
....*....|....*....|....*....|..
gi 167860150 914 GQTRTVQVIKLISKDSIEDCMLRVGQEKLKLE 945
Cdd:PLN03142 585 GQKKEVQVFRFCTEYTIEEKVIERAYKKLALD 616
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
448-671 |
5.71e-77 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 251.12 E-value: 5.71e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHL-YEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLaCEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDiLTGLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLL 606
Cdd:cd18003 81 YYGSAKERKLKRQG-WMKPNSFHVCITSYQLVV---QDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167860150 607 TGTPLQNNLLELMSLLNFIMPSMFSSSTSqISKMFS---TRSSEEESSFHKDRIAQARLIMKPFILRR 671
Cdd:cd18003 157 TGTPLQNSLMELWSLMHFLMPHIFQSHQE-FKEWFSnplTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
451-732 |
2.91e-75 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 248.75 E-value: 2.91e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 451 YQLIGLKWLI-LLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIK--GPHLITVPSSTLDNWVRELGLWC--PSLKVL 525
Cdd:pfam00176 1 YQIEGVNWMLsLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNwgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 526 IYYGSVEDRKYLRQDILTgLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLL 605
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNF-LADFDVVITTYETLR---KHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 606 LTGTPLQNNLLELMSLLNFIMPSMFSSSTS---QISKMFSTRSSeeessfhKDRIAQARLIMKPFILRRVKSEVLKELPP 682
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSLSTfrnWFDRPIERGGG-------KKGVSRLHKLLKPFLLRRTKKDVEKSLPP 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 167860150 683 KMEKIEMCPMSDAQHKLYD--ILFKRLKKTPNGDK-----RELCNVMMQLRKMANHP 732
Cdd:pfam00176 230 KVEYILFCRLSKLQRKLYQtfLLKKDLNAIKTGEGgreikASLLNILMRLRKICNHP 286
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
448-627 |
8.42e-74 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 240.55 E-value: 8.42e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHL-YEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLlKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKylRQDILTGLIDFNIIVSTYNlTIGNDHDRslFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLL 606
Cdd:cd17919 81 YHGSQRERA--QIRAKEKLDKFDVVLTTYE-TLRRDKAS--LRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLL 155
|
170 180
....*....|....*....|.
gi 167860150 607 TGTPLQNNLLELMSLLNFIMP 627
Cdd:cd17919 156 TGTPLQNNLEELWALLDFLDP 176
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
447-673 |
2.98e-73 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 241.52 E-value: 2.98e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 447 KLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18009 3 VMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDIL---TGLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHR 603
Cdd:cd18009 83 YHGTKEERERLRKKIMkreGTLQDFPVVVTSYEIAM---RDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167860150 604 LLLTGTPLQNNLLELMSLLNFIMPSMFSSSTS-----QISKMFSTRSSEEES--SFHKDRIAQARLIMKPFILRRVK 673
Cdd:cd18009 160 LLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSfeswfDFSSLSDNAADISNLseEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
447-673 |
6.16e-69 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 229.13 E-value: 6.16e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 447 KLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYE-KGIKGPHLITVPSSTLDNWVRELGLWCPSLKVL 525
Cdd:cd17997 3 TMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 526 IYYGSVEDRK-YLRQDILTGliDFNIIVSTYNLTIGNdhdRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRL 604
Cdd:cd17997 83 VLIGDKEERAdIIRDVLLPG--KFDVCITSYEMVIKE---KTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRL 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 167860150 605 LLTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFSTRSSEEESsfhKDRIAQARLIMKPFILRRVK 673
Cdd:cd17997 158 LLTGTPLQNNLHELWALLNFLLPDVFTSS-EDFDEWFNVNNCDDDN---QEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
445-673 |
9.21e-67 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 223.40 E-value: 9.21e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 445 NLKLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYE-KGIKGPHLITVPSSTLDNWVRELGLWCPSLK 523
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEkKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 524 VLIYYGSVEDRKYLRQDILTGliDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMT-INAEH 602
Cdd:cd17996 81 KIVYKGTPDVRKKLQSQIRAG--KFNVLLTTYEYII---KDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 603 RLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSqISKMFSTRSSEEESSfHKDRIAQA-------RL--IMKPFILRRVK 673
Cdd:cd17996 156 RLLLTGTPLQNNLPELWALLNFLLPKIFKSCKT-FEQWFNTPFANTGEQ-VKIELNEEetlliirRLhkVLRPFLLRRLK 233
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
448-673 |
4.65e-62 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 209.73 E-value: 4.65e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLIY 527
Cdd:cd18012 5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRKYLRQdiltgLIDFNIIVSTYNLtIGNDHDrsLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLT 607
Cdd:cd18012 85 HGTKRKREKLRA-----LEDYDLVITSYGL-LRRDIE--LLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALT 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167860150 608 GTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFSTRSSEEESsfhKDRIAQARLIMKPFILRRVK 673
Cdd:cd18012 157 GTPIENHLGELWSIFDFLNPGLLGSY-KRFKKRFAKPIEKDGD---EEALEELKKLISPFILRRLK 218
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
448-671 |
4.95e-61 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 207.36 E-value: 4.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYE-KGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEeHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQ-----DILTGLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAE 601
Cdd:cd18002 81 YWGNPKDRKVLRKfwdrkNLYTRDAPFHVVITSYQLVV---QDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167860150 602 HRLLLTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFST---RSSEEESSFHKDRIAQARLIMKPFILRR 671
Cdd:cd18002 158 NRLLLTGTPIQNSMAELWALLHFIMPTLFDSH-DEFNEWFSKdieSHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
447-671 |
2.35e-58 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 199.50 E-value: 2.35e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 447 KLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLY-EKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVL 525
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFhSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 526 IYYGSVEDRKYLRQDIL----TGLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAE 601
Cdd:cd17993 81 VYLGDIKSRDTIREYEFyfsqTKKLKFNVLLTTYEIIL---KDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTN 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 602 HRLLLTGTPLQNNLLELMSLLNFIMPSMFSsstsqISKMFSTrsseEESSFHKDRIAQARLIMKPFILRR 671
Cdd:cd17993 158 NRLLITGTPLQNSLKELWALLHFLMPGKFD-----IWEEFEE----EHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
448-671 |
4.77e-58 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 198.63 E-value: 4.77e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEK-GIKGPHLITVPSSTLDNWVRELGLWCPsLKVLI 526
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVeGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQ----------DILTGLIDFNIIVSTYNLTIGndhDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLM 596
Cdd:cd17995 80 YHGSGESRQIIQQyemyfkdaqgRKKKGVYKFDVLITTYEMVIA---DAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLK 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 167860150 597 TINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSSEEESSFHKdriaqarlIMKPFILRR 671
Cdd:cd17995 157 KLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFGDLKTAEQVEKLQA--------LLKPYMLRR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
793-925 |
7.14e-53 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 180.75 E-value: 7.14e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 793 EKALILDSGKFALLTKTLAKLKEKGDRVVLFSQFTMMLDIVEILLKHLDHQYVRLDGSTPMAERIGLIDKYNTNPEIFVF 872
Cdd:cd18793 3 PKIEEVVSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVF 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 167860150 873 LLSTRAGGQGINLASANTVILHDIDCNPFNDKQAEDRCHRMGQTRTVQVIKLI 925
Cdd:cd18793 83 LLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
447-683 |
5.92e-51 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 179.48 E-value: 5.92e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 447 KLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHL-YEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVL 525
Cdd:cd18064 15 KLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMkHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 526 IYYGSVEDRK-YLRQDILTGliDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRL 604
Cdd:cd18064 95 CLIGDKDQRAaFVRDVLLPG--EWDVCVTSYEMLI---KEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRL 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 167860150 605 LLTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFSTRSSEEESSFhkdrIAQARLIMKPFILRRVKSEVLKELPPK 683
Cdd:cd18064 170 LLTGTPLQNNLHELWALLNFLLPDVFNSA-EDFDSWFDTNNCLGDQKL----VERLHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
448-671 |
1.39e-50 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 177.63 E-value: 1.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEK-GIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRlKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDILTGLiDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLL 606
Cdd:cd18006 81 YMGDKEKRLDLQQDIKSTN-RFHVLLTTYEICL---KDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167860150 607 TGTPLQNNLLELMSLLNFIMPSMFSSSTSQ--ISKMFSTRSSEEEssfhkdrIAQARLIMKPFILRR 671
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFPKDKLDdfIKAYSETDDESET-------VEELHLLLQPFLLRR 216
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
437-671 |
2.67e-50 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 177.50 E-value: 2.67e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 437 KQPKVLNS-NLKLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKG-IKGPHLITVPSSTLDNWVRE 514
Cdd:cd18054 9 KQPSYIGGeNLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHqLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 515 LGLWCPSLKVLIYYGSVEDRKYLRQ----DILTGLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSL 590
Cdd:cd18054 89 FEIWAPEINVVVYIGDLMSRNTIREyewiHSQTKRLKFNALITTYEILL---KDKTVLGSINWAFLGVDEAHRLKNDDSL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 591 RYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFsSSTSQISKMFSTRSSEEESSFHKdriaqarlIMKPFILR 670
Cdd:cd18054 166 LYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKF-EFWEDFEEDHGKGRENGYQSLHK--------VLEPFLLR 236
|
.
gi 167860150 671 R 671
Cdd:cd18054 237 R 237
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
448-673 |
1.42e-46 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 166.73 E-value: 1.42e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHL-YEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLkHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRK-YLRQDILTGliDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLL 605
Cdd:cd18065 96 LIGDKDARAaFIRDVMMPG--EWDVCVTSYEMVI---KEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLL 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167860150 606 LTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFSTRSSEEESSFhkdrIAQARLIMKPFILRRVK 673
Cdd:cd18065 171 LTGTPLQNNLHELWALLNFLLPDVFNSA-DDFDSWFDTKNCLGDQKL----VERLHAVLKPFLLRRIK 233
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
451-627 |
2.91e-45 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 161.34 E-value: 2.91e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 451 YQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHL-YEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLI--- 526
Cdd:cd18000 4 YQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVVlhs 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 ---------YYGSVEDRKYLRQDILTgliDFNIIVSTYnltigndhdrSLFRKLKLK-------YAVFDEGHMLKNMN-- 588
Cdd:cd18000 84 sgsgtgseeKLGSIERKSQLIRKVVG---DGGILITTY----------EGFRKHKDLllnhnwqYVILDEGHKIRNPDae 150
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 167860150 589 -SLRYRHLMTInaeHRLLLTGTPLQNNLLELMSLLNFIMP 627
Cdd:cd18000 151 iTLACKQLRTP---HRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
448-671 |
4.76e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 162.13 E-value: 4.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCpSLKVLIY 527
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRKYLRQ----------DILTGLIDFNIIVSTYNLTIGndhDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMT 597
Cdd:cd18058 80 HGSQISRQMIQQyemyyrdeqgNPLSGIFKFQVVITTFEMILA---DCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167860150 598 INAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPFILRR 671
Cdd:cd18058 157 MALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT--------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
436-673 |
5.57e-45 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 162.91 E-value: 5.57e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 436 IKQPKVLNSNLKLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYE-KGIKGPHLITVPSSTLDNWVRE 514
Cdd:cd18062 12 VEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEhKRINGPFLIIVPLSTLSNWVYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 515 LGLWCPSLKVLIYYGSVEDRKYLRQDILTGliDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRH 594
Cdd:cd18062 92 FDKWAPSVVKVSYKGSPAARRAFVPQLRSG--KFNVLLTTYEYII---KDKQILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 595 LMT-INAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFsSSTSQISKMFSTRSSEEESSFHKDR------IAQARLIMKPF 667
Cdd:cd18062 167 LNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIF-KSCSTFEQWFNAPFAMTGEKVDLNEeetiliIRRLHKVLRPF 245
|
....*.
gi 167860150 668 ILRRVK 673
Cdd:cd18062 246 LLRRLK 251
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
451-671 |
6.21e-45 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 162.16 E-value: 6.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 451 YQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLIYYG- 529
Cdd:cd18001 4 HQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFHGt 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 530 SVEDRKYLRQDILTGlidFNIIVSTYNLTIGNDHDRSLF--RKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLT 607
Cdd:cd18001 84 SKKERERNLERIQRG---GGVLLTTYGMVLSNTEQLSADdhDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167860150 608 GTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFS---TRSSEEESSFHKDRIAQA-----RLIMKPFILRR 671
Cdd:cd18001 161 GTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFEnpiTRGRDKDATQGEKALGSEvaenlRQIIKPYFLRR 232
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
436-673 |
1.75e-44 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 161.38 E-value: 1.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 436 IKQPKVLNSNLKLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYE-KGIKGPHLITVPSSTLDNWVRE 514
Cdd:cd18063 12 VEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEhKRLNGPYLIIVPLSTLSNWTYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 515 LGLWCPSLKVLIYYGSVEDRKYLRQDILTGliDFNIIVSTYNLTIGNDHdrsLFRKLKLKYAVFDEGHMLKNMNSLRYRH 594
Cdd:cd18063 92 FDKWAPSVVKISYKGTPAMRRSLVPQLRSG--KFNVLLTTYEYIIKDKH---ILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 595 LMT-INAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTS---QISKMFSTRSSEEESSFHKDRIAQARL--IMKPFI 668
Cdd:cd18063 167 LNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTfeqWFNAPFAMTGERVDLNEEETILIIRRLhkVLRPFL 246
|
....*
gi 167860150 669 LRRVK 673
Cdd:cd18063 247 LRRLK 251
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
448-671 |
2.62e-43 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 157.45 E-value: 2.62e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLIllhqhKLSGILADEMGLGKTIQAIAF-LAHLYEKGIKGPH-----------------LITVPSSTLD 509
Cdd:cd18008 1 LLPYQKQGLAWML-----PRGGILADEMGLGKTIQALALiLATRPQDPKIPEEleenssdpkklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 510 NWVRELG--LWCPSLKVLIYYGSvedrkyLRQDILTGLIDFNIIVSTYNlTIGND---HDRSLFRKLKLKYA-------- 576
Cdd:cd18008 76 QWKDEIEkhTKPGSLKVYVYHGS------KRIKSIEELSDYDIVITTYG-TLASEfpkNKKGGGRDSKEKEAsplhrirw 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 577 ---VFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMP---SMFSSSTSQISKMFSTRsseees 650
Cdd:cd18008 149 yrvILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVepfGDYPWFNSDISKPFSKN------ 222
|
250 260
....*....|....*....|...
gi 167860150 651 sfhkDRIAQARL--IMKPFILRR 671
Cdd:cd18008 223 ----DRKALERLqaLLKPILLRR 241
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
437-671 |
2.73e-43 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 157.52 E-value: 2.73e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 437 KQPKVL--NSNLKLQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLY-EKGIKGPHLITVPSSTLDNWVR 513
Cdd:cd18053 8 KQPSYIggHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFhEHQLYGPFLLVVPLSTLTSWQR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 514 ELGLWCPSLKVLIYYGSVEDRKYLR----QDILTGLIDFNIIVSTYNLTIgndHDRSLFRKLKLKYAVFDEGHMLKNMNS 589
Cdd:cd18053 88 EIQTWAPQMNAVVYLGDINSRNMIRthewMHPQTKRLKFNILLTTYEILL---KDKSFLGGLNWAFIGVDEAHRLKNDDS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 590 LRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFsSSTSQISKMFSTRSSEEESSFHKDriaqarliMKPFIL 669
Cdd:cd18053 165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKF-SSWEDFEEEHGKGREYGYASLHKE--------LEPFLL 235
|
..
gi 167860150 670 RR 671
Cdd:cd18053 236 RR 237
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
448-671 |
1.39e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 154.83 E-value: 1.39e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCpSLKVLIY 527
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRKYLRQ----------DILTGLIDFNIIVSTYNLTIGndhDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMT 597
Cdd:cd18060 80 HGSLASRQMIQQyemyckdsrgRLIPGAYKFDALITTFEMILS---DCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKH 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167860150 598 INAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPFILRR 671
Cdd:cd18060 157 MDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT--------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
448-671 |
1.03e-41 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 152.89 E-value: 1.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLA---HLYEKGIKG---PHLITVPSSTLDNWVRELGLWCP- 520
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSFNSenlPSLVVCPPTLVGHWVAEIKKYFPn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 521 -SLKVLIYYGSVEDRKYLRQDILTGlidfNIIVSTYNlTIGNDHDrsLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTIN 599
Cdd:cd17999 81 aFLKPLAYVGPPQERRRLREQGEKH----NVIVASYD-VLRNDIE--VLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 600 AEHRLLLTGTPLQNNLLELMSLLNFIMPSmFSSSTSQISKMFS-----TRSSEEESSFHKDRIAQARLIMK---PFILRR 671
Cdd:cd17999 154 ANHRLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLkpilaSRDSKASAKEQEAGALALEALHKqvlPFLLRR 232
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
448-671 |
5.52e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 149.51 E-value: 5.52e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKG-IKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGhSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSvedrkylrqdiltglidfNIIVSTYNL-TIgndhDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLL 605
Cdd:cd17994 81 YVGD------------------HVLLTSYELiSI----DQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLL 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167860150 606 LTGTPLQNNLLELMSLLNFIMPSMFSSSTS------QISKmfstrsseeessfhKDRIAQARLIMKPFILRR 671
Cdd:cd17994 139 LTGTPLQNNLEELFHLLNFLTPERFNNLQGfleefaDISK--------------EDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
448-671 |
9.54e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 149.80 E-value: 9.54e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCpSLKVLIY 527
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRK-------YLRQD---ILTGLIDFNIIVSTYNLTIGndhDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMT 597
Cdd:cd18059 80 HGSQASRRtiqlyemYFKDPqgrVIKGSYKFHAIITTFEMILT---DCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKM 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167860150 598 INAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPFILRR 671
Cdd:cd18059 157 MDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT--------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
448-671 |
3.09e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 148.23 E-value: 3.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCpSLKVLIY 527
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRKYLRQ----------DILTGLIDFNIIVSTYNLTIGNDHDrslFRKLKLKYAVFDEGHMLKNMNSLRYRHLMT 597
Cdd:cd18061 80 HGSLISRQMIQQyemyfrdsqgRIIRGAYRFQAIITTFEMILGGCPE---LNAIDWRCVIIDEAHRLKNKNCKLLEGLKL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167860150 598 INAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPFILRR 671
Cdd:cd18061 157 MNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT--------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
448-671 |
2.26e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 140.20 E-value: 2.26e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKG-IKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGhSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDILT------------------GLIDFNIIVSTYNL-TIgndhDRSLFRKLKLKYAVFDEGHMLKNM 587
Cdd:cd18057 81 YTGDKESRSVIRENEFSfednairsgkkvfrmkkeAQIKFHVLLTSYELiTI----DQAILGSIEWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 588 NSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPF 667
Cdd:cd18057 157 QSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK--------EDQIKKLHDLLGPH 228
|
....
gi 167860150 668 ILRR 671
Cdd:cd18057 229 MLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
448-671 |
2.53e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 140.15 E-value: 2.53e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKG-IKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGhTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDILT------------------GLIDFNIIVSTYNL-TIgndhDRSLFRKLKLKYAVFDEGHMLKNM 587
Cdd:cd18055 81 YTGDKDSRAIIRENEFSfddnavkggkkafkmkreAQVKFHVLLTSYELvTI----DQAALGSIRWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 588 NSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPF 667
Cdd:cd18055 157 QSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK--------EDQIKKLHDLLGPH 228
|
....
gi 167860150 668 ILRR 671
Cdd:cd18055 229 MLRR 232
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
448-671 |
7.29e-35 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 133.18 E-value: 7.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLI--LLHQHKLSG---ILADEMGLGKTIQAIAFLAHLYEKGIKGPH-----LITVPSSTLDNWVRELGL 517
Cdd:cd18004 1 LRPHQREGVQFLYdcLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 518 WCPS--LKVLIYYGSVEDRKyLRQDILTGLIDFNIIVSTYNLTIgnDHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHL 595
Cdd:cd18004 81 WLGLrrIKVVTADGNAKDVK-ASLDFFSSASTYPVLIISYETLR--RHAEKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 596 MTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFSTR--------SSEEESSFHKDRIAQARLIMKPF 667
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSL-ASFRKVFEEPilrsrdpdASEEDKELGAERSQELSELTSRF 236
|
....
gi 167860150 668 ILRR 671
Cdd:cd18004 237 ILRR 240
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
448-671 |
1.51e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 132.11 E-value: 1.51e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKG-IKGPHLITVPSSTLDNWVRELGLWCPSLKVLI 526
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGhSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDILT------------------GLIDFNIIVSTYNL-TIgndhDRSLFRKLKLKYAVFDEGHMLKNM 587
Cdd:cd18056 81 YVGDKDSRAIIRENEFSfednairggkkasrmkkeASVKFHVLLTSYELiTI----DMAILGSIDWACLIVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 588 NSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSseeessfhKDRIAQARLIMKPF 667
Cdd:cd18056 157 QSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAK--------EDQIKKLHDMLGPH 228
|
....
gi 167860150 668 ILRR 671
Cdd:cd18056 229 MLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
448-671 |
5.03e-33 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 128.27 E-value: 5.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEK---------------------GIKGPHLITVPSS 506
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGKtgtrrdrennrprfkkkppasSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 507 TLDNWVRELGLWcPSLKVLIYYGSVEDRKyLRQDILTGLIDfnIIVSTYNlTIGNDHDRslFRKLKLKYAVFDEGHMLKN 586
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDE-LEGRLKAGRLE--VVVTTYD-TLRRCIDS--LNSINWSAVIADEAHRIKN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 587 MNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSStSQISKMFST------RSSEEESSFHKDRIAQA 660
Cdd:cd18005 154 PKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSR-SQFKKHFSEpikrgqRHTATARELRLGRKRKQ 232
|
250
....*....|...
gi 167860150 661 RL--IMKPFILRR 671
Cdd:cd18005 233 ELavKLSKFFLRR 245
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
470-644 |
9.31e-30 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 118.55 E-value: 9.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 470 ILADEMGLGKTIQAIAFLaHLYEKGIKG---PhLITVPSSTLDNWVRELGLWCPSlKVLIYYGSVEDRKYLRQDILTGLI 546
Cdd:cd18007 30 ILAHTMGLGKTLQVITFL-HTYLAAAPRrsrP-LVLCPASTLYNWEDEFKKWLPP-DLRPLLVLVSLSASKRADARLRKI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 547 -----DFNIIVSTYNL---TIGNDH-----DRSLFRKLKLKYA---VFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTP 610
Cdd:cd18007 107 nkwhkEGGVLLIGYELfrnLASNATtdprlKQEFIAALLDPGPdllVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTP 186
|
170 180 190
....*....|....*....|....*....|....
gi 167860150 611 LQNNLLELMSLLNFIMPSMFSSSTsQISKMFSTR 644
Cdd:cd18007 187 LQNNLKEYWTMVDFARPKYLGTLK-EFKKKFVKP 219
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
446-628 |
1.70e-27 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 110.66 E-value: 1.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 446 LKLQAYQLIGLKWLillHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTL-DNWVRELGLWCPS--L 522
Cdd:smart00487 7 EPLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLGPSlgL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 523 KVLIYYGSvEDRKYLRQDILTGliDFNIIVSTYNlTIGNDHDRSLFRKLKLKYAVFDEGHMLKNMNslRYRHLMTI---- 598
Cdd:smart00487 84 KVVGLYGG-DSKREQLRKLESG--KTDILVTTPG-RLLDLLENDKLSLSNVDLVILDEAHRLLDGG--FGDQLEKLlkll 157
|
170 180 190
....*....|....*....|....*....|....
gi 167860150 599 -NAEHRLLLTGTP---LQNNLLELMSLLNFIMPS 628
Cdd:smart00487 158 pKNVQLLLLSATPpeeIENLLELFLNDPVFIDVG 191
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
448-634 |
2.86e-24 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 101.90 E-value: 2.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLIllhQHKLSGILADEMGLGKTIQAIAFLAHLYEkgiKGPHLITVPSSTLDNWVRELGLWCPSLKVLIY 527
Cdd:cd18010 1 LLPFQREGVCFAL---RRGGRVLIADEMGLGKTVQAIAIAAYYRE---EWPLLIVCPSSLRLTWADEIERWLPSLPPDDI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 528 YGSVEDRKYLRQDiltgliDFNIIVSTYNLTIGNdhdRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTI--NAEHRLL 605
Cdd:cd18010 75 QVIVKSKDGLRDG------DAKVVIVSYDLLRRL---EKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVIL 145
|
170 180
....*....|....*....|....*....
gi 167860150 606 LTGTPLQNNLLELMSLLNFIMPSMFSSST 634
Cdd:cd18010 146 LSGTPALSRPIELFTQLDALDPKLFGRFH 174
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
470-632 |
5.78e-24 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 101.78 E-value: 5.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 470 ILADEMGLGKTIQAIAFLAHLYEKGIKGPHLI-----TVPSSTLDNWVRELGLWC-PSLKVLIYYG---SVEDRKYLRQD 540
Cdd:cd18067 28 IMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaivVSPSSLVKNWANELGKWLgGRLQPLAIDGgskKEIDRKLVQWA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 541 ILTG--LIDFNIIVSTYNLTIGNDHdrslFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLEL 618
Cdd:cd18067 108 SQQGrrVSTPVLIISYETFRLHVEV----LQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEY 183
|
170
....*....|....
gi 167860150 619 MSLLNFIMPSMFSS 632
Cdd:cd18067 184 FSLVNFVNPGILGT 197
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
469-625 |
2.13e-23 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 100.24 E-value: 2.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 469 GILADEMGLGKTIQAIAFLAhlyekgiKGPHLITVPSSTLDNWVRELGLWCPS--LKVLIYYGSVedrkylRQDILTGLI 546
Cdd:cd18071 51 GILADDMGLGKTLTTISLIL-------ANFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGE------RNRDPKLLS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 547 DFNIIVSTYNLTIGND--HDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNF 624
Cdd:cd18071 118 KYDIVLTTYNTLASDFgaKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSF 197
|
.
gi 167860150 625 I 625
Cdd:cd18071 198 L 198
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
801-914 |
3.23e-22 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 92.27 E-value: 3.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 801 GKFALLTKTLAKlkEKGDRVVLFSQFTMMLDIvEILLKHLDHQYVRLDGSTPMAERIGLIDKYNTNPeiFVFLLSTRAGG 880
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 167860150 881 QGINLASANTVILHDIDCNPFNDKQAEDRCHRMG 914
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
463-635 |
2.41e-21 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 94.14 E-value: 2.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 463 HQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPH------LITVPSSTLDNWVRELGLWCPSLKVLIYygSVEDRKY 536
Cdd:cd18066 21 VNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikraLIVTPGSLVKNWKKEFQKWLGSERIKVF--TVDQDHK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 537 LRQDILTGLidFNIIVSTYNLTIGNDHDrslFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLL 616
Cdd:cd18066 99 VEEFIASPL--YSVLIISYEMLLRSLDQ---ISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQ 173
|
170
....*....|....*....
gi 167860150 617 ELMSLLNFIMPSMFSSSTS 635
Cdd:cd18066 174 EFFALIDFVNPGILGSLST 192
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
470-641 |
1.86e-18 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 85.25 E-value: 1.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 470 ILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCPS-----------LKVLIYyGSVEDRKYLR 538
Cdd:cd18069 32 ILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPPpealpnvrprpFKVFIL-NDEHKTTAAR 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 539 QDILTGLID----FNIIVSTYNLTIGNDhdrslfrklklkYAVFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNN 614
Cdd:cd18069 111 AKVIEDWVKdggvLLMGYEMFRLRPGPD------------VVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNN 178
|
170 180
....*....|....*....|....*..
gi 167860150 615 LLELMSLLNFIMPSMFSSSTSqISKMF 641
Cdd:cd18069 179 LIEYWCMVDFVRPDFLGTRQE-FSNMF 204
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
469-634 |
2.39e-18 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 85.71 E-value: 2.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 469 GILADEMGLGKTIQAIAFLaH---LYEKGIKGPH-LITVPSSTLDNWVRELGLWCPSLK--------VLIYYGSVEDRKY 536
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFL-HtvlLCEKLENFSRvLVVCPLNTVLNWLNEFEKWQEGLKdeekievnELATYKRPQERSY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 537 LRQDILTgliDFNIIVSTY----NLTIGND-----HDRSLFRKLKLK----YAVFDEGHMLKNMNSLRYRHLMTINAEHR 603
Cdd:cd18068 110 KLQRWQE---EGGVMIIGYdmyrILAQERNvksreKLKEIFNKALVDpgpdFVVCDEGHILKNEASAVSKAMNSIRTKRR 186
|
170 180 190
....*....|....*....|....*....|.
gi 167860150 604 LLLTGTPLQNNLLELMSLLNFIMPSMFSSST 634
Cdd:cd18068 187 IVLTGTPLQNNLIEYHCMVNFVKPNLLGTIK 217
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
448-670 |
5.19e-18 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 84.70 E-value: 5.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLhqhklSGILADEMGLGKTIQAIAF-LAH---------------------LYEKGIK----GPHLI 501
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALiLLHprpdndldaadddsdemvccpDCLVAETpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 502 TVPSSTLDNWVRELGLWCP-SLKVLIYYGsVEDRKYLRQDILTGLIDFNIIVSTYNlTIGND--------HDRSLfRKLK 572
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQG-VKKDGALASPAPEILAEYDIVVTTYD-VLRTElhyaeanrSNRRR-RRQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 573 LKYA-------------VFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISK 639
Cdd:cd18070 153 RYEAppsplvlvewwrvCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWARV 232
|
250 260 270
....*....|....*....|....*....|.
gi 167860150 640 MFSTRSSeeessfhKDRIAQARLIMKPFILR 670
Cdd:cd18070 233 LIRPQGR-------NKAREPLAALLKELLWR 256
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
831-914 |
2.83e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 77.25 E-value: 2.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 831 DIVEILLKHLDHQYVRLDGSTPMAERIGLIDKYNTNPeiFVFLLSTRAGGQGINLASANTVILHDIDCNPFNDKQAEDRC 910
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 167860150 911 HRMG 914
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
448-671 |
3.81e-17 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 81.76 E-value: 3.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLSG-ILADEMGLGKTIQAIAFL--------------AHLYEKGIK---------GPHLITV 503
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALIlaqkntqnrkeeekEKALTEWESkkdstlvpsAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 504 PSSTLDNWVRELGLWCPS--LKVLIYYGSVedrkylRQDILTGLIDFNIIVSTYNL------TIGNDHDRSLFRKLKLKY 575
Cdd:cd18072 81 PASLVHQWKNEVESRVASnkLRVCLYHGPN------RERIGEVLRDYDIVITTYSLvakeipTYKEESRSSPLFRIAWAR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 576 AVFDEGHMLKNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFStrsseeessfhKD 655
Cdd:cd18072 155 IILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDN-----------KS 223
|
250
....*....|....*...
gi 167860150 656 RIAQARL--IMKPFILRR 671
Cdd:cd18072 224 RKGGERLniLTKSLLLRR 241
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
448-631 |
8.26e-17 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 80.03 E-value: 8.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKWLILLHQHKLsgILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELG--LWCPSLKVl 525
Cdd:cd18011 1 PLPHQIDAVLRALRKPPVRL--LLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQdkFGLPFLIL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 526 iyygSVEDRKYLRQDILTGLIDFNIIVSTYNLTIGNDHDRSLFRKLKLKYAVFDEGHMLKNMN----SLRYRHLMTI--N 599
Cdd:cd18011 78 ----DRETAAQLRRLIGNPFEEFPIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGggkeTKRYKLGRLLakR 153
|
170 180 190
....*....|....*....|....*....|..
gi 167860150 600 AEHRLLLTGTPLQNNLLELMSLLNFIMPSMFS 631
Cdd:cd18011 154 ARHVLLLTATPHNGKEEDFRALLSLLDPGRFA 185
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
448-610 |
1.75e-10 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 60.01 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 448 LQAYQLIGLKwLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGIkgphLITVPSSTLDN-WVRELglwcpslkvlI 526
Cdd:cd17926 1 LRPYQEEALE-AWLAHKNNRRGILVLPTGSGKTLTALALIAYLKELRT----LIVVPTDALLDqWKERF----------E 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDILTGLIDFNIIVSTYNLTIGNDHDRSLFRKLKLkYAVFDEGHmlkNMNSLRYRHLMTI-NAEHRLL 605
Cdd:cd17926 66 DFLGDSSIGLIGGGKKKDFDDANVVVATYQSLSNLAEEEKDLFDQFG-LLIVDEAH---HLPAKTFSEILKElNAKYRLG 141
|
....*
gi 167860150 606 LTGTP 610
Cdd:cd17926 142 LTATP 146
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
451-618 |
3.82e-08 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 55.05 E-value: 3.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 451 YQLIGLKWLIllhQHKLSGILADeMGLGKTIQAIAFLAHLYEKGIKGPHLITVP----SSTldnWVRELGLWcPSLKVLI 526
Cdd:cd18013 4 YQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPlrvaRST---WPDEVEKW-NHLRNLT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 527 YYGSVEDRKYLRQDILTgliDFNIIVSTYNLTigNDHDRSLFRKLKLKYAVFDEGHMLKNMNSLRYRHLMTIN--AEHRL 604
Cdd:cd18013 76 VSVAVGTERQRSKAANT---PADLYVINRENL--KWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRpvIKRLI 150
|
170
....*....|....
gi 167860150 605 LLTGTPLQNNLLEL 618
Cdd:cd18013 151 GLTGTPSPNGLMDL 164
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
440-610 |
4.94e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 56.96 E-value: 4.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 440 KVLNSNLKLQAYQLIGL-KWLILLHQHKLSGILADEMGLGKTIQAIAFLAHLYEKGikgPHLITVPSSTL-DNWVRELgl 517
Cdd:COG1061 73 EASGTSFELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGK---RVLVLVPRRELlEQWAEEL-- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 518 wcpsLKVLIYYGSVEDRKYlrqdiltglIDFNIIVSTYNLTIGNDHDRSLFRKLKLkyAVFDEGHmlkNMNSLRYRHLMT 597
Cdd:COG1061 148 ----RRFLGDPLAGGGKKD---------SDAPITVATYQSLARRAHLDELGDRFGL--VIIDEAH---HAGAPSYRRILE 209
|
170
....*....|....
gi 167860150 598 -INAEHRLLLTGTP 610
Cdd:COG1061 210 aFPAAYRLGLTATP 223
|
|
| DpdE |
NF041062 |
protein DpdE; |
471-631 |
8.39e-08 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 56.52 E-value: 8.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 471 LADEMGLGKTIQA-IAFLAHLYEKgikgPH---LITVPSSTLDNWVRELglwcpslkvliyygsvEDRKYLRQdiltgLI 546
Cdd:NF041062 175 LADEVGLGKTIEAgLVIRQHLLDN----PDarvLVLVPDALVRQWRREL----------------RDKFFLDD-----FP 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 547 DFNIIVSTYnltigNDHDRSLFRKLKLKYAVFDEGHMLKNMN-------SLRYRHLMTI--NAEHRLLLTGTPLQNNLLE 617
Cdd:NF041062 230 GARVRVLSH-----EEPERWEPLLDAPDLLVVDEAHQLARLAwsgdppeRARYRELAALahAAPRLLLLSATPVLGNEET 304
|
170
....*....|....
gi 167860150 618 LMSLLNFIMPSMFS 631
Cdd:NF041062 305 FLALLHLLDPDLYP 318
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
469-609 |
4.15e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 44.70 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167860150 469 GILADEMGLGKTIQAIAFLAHLYEKGIKGPhLITVPSSTLDN----WVRELGLWcpSLKVLIYYGSV---EDRKYLRQDI 541
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKV-LVLVPTKALALqtaeRLRELFGP--GIRVAVLVGGSsaeEREKNKLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167860150 542 ltglidfNIIVSTYNlTIGND---HDRSLFRklKLKYAVFDEGHML------KNMNSLRYRHLMTINAEhRLLLTGT 609
Cdd:cd00046 81 -------DIIIATPD-MLLNLllrEDRLFLK--DLKLIIVDEAHALlidsrgALILDLAVRKAGLKNAQ-VILLSAT 146
|
|
| ComEA |
COG1555 |
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ... |
348-381 |
6.94e-03 |
|
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];
Pssm-ID: 441164 [Multi-domain] Cd Length: 72 Bit Score: 36.38 E-value: 6.94e-03
10 20 30
....*....|....*....|....*....|....*...
gi 167860150 348 ASLDELALISGCSIKKAQKIISLR----PFNTWKDVKE 381
Cdd:COG1555 18 ATAEELQTLPGIGPKLAQRIVEYRekngPFKSVEDLLE 55
|
|
| |
