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Conserved domains on  [gi|67190736|ref|NP_001019979|]
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B-cell CLL/lymphoma 7 protein family member A isoform b [Homo sapiens]

Protein Classification

BCL_N domain-containing protein( domain architecture ID 10520246)

BCL_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCL_N pfam04714
BCL7, N-terminal conserver region; Members of the BCL family have significant sequence ...
 4-50 8.28e-28

BCL7, N-terminal conserver region; Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.


:

Pssm-ID: 461406  Cd Length: 48  Bit Score: 99.48  E-value: 8.28e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 67190736     4 RSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVP 50
Cdd:pfam04714   2 RSLRAETRSRAKDDVKRVILSIEKVRKWEKKWVTIGDTSMRIYKWVP 48
PHA02664 super family cl22678
hypothetical protein; Provisional
 72-205 2.51e-03

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA02664:

Pssm-ID: 177447  Cd Length: 534  Bit Score: 38.06  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67190736   72 GSEVTTPENSSSPGmmdmhddnsnqSSIADASPIKQENSSNSSPAPEPNSAVPSDGTEAKVDEAQADGKEhPGAEDASDE 151
Cdd:PHA02664 403 GSPMAAPEEGRAAA-----------AAAAANAPADQDVEAEAHDEFDQDPGAPAHADRADSDEDDMDEQE-SGDERADGE 470

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 67190736  152 QNSQSSMEHSMNSSEkvDRQPSGDSGLAAET-SAISQDLEGVPPSKKMKLEASQQ 205
Cdd:PHA02664 471 DDSDSSYSYSTTSSE--DESDSADDSWGDESdSGIEHDDGGVGQAIEEEEEEERA 523
 
Name Accession Description Interval E-value
BCL_N pfam04714
BCL7, N-terminal conserver region; Members of the BCL family have significant sequence ...
 4-50 8.28e-28

BCL7, N-terminal conserver region; Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.


Pssm-ID: 461406  Cd Length: 48  Bit Score: 99.48  E-value: 8.28e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 67190736     4 RSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVP 50
Cdd:pfam04714   2 RSLRAETRSRAKDDVKRVILSIEKVRKWEKKWVTIGDTSMRIYKWVP 48
PHA02664 PHA02664
hypothetical protein; Provisional
 72-205 2.51e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 38.06  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67190736   72 GSEVTTPENSSSPGmmdmhddnsnqSSIADASPIKQENSSNSSPAPEPNSAVPSDGTEAKVDEAQADGKEhPGAEDASDE 151
Cdd:PHA02664 403 GSPMAAPEEGRAAA-----------AAAAANAPADQDVEAEAHDEFDQDPGAPAHADRADSDEDDMDEQE-SGDERADGE 470

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 67190736  152 QNSQSSMEHSMNSSEkvDRQPSGDSGLAAET-SAISQDLEGVPPSKKMKLEASQQ 205
Cdd:PHA02664 471 DDSDSSYSYSTTSSE--DESDSADDSWGDESdSGIEHDDGGVGQAIEEEEEEERA 523
 
Name Accession Description Interval E-value
BCL_N pfam04714
BCL7, N-terminal conserver region; Members of the BCL family have significant sequence ...
 4-50 8.28e-28

BCL7, N-terminal conserver region; Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.


Pssm-ID: 461406  Cd Length: 48  Bit Score: 99.48  E-value: 8.28e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 67190736     4 RSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVP 50
Cdd:pfam04714   2 RSLRAETRSRAKDDVKRVILSIEKVRKWEKKWVTIGDTSMRIYKWVP 48
PHA02664 PHA02664
hypothetical protein; Provisional
 72-205 2.51e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 38.06  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67190736   72 GSEVTTPENSSSPGmmdmhddnsnqSSIADASPIKQENSSNSSPAPEPNSAVPSDGTEAKVDEAQADGKEhPGAEDASDE 151
Cdd:PHA02664 403 GSPMAAPEEGRAAA-----------AAAAANAPADQDVEAEAHDEFDQDPGAPAHADRADSDEDDMDEQE-SGDERADGE 470

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 67190736  152 QNSQSSMEHSMNSSEkvDRQPSGDSGLAAET-SAISQDLEGVPPSKKMKLEASQQ 205
Cdd:PHA02664 471 DDSDSSYSYSTTSSE--DESDSADDSWGDESdSGIEHDDGGVGQAIEEEEEEERA 523
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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