NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|68161509|ref|NP_001020130|]
View 

actin-related protein 2/3 complex subunit 4 isoform b [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ARPC4 super family cl05433
ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 ...
 1-76 1.90e-44

ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.


The actual alignment was detected with superfamily member pfam05856:

Pssm-ID: 471245  Cd Length: 166  Bit Score: 140.43  E-value: 1.90e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68161509     1 MRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLK 76
Cdd:pfam05856  91 TRFLMQRAEAFIILRRKPVEGYDISFLITNHHTEQMGKHKLIDFIITFMEEIDKEISEMKLSLNARARIVAEEYLA 166
 
Name Accession Description Interval E-value
ARPC4 pfam05856
ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 ...
 1-76 1.90e-44

ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.


Pssm-ID: 461760  Cd Length: 166  Bit Score: 140.43  E-value: 1.90e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68161509     1 MRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLK 76
Cdd:pfam05856  91 TRFLMQRAEAFIILRRKPVEGYDISFLITNHHTEQMGKHKLIDFIITFMEEIDKEISEMKLSLNARARIVAEEYLA 166
PTZ00278 PTZ00278
ARP2/3 complex subunit; Provisional
 1-78 3.73e-39

ARP2/3 complex subunit; Provisional


Pssm-ID: 240342  Cd Length: 174  Bit Score: 127.16  E-value: 3.73e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68161509    1 MRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF 78
Cdd:PTZ00278  95 VSFLAQRAEQFVILRRKPIPGYDISFLITNFHTENMFKHKLIDFIIDFMEDIDKDISDMKLNVNTRARIAAPEFFKAL 172
 
Name Accession Description Interval E-value
ARPC4 pfam05856
ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 ...
 1-76 1.90e-44

ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.


Pssm-ID: 461760  Cd Length: 166  Bit Score: 140.43  E-value: 1.90e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68161509     1 MRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLK 76
Cdd:pfam05856  91 TRFLMQRAEAFIILRRKPVEGYDISFLITNHHTEQMGKHKLIDFIITFMEEIDKEISEMKLSLNARARIVAEEYLA 166
PTZ00278 PTZ00278
ARP2/3 complex subunit; Provisional
 1-78 3.73e-39

ARP2/3 complex subunit; Provisional


Pssm-ID: 240342  Cd Length: 174  Bit Score: 127.16  E-value: 3.73e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68161509    1 MRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF 78
Cdd:PTZ00278  95 VSFLAQRAEQFVILRRKPIPGYDISFLITNFHTENMFKHKLIDFIIDFMEDIDKDISDMKLNVNTRARIAAPEFFKAL 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH