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Conserved domains on  [gi|70995235|ref|NP_001020751|]
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nuclear protein AMMECR1 isoform 2 [Homo sapiens]

Protein Classification

AMMECR1 domain-containing protein( domain architecture ID 10486934)

AMMECR1 domain-containing protein such as human nuclear protein AMMECR1 that is implicated in the AMME complex, an X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, sensorineural hearing loss, intellectual disability, midface hypoplasia, and elliptocytosis

PubMed:  10049589|17715145

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
 159-264 3.28e-42

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


:

Pssm-ID: 460368  Cd Length: 167  Bit Score: 142.98  E-value: 3.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235   159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYLDWEVGVHGIRIefinEKGsKRTATYLPEVAKEQGWDHIQTIDSLL 238
Cdd:pfam01871  68 AFRDPRFPPLTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLII----EKG-GRSGTLLPQVAVEQGWDPEEFLDHLC 142

                          90       100
                  ....*....|....*....|....*.
gi 70995235   239 RKGGYKApiTNEFRKTIKLTRYRSEK 264
Cdd:pfam01871 143 RKAGLPP--DAWRDEDVKLYRFEAEV 166
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
 159-264 3.28e-42

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 460368  Cd Length: 167  Bit Score: 142.98  E-value: 3.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235   159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYLDWEVGVHGIRIefinEKGsKRTATYLPEVAKEQGWDHIQTIDSLL 238
Cdd:pfam01871  68 AFRDPRFPPLTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLII----EKG-GRSGTLLPQVAVEQGWDPEEFLDHLC 142

                          90       100
                  ....*....|....*....|....*.
gi 70995235   239 RKGGYKApiTNEFRKTIKLTRYRSEK 264
Cdd:pfam01871 143 RKAGLPP--DAWRDEDVKLYRFEAEV 166
AMMECR1 COG2078
Predicted RNA modification protein, AMMECR1 domain [General function prediction only];
159-264 1.38e-21

Predicted RNA modification protein, AMMECR1 domain [General function prediction only];


Pssm-ID: 441681  Cd Length: 184  Bit Score: 89.41  E-value: 1.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235 159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYL-DWEVGVHGIRIefinEKGSKRtATYLPEVAKEQGWDHIQTIDSL 237
Cdd:COG2078  79 AFEDPRFPPVTPEELDDLTIEVSVLSPPEPIEDLLeELEPGRDGLIV----EKGGRR-GLLLPQVAWEGLWDPEEFLAHL 153

                        90       100       110
                ....*....|....*....|....*....|..
gi 70995235 238 LRKGG-----YKAPITnefrktiKLTRYRSEK 264
Cdd:COG2078 154 CRKAGlppdaWKDPDV-------KVYRFEVEV 178
AmmeMemoSam_A TIGR04335
AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain ...
 144-264 2.33e-16

AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain family as AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Members of the present family occur as part of a three gene system with a homolog of the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility), and an uncharacterized radical SAM enzyme.


Pssm-ID: 275134  Cd Length: 174  Bit Score: 74.93  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235   144 GYQQPRTPRFTNEPY-----ALKDSRFPPMTRDELPRLFCSVSLLT-----NFEDVCDYL-DWEVGVHGIriefINEKGS 212
Cdd:TIGR04335  51 GTIEADRPLVEDVAEnaiaaAFKDPRFPPLTEDELDRLTIEVSVLSppeplPVEDEEELLeELRPGRDGL----ILEDGG 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 70995235   213 KRtATYLPEVAKEQGwDHIQTIDSLLRKGGYKApitNEFRKTIKLTRYRSEK 264
Cdd:TIGR04335 127 RR-GLFLPQVWEELP-DPEEFLRHLCLKAGLPP---DAWRDDVTIYRFTVEV 173
PRK00801 PRK00801
hypothetical protein; Provisional
 159-232 5.93e-05

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 43.12  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235  159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDV-------CDYLdwEVGVHGIriefINEKGSKrTATYLPEVAKEQGWDHI 231
Cdd:PRK00801  81 ATRDPRFPPVKLEEMDEITVEVTVLTPPELIegppeelPEKI--EVGRHGL----IVKKGIY-SGLLLPQVAPEWGFDSE 153


                 .
gi 70995235  232 Q 232
Cdd:PRK00801 154 E 154
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
 159-264 3.28e-42

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 460368  Cd Length: 167  Bit Score: 142.98  E-value: 3.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235   159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYLDWEVGVHGIRIefinEKGsKRTATYLPEVAKEQGWDHIQTIDSLL 238
Cdd:pfam01871  68 AFRDPRFPPLTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLII----EKG-GRSGTLLPQVAVEQGWDPEEFLDHLC 142

                          90       100
                  ....*....|....*....|....*.
gi 70995235   239 RKGGYKApiTNEFRKTIKLTRYRSEK 264
Cdd:pfam01871 143 RKAGLPP--DAWRDEDVKLYRFEAEV 166
AMMECR1 COG2078
Predicted RNA modification protein, AMMECR1 domain [General function prediction only];
159-264 1.38e-21

Predicted RNA modification protein, AMMECR1 domain [General function prediction only];


Pssm-ID: 441681  Cd Length: 184  Bit Score: 89.41  E-value: 1.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235 159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYL-DWEVGVHGIRIefinEKGSKRtATYLPEVAKEQGWDHIQTIDSL 237
Cdd:COG2078  79 AFEDPRFPPVTPEELDDLTIEVSVLSPPEPIEDLLeELEPGRDGLIV----EKGGRR-GLLLPQVAWEGLWDPEEFLAHL 153

                        90       100       110
                ....*....|....*....|....*....|..
gi 70995235 238 LRKGG-----YKAPITnefrktiKLTRYRSEK 264
Cdd:COG2078 154 CRKAGlppdaWKDPDV-------KVYRFEVEV 178
AmmeMemoSam_A TIGR04335
AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain ...
 144-264 2.33e-16

AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain family as AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Members of the present family occur as part of a three gene system with a homolog of the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility), and an uncharacterized radical SAM enzyme.


Pssm-ID: 275134  Cd Length: 174  Bit Score: 74.93  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235   144 GYQQPRTPRFTNEPY-----ALKDSRFPPMTRDELPRLFCSVSLLT-----NFEDVCDYL-DWEVGVHGIriefINEKGS 212
Cdd:TIGR04335  51 GTIEADRPLVEDVAEnaiaaAFKDPRFPPLTEDELDRLTIEVSVLSppeplPVEDEEELLeELRPGRDGL----ILEDGG 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 70995235   213 KRtATYLPEVAKEQGwDHIQTIDSLLRKGGYKApitNEFRKTIKLTRYRSEK 264
Cdd:TIGR04335 127 RR-GLFLPQVWEELP-DPEEFLRHLCLKAGLPP---DAWRDDVTIYRFTVEV 173
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
 159-263 7.42e-16

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 74.47  E-value: 7.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235   159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDV-----CDYL-DWEVGVHGIRIEFinekGSKRtATYLPEVAKEQGWDHIQ 232
Cdd:TIGR00296  83 ATEDPRFPPVQLEELDDIKVEVSILTPPETIfvggpKDYPfDIEIGRHGLIVEF----GPKR-GLLLPQVAVEYGWDAEE 157

                          90       100       110
                  ....*....|....*....|....*....|.
gi 70995235   233 TIDSLLRKGGYkaPITNEFRKTIKLTRYRSE 263
Cdd:TIGR00296 158 FLANLCMKAGL--PPDCFLTYGIEVYRFEGQ 186
PRK00801 PRK00801
hypothetical protein; Provisional
 159-232 5.93e-05

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 43.12  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995235  159 ALKDSRFPPMTRDELPRLFCSVSLLTNFEDV-------CDYLdwEVGVHGIriefINEKGSKrTATYLPEVAKEQGWDHI 231
Cdd:PRK00801  81 ATRDPRFPPVKLEEMDEITVEVTVLTPPELIegppeelPEKI--EVGRHGL----IVKKGIY-SGLLLPQVAPEWGFDSE 153


                 .
gi 70995235  232 Q 232
Cdd:PRK00801 154 E 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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