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Conserved domains on  [gi|71989721|ref|NP_001022177|]
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Period protein homolog lin-42 [Caenorhabditis elegans]

Protein Classification

PAS domain-containing protein( domain architecture ID 10062837)

PAS domain-containing protein binds ligand(s) and may act as sensors for light and oxygen in signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 168-271 2.58e-09

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


:

Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 54.95  E-value: 2.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989721 168 TFITKHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNsrgKIVKSIADLRLVAHNGSILRC 247
Cdd:cd00130   3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS---GGEPVTLEVRLRRKDGSVIWV 79

                        90       100
                ....*....|....*....|....
gi 71989721 248 QTEWSAYVNPWTRKMELVVARHRI 271
Cdd:cd00130  80 LVSLTPIRDEGGEVIGLLGVVRDI 103
 
Name Accession Description Interval E-value
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 168-271 2.58e-09

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 54.95  E-value: 2.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989721 168 TFITKHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNsrgKIVKSIADLRLVAHNGSILRC 247
Cdd:cd00130   3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS---GGEPVTLEVRLRRKDGSVIWV 79

                        90       100
                ....*....|....*....|....
gi 71989721 248 QTEWSAYVNPWTRKMELVVARHRI 271
Cdd:cd00130  80 LVSLTPIRDEGGEVIGLLGVVRDI 103
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 169-271 4.85e-09

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 54.22  E-value: 4.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989721   169 FITKHSSTCALTHIDyASIPY-LGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNSRGKivKSIADLRLVAHNGSILRC 247
Cdd:pfam14598   4 FTTRHDIDGKIISCD-TRAPFsLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGR--ATSPSYRLRLRDGDFLSV 80

                          90       100
                  ....*....|....*....|....
gi 71989721   248 QTEWSAYVNPWTRKMELVVARHRI 271
Cdd:pfam14598  81 HTKSKLFLNQNSNQQPFIMCTHTI 104
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 162-223 3.23e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 39.30  E-value: 3.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71989721    162 SNFHVFTFItkHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHN 223
Cdd:smart00091   8 ESLPDGIFV--LDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
 
Name Accession Description Interval E-value
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 168-271 2.58e-09

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 54.95  E-value: 2.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989721 168 TFITKHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNsrgKIVKSIADLRLVAHNGSILRC 247
Cdd:cd00130   3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS---GGEPVTLEVRLRRKDGSVIWV 79

                        90       100
                ....*....|....*....|....
gi 71989721 248 QTEWSAYVNPWTRKMELVVARHRI 271
Cdd:cd00130  80 LVSLTPIRDEGGEVIGLLGVVRDI 103
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 169-271 4.85e-09

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 54.22  E-value: 4.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989721   169 FITKHSSTCALTHIDyASIPY-LGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNSRGKivKSIADLRLVAHNGSILRC 247
Cdd:pfam14598   4 FTTRHDIDGKIISCD-TRAPFsLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGR--ATSPSYRLRLRDGDFLSV 80

                          90       100
                  ....*....|....*....|....
gi 71989721   248 QTEWSAYVNPWTRKMELVVARHRI 271
Cdd:pfam14598  81 HTKSKLFLNQNSNQQPFIMCTHTI 104
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 162-223 3.23e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 39.30  E-value: 3.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71989721    162 SNFHVFTFItkHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHN 223
Cdd:smart00091   8 ESLPDGIFV--LDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 163-271 2.14e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 38.17  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989721   163 NFHVFTFITKHSSTCALTHIDYASIpyLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNSRGKivKSIADLRLVAHNG 242
Cdd:pfam00989   9 SLPDGIFVVDEDGRILYVNAAAEEL--LGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEE--SRGFEVSFRVPDG 84

                          90       100
                  ....*....|....*....|....*....
gi 71989721   243 SILRCQTEWSAYVNPWTRKMELVVARHRI 271
Cdd:pfam00989  85 RPRHVEVRASPVRDAGGEILGFLGVLRDI 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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