nanos homolog 2 [Homo sapiens]
Protein Classification
nanos family protein( domain architecture ID 10530272)
nanos family protein contains a zinc finger domain (called nanos RNA binding domain), similar to Drosophila melanogaster protein nanos, a maternal RNA-binding protein that is required for germ cells proliferation and self-renewal
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| zf-nanos | pfam05741 | Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ... |
63-116 | 6.90e-36 | ||
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development. : Pssm-ID: 461728 Cd Length: 54 Bit Score: 117.68 E-value: 6.90e-36
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| Name | Accession | Description | Interval | E-value | ||
| zf-nanos | pfam05741 | Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ... |
63-116 | 6.90e-36 | ||
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development. Pssm-ID: 461728 Cd Length: 54 Bit Score: 117.68 E-value: 6.90e-36
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| Name | Accession | Description | Interval | E-value | ||
| zf-nanos | pfam05741 | Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ... |
63-116 | 6.90e-36 | ||
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development. Pssm-ID: 461728 Cd Length: 54 Bit Score: 117.68 E-value: 6.90e-36
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