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Conserved domains on  [gi|71143156|ref|NP_001025034|]
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UPF0669 protein C6orf120 isoform 1 precursor [Homo sapiens]

Protein Classification

UPF0669 family protein( domain architecture ID 11246788)

UPF0669 family protein similar to Homo sapiens protein C6orf120, which may be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0669 pfam17065
Putative cytokine, C6ORF120; C6orf120 is a secreted protein that promotes cell cycle ...
 8-191 1.06e-121

Putative cytokine, C6ORF120; C6orf120 is a secreted protein that promotes cell cycle progression of CD4(+) T-cells, not hepatocytes. In humans it has its main role in tunicamycin-induced CD4(+) T apoptosis that may be associated with endoplasmatic reticulum stress. This suggests that it might be a new cytokine with immununoregulatory function that is selective for CD4+ T cells. It is mainly expressed in hepatocytes and cells in germinal centre of lymph nodes.


:

Pssm-ID: 293670  Cd Length: 185  Bit Score: 341.42  E-value: 1.06e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143156     8 AAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHP 87
Cdd:pfam17065   2 AAPWRGALLLSLASQALGLAQCLEEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIILQMQSLKGDADLYVSDSTLHP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143156    88 SFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDA 167
Cdd:pfam17065  82 SFDEYELQSTTCGQDVVSIPAHFRRPVGIGIYGHPSHMESEFEMKVYYDRTVAEYPFGEASYSSDETEASQKQSQTPEDA 161

                         170       180
                  ....*....|....*....|....
gi 71143156   168 SQEEESVLWTILISILKLVLEILF 191
Cdd:pfam17065 162 SQEEESVLWTILIGILKLVLEILF 185
 
Name Accession Description Interval E-value
UPF0669 pfam17065
Putative cytokine, C6ORF120; C6orf120 is a secreted protein that promotes cell cycle ...
 8-191 1.06e-121

Putative cytokine, C6ORF120; C6orf120 is a secreted protein that promotes cell cycle progression of CD4(+) T-cells, not hepatocytes. In humans it has its main role in tunicamycin-induced CD4(+) T apoptosis that may be associated with endoplasmatic reticulum stress. This suggests that it might be a new cytokine with immununoregulatory function that is selective for CD4+ T cells. It is mainly expressed in hepatocytes and cells in germinal centre of lymph nodes.


Pssm-ID: 293670  Cd Length: 185  Bit Score: 341.42  E-value: 1.06e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143156     8 AAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHP 87
Cdd:pfam17065   2 AAPWRGALLLSLASQALGLAQCLEEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIILQMQSLKGDADLYVSDSTLHP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143156    88 SFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDA 167
Cdd:pfam17065  82 SFDEYELQSTTCGQDVVSIPAHFRRPVGIGIYGHPSHMESEFEMKVYYDRTVAEYPFGEASYSSDETEASQKQSQTPEDA 161

                         170       180
                  ....*....|....*....|....
gi 71143156   168 SQEEESVLWTILISILKLVLEILF 191
Cdd:pfam17065 162 SQEEESVLWTILIGILKLVLEILF 185
 
Name Accession Description Interval E-value
UPF0669 pfam17065
Putative cytokine, C6ORF120; C6orf120 is a secreted protein that promotes cell cycle ...
 8-191 1.06e-121

Putative cytokine, C6ORF120; C6orf120 is a secreted protein that promotes cell cycle progression of CD4(+) T-cells, not hepatocytes. In humans it has its main role in tunicamycin-induced CD4(+) T apoptosis that may be associated with endoplasmatic reticulum stress. This suggests that it might be a new cytokine with immununoregulatory function that is selective for CD4+ T cells. It is mainly expressed in hepatocytes and cells in germinal centre of lymph nodes.


Pssm-ID: 293670  Cd Length: 185  Bit Score: 341.42  E-value: 1.06e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143156     8 AAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHP 87
Cdd:pfam17065   2 AAPWRGALLLSLASQALGLAQCLEEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIILQMQSLKGDADLYVSDSTLHP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143156    88 SFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDA 167
Cdd:pfam17065  82 SFDEYELQSTTCGQDVVSIPAHFRRPVGIGIYGHPSHMESEFEMKVYYDRTVAEYPFGEASYSSDETEASQKQSQTPEDA 161

                         170       180
                  ....*....|....*....|....
gi 71143156   168 SQEEESVLWTILISILKLVLEILF 191
Cdd:pfam17065 162 SQEEESVLWTILIGILKLVLEILF 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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