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Conserved domains on  [gi|73760407|ref|NP_001027451|]
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transcription factor AP-2-alpha isoform b [Homo sapiens]

Protein Classification

AP-2 family transcription factor( domain architecture ID 10505561)

AP-2 family transcription factor is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TF_AP-2 pfam03299
Transcription factor AP-2;
205-399 2.50e-114

Transcription factor AP-2;


:

Pssm-ID: 460877  Cd Length: 196  Bit Score: 333.05  E-value: 2.50e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760407   205 FCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLT 284
Cdd:pfam03299   1 FCEVPGRLSLLSSTSKYKVTVAEVRRRLSGPECLNASLLGGNLRRAKSKNGGEILREKLEKIGLKLPAGRRKAANVTLFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760407   285 SLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQH-SDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILE 363
Cdd:pfam03299  81 SLVEGEALHLAKDLGKLCETEFPAKQIAEELVREHlGDPNELEARKNMLEAFKQCMSELVDLLSSVRPPLTGRVPKPSKN 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 73760407   364 PGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA 399
Cdd:pfam03299 161 NSLNHSMEHFSLATHGFGIPAQRAWLRALQKIGEEM 196
 
Name Accession Description Interval E-value
TF_AP-2 pfam03299
Transcription factor AP-2;
205-399 2.50e-114

Transcription factor AP-2;


Pssm-ID: 460877  Cd Length: 196  Bit Score: 333.05  E-value: 2.50e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760407   205 FCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLT 284
Cdd:pfam03299   1 FCEVPGRLSLLSSTSKYKVTVAEVRRRLSGPECLNASLLGGNLRRAKSKNGGEILREKLEKIGLKLPAGRRKAANVTLFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760407   285 SLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQH-SDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILE 363
Cdd:pfam03299  81 SLVEGEALHLAKDLGKLCETEFPAKQIAEELVREHlGDPNELEARKNMLEAFKQCMSELVDLLSSVRPPLTGRVPKPSKN 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 73760407   364 PGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA 399
Cdd:pfam03299 161 NSLNHSMEHFSLATHGFGIPAQRAWLRALQKIGEEM 196
 
Name Accession Description Interval E-value
TF_AP-2 pfam03299
Transcription factor AP-2;
205-399 2.50e-114

Transcription factor AP-2;


Pssm-ID: 460877  Cd Length: 196  Bit Score: 333.05  E-value: 2.50e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760407   205 FCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLT 284
Cdd:pfam03299   1 FCEVPGRLSLLSSTSKYKVTVAEVRRRLSGPECLNASLLGGNLRRAKSKNGGEILREKLEKIGLKLPAGRRKAANVTLFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73760407   285 SLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQH-SDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILE 363
Cdd:pfam03299  81 SLVEGEALHLAKDLGKLCETEFPAKQIAEELVREHlGDPNELEARKNMLEAFKQCMSELVDLLSSVRPPLTGRVPKPSKN 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 73760407   364 PGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA 399
Cdd:pfam03299 161 NSLNHSMEHFSLATHGFGIPAQRAWLRALQKIGEEM 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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