NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|83716015|ref|NP_001028335|]
View 

epoxide hydrolase 3 isoform 1 [Mus musculus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 144-422 5.84e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 139.75  E-value: 5.84e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 144 VKSSGLRLHYVSAGHgNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVdcYTIDLLLDDIKDTI 223
Cdd:COG0596   7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 224 LGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANgppmsviqeysihhigqifrsnymflfqlpwlpekllsmSDF 303
Cdd:COG0596  84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD---------------------------------------EVL 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 304 QILKDTFTHrkngiPGLTPSELEAFLYHFSQPgcltgpinyyrnvfrNFPLEPKKLSTPTLLLWGEKDFAFQQGLVEAIG 383
Cdd:COG0596 125 AALAEPLRR-----PGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 83716015 384 RHFVPGRLesHILPGSGHWIPQSHPQEMHQYMWAFLQDL 422
Cdd:COG0596 185 ELLPNAEL--VVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 144-422 5.84e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 139.75  E-value: 5.84e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 144 VKSSGLRLHYVSAGHgNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVdcYTIDLLLDDIKDTI 223
Cdd:COG0596   7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 224 LGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANgppmsviqeysihhigqifrsnymflfqlpwlpekllsmSDF 303
Cdd:COG0596  84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD---------------------------------------EVL 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 304 QILKDTFTHrkngiPGLTPSELEAFLYHFSQPgcltgpinyyrnvfrNFPLEPKKLSTPTLLLWGEKDFAFQQGLVEAIG 383
Cdd:COG0596 125 AALAEPLRR-----PGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 83716015 384 RHFVPGRLesHILPGSGHWIPQSHPQEMHQYMWAFLQDL 422
Cdd:COG0596 185 ELLPNAEL--VVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK05855 PRK05855
SDR family oxidoreductase;
144-411 5.37e-24

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 104.29  E-value: 5.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  144 VKSSGLRLHYVSAGHGNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVDCYTIDLLLDDIKDTI 223
Cdd:PRK05855   8 VSSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  224 LGLGYSKCI-LVSHDWGASLAWEF--------------SIYYPSLVE-----RMVVANGPPMSVIQEysihhIGQIFRSN 283
Cdd:PRK05855  88 DAVSPDRPVhLLAHDWGSIQGWEAvtrpraagriasftSVSGPSLDHvgfwlRSGLRRPTPRRLARA-----LGQLLRSW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  284 YMFLFQLPWLPEKLLsmsdfqilkdtfthrKNGIPGLTPSELEAF-------LYHFSQPGCLTGPINYYR-NVFRNFpLE 355
Cdd:PRK05855 163 YIYLFHLPVLPELLW---------------RLGLGRAWPRLLRRVegtpvdpIPTQTTLSDGAHGVKLYRaNMIRSL-SR 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 83716015  356 PKKLST--PTLLLWGEKDFAFQQGLVEAIGRhFVPgRLESHILPGsGHWIPQSHPQEM 411
Cdd:PRK05855 227 PRERYTdvPVQLIVPTGDPYVRPALYDDLSR-WVP-RLWRREIKA-GHWLPMSHPQVL 281
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 162-403 3.38e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.88  E-value: 3.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   162 PLMLFLHGFPENWFSWRYQLREFQ-SHFHVVAVDMRGYSPSDAPKEVDCYTIDLLLDDIKDTILGLGYSKCILVSHDWGA 240
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   241 SLAWEFSIYYPSLVeRMVVANGPPMSViqeysiHHIGQIFRsnyMFLFQLPWLPEKLL----------SMSDFQILKDTF 310
Cdd:pfam00561  81 LIALAYAAKYPDRV-KALVLLGALDPP------HELDEADR---FILALFPGFFDGFVadfapnplgrLVAKLLALLLLR 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   311 THRKNGIPGLTPS------ELEAFLYHFSQPGCLTGPINYYRNVFRNfplepkkLSTPTLLLWGEKDFAFQQGLVEAIGR 384
Cdd:pfam00561 151 LRLLKALPLLNKRfpsgdyALAKSLVTGALLFIETWSTELRAKFLGR-------LDEPTLIIWGDQDPLVPPQALEKLAQ 223

                         250
                  ....*....|....*....
gi 83716015   385 HFvpGRLESHILPGSGHWI 403
Cdd:pfam00561 224 LF--PNARLVVIPDAGHFA 240
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 144-422 5.84e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 139.75  E-value: 5.84e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 144 VKSSGLRLHYVSAGHgNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVdcYTIDLLLDDIKDTI 223
Cdd:COG0596   7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 224 LGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANgppmsviqeysihhigqifrsnymflfqlpwlpekllsmSDF 303
Cdd:COG0596  84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD---------------------------------------EVL 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 304 QILKDTFTHrkngiPGLTPSELEAFLYHFSQPgcltgpinyyrnvfrNFPLEPKKLSTPTLLLWGEKDFAFQQGLVEAIG 383
Cdd:COG0596 125 AALAEPLRR-----PGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 83716015 384 RHFVPGRLesHILPGSGHWIPQSHPQEMHQYMWAFLQDL 422
Cdd:COG0596 185 ELLPNAEL--VVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK05855 PRK05855
SDR family oxidoreductase;
144-411 5.37e-24

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 104.29  E-value: 5.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  144 VKSSGLRLHYVSAGHGNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVDCYTIDLLLDDIKDTI 223
Cdd:PRK05855   8 VSSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  224 LGLGYSKCI-LVSHDWGASLAWEF--------------SIYYPSLVE-----RMVVANGPPMSVIQEysihhIGQIFRSN 283
Cdd:PRK05855  88 DAVSPDRPVhLLAHDWGSIQGWEAvtrpraagriasftSVSGPSLDHvgfwlRSGLRRPTPRRLARA-----LGQLLRSW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  284 YMFLFQLPWLPEKLLsmsdfqilkdtfthrKNGIPGLTPSELEAF-------LYHFSQPGCLTGPINYYR-NVFRNFpLE 355
Cdd:PRK05855 163 YIYLFHLPVLPELLW---------------RLGLGRAWPRLLRRVegtpvdpIPTQTTLSDGAHGVKLYRaNMIRSL-SR 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 83716015  356 PKKLST--PTLLLWGEKDFAFQQGLVEAIGRhFVPgRLESHILPGsGHWIPQSHPQEM 411
Cdd:PRK05855 227 PRERYTdvPVQLIVPTGDPYVRPALYDDLSR-WVP-RLWRREIKA-GHWLPMSHPQVL 281
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 162-403 3.38e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.88  E-value: 3.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   162 PLMLFLHGFPENWFSWRYQLREFQ-SHFHVVAVDMRGYSPSDAPKEVDCYTIDLLLDDIKDTILGLGYSKCILVSHDWGA 240
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   241 SLAWEFSIYYPSLVeRMVVANGPPMSViqeysiHHIGQIFRsnyMFLFQLPWLPEKLL----------SMSDFQILKDTF 310
Cdd:pfam00561  81 LIALAYAAKYPDRV-KALVLLGALDPP------HELDEADR---FILALFPGFFDGFVadfapnplgrLVAKLLALLLLR 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   311 THRKNGIPGLTPS------ELEAFLYHFSQPGCLTGPINYYRNVFRNfplepkkLSTPTLLLWGEKDFAFQQGLVEAIGR 384
Cdd:pfam00561 151 LRLLKALPLLNKRfpsgdyALAKSLVTGALLFIETWSTELRAKFLGR-------LDEPTLIIWGDQDPLVPPQALEKLAQ 223

                         250
                  ....*....|....*....
gi 83716015   385 HFvpGRLESHILPGSGHWI 403
Cdd:pfam00561 224 LF--PNARLVVIPDAGHFA 240
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
146-424 1.47e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 66.96  E-value: 1.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 146 SSGLRLH---YVSAGHGNGPLMLFLHGFPEN-WFSWRYQLREFQSH-FHVVAVDMRGYSPSDApkevdcytiDLLLDDIK 220
Cdd:COG1506   5 ADGTTLPgwlYLPADGKKYPVVVYVHGGPGSrDDSFLPLAQALASRgYAVLAPDYRGYGESAG---------DWGGDEVD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 221 DTILGLGY---------SKCILVSHDWGASLAWEFSIYYPSLVeRMVVANGPPmsviqeysihhigqifrsnymflfqlp 291
Cdd:COG1506  76 DVLAAIDYlaarpyvdpDRIGIYGHSYGGYMALLAAARHPDRF-KAAVALAGV--------------------------- 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 292 wlpekllsmSDFQILKDTFTHRKNGIPGlTPSELEAFLYHFSqpgcltgPINYyrnvfrnfplePKKLSTPTLLLWGEKD 371
Cdd:COG1506 128 ---------SDLRSYYGTTREYTERLMG-GPWEDPEAYAARS-------PLAY-----------ADKLKTPLLLIHGEAD 179

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 83716015 372 FA--FQQG--LVEAIGRHFVPGRLesHILPGSGHWIPQSHPQEMHQYMWAFLQDLLG 424
Cdd:COG1506 180 DRvpPEQAerLYEALKKAGKPVEL--LVYPGEGHGFSGAGAPDYLERILDFLDRHLK 234
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 146-411 1.87e-11

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 64.49  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  146 SSGLRLHYVSagHGNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVDcYTIDLLLDDIKDTILG 225
Cdd:PRK03204  21 SSRGRIHYID--EGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFG-YQIDEHARVIGEFVDH 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  226 LGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANgppmsviqeysihhigqifrsnyMFLFQLPWLPEKLLS--MSD- 302
Cdd:PRK03204  98 LGLDRYLSMGQDWGGPISMAVAVERADRVRGVVLGN-----------------------TWFWPADTLAMKAFSrvMSSp 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  303 ---FQILKDTFTHRKNGIPGL--TPSELEAFLYHFSQP--------GCLTGPINYYRNVFRNFPLE-PKKLST-PTLLLW 367
Cdd:PRK03204 155 pvqYAILRRNFFVERLIPAGTehRPSSAVMAHYRAVQPnaaarrgvAEMPKQILAARPLLARLAREvPATLGTkPTLLVW 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 83716015  368 GEKDFAFQ-QGLVEAIGRHFvpGRLESHILPGSGHWIPQSHPQEM 411
Cdd:PRK03204 235 GMKDVAFRpKTILPRLRATF--PDHVLVELPNAKHFIQEDAPDRI 277
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 139-262 4.99e-11

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 63.45  E-value: 4.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  139 VSVPPVKSSGLRLHYVSAGHGNGPLMLFLHGFPenwfSWRYQLREFQSHF-----HVVAVDMRGYSPSDAPKEVDCYTID 213
Cdd:PRK00870  24 VDVDDGDGGPLRMHYVDEGPADGPPVLLLHGEP----SWSYLYRKMIPILaaaghRVIAPDLIGFGRSDKPTRREDYTYA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 83716015  214 LLLDDIKDTILGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANG 262
Cdd:PRK00870 100 RHVEWMRSWFEQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVANT 148
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
146-421 2.06e-09

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 57.32  E-value: 2.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 146 SSGLRLHYVS--AGHGNGPLMLFLHGFPENWFSWRYQLREFQSH-FHVVAVDMRGYSPSDAPKeVDCYTIDLLLDDIK-- 220
Cdd:COG2267  11 RDGLRLRGRRwrPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPR-GHVDSFDDYVDDLRaa 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 221 -DTILGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANgppmsviqeysihhigqifrsnymflfqlPWLPEKLLS 299
Cdd:COG2267  90 lDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLA-----------------------------PAYRADPLL 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015 300 MSDFQILKDTFTHRkngipgltpseleaflyhfsqpgcltgpinyyrnvfrnfplEPKKLSTPTLLLWGEKDFAFQQGLV 379
Cdd:COG2267 141 GPSARWLRALRLAE-----------------------------------------ALARIDVPVLVLHGGADRVVPPEAA 179

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 83716015 380 EAIGRHFVPgRLESHILPGSGHWIPQSHPQE-MHQYMWAFLQD 421
Cdd:COG2267 180 RRLAARLSP-DVELVLLPGARHELLNEPAREeVLAAILAWLER 221
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 148-422 6.88e-09

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 56.54  E-value: 6.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  148 GLRLHYVSagHGNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKE----------VDCYTIDLLLD 217
Cdd:PRK03592  16 GSRMAYIE--TGEGDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKPDIdytfadharyLDAWFDALGLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  218 DIkdtilglgyskcILVSHDWGASLAWEFSIYYPSLVERMVVANG--PPMSvIQEYSIHHIG--QIFRS---NYMFLFQL 290
Cdd:PRK03592  94 DV------------VLVGHDWGSALGFDWAARHPDRVRGIAFMEAivRPMT-WDDFPPAVRElfQALRSpgeGEEMVLEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  291 PWLPEKLLSMSdfqILKdtfthrkngipGLTPSELEAFLYHFSQPG----CLTGPinyyrnvfRNFPL--EPKKL----- 359
Cdd:PRK03592 161 NVFIERVLPGS---ILR-----------PLSDEEMAVYRRPFPTPEsrrpTLSWP--------RELPIdgEPADVvalve 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83716015  360 ---------STPTLLLWGEKDFAFQQGLVEAIGRHFVPGRLESHILPGsGHWIPQSHPQEMHQYMWAFLQDL 422
Cdd:PRK03592 219 eyaqwlatsDVPKLLINAEPGAILTTGAIRDWCRSWPNQLEITVFGAG-LHFAQEDSPEEIGAAIAAWLRRL 289
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 150-410 4.19e-08

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 54.89  E-value: 4.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  150 RLHYVSAGHGNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVDC--YTIDLLLDDIKDTILGLG 227
Cdd:PLN03084 116 RWFCVESGSNNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQPGYGfnYTLDEYVSSLESLIDELK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  228 YSKCILVSHDWGASLAWEFSIYYPSLVERMVVANgPPM--------SVIQEYSIHHIGQIFRSNymflfQLPWLPEKLLS 299
Cdd:PLN03084 196 SDKVSLVVQGYFSPPVVKYASAHPDKIKKLILLN-PPLtkehaklpSTLSEFSNFLLGEIFSQD-----PLRASDKALTS 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  300 MSDFQILK-DTFTHRKngiPGLTPSE----LEAFLYHFSQPgcLTGPINYYRNVfrnfpLEPKKLSTPTLLLWGEKDFAF 374
Cdd:PLN03084 270 CGPYAMKEdDAMVYRR---PYLTSGSsgfaLNAISRSMKKE--LKKYIEEMRSI-----LTDKNWKTPITVCWGLRDRWL 339

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 83716015  375 QQGLVEAIGRHFVPGRLEshiLPGSGHwipqsHPQE 410
Cdd:PLN03084 340 NYDGVEDFCKSSQHKLIE---LPMAGH-----HVQE 367
PLN02578 PLN02578
hydrolase
 148-371 5.31e-08

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 54.46  E-value: 5.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  148 GLRLHYVSAGHGNgPLMLfLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDapKEVDCYTIDLLLDDIKDTILGLG 227
Cdd:PLN02578  75 GHKIHYVVQGEGL-PIVL-IHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSD--KALIEYDAMVWRDQVADFVKEVV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  228 YSKCILVSHDWGASLAWEFSIYYPSLVERMVVAN-----GPPM-----------SVIQEYSIHHIGQIFRSNYM-FLFQL 290
Cdd:PLN02578 151 KEPAVLVGNSLGGFTALSTAVGYPELVAGVALLNsagqfGSESrekeeaivveeTVLTRFVVKPLKEWFQRVVLgFLFWQ 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  291 PWLPEKLLSmsdfqILKDTFTHRKNGIPGLTPSeleaflyhFSQPGclTGPiN----YYRNVFRnFPLEP---------K 357
Cdd:PLN02578 231 AKQPSRIES-----VLKSVYKDKSNVDDYLVES--------ITEPA--ADP-NagevYYRLMSR-FLFNQsrytldsllS 293

                        250
                 ....*....|....
gi 83716015  358 KLSTPTLLLWGEKD 371
Cdd:PLN02578 294 KLSCPLLLLWGDLD 307
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 164-411 1.21e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 52.09  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   164 MLFLHGFpenWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPkevdCYTIDlLLDDIKDTILGLGYSK-CILVSHDWGASL 242
Cdd:pfam12697   1 VVLVHGA---GLSAAPLAALLAAGVAVLAPDLPGHGSSSPP----PLDLA-DLADLAALLDELGAARpVVLVGHSLGGAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   243 AWEFSIYYPsLVERMVVANGPPMSVIQEYSIHHIGQIFRSNYMFLFQLPWLPEKLLSMSDFQilkdtfthrkngipgltp 322
Cdd:pfam12697  73 ALAAAAAAL-VVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPAD------------------ 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   323 SELEAFLYHFSQpgcltgpinyYRNVFRNFPLEPKKLSTPTLLLWGEKDFAFQQGLVEAIGRhfvPGRLESHILPGSGHW 402
Cdd:pfam12697 134 AEWAAALARLAA----------LLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLLAA---LAGARLVVLPGAGHL 200


                  ....*....
gi 83716015   403 iPQSHPQEM 411
Cdd:pfam12697 201 -PLDDPEEV 208
PRK10673 PRK10673
esterase;
182-280 8.48e-04

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 40.87  E-value: 8.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  182 REFQSHFHVVAVDMR--GYSPSDapKEVDcYTIdlLLDDIKDTILGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVV 259
Cdd:PRK10673  37 RDLVNDHDIIQVDMRnhGLSPRD--PVMN-YPA--MAQDLLDTLDALQIEKATFIGHSMGGKAVMALTALAPDRIDKLVA 111

                         90       100
                 ....*....|....*....|.
gi 83716015  260 ANGPPMsviqEYSIHHIGQIF 280
Cdd:PRK10673 112 IDIAPV----DYHVRRHDEIF 128
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
157-271 1.40e-03

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 40.39  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  157 GHGNGPLMLfLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEvdcytidLLLDDIKDTILGLGYSKCILVSH 236
Cdd:PRK10349  10 GQGNVHLVL-LHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGA-------LSLADMAEAVLQQAPDKAIWLGW 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 83716015  237 DWGASLAWEFSIYYPSLVERMV-VANGPPMSVIQEY 271
Cdd:PRK10349  82 SLGGLVASQIALTHPERVQALVtVASSPCFSARDEW 117
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 148-411 4.12e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 38.95  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  148 GLRLHYVSAGhGNGPLMLFLHGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVDC-----YTIDLLLDDIKDT 222
Cdd:PLN02824  17 GYNIRYQRAG-TSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKPNPRSAppnsfYTFETWGEQLNDF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  223 ILGLGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVAN--------------GPPM-----SVIQEYSihhIGQIFrsn 283
Cdd:PLN02824  96 CSDVVGDPAFVICNSVGGVVGLQAAVDAPELVRGVMLINislrglhikkqpwlGRPFikafqNLLRETA---VGKAF--- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015  284 ymflFQLPWLPEKLLSmsdfqILKDTFtHRKNGI----------PGLTPSELEAFLYHFSQPGcltGPInyyrnvfrnfp 353
Cdd:PLN02824 170 ----FKSVATPETVKN-----ILCQCY-HDDSAVtdelveailrPGLEPGAVDVFLDFISYSG---GPL----------- 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 83716015  354 lePKKL----STPTLLLWGEKDfafqqgLVEAI--GRHFVP-GRLESHI-LPGSGHwIPQSHPQEM 411
Cdd:PLN02824 226 --PEELlpavKCPVLIAWGEKD------PWEPVelGRAYANfDAVEDFIvLPGVGH-CPQDEAPEL 282
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
341-424 4.31e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 38.36  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   341 PINYYRNVFRNfplepkklsTPTLLLWGEKDF--AFQQG--LVEAIGRHFVPGRLesHILPGSGHWI--PQSHPQEmHQY 414
Cdd:pfam00326 134 PYSPADNVKVY---------PPLLLIHGLLDDrvPPWQSlkLVAALQRKGVPFLL--LIFPDEGHGIgkPRNKVEE-YAR 201

                          90
                  ....*....|
gi 83716015   415 MWAFLQDLLG 424
Cdd:pfam00326 202 ELAFLLEYLG 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 163-401 5.58e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 38.35  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   163 LMLFLHGFpeNWFSWRYQL--REFQSH-FHVVAVDMRGYSPSDaPKEVDCYTIDLLLDDIkDTILGL-----GYSKCILV 234
Cdd:pfam12146   6 VVVLVHGL--GEHSGRYAHlaDALAAQgFAVYAYDHRGHGRSD-GKRGHVPSFDDYVDDL-DTFVDKireehPGLPLFLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   235 SHDWGASLAWEFSIYYPSLVERMVVANgpPMSVIQEYSIHHIGQIFRsnYMFLFQLPWLPEKLlsmsdfQILKDTFTHRk 314
Cdd:pfam12146  82 GHSMGGLIAALYALRYPDKVDGLILSA--PALKIKPYLAPPILKLLA--KLLGKLFPRLRVPN------NLLPDSLSRD- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716015   315 ngipgltPSELEAF----LYHFsqpgclTGPINYYRNVFR--NFPLEP-KKLSTPTLLLWGEKDF----AFQQGLVEAIG 383
Cdd:pfam12146 151 -------PEVVAAYaadpLVHG------GISARTLYELLDagERLLRRaAAITVPLLLLHGGADRvvdpAGSREFYERAG 217

                         250
                  ....*....|....*...
gi 83716015   384 RhfvpGRLESHILPGSGH 401
Cdd:pfam12146 218 S----TDKTLKLYPGLYH 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH