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Conserved domains on  [gi|154759253|ref|NP_001028891|]
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zinc finger protein 404 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-51 2.81e-22

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 2.81e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 154759253     6 LTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLDFNFTT 51
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPK 46
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-546 2.00e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 158 PYECNECGKAFVVFQHFIRHRKIHTDLKPYECN--GCEKAFRFYSQLIQHQIIHTGMKPYECKQCGKafRRHSHLTEHQK 235
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 236 IHVGLKPFECkeCGETFRLYRHMCLHQKIHHGVKPYK--CKECGKAFGHRSSLYQHKKIHSgEKPYKCEQCEKAFVRSYL 313
Cdd:COG5048  111 SSSSSNSNDN--NLLSSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHP-PLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 314 LveHQRSHTGEKPHECMECGKAFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTFK 393
Cdd:COG5048  188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 394 LHSYLIQHQIIHTD-------LKPYECKQCGKAFSRVGDLKTHQ--SIHAGE--KPYECKE--CGKTFRLNSQLIYHQTI 460
Cdd:COG5048  266 PTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 461 HTGLKPYVCK--ECKKAFRSIS-----GLSQHKRIHTGEKPYEC--KECDKAFNRSDRLTQHETIHTGVKP--QKCKECG 529
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        410
                 ....*....|....*..
gi 154759253 530 KAFSHCYQLSQHQRFHH 546
Cdd:COG5048  426 KSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-51 2.81e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 2.81e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 154759253     6 LTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLDFNFTT 51
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPK 46
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 3.00e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.00e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 154759253    5 PLTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 8.21e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 8.21e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 154759253   6 LTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-546 2.00e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 158 PYECNECGKAFVVFQHFIRHRKIHTDLKPYECN--GCEKAFRFYSQLIQHQIIHTGMKPYECKQCGKafRRHSHLTEHQK 235
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 236 IHVGLKPFECkeCGETFRLYRHMCLHQKIHHGVKPYK--CKECGKAFGHRSSLYQHKKIHSgEKPYKCEQCEKAFVRSYL 313
Cdd:COG5048  111 SSSSSNSNDN--NLLSSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHP-PLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 314 LveHQRSHTGEKPHECMECGKAFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTFK 393
Cdd:COG5048  188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 394 LHSYLIQHQIIHTD-------LKPYECKQCGKAFSRVGDLKTHQ--SIHAGE--KPYECKE--CGKTFRLNSQLIYHQTI 460
Cdd:COG5048  266 PTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 461 HTGLKPYVCK--ECKKAFRSIS-----GLSQHKRIHTGEKPYEC--KECDKAFNRSDRLTQHETIHTGVKP--QKCKECG 529
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        410
                 ....*....|....*..
gi 154759253 530 KAFSHCYQLSQHQRFHH 546
Cdd:COG5048  426 KSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 4.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.11e-04
                          10        20
                  ....*....|....*....|....*
gi 154759253  482 LSQHKRIHTGEKPYECKECDKAFNR 506
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 385-429 5.66e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 154759253 385 CKECGKTFKLHSYLIQHQIIHTdlkpYECKQCGKAFSRVGDLKTH 429
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-51 2.81e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 2.81e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 154759253     6 LTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLDFNFTT 51
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPK 46
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 3.00e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.00e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 154759253    5 PLTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 8.21e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 8.21e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 154759253   6 LTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-546 2.00e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 158 PYECNECGKAFVVFQHFIRHRKIHTDLKPYECN--GCEKAFRFYSQLIQHQIIHTGMKPYECKQCGKafRRHSHLTEHQK 235
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 236 IHVGLKPFECkeCGETFRLYRHMCLHQKIHHGVKPYK--CKECGKAFGHRSSLYQHKKIHSgEKPYKCEQCEKAFVRSYL 313
Cdd:COG5048  111 SSSSSNSNDN--NLLSSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHP-PLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 314 LveHQRSHTGEKPHECMECGKAFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTFK 393
Cdd:COG5048  188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 394 LHSYLIQHQIIHTD-------LKPYECKQCGKAFSRVGDLKTHQ--SIHAGE--KPYECKE--CGKTFRLNSQLIYHQTI 460
Cdd:COG5048  266 PTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 461 HTGLKPYVCK--ECKKAFRSIS-----GLSQHKRIHTGEKPYEC--KECDKAFNRSDRLTQHETIHTGVKP--QKCKECG 529
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        410
                 ....*....|....*..
gi 154759253 530 KAFSHCYQLSQHQRFHH 546
Cdd:COG5048  426 KSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-510 1.11e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 106 CFSQMIFKKHKSLP----LHKRNNTREKSYECKEY--KKGFRKYLHLTEHLRDHTGVIPYECN-ECGKAFVVFQHFIRHR 178
Cdd:COG5048   33 PDSCPNCTDSFSRLehltRHIRSHTGEKPSQCSYSgcDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 179 KIHTDLKPYECNGCEKAFRFYSQLIQHQIIHTGMKPYECKQCGKAFRRHShltEHQKIHVGLKPFECKECGETFRlyrHM 258
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLHPPLPANSLSKDPSSNL---SL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 259 CLHQKIHHGVKPYKCKECGKAFGHRSSLYQHKKIHSGEKPYKCEQCEKAFVRSYLLVEHQRSHTGEKPHECMECGKAFG- 337
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLp 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 338 -KGSSLLKHKRIHSSE-----KLYDCKDCGKAFCRGSQLTQHQR--IHTGE--KPHECKE--CGKTFKLHSYLIQHQIIH 405
Cdd:COG5048  267 tASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 406 TDLKPYECK--QCGKAFSRVGDLKTHQSIHA-----GEKPYEC--KECGKTFRLNSQLIYHQTIHTGLKPYVCK--ECKK 474
Cdd:COG5048  347 TSISPAKEKllNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 154759253 475 AFRSISGLSQHKRIHTGEKPYECkECDKAFNRSDRL 510
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-526 2.99e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 212 MKPYECKQCGKAFRRHSHLTEHQKIHVGLKPFECKECGETFRLYRHMCL--HQKIHHGVKPYKCKECGKAFghRSSLYQH 289
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLS--NSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 290 KKIHSGEKPYKCEQCEkafvrSYLLVEHQRSHTGEKPHECMECGKAFGKGSSLLKHKRIHSSEKLYDCKD---CGKAFCR 366
Cdd:COG5048  109 SLSSSSSNSNDNNLLS-----SHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 367 GSQLTQHQRIHTGEKPHECKECGKTFKLHSyLIQHQIIHTDLKPYECKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGK 446
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 447 TFRLNSQLIYHQTIHTG-------LKPYVCKECKKAFRSISGLSQHKR--IHTGE--KPYECKE--CDKAFNRSDRLTQH 513
Cdd:COG5048  263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330
                 ....*....|...
gi 154759253 514 ETIHTGVKPQKCK 526
Cdd:COG5048  343 ILLHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
51-362 4.81e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253  51 TESNKLSSEKRNYEVNAYHQETWKRNKT-FNLMRFIFRTDPQYTIEFGRQQRPKVG---------CFSQMIFKKHKSLPL 120
Cdd:COG5048  140 LLSISNLRNNPLPGNNSSSVNTPQSNSLhPPLPANSLSKDPSSNLSLLISSNVSTSipsssenspLSSSYSIPSSSSDQN 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 121 HKRNNTREKSYEC-KEYKKGFRKYLHLTEHLRDHTGVIPYECNECGKafvvFQHFIRHRKIHTD-------LKPYECNGC 192
Cdd:COG5048  220 LENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP----TASSQSSSPNESDsssekgfSLPIKSKQC 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 193 EKAFRFYSQLIQHQ--IIHTGM--KPYEC--KQCGKAFRRHSHLTEHQKIHVGLKPFECKECGETFrlyrhmclhqKIHH 266
Cdd:COG5048  296 NISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS----------KFSP 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 267 GVKPYkckecgkafgHRSSLYQHKKIHSGEKPYKCEQ-CEKAFVRSYLLVEHQRSHTGEKPHECM--ECGKAFGKGSSLL 343
Cdd:COG5048  366 LLNNE----------PPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                        330
                 ....*....|....*....
gi 154759253 344 KHKRIHSSEKLYDCKDCGK 362
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 4.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.11e-04
                          10        20
                  ....*....|....*....|....*
gi 154759253  482 LSQHKRIHTGEKPYECKECDKAFNR 506
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-393 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....
gi 154759253  370 LTQHQRIHTGEKPHECKECGKTFK 393
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 407-486 2.62e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 407 DLKPYECK--QCGKAFSRVGDLKTHQsIHAgekpyeckECGKTFRLNSQLIYHQTIHTGLKPYVCKECKKAFRSISGLSQ 484
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 154759253 485 HK 486
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 379-459 3.25e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154759253 379 GEKPHECK--ECGKTFKlHSYLIQHQIIHtdlkpyecKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGKTFRLNSQLIY 456
Cdd:COG5189  346 DGKPYKCPveGCNKKYK-NQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 154759253 457 HQT 459
Cdd:COG5189  417 HRK 419
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 385-429 5.66e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 154759253 385 CKECGKTFKLHSYLIQHQIIHTdlkpYECKQCGKAFSRVGDLKTH 429
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-336 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|...
gi 154759253  314 LVEHQRSHTGEKPHECMECGKAF 336
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
CpXC pfam14353
CpXC protein; This presumed domain is functionally uncharacterized. This domain is found in ...
 413-458 6.75e-03

CpXC protein; This presumed domain is functionally uncharacterized. This domain is found in bacteria and archaea, and is typically between 122 and 134 amino acids in length. It contains four conserved cysteines forming two CpXC motifs.


Pssm-ID: 433895  Cd Length: 121  Bit Score: 36.93  E-value: 6.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 154759253  413 CKQCGKAFsrvgDLKTHQSIHAGEKP-------------YECKECGKTFRLNSQLIYHQ 458
Cdd:pfam14353   3 CPKCGKEF----EAEVWTSINADEDPelkekvldgslfsFTCPKCGASFRLEYPLLYHD 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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