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Conserved domains on  [gi|76677903|ref|NP_001029095|]
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GTPase IMAP family member 8 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 49-247 4.70e-85

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 265.94  E-value: 4.70e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  49 LRLLLLGKQGAGKSATGNTILGKAVFESRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDLL 128
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 129 AD-PYVLLLVTPIGHSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQNHIESKKYLKKLIENIGSQRCCAFN 207
Cdd:cd01852  81 APgPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 76677903 208 NKADKKQQELQVSQFLDAIEFLMME-SPGTYFEPLKTENSG 247
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVREnGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 475-655 7.22e-71

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 228.96  E-value: 7.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 475 LNIILLGRSGVGKSATGNTILGRPAFVSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSLNQMSGTeknPAQLKKEIKQCL 554
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS---PEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 555 LQnCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLYDFTNNTkNKVLKRIFKKCKGR 634
Cdd:cd01852  78 SL-SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGR 155

                       170       180
                ....*....|....*....|.
gi 76677903 635 VCAFNNKETGEDQETQVKALL 655
Cdd:cd01852 156 YVAFNNKAKGREQEQQVKELL 176
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 284-477 3.98e-66

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd01852:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 201  Bit Score: 216.25  E-value: 3.98e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 284 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSeKQRVTEAFASHSRLWNQKKFLIIDSPEISSWKLDESDVKE-------H 356
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLS-ASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKeiirclsL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 357 TFPGPHAFLLVTPLGSSLKSGDSVFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKEND-ALCNLIQIFEGRYAVF 435
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCeALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 76677903 436 NYRATVEEEQSQVGKLLSQIESVVQHHNNKPCVIREKELLNI 477
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 49-247 4.70e-85

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 265.94  E-value: 4.70e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  49 LRLLLLGKQGAGKSATGNTILGKAVFESRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDLL 128
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 129 AD-PYVLLLVTPIGHSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQNHIESKKYLKKLIENIGSQRCCAFN 207
Cdd:cd01852  81 APgPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 76677903 208 NKADKKQQELQVSQFLDAIEFLMME-SPGTYFEPLKTENSG 247
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVREnGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 475-655 7.22e-71

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 228.96  E-value: 7.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 475 LNIILLGRSGVGKSATGNTILGRPAFVSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSLNQMSGTeknPAQLKKEIKQCL 554
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS---PEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 555 LQnCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLYDFTNNTkNKVLKRIFKKCKGR 634
Cdd:cd01852  78 SL-SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGR 155

                       170       180
                ....*....|....*....|.
gi 76677903 635 VCAFNNKETGEDQETQVKALL 655
Cdd:cd01852 156 YVAFNNKAKGREQEQQVKELL 176
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 284-477 3.98e-66

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 216.25  E-value: 3.98e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 284 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSeKQRVTEAFASHSRLWNQKKFLIIDSPEISSWKLDESDVKE-------H 356
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLS-ASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKeiirclsL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 357 TFPGPHAFLLVTPLGSSLKSGDSVFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKEND-ALCNLIQIFEGRYAVF 435
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCeALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 76677903 436 NYRATVEEEQSQVGKLLSQIESVVQHHNNKPCVIREKELLNI 477
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 475-664 2.87e-61

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 203.22  E-value: 2.87e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   475 LNIILLGRSGVGKSATGNTILGRPAFVSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSLnqmSGTEKNPAQLKKEIKQCL 554
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGL---FDLSVSNDFISKEIIRCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   555 LQnCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLYDFTNNTKNKVLKRIFKkckgr 634
Cdd:pfam04548  78 LL-AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLR----- 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 76677903   635 vcafnnKETGEDQETQVKALLTIANDLKRS 664
Cdd:pfam04548 152 ------TADGEEKEEQVQQLLALVEAIVKE 175
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 49-238 8.40e-56

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 188.59  E-value: 8.40e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903    49 LRLLLLGKQGAGKSATGNTILGKAVFESRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDLL 128
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   129 AD-PYVLLLVTPIGHSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQNHIE--SKKYLKKLIEnigsqrcca 205
Cdd:pfam04548  81 EPgPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSdgCPEFLKEVLR--------- 151

                         170       180       190
                  ....*....|....*....|....*....|...
gi 76677903   206 fnnKADKKQQELQVSQFLDAIEFLMMESPGTYF 238
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKPY 181
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 284-466 5.42e-45

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 159.31  E-value: 5.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   284 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEkQRVTEAFASHSRLWNQKKFLIIDSPEISSWKLDESDVKEH------- 356
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRA-QGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEiirclll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   357 TFPGPHAFLLVTPLGSSLKSGDSVFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKE--NDALCNLIQifegryav 434
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgcPEFLKEVLR-------- 151

                         170       180       190
                  ....*....|....*....|....*....|..
gi 76677903   435 fnyRATVEEEQSQVGKLLSQIESVVQHHNNKP 466
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKP 180
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 48-171 1.27e-08

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 58.43  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903    48 TLRLLLLGKQGAGKSATGNTILGKAVFeSRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDL 127
Cdd:TIGR00993 118 SLNILVLGKSGVGKSATINSIFGEVKF-STDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSASDQSKNEKILSSVKKF 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 76677903   128 LAD--PYVLLLVTPIGHSTEE--DKKTIEGIQGVFGPQAYRHMIVVFT 171
Cdd:TIGR00993 197 IKKnpPDIVLYVDRLDMQTRDsnDLPLLRTITDVLGPSIWFNAIVTLT 244
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 475-553 4.31e-07

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 53.42  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   475 LNIILLGRSGVGKSATGNTILGRPAFvSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSL----NQMSGTEKNPAQLKKEI 550
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGEVKF-STDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLkssaSDQSKNEKILSSVKKFI 197


                  ...
gi 76677903   551 KQC 553
Cdd:TIGR00993 198 KKN 200
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 265-351 8.94e-05

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 45.71  E-value: 8.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   265 SKKRQPQITGPGWDRDTPELRVLLMGKRGVGKSAAGNSILGKQvfKTQFSEKQRVTEAFASHSRLWNQKKFLIIDSPEIS 344
Cdd:TIGR00993 100 AKAMAEQLEAEGQDPLDFSLNILVLGKSGVGKSATINSIFGEV--KFSTDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLK 177


                  ....*..
gi 76677903   345 SWKLDES 351
Cdd:TIGR00993 178 SSASDQS 184
PRK04213 PRK04213
GTP-binding protein EngB;
470-568 1.82e-03

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 40.29  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  470 REKELLNIILLGRSGVGKSatgntilgrpAFVSQLRAQPVTsrsqSGRR---TL-----DWQDIVVVDTPSLNQMSGTEK 541
Cdd:PRK04213   5 RPDRKPEIVFVGRSNVGKS----------TLVRELTGKKVR----VGKRpgvTRkpnhyDWGDFILTDLPGFGFMSGVPK 70

                         90       100
                 ....*....|....*....|....*...
gi 76677903  542 N-PAQLKKEIKQCLLQNCEEgMKVFVLV 568
Cdd:PRK04213  71 EvQEKIKDEIVRYIEDNADR-ILAAVLV 97
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 49-247 4.70e-85

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 265.94  E-value: 4.70e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  49 LRLLLLGKQGAGKSATGNTILGKAVFESRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDLL 128
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 129 AD-PYVLLLVTPIGHSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQNHIESKKYLKKLIENIGSQRCCAFN 207
Cdd:cd01852  81 APgPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 76677903 208 NKADKKQQELQVSQFLDAIEFLMME-SPGTYFEPLKTENSG 247
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVREnGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 475-655 7.22e-71

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 228.96  E-value: 7.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 475 LNIILLGRSGVGKSATGNTILGRPAFVSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSLNQMSGTeknPAQLKKEIKQCL 554
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS---PEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 555 LQnCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLYDFTNNTkNKVLKRIFKKCKGR 634
Cdd:cd01852  78 SL-SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGR 155

                       170       180
                ....*....|....*....|.
gi 76677903 635 VCAFNNKETGEDQETQVKALL 655
Cdd:cd01852 156 YVAFNNKAKGREQEQQVKELL 176
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 284-477 3.98e-66

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 216.25  E-value: 3.98e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 284 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSeKQRVTEAFASHSRLWNQKKFLIIDSPEISSWKLDESDVKE-------H 356
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLS-ASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKeiirclsL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 357 TFPGPHAFLLVTPLGSSLKSGDSVFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKEND-ALCNLIQIFEGRYAVF 435
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCeALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 76677903 436 NYRATVEEEQSQVGKLLSQIESVVQHHNNKPCVIREKELLNI 477
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 475-664 2.87e-61

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 203.22  E-value: 2.87e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   475 LNIILLGRSGVGKSATGNTILGRPAFVSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSLnqmSGTEKNPAQLKKEIKQCL 554
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGL---FDLSVSNDFISKEIIRCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   555 LQnCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLYDFTNNTKNKVLKRIFKkckgr 634
Cdd:pfam04548  78 LL-AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLR----- 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 76677903   635 vcafnnKETGEDQETQVKALLTIANDLKRS 664
Cdd:pfam04548 152 ------TADGEEKEEQVQQLLALVEAIVKE 175
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 49-238 8.40e-56

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 188.59  E-value: 8.40e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903    49 LRLLLLGKQGAGKSATGNTILGKAVFESRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDLL 128
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   129 AD-PYVLLLVTPIGHSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQNHIE--SKKYLKKLIEnigsqrcca 205
Cdd:pfam04548  81 EPgPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSdgCPEFLKEVLR--------- 151

                         170       180       190
                  ....*....|....*....|....*....|...
gi 76677903   206 fnnKADKKQQELQVSQFLDAIEFLMMESPGTYF 238
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKPY 181
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 284-466 5.42e-45

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 159.31  E-value: 5.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   284 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEkQRVTEAFASHSRLWNQKKFLIIDSPEISSWKLDESDVKEH------- 356
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRA-QGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEiirclll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   357 TFPGPHAFLLVTPLGSSLKSGDSVFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKE--NDALCNLIQifegryav 434
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgcPEFLKEVLR-------- 151

                         170       180       190
                  ....*....|....*....|....*....|..
gi 76677903   435 fnyRATVEEEQSQVGKLLSQIESVVQHHNNKP 466
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKP 180
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 36-171 9.19e-12

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 65.80  E-value: 9.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  36 QESNFKQsQGTSTLRLLLLGKQGAGKSATGNTILG--KAVFeSRFShhMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGc 113
Cdd:cd01853  20 LEAKLKK-ELDFSLTILVLGKTGVGKSSTINSIFGerKVSV-SAFQ--SETLRPREVSRTVDGFKLNIIDTPGLLESQD- 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 76677903 114 PEVQQQNLRQCLDLLAD--PYVLLLVTPIGHSTEE--DKKTIEGIQGVFGPQAYRHMIVVFT 171
Cdd:cd01853  95 QRVNRKILSIIKRFLKKktIDVVLYVDRLDMYRVDnlDVPLLRAITDSFGPSIWRNAIVVLT 156
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 48-171 1.27e-08

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 58.43  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903    48 TLRLLLLGKQGAGKSATGNTILGKAVFeSRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDL 127
Cdd:TIGR00993 118 SLNILVLGKSGVGKSATINSIFGEVKF-STDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSASDQSKNEKILSSVKKF 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 76677903   128 LAD--PYVLLLVTPIGHSTEE--DKKTIEGIQGVFGPQAYRHMIVVFT 171
Cdd:TIGR00993 197 IKKnpPDIVLYVDRLDMQTRDsnDLPLLRTITDVLGPSIWFNAIVTLT 244
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 475-602 1.96e-08

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 55.79  E-value: 1.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 475 LNIILLGRSGVGKSATGNTILGRP-----AFvsqlraQPVTSRSQSGRRTLDWQDIVVVDTPSLNQMSGTEKNPAQLKKe 549
Cdd:cd01853  32 LTILVLGKTGVGKSSTINSIFGERkvsvsAF------QSETLRPREVSRTVDGFKLNIIDTPGLLESQDQRVNRKILSI- 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 76677903 550 IKQCLLqNCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFT 602
Cdd:cd01853 105 IKRFLK-KKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 475-553 4.31e-07

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 53.42  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   475 LNIILLGRSGVGKSATGNTILGRPAFvSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSL----NQMSGTEKNPAQLKKEI 550
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGEVKF-STDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLkssaSDQSKNEKILSSVKKFI 197


                  ...
gi 76677903   551 KQC 553
Cdd:TIGR00993 198 KKN 200
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 271-341 1.18e-06

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 50.39  E-value: 1.18e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 76677903 271 QITGPGWDRDTPELRVLLMGKRGVGKSAAGNSILGKQVFKTQ-F-SEKQRVTEAfashSRLWNQKKFLIIDSP 341
Cdd:cd01853  19 ELEAKLKKELDFSLTILVLGKTGVGKSSTINSIFGERKVSVSaFqSETLRPREV----SRTVDGFKLNIIDTP 87
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 479-656 4.48e-05

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 44.37  E-value: 4.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 479 LLGRSGVGKSATGNTILGRPaFVSQLRAQPVTSRSQSGRRTLDWQ--DIVVVDTPSLNQMSGtEKNPAQLKKEIKQCLLq 556
Cdd:cd00882   2 VVGRGGVGKSSLLNALLGGE-VGEVSDVPGTTRDPDVYVKELDKGkvKLVLVDTPGLDEFGG-LGREELARLLLRGADL- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 557 nceegmkvFVLVFQLGRFTQEDEAVVEQLEASFEENImkYMIVLFTRKedlgdgDLYDFTNNTKNKVLKRIFKKCKGRVC 636
Cdd:cd00882  79 --------ILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGNKI------DLLEEREVEELLRLEELAKILGVPVF 142

                       170       180
                ....*....|....*....|
gi 76677903 637 AFNNKeTGEDQETQVKALLT 656
Cdd:cd00882 143 EVSAK-TGEGVDELFEKLIE 161
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 39-189 4.74e-05

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 46.05  E-value: 4.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903    39 NFKQsQGTSTLRLLLLGKQGAGKSATGNTILGKAV-----FESRFSHHMVTKRCQSesvsvrGKQVIVIDTPDLFSSlGC 113
Cdd:TIGR00991  30 KLKE-EDVSSLTILVMGKGGVGKSSTVNSIIGERIatvsaFQSEGLRPMMVSRTRA------GFTLNIIDTPGLIEG-GY 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   114 PEVQQQNL--RQCLDLLADpyVLLLVTPIG--HSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQ-NHIESK 188
Cdd:TIGR00991 102 INDQAVNIikRFLLGKTID--VLLYVDRLDayRVDTLDGQVIRAITDSFGKDIWRKSLVVLTHAQFSPPDGLEyNDFFSK 179


                  .
gi 76677903   189 K 189
Cdd:TIGR00991 180 R 180
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 475-627 5.51e-05

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 45.66  E-value: 5.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   475 LNIILLGRSGVGKSATGNTILG-RPAFVSQLRAQ---PV-TSRSQSGrRTLDwqdivVVDTPSLnqMSGTEKNPAQLKKe 549
Cdd:TIGR00991  39 LTILVMGKGGVGKSSTVNSIIGeRIATVSAFQSEglrPMmVSRTRAG-FTLN-----IIDTPGL--IEGGYINDQAVNI- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   550 IKQCLLqnceeGMKVFVLVF----QLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKE-DLGDGDLYD-FTNNTKNKV 623
Cdd:TIGR00991 110 IKRFLL-----GKTIDVLLYvdrlDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVLTHAQfSPPDGLEYNdFFSKRSEAL 184


                  ....
gi 76677903   624 LKRI 627
Cdd:TIGR00991 185 LRVI 188
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 265-351 8.94e-05

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 45.71  E-value: 8.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   265 SKKRQPQITGPGWDRDTPELRVLLMGKRGVGKSAAGNSILGKQvfKTQFSEKQRVTEAFASHSRLWNQKKFLIIDSPEIS 344
Cdd:TIGR00993 100 AKAMAEQLEAEGQDPLDFSLNILVLGKSGVGKSATINSIFGEV--KFSTDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLK 177


                  ....*..
gi 76677903   345 SWKLDES 351
Cdd:TIGR00993 178 SSASDQS 184
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 287-399 1.01e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 43.21  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 287 LLMGKRGVGKSAAGNSILGKQVFKTqfSEKQRVTEA--FASHSRLWNQKKFLIIDSPEISSW-KLDESDVKEHTFPGPHA 363
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEV--SDVPGTTRDpdVYVKELDKGKVKLVLVDTPGLDEFgGLGREELARLLLRGADL 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 76677903 364 FLLVTPLGSSLKSGDSVFSIIKRIFGEKfIKFTIIL 399
Cdd:cd00882  79 ILLVVDSTDRESEEDAKLLILRRLRKEG-IPIILVG 113
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 476-603 2.03e-04

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 41.45  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   476 NIILLGRSGVGKSATGNTILGRPAFVSqlrAQP-VTSRSQSGRRTLDWQDIVVVDTPSLNQMSGTEKNPAQLKKEIKQCL 554
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVS---DYPgTTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAFLAIIEAD 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 76677903   555 LqnceegmkVFVLVFQLGRFTQEDEAVVEQLeasfeENIMKYMIVLFTR 603
Cdd:pfam01926  78 L--------ILFVVDSEEGITPLDEELLELL-----RENKKPIILVLNK 113
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 52-209 8.66e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 40.52  E-value: 8.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  52 LLLGKQGAGKSATGNTILGKAVFESRFSHHmVTKRCQSESVSVRGKQVIV--IDTPDL--FSSLGCPEVQQQNLRQClDL 127
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPG-TTRDPDVYVKELDKGKVKLvlVDTPGLdeFGGLGREELARLLLRGA-DL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903 128 ladpyVLLLVTPIGHSTEEDKKTIEGIQGVFGPqayRHMIVVFTREDELGEDTlqnhiESKKYLKKLIENIGSQRCCAFN 207
Cdd:cd00882  79 -----ILLVVDSTDRESEEDAKLLILRRLRKEG---IPIILVGNKIDLLEERE-----VEELLRLEELAKILGVPVFEVS 145


                ..
gi 76677903 208 NK 209
Cdd:cd00882 146 AK 147
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 283-417 1.40e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 40.05  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   283 ELRVLLMGKRGVGKSAAGNSILGKQVFKTqfSEKQRVTEAFASHSRLWN--QKKFLIIDSPEISswklDESDVKEHTFPG 360
Cdd:TIGR00231   1 DIKIVIVGHPNVGKSTLLNSLLGNKGSIT--EYYPGTTRNYVTTVIEEDgkTYKFNLLDTAGQE----DYDAIRRLYYPQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 76677903   361 PHAFLLVTPLGSSLKSGDS-VFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKE 417
Cdd:TIGR00231  75 VERSLRVFDIVILVLDVEEiLEKQTKEIIHHADSGVPIILVGNKIDLKDADLKTHVAS 132
PRK04213 PRK04213
GTP-binding protein EngB;
470-568 1.82e-03

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 40.29  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903  470 REKELLNIILLGRSGVGKSatgntilgrpAFVSQLRAQPVTsrsqSGRR---TL-----DWQDIVVVDTPSLNQMSGTEK 541
Cdd:PRK04213   5 RPDRKPEIVFVGRSNVGKS----------TLVRELTGKKVR----VGKRpgvTRkpnhyDWGDFILTDLPGFGFMSGVPK 70

                         90       100
                 ....*....|....*....|....*...
gi 76677903  542 N-PAQLKKEIKQCLLQNCEEgMKVFVLV 568
Cdd:PRK04213  71 EvQEKIKDEIVRYIEDNADR-ILAAVLV 97
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
 478-558 6.22e-03

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 38.93  E-value: 6.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76677903   478 ILLGRSGVGKSATGNTILGRpafVSQlRAQPVTSRSQSGRRT------LDWQDIVVVDTPSLNQMSGTEKNPAQLK---- 547
Cdd:TIGR00157 124 VFAGQSGVGKSSLINALDPS---VKQ-QVNDISSKLGLGKHTtthvelFHFHGGLIADTPGFNEFGLWHLEPEQLTqgfv 199

                          90
                  ....*....|....
gi 76677903   548 ---KEIKQCLLQNC 558
Cdd:TIGR00157 200 efrDYLGLCKFRDC 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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