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Conserved domains on  [gi|83267868|ref|NP_001032584|]
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dynein light chain 1, cytoplasmic [Homo sapiens]

Protein Classification

dynein light chain( domain architecture ID 16901482)

dynein light chain is a non-catalytic accessory component of the cytoplasmic dynein complex and is thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function

CATH:  3.30.740.10
Gene Ontology:  GO:0045505|GO:0007017|GO:0030286
PubMed:  17546040|19805907|36861883
SCOP:  3000821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_DYNLL1_DYNLL2 cd21452
dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) ...
 5-88 2.02e-66

dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; The cytoplasmic dynein light chain 1 (DYNLL1) family includes DYNLL1 and DYNLL2. DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Both DYNLL1 and DYNLL2 (also called 8 kDa dynein light chain b, or DLC8b, or dynein light chain LC8-type 2, or DLC2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The model corresponds to the dynein light chain (DLC)-like domain of DYNLL1 and DYNLL2.


:

Pssm-ID: 412000  Cd Length: 84  Bit Score: 193.47  E-value: 2.02e-66
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868  5 KAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAIL 84
Cdd:cd21452  1 KAVIKNADMPEEMQQDAIELATQALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGRNFGSYVTHETKHFIYFYIGQVAIL 80


               ....
gi 83267868 85 LFKS 88
Cdd:cd21452 81 LFKS 84
 
Name Accession Description Interval E-value
DLC-like_DYNLL1_DYNLL2 cd21452
dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) ...
 5-88 2.02e-66

dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; The cytoplasmic dynein light chain 1 (DYNLL1) family includes DYNLL1 and DYNLL2. DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Both DYNLL1 and DYNLL2 (also called 8 kDa dynein light chain b, or DLC8b, or dynein light chain LC8-type 2, or DLC2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The model corresponds to the dynein light chain (DLC)-like domain of DYNLL1 and DYNLL2.


Pssm-ID: 412000  Cd Length: 84  Bit Score: 193.47  E-value: 2.02e-66
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868  5 KAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAIL 84
Cdd:cd21452  1 KAVIKNADMPEEMQQDAIELATQALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGRNFGSYVTHETKHFIYFYIGQVAIL 80


               ....
gi 83267868 85 LFKS 88
Cdd:cd21452 81 LFKS 84
PTZ00059 PTZ00059
dynein light chain; Provisional
 1-89 8.89e-63

dynein light chain; Provisional


Pssm-ID: 185421  Cd Length: 90  Bit Score: 184.63  E-value: 8.89e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868   1 MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQ 80
Cdd:PTZ00059  2 MSDRKAVVKNADMSEDMQQDAIDCANQALEKFNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQ 81


                ....*....
gi 83267868  81 VAILLFKSG 89
Cdd:PTZ00059 82 VAILLFKSG 90
Dynein_light pfam01221
Dynein light chain type 1;
5-87 2.13e-51

Dynein light chain type 1;


Pssm-ID: 460119  Cd Length: 83  Bit Score: 155.38  E-value: 2.13e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868    5 KAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAIL 84
Cdd:pfam01221  1 KAVIKASDMPEEMQQEAIEIAQEALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGKNFGSYVTHETGHFIYFYIGNLAIL 80


                 ...
gi 83267868   85 LFK 87
Cdd:pfam01221 81 LFK 83
 
Name Accession Description Interval E-value
DLC-like_DYNLL1_DYNLL2 cd21452
dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) ...
 5-88 2.02e-66

dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; The cytoplasmic dynein light chain 1 (DYNLL1) family includes DYNLL1 and DYNLL2. DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Both DYNLL1 and DYNLL2 (also called 8 kDa dynein light chain b, or DLC8b, or dynein light chain LC8-type 2, or DLC2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The model corresponds to the dynein light chain (DLC)-like domain of DYNLL1 and DYNLL2.


Pssm-ID: 412000  Cd Length: 84  Bit Score: 193.47  E-value: 2.02e-66
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868  5 KAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAIL 84
Cdd:cd21452  1 KAVIKNADMPEEMQQDAIELATQALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGRNFGSYVTHETKHFIYFYIGQVAIL 80


               ....
gi 83267868 85 LFKS 88
Cdd:cd21452 81 LFKS 84
PTZ00059 PTZ00059
dynein light chain; Provisional
 1-89 8.89e-63

dynein light chain; Provisional


Pssm-ID: 185421  Cd Length: 90  Bit Score: 184.63  E-value: 8.89e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868   1 MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQ 80
Cdd:PTZ00059  2 MSDRKAVVKNADMSEDMQQDAIDCANQALEKFNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQ 81


                ....*....
gi 83267868  81 VAILLFKSG 89
Cdd:PTZ00059 82 VAILLFKSG 90
Dynein_light pfam01221
Dynein light chain type 1;
5-87 2.13e-51

Dynein light chain type 1;


Pssm-ID: 460119  Cd Length: 83  Bit Score: 155.38  E-value: 2.13e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868    5 KAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAIL 84
Cdd:pfam01221  1 KAVIKASDMPEEMQQEAIEIAQEALEKYNIEKDIAAYIKKEFDKKYGPTWHCIVGKNFGSYVTHETGHFIYFYIGNLAIL 80


                 ...
gi 83267868   85 LFK 87
Cdd:pfam01221 81 LFK 83
DLC-like_DYNLL1-like cd21450
dynein light chain (DLC)-like domain found in cytoplasmic dynein light chain 1 (DYNLL1), ...
 20-87 5.28e-35

dynein light chain (DLC)-like domain found in cytoplasmic dynein light chain 1 (DYNLL1), axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs) and similar proteins; The family includes cytoplasmic dynein light chain 1 (DYNLL1), DYNLL2, axonemal dynein light chain 4 (DNAL4), and tegumental-allergen-like proteins (TALs). DYNLL1, also called protein inhibitor of neuronal nitric oxide synthase (PIN), or 8 kDa dynein light chain (DLC8), or dynein light chain LC8-type 1 (DLC1), is one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. It may play a role in changing or maintaining the spatial distribution of cytoskeletal structures. DYNLL2, also called cytoplasmic dynein light chain 2, or 8 kDa dynein light chain b (DLC8b), or dynein light chain LC8-type 2 (DLC2), is one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. It produces force towards the minus ends of microtubules. TALs, also called tegument antigens, are characterized by two N-terminal EF-hand motifs and a C-terminal region resembling a dynein light chain (DLC)-like domain. They were mainly found in parasitic platyhelminth species. TALs are strongly associated with the tegument, a syncytial structure that forms the outer layer of the organism. They may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes.


Pssm-ID: 411998  Cd Length: 68  Bit Score: 113.78  E-value: 5.28e-35
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 83267868 20 DSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFK 87
Cdd:cd21450  1 DAVEIAAEALEKYKSEKDIAKYIKKELDKKYGPTWHCIVGKSFGSSVTHEPGTFIYFKVGDLAVLLFK 68
DLC-like_DNAL4 cd21453
dynein light chain (DLC)-like domain found in axonemal dynein light chain 4 (DNAL4) and ...
 7-87 1.89e-26

dynein light chain (DLC)-like domain found in axonemal dynein light chain 4 (DNAL4) and similar proteins; Axonemal dynein light chain 4 (DNAL4) is a force generating protein of respiratory cilia. It produces force towards the minus ends of microtubules. The model corresponds to the dynein light chain (DLC)-like domain of DNAL4.


Pssm-ID: 412001  Cd Length: 83  Bit Score: 92.58  E-value: 1.89e-26
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868  7 VIKNADMSEEMQQDSVECATQALEKYNIEKDIAA-HIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIY-FYLGQVAIL 84
Cdd:cd21453  1 LVKHSDMPEEMRTEAVEICVTACEKFSNNNELAAkMIKETLDKKFGPSWHVVVGEGFGFEITYEVKNLLYmFFGGNLAIL 80


               ...
gi 83267868 85 LFK 87
Cdd:cd21453 81 VWK 83
PLN03058 PLN03058
dynein light chain type 1 family protein; Provisional
 8-88 2.21e-23

dynein light chain type 1 family protein; Provisional


Pssm-ID: 166697 [Multi-domain]  Cd Length: 128  Bit Score: 86.20  E-value: 2.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868    8 IKNADMSEEMQQDSVECATQALEKYNIEKD---IAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAIL 84
Cdd:PLN03058  38 VRASDMPLVLQNRAFSCARDILDAMPGKLDskrLALALKKEFDSAYGPAWHCIVGTSFGSYVTHSTGGFLYFSIDKVYIL 117


                 ....
gi 83267868   85 LFKS 88
Cdd:PLN03058 118 LFKT 121
DLC-like_TAL cd21454
dynein light chain (DLC)-like domain found in the family of tegumental-allergen-like proteins ...
 11-88 7.34e-12

dynein light chain (DLC)-like domain found in the family of tegumental-allergen-like proteins (TALs); Tegumental-allergen-like proteins (TALs), also called tegument antigens, are characterized by two N-terminal EF-hand motifs and a C-terminal region resembling a dynein light chain (DLC)-like domain. They were mainly found in parasitic platyhelminth species. TALs are strongly associated with the tegument, a syncytial structure that forms the outer layer of the organism. They may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. The model corresponds to the dynein light chain (DLC)-like domain of TAL.


Pssm-ID: 412002  Cd Length: 87  Bit Score: 55.67  E-value: 7.34e-12
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868 11 ADMSEEMQQDSVECATQAL-EKYNI-EKDIAAHIKKEFDKKYNPTWHCIVGRN-FGSYVTHETKHFIYFYLGQVAILLFK 87
Cdd:cd21454  7 ADMPLEMQVKILEKVRELLrESKKKnLKELVQELKRYLDERYGRLWHVVIVRGsYWASYSHEPGTSFHFRLGDYIYLVWR 86


               .
gi 83267868 88 S 88
Cdd:cd21454 87 T 87
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 20-87 5.28e-06

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 40.78  E-value: 5.28e-06
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83267868 20 DSVECATQALEKYN------------IEKDIAAHIKKEFDKKYNP--TWHCIVGR--------NFGSYVTHE--TKHFIY 75
Cdd:cd21449  1 LIREIIKEVLESILddkeydplklkeIAKKISEEIKEKLKELSPSryKYIVHVTIsenngqgiRADSGCLWDpdTDGFVS 80

                       90
               ....*....|....*.
gi 83267868 76 FYLG----QVAILLFK 87
Cdd:cd21449 81 EVYEndniICTVTVFG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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