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Conserved domains on  [gi|83715978|ref|NP_001032898|]
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cadherin-3 isoform a preproprotein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 211-316 2.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 211 TFRGSVLEGVMPGTSVMQVTATDEDDAVNtynGVVAYSIHSQEPKEphdlMFTIHKSTGTISVISSgLDREKVPEYRLTV 290
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 83715978 291 QATDMDGEGSTTTAEAVVQILDANDN 316
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-428 6.40e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 6.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 325 YEAWVPEN-EVGHEVQRLTVTDLDVPnsPAWRATYHIVGGDDGDHFTIttHPETnqGVLTTKKGLDFEAQDQHTLYVEVT 403
Cdd:cd11304   2 YEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 83715978 404 NEAPFAvklPTATATVVVHVKDVNE 428
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 103-203 8.19e-24

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 96.26  E-value: 8.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 103 MPPIFVPENGKGPfpQRLNQLKSNKDRGTKIFYSITGPGADSPPeGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSE 182
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 83715978 183 NGASVEEPMNISIIVTDQNDN 203
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 758-817 1.85e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 94.14  E-value: 1.85e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   758 ANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYG 817
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 443-536 4.28e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 4.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 443 EGISIGELVCIYTAQDPDKED-QKISYTISR-DPANWLAVDPDSGQITAAGILDREdeqfvKNNVYEVMVLATDSGNPPT 520
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGEnGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 83715978 521 TGTGTLLLTLTDINDH 536
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 536-630 6.75e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 36.51  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   536 HGPIPEPRQIiicnqSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWmaEVSEkgDTVALSLKKFL---KQDTYDLHLS 612
Cdd:pfam00028   2 SASVPENAPV-----GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF--RIDP--DTGDISTTKPLdreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 83715978   613 LSDHG--NREQLTMIRATVC 630
Cdd:pfam00028  73 ATDSGgpPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 211-316 2.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 211 TFRGSVLEGVMPGTSVMQVTATDEDDAVNtynGVVAYSIHSQEPKEphdlMFTIHKSTGTISVISSgLDREKVPEYRLTV 290
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 83715978 291 QATDMDGEGSTTTAEAVVQILDANDN 316
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-428 6.40e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 6.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 325 YEAWVPEN-EVGHEVQRLTVTDLDVPnsPAWRATYHIVGGDDGDHFTIttHPETnqGVLTTKKGLDFEAQDQHTLYVEVT 403
Cdd:cd11304   2 YEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 83715978 404 NEAPFAvklPTATATVVVHVKDVNE 428
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVND 97
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 103-203 8.19e-24

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 96.26  E-value: 8.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 103 MPPIFVPENGKGPfpQRLNQLKSNKDRGTKIFYSITGPGADSPPeGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSE 182
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 83715978 183 NGASVEEPMNISIIVTDQNDN 203
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 758-817 1.85e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 94.14  E-value: 1.85e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   758 ANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYG 817
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
212-311 1.59e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   212 FRGSVLEGVMPGTSVMQVTATDEDDAVNtynGVVAYSIHSQEPkephDLMFTIHKSTGTISVISSgLDREKVPEYRLTVQ 291
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPN---GRIFYSILGGGP----GGNFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 83715978   292 ATDMDGEGSTTTAEAVVQIL 311
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 230-318 6.45e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 6.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    230 TATDEDDAVNtynGVVAYSIHSqepkEPHDLMFTIHKSTGTISVISSgLDREKVPEYRLTVQATDMDGEGSTTTAEAVVQ 309
Cdd:smart00112   1 SATDADSGEN---GKVTYSILS----GNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 83715978    310 ILDANDNAP 318
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
325-423 2.02e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   325 YEAWVPENE-VGHEVQRLTVTDLDVPnsPAWRATYHIVGGDDGDHFTITTHPetnqGVLTTKKGLDFEAQDQHTLYVEVT 403
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|
gi 83715978   404 NEAPFAvklPTATATVVVHV 423
Cdd:pfam00028  75 DSGGPP---LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 342-430 1.57e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    342 TVTDLDVPNSpaWRATYHIVGGDDGDHFTItthpETNQGVLTTKKGLDFEAQDQHTLYVEVTNEAPfavKLPTATATVVV 421
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG---PPLSSTATVTI 71


                   ....*....
gi 83715978    422 HVKDVNEAP 430
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
104-198 1.87e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   104 PPIFVPENGK-GPFPQRLNQLKSNKDRGTKIFYSITGPGadspPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSE 182
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 83715978   183 NGASVEEPMNISIIVT 198
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 443-536 4.28e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 4.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 443 EGISIGELVCIYTAQDPDKED-QKISYTISR-DPANWLAVDPDSGQITAAGILDREdeqfvKNNVYEVMVLATDSGNPPT 520
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGEnGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 83715978 521 TGTGTLLLTLTDINDH 536
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
443-519 5.29e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 5.29e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83715978   443 EGISIGELVCIYTAQDPDKED-QKISYTISRD-PANWLAVDPDSGQITAAGILDREdeqfvKNNVYEVMVLATDSGNPP 519
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPnGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSGGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 125-205 2.77e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    125 SNKDRGT--KIFYSITGPGADsppeGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSENGASVEEPMNISIIVTDQND 202
Cdd:smart00112   3 TDADSGEngKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 83715978    203 NKP 205
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 455-538 5.11e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 5.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    455 TAQDPDK-EDQKISYTISR-DPANWLAVDPDSGQITAAGILDREDEQfvknnVYEVMVLATDSGNPPTTGTGTLLLTLTD 532
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 83715978    533 INDHGP 538
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
536-630 6.75e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.51  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   536 HGPIPEPRQIiicnqSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWmaEVSEkgDTVALSLKKFL---KQDTYDLHLS 612
Cdd:pfam00028   2 SASVPENAPV-----GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF--RIDP--DTGDISTTKPLdreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 83715978   613 LSDHG--NREQLTMIRATVC 630
Cdd:pfam00028  73 ATDSGgpPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 211-316 2.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 211 TFRGSVLEGVMPGTSVMQVTATDEDDAVNtynGVVAYSIHSQEPKEphdlMFTIHKSTGTISVISSgLDREKVPEYRLTV 290
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 83715978 291 QATDMDGEGSTTTAEAVVQILDANDN 316
Cdd:cd11304  73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-428 6.40e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 6.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 325 YEAWVPEN-EVGHEVQRLTVTDLDVPnsPAWRATYHIVGGDDGDHFTIttHPETnqGVLTTKKGLDFEAQDQHTLYVEVT 403
Cdd:cd11304   2 YEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 83715978 404 NEAPFAvklPTATATVVVHVKDVNE 428
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVND 97
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 103-203 8.19e-24

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 96.26  E-value: 8.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 103 MPPIFVPENGKGPfpQRLNQLKSNKDRGTKIFYSITGPGADSPPeGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSE 182
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 83715978 183 NGASVEEPMNISIIVTDQNDN 203
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 758-817 1.85e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 94.14  E-value: 1.85e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   758 ANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYG 817
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
212-311 1.59e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   212 FRGSVLEGVMPGTSVMQVTATDEDDAVNtynGVVAYSIHSQEPkephDLMFTIHKSTGTISVISSgLDREKVPEYRLTVQ 291
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPN---GRIFYSILGGGP----GGNFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 83715978   292 ATDMDGEGSTTTAEAVVQIL 311
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 230-318 6.45e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 6.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    230 TATDEDDAVNtynGVVAYSIHSqepkEPHDLMFTIHKSTGTISVISSgLDREKVPEYRLTVQATDMDGEGSTTTAEAVVQ 309
Cdd:smart00112   1 SATDADSGEN---GKVTYSILS----GNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 83715978    310 ILDANDNAP 318
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
325-423 2.02e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   325 YEAWVPENE-VGHEVQRLTVTDLDVPnsPAWRATYHIVGGDDGDHFTITTHPetnqGVLTTKKGLDFEAQDQHTLYVEVT 403
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|
gi 83715978   404 NEAPFAvklPTATATVVVHV 423
Cdd:pfam00028  75 DSGGPP---LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 342-430 1.57e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    342 TVTDLDVPNSpaWRATYHIVGGDDGDHFTItthpETNQGVLTTKKGLDFEAQDQHTLYVEVTNEAPfavKLPTATATVVV 421
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG---PPLSSTATVTI 71


                   ....*....
gi 83715978    422 HVKDVNEAP 430
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
104-198 1.87e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   104 PPIFVPENGK-GPFPQRLNQLKSNKDRGTKIFYSITGPGadspPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSE 182
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 83715978   183 NGASVEEPMNISIIVT 198
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 443-536 4.28e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 4.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 443 EGISIGELVCIYTAQDPDKED-QKISYTISR-DPANWLAVDPDSGQITAAGILDREdeqfvKNNVYEVMVLATDSGNPPT 520
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGEnGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 83715978 521 TGTGTLLLTLTDINDH 536
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
443-519 5.29e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 5.29e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83715978   443 EGISIGELVCIYTAQDPDKED-QKISYTISRD-PANWLAVDPDSGQITAAGILDREdeqfvKNNVYEVMVLATDSGNPP 519
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPnGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSGGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 125-205 2.77e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    125 SNKDRGT--KIFYSITGPGADsppeGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSENGASVEEPMNISIIVTDQND 202
Cdd:smart00112   3 TDADSGEngKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 83715978    203 NKP 205
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 455-538 5.11e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 5.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978    455 TAQDPDK-EDQKISYTISR-DPANWLAVDPDSGQITAAGILDREDEQfvknnVYEVMVLATDSGNPPTTGTGTLLLTLTD 532
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 83715978    533 INDHGP 538
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 106-203 1.31e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 1.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978 106 IFVPENGkgPFPQRLNQLK-SNKDRGT--KIFYSITGPgadsPPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSE 182
Cdd:cd11304   4 VSVPENA--PPGTVVLTVSaTDPDSGEngEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 83715978 183 NGASVEEPMNISIIVTDQNDN 203
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
536-630 6.75e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.51  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83715978   536 HGPIPEPRQIiicnqSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWmaEVSEkgDTVALSLKKFL---KQDTYDLHLS 612
Cdd:pfam00028   2 SASVPENAPV-----GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF--RIDP--DTGDISTTKPLdreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 83715978   613 LSDHG--NREQLTMIRATVC 630
Cdd:pfam00028  73 ATDSGgpPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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