NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|91807110|ref|NP_001035120|]
View 

leukocyte antigen CD37 isoform B [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626516)

tetraspanin family protein similar to CD37 antigen (also known as tetraspanin-26), a transmembrane (TM) protein with four TM segments which may act as a molecular facilitator in diverse processes such as in the immune system, fusion, adhesion, migration to apoptosis, and alterations of cell morphology

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 40-175 3.61e-55

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


:

Pssm-ID: 239413  Cd Length: 117  Bit Score: 171.41  E-value: 3.61e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  40 ISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQvLILRGNGSEaHRVPCSCYNLSAT 119
Cdd:cd03160   1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKNSSE-PLYPCSCCNSSAT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 91807110 120 NDStildkvilpqlsrlghlarSRHSADICAVPA--ESHIYREGCAQGLQKWLHNNLI 175
Cdd:cd03160  79 ADS-------------------PRPSKGFCEAPAslDWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
1-200 7.14e-18

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 77.74  E-value: 7.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110     1 MGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTI-QKYGTNPE-ETAAEESWDYV 78
Cdd:pfam00335  56 FLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDlYSCLNSALDSL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110    79 QFQLRCCGwhypqdwfqvlilrgngseahrvpcscynlsatndstildkvilpqlsrlghlarsrhsadicavpaeshiy 158
Cdd:pfam00335 136 QSEFGCCG------------------------------------------------------------------------ 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 91807110   159 reGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCR 200
Cdd:pfam00335 144 --GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 40-175 3.61e-55

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 171.41  E-value: 3.61e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  40 ISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQvLILRGNGSEaHRVPCSCYNLSAT 119
Cdd:cd03160   1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKNSSE-PLYPCSCCNSSAT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 91807110 120 NDStildkvilpqlsrlghlarSRHSADICAVPA--ESHIYREGCAQGLQKWLHNNLI 175
Cdd:cd03160  79 ADS-------------------PRPSKGFCEAPAslDWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
1-200 7.14e-18

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 77.74  E-value: 7.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110     1 MGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTI-QKYGTNPE-ETAAEESWDYV 78
Cdd:pfam00335  56 FLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDlYSCLNSALDSL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110    79 QFQLRCCGwhypqdwfqvlilrgngseahrvpcscynlsatndstildkvilpqlsrlghlarsrhsadicavpaeshiy 158
Cdd:pfam00335 136 QSEFGCCG------------------------------------------------------------------------ 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 91807110   159 reGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCR 200
Cdd:pfam00335 144 --GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 40-175 3.61e-55

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 171.41  E-value: 3.61e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  40 ISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQvLILRGNGSEaHRVPCSCYNLSAT 119
Cdd:cd03160   1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKNSSE-PLYPCSCCNSSAT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 91807110 120 NDStildkvilpqlsrlghlarSRHSADICAVPA--ESHIYREGCAQGLQKWLHNNLI 175
Cdd:cd03160  79 ADS-------------------PRPSKGFCEAPAslDWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
1-200 7.14e-18

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 77.74  E-value: 7.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110     1 MGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTI-QKYGTNPE-ETAAEESWDYV 78
Cdd:pfam00335  56 FLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDlYSCLNSALDSL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110    79 QFQLRCCGwhypqdwfqvlilrgngseahrvpcscynlsatndstildkvilpqlsrlghlarsrhsadicavpaeshiy 158
Cdd:pfam00335 136 QSEFGCCG------------------------------------------------------------------------ 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 91807110   159 reGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCR 200
Cdd:pfam00335 144 --GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 42-174 3.26e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 68.30  E-value: 3.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  42 TQRAQLERSLRDVVEKTIQKYGTNPEETAAeesWDYVQFQLRCCGWHYPQDWfqvlilrgnGSEAHRVPCSCYNLSATND 121
Cdd:cd03127   2 VYRDQLESLVSDTLNDAWDEYYVDDDFQEA---MDALQSTFECCGVNGPTDY---------LDLRLLVPSSCCKGTDGNC 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 91807110 122 StildkvilpqlsrlghlarsrhsadicavpaeSHIYREGCAQGLQKWLHNNL 174
Cdd:cd03127  70 G--------------------------------LNLYTEGCLEKLVDFLRSNL 90
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 44-174 4.41e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 46.59  E-value: 4.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  44 RAQLERSLRDVVEKTIQKYGT--NPEETAAeesWDYVQFQLRCCGWHYPQDWFQVLILRgngseahRVPCSCYnlsatnd 121
Cdd:cd03165   4 REKVDLTAKDDLKEGLELYGTrnNRGLTNA---WDITQTEFRCCGVTNYTDWYEVLGEN-------RVPDSCC------- 66

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 91807110 122 stildkvilpqlsrlghlarSRHSADiCAVPAESHIYREGCAQGLQKWLHNNL 174
Cdd:cd03165  67 --------------------QEDSQD-CGRNPTELWWKTGCYEKVQQWLVDNL 98
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 46-177 1.33e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 44.78  E-value: 1.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  46 QLERSLRDVVEKTIQKYGTNPEETAAeesWDYVQFQLRCCGWHYPQDWfqvlilrgnGSEahrVPCSCyNLSATNDSTil 125
Cdd:cd03164   6 KLNNYVKEGLTDSLEQYHKDNNTSEA---WDMIQSNLQCCGINGTTDW---------GSG---VPSSC-CSSDTEYKV-- 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 91807110 126 dkvilpqlsrlghlarsrhsadicavpaeshiyrEGCAQGLQKWLHNNLISI 177
Cdd:cd03164  68 ----------------------------------EGCYKKLKNWFESNFLYT 85
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 51-127 2.88e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 44.34  E-value: 2.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  51 LRDVVEKTIQKY-----GTNPEETAAeeswDYVQFQLRCCGWHYPQDWFQVLILrgNGSEAHRVPCSCYNLSATNDSTIL 125
Cdd:cd03163   8 VEDELNPSIDKVfnkynGTNAESRAV----DYLQRQLQCCGIHNYTDWENTPWF--KESKNNSVPLSCCKETFTSCTGSL 81


                ..
gi 91807110 126 DK 127
Cdd:cd03163  82 TQ 83
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 46-113 3.12e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 41.56  E-value: 3.12e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 91807110  46 QLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCSC 113
Cdd:cd03155   6 QLEDELKESLKRTMQENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWINSNEANGRLVPDSC 73
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 44-174 1.59e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 39.38  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  44 RAQLERSLRDVVEKTIQKYGTNPEETaaeESWDYVQFQLRCCGWHYPQDWFQVLILRGNgseahRVPCS-CYNLSATnds 122
Cdd:cd03166   4 RDKVMSEFNDSFNQMISNYNKTNDFR---KILDRMQKDLKCCGANNYTDWENIPSLDTD-----SVPDScCINVTKG--- 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 91807110 123 tildkvilpqlsrlghlarsrhsadiCAVPA-ESHIYREGCAQGLQKWLHNNL 174
Cdd:cd03166  73 --------------------------CGINFdEKVIHLEGCVTKIEGWLKKNI 99
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 44-96 4.48e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 38.95  E-value: 4.48e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 91807110  44 RAQLERSLRDVVEKTIQKYG--TNPEETAAEESWDYVQFQLRCCGWHYPQDWFQV 96
Cdd:cd03162   4 RGSLEESLKTGLKNAMKFYKdtDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEI 58
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 76-174 4.59e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 38.56  E-value: 4.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  76 DYVQFQLRCCGWHYPQDW-----FQVLILrGNGSEAHRVPCSCYNlsatndSTILDKVILPQLsrlGHLARSRHSADIca 150
Cdd:cd03159  33 DFLQEYWQCCGARGPDDWnlniyFNCTDS-NPSRERCGVPFSCCV------KDPAEDVVNTQC---GYDVRKKPELEL-- 100

                        90       100
                ....*....|....*....|....
gi 91807110 151 vpaESHIYREGCAQGLQKWLHNNL 174
Cdd:cd03159 101 ---QHHIHTKGCVQAFEKWLQDNL 121
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 46-113 1.97e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 36.74  E-value: 1.97e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  46 QLERSLRDVVEKTIQK-YGTNPEETAAeesWDYVQFQLRCCGWHYPQDWFQVL-ILRGNGSEAHRVPCSC 113
Cdd:cd03156   8 DLEDSFKNLLKNNYGNyNSTGDAITST---WNRVMIELKCCGVNGPTDFVDSTsFFRQKNEPNSPYPESC 74
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 44-174 2.16e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 36.67  E-value: 2.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  44 RAQLERSLRDVVEKTIQKYGTNPEetaAEESWDYVQFQLRCCGWHYPQDWFQVLILR--GNGSEAHRVPCSCYnLSATND 121
Cdd:cd03167   4 WGPLQDGLEHTLRLAIAHYQDDPD---LRFLIDQVQLGLQCCGASSYQDWQQNLYFNcsSPGVQACSLPASCC-IDPRED 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 91807110 122 STILDKVILPQLSRLGHLArsrhsadicavpAESHIYREGCAQGLQKWLHNNL 174
Cdd:cd03167  80 GAVVNDQCGFGALGLDEDA------------AQRVVHLGGCGPPLRRWLRGNL 120
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 44-132 8.58e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 34.64  E-value: 8.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91807110  44 RAQLERSLRDVVEKTIQKYGTNPEETAAeesWDYVQFQLRCCGWHYPQDWFQVLILRGNGseahrVPCSC------YNLS 117
Cdd:cd03161   4 RHEIKGTFLRTYNEAVSNYNGDDERSDA---VDTVQRTLHCCGVENYTDWLNSPYFLEKG-----IPLSCcknrsdCSPQ 75

                        90
                ....*....|....*
gi 91807110 118 ATNDSTILDKVILPQ 132
Cdd:cd03161  76 DLKNLTKAATKVYQQ 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH