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Conserved domains on  [gi|94158203|ref|NP_001035334|]
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sulfotransferase 4A1 [Danio rerio]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
47-277 3.81e-65

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 204.11  E-value: 3.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203    47 DIWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLEIIQELTSPRLIKSHLPYR 115
Cdd:pfam00685   3 DVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLPLH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   116 FLPSAMHNGEGKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLFLK 195
Cdd:pfam00685  83 LLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   196 YEDMYKDLGTLVEQLARFLGVSCDKAQLESLVE-------SSNqlieQCCNSEALSIC------RGRVGLWKDVFTVSMN 262
Cdd:pfam00685 163 YEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKhlsfenmKGN----PCLNYSKLPKEvspffrKGLVGDWKNYFTPEQA 238

                         250
                  ....*....|....*
gi 94158203   263 EKFDVIYRQKMAKSD 277
Cdd:pfam00685 239 EKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
47-277 3.81e-65

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 204.11  E-value: 3.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203    47 DIWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLEIIQELTSPRLIKSHLPYR 115
Cdd:pfam00685   3 DVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLPLH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   116 FLPSAMHNGEGKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLFLK 195
Cdd:pfam00685  83 LLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   196 YEDMYKDLGTLVEQLARFLGVSCDKAQLESLVE-------SSNqlieQCCNSEALSIC------RGRVGLWKDVFTVSMN 262
Cdd:pfam00685 163 YEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKhlsfenmKGN----PCLNYSKLPKEvspffrKGLVGDWKNYFTPEQA 238

                         250
                  ....*....|....*
gi 94158203   263 EKFDVIYRQKMAKSD 277
Cdd:pfam00685 239 EKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 9-278 1.39e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 89.98  E-value: 1.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203    9 PSTP-IEYESKYFehhgvrLPPFCRGKMDEIANFSLRSSDIWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNID 83
Cdd:PLN02164  48 PKEPlIEYGGHWW------LQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPH 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   84 EQLPVLE-----YPQpgLEIIQELTSPrLIKSHLPYRFLPSAMHNGEGKVIYMARNPKDLVVSYYQFHRSLRT-----MS 153
Cdd:PLN02164 122 EFVPYIEidfpfFPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203  154 YRGTFQEFCRRFMndklGYGSWFEHVQEFWEHRMDS--NVLFLKYEDMYKDLGTLVEQLARFLGVSCDKAQLES-LVESS 230
Cdd:PLN02164 199 LEESFDMFCRGLS----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEKgVVEKV 274

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 94158203  231 NQLieqcCNSEALS-----------------------ICRGRVGLWKDVFTVSMNEKFDVIYRQKMAKSDL 278
Cdd:PLN02164 275 VKL----CSFETLKnleankgekdredrpavyansayFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
47-277 3.81e-65

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 204.11  E-value: 3.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203    47 DIWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLEIIQELTSPRLIKSHLPYR 115
Cdd:pfam00685   3 DVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLPLH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   116 FLPSAMHNGEGKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLFLK 195
Cdd:pfam00685  83 LLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   196 YEDMYKDLGTLVEQLARFLGVSCDKAQLESLVE-------SSNqlieQCCNSEALSIC------RGRVGLWKDVFTVSMN 262
Cdd:pfam00685 163 YEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKhlsfenmKGN----PCLNYSKLPKEvspffrKGLVGDWKNYFTPEQA 238

                         250
                  ....*....|....*
gi 94158203   263 EKFDVIYRQKMAKSD 277
Cdd:pfam00685 239 EKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 9-278 1.39e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 89.98  E-value: 1.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203    9 PSTP-IEYESKYFehhgvrLPPFCRGKMDEIANFSLRSSDIWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNID 83
Cdd:PLN02164  48 PKEPlIEYGGHWW------LQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPH 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   84 EQLPVLE-----YPQpgLEIIQELTSPrLIKSHLPYRFLPSAMHNGEGKVIYMARNPKDLVVSYYQFHRSLRT-----MS 153
Cdd:PLN02164 122 EFVPYIEidfpfFPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203  154 YRGTFQEFCRRFMndklGYGSWFEHVQEFWEHRMDS--NVLFLKYEDMYKDLGTLVEQLARFLGVSCDKAQLES-LVESS 230
Cdd:PLN02164 199 LEESFDMFCRGLS----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEKgVVEKV 274

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 94158203  231 NQLieqcCNSEALS-----------------------ICRGRVGLWKDVFTVSMNEKFDVIYRQKMAKSDL 278
Cdd:PLN02164 275 VKL----CSFETLKnleankgekdredrpavyansayFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
48-216 1.02e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 56.53  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203    48 IWIVTYPKSGTSLLQEVVylvsqGADPDEIGLM----NIDEQLPVLEYPQPGLEIIQELTSP--RLIK---SHLPY---- 114
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLL-----AAHPDVRPPEetwfVIPRILALLQAWGKSLEALARVPSYarWLCDkspSHLFHldll 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158203   115 -RFLPSAmhngegKVIYMARNPKDLVV-SYYQFHRSLRTmSYRGTFQEFCRRFMNDklgygsWFEHVQEFWEHRM---DS 189
Cdd:pfam13469  76 lKAFPDA------KFIHLHRDPVDTVIsSYCSLFGFTLS-SYSTAFLRDIGLALAR------WSRAYERLMAARArvpPG 142

                         170       180
                  ....*....|....*....|....*..
gi 94158203   190 NVLFLKYEDMYKDLGTLVEQLARFLGV 216
Cdd:pfam13469 143 RFLDVRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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