NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|96304457|ref|NP_001035739|]
View 

low molecular weight phosphotyrosine protein phosphatase isoform d [Homo sapiens]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-84 3.12e-41

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 132.95  E-value: 3.12e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 96304457   7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNiSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDLK 84
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSgHRARQLTAEDFD 78
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-84 3.12e-41

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 132.95  E-value: 3.12e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 96304457   7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNiSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDLK 84
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSgHRARQLTAEDFD 78
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
9-84 2.44e-32

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 110.16  E-value: 2.44e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 96304457     9 VLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDLK 84
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFA 76
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
6-83 4.33e-25

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 91.76  E-value: 4.33e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 96304457   6 TKSVLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGyeiGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDL 83
Cdd:COG0394   3 PKRVLFVCTGNICRSPMAEALLRHLA-----GGRVEVDSAGTEP---GGPVDPRAVAVLAERGIDLSgHRSRQLDEEDL 73
LMWPc smart00226
Low molecular weight phosphatase family;
9-84 4.34e-23

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 86.37  E-value: 4.34e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 96304457      9 VLFVCLGNICRSPIAEAVFRKLVTDqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMSHVARQVPSLDLK 84
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGD-----RVKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFK 70
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 8-78 1.03e-09

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 52.33  E-value: 1.03e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 96304457    8 SVLFVCLGNICRSPIAEAVFRKLVTdqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQV 78
Cdd:PRK11391   4 SILVVCTGNICRSPIGERLLRKRLP------GVKVKSAGVHGL-VKHPADATAADVAANHGVSLEgHAGRKL 68
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-84 3.12e-41

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 132.95  E-value: 3.12e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 96304457   7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNiSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDLK 84
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSgHRARQLTAEDFD 78
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
9-84 2.44e-32

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 110.16  E-value: 2.44e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 96304457     9 VLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDLK 84
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFA 76
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
6-83 4.33e-25

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 91.76  E-value: 4.33e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 96304457   6 TKSVLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGyeiGNPPDYRGQSCMKRHGIPMS-HVARQVPSLDL 83
Cdd:COG0394   3 PKRVLFVCTGNICRSPMAEALLRHLA-----GGRVEVDSAGTEP---GGPVDPRAVAVLAERGIDLSgHRSRQLDEEDL 73
LMWPc smart00226
Low molecular weight phosphatase family;
9-84 4.34e-23

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 86.37  E-value: 4.34e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 96304457      9 VLFVCLGNICRSPIAEAVFRKLVTDqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMSHVARQVPSLDLK 84
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGD-----RVKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFK 70
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 8-83 3.51e-21

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 81.77  E-value: 3.51e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 96304457   8 SVLFVCLGNICRSPIAEAVFRKLVTDQnisenWRVDSAATSGYEiGNPPDYRGQSCMKRHGIPMSHVARQVPSLDL 83
Cdd:cd00115   1 SILFICTGNICRSPMAEAIFKQLLGDE-----WKVDSAGTGAHH-GEGADPRAVRVLKEVGIDISHRSDQIKSEHL 70
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 7-78 2.00e-15

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 67.07  E-value: 2.00e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 96304457   7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNISenwrVDSAATSGYEiGNPPDYRGQSCMKRHGIPMS-HVARQV 78
Cdd:cd16344   1 MKILFVCTGNTCRSPMAEAILKKLLEELDVE----VKSAGIFAVD-GSPASPNAVEVLKEKGIDLSgHRSQQL 68
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 8-78 1.03e-09

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 52.33  E-value: 1.03e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 96304457    8 SVLFVCLGNICRSPIAEAVFRKLVTdqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQV 78
Cdd:PRK11391   4 SILVVCTGNICRSPIGERLLRKRLP------GVKVKSAGVHGL-VKHPADATAADVAANHGVSLEgHAGRKL 68
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 9-73 5.65e-08

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 47.44  E-value: 5.65e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 96304457   9 VLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGYEIgNPpdyRGQSCMKRHGIPMSH 73
Cdd:cd16345   2 VLFLCTGNSARSQMAEALLRHLG-----GDRFEAYSAGSEPAGV-NP---LAIEVMKEIGIDISG 57
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
9-86 2.10e-06

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 43.74  E-value: 2.10e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 96304457    9 VLFVCLGNICRSPIAEAVFrklvtdQNISENWRVDSAATsGYEIGNPPDYRGQSCMKRHGIPM-SHVARQVPSldlKLC 86
Cdd:PRK10126   5 ILVVCVGNICRSPTAERLL------QRYHPELKVESAGL-GALVGKGADPTAISVAAEHQLSLeGHCARQISR---RLC 73
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
6-48 2.72e-05

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 39.82  E-value: 2.72e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 96304457   6 TKSVLFVCLGNICRSPIAEAVFRKlvtdqniSENWRVDSAATS 48
Cdd:COG4551   1 MMNVLFVCSRNRWRSPTAEQVFRN-------HPGVEVRSAGTS 36
PRK13530 PRK13530
arsenate reductase (thioredoxin);
7-73 5.06e-04

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 37.03  E-value: 5.06e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 96304457    7 KSVLFVCLGNICRSPIAEAVFRKLVTDQnisenWRVDSAATSGYEIgNPPDYRGqscMKRHGIPMSH 73
Cdd:PRK13530   4 KTIYFLCTGNSCRSQMAEGWGKQYLGDK-----WNVYSAGIEAHGV-NPNAIKA---MKEVGIDISN 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH