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Conserved domains on  [gi|100913209|ref|NP_001035757|]
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heat shock factor protein 4 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HSF smart00415
heat shock factor;
16-120 2.92e-55

heat shock factor;


:

Pssm-ID: 214654  Cd Length: 105  Bit Score: 179.79  E-value: 2.92e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209    16 PVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPE 95
Cdd:smart00415   1 QPPPFLTKLYLLVEDPSTDKIISWSPSGKSFVIWDPEEFAKNLLPRYFKHNNFSSFVRQLNMYGFRKVDPEFQGILYNFT 80
                           90       100
                   ....*....|....*....|....*
gi 100913209    96 RDHVEFQHPSFVRGREQLLERVRRK 120
Cdd:smart00415  81 SDQWEFANPDFVRGQPELLRNIKRK 105
Rootletin super family cl23727
Ciliary rootlet component, centrosome cohesion;
110-177 3.75e-03

Ciliary rootlet component, centrosome cohesion;


The actual alignment was detected with superfamily member pfam15035:

Pssm-ID: 464459 [Multi-domain]  Cd Length: 190  Bit Score: 38.48  E-value: 3.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 100913209  110 REQLlERVRRKVPALRgddgrwrpEDLGRLLGEVQALRGVQESTEARLRELRQ---------QNEI--LWREVVTLRQS 177
Cdd:pfam15035  98 REQL-EQASRANEALR--------EDLQKLTNDWERAREELEQKESEWRKEEEafneylsseHSRLlsLWREVVAVRRQ 167
 
Name Accession Description Interval E-value
HSF smart00415
heat shock factor;
16-120 2.92e-55

heat shock factor;


Pssm-ID: 214654  Cd Length: 105  Bit Score: 179.79  E-value: 2.92e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209    16 PVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPE 95
Cdd:smart00415   1 QPPPFLTKLYLLVEDPSTDKIISWSPSGKSFVIWDPEEFAKNLLPRYFKHNNFSSFVRQLNMYGFRKVDPEFQGILYNFT 80
                           90       100
                   ....*....|....*....|....*
gi 100913209    96 RDHVEFQHPSFVRGREQLLERVRRK 120
Cdd:smart00415  81 SDQWEFANPDFVRGQPELLRNIKRK 105
HSF_DNA-bind pfam00447
HSF-type DNA-binding;
20-120 1.25e-51

HSF-type DNA-binding;


Pssm-ID: 459813  Cd Length: 98  Bit Score: 170.06  E-value: 1.25e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209   20 FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQgglLRPERDHV 99
Cdd:pfam00447   1 FLRKLYRMLEDPETDDIISWSDDGDSFVILDPEEFAKEVLPKYFKHSNFSSFVRQLNMYGFHKVKDLSS---SKSMGDSW 77
                          90       100
                  ....*....|....*....|.
gi 100913209  100 EFQHPSFVRGREQLLERVRRK 120
Cdd:pfam00447  78 EFRHPNFRRGRPDLLKNIKRK 98
HSF1 COG5169
Heat shock transcription factor [Transcription];
14-195 7.78e-35

Heat shock transcription factor [Transcription];


Pssm-ID: 227497 [Multi-domain]  Cd Length: 282  Bit Score: 131.78  E-value: 7.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209  14 PSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKvVSIEQGGLLR 93
Cdd:COG5169    7 WSQPKEFVHKLYQILEEPEYYKLIQWSPDGRSFVILDPEEFTKVILPRYFKHGNFASFVRQLNKYGFHK-VSHKSGQRSY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209  94 PERDHVEFQHPSFVRGREQLLERV-RRKVPALRGD-DGRWRPEDLGrllGEVQALRGVQESTEARLRELRQQNEILWREV 171
Cdd:COG5169   86 YNENVWEFGNKNFQLGMIELLKKIkRKKAPSNRVDsNNESKDAMMN---IEVENIILPQSELYNSLSSLSNVNQTLLLYL 162
                        170       180
                 ....*....|....*....|....
gi 100913209 172 VTLRQSHGQQHRVIGKLIQCLFGP 195
Cdd:COG5169  163 NELKEYNYRNLRTIDDINAMLADL 186
Rootletin pfam15035
Ciliary rootlet component, centrosome cohesion;
110-177 3.75e-03

Ciliary rootlet component, centrosome cohesion;


Pssm-ID: 464459 [Multi-domain]  Cd Length: 190  Bit Score: 38.48  E-value: 3.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 100913209  110 REQLlERVRRKVPALRgddgrwrpEDLGRLLGEVQALRGVQESTEARLRELRQ---------QNEI--LWREVVTLRQS 177
Cdd:pfam15035  98 REQL-EQASRANEALR--------EDLQKLTNDWERAREELEQKESEWRKEEEafneylsseHSRLlsLWREVVAVRRQ 167
 
Name Accession Description Interval E-value
HSF smart00415
heat shock factor;
16-120 2.92e-55

heat shock factor;


Pssm-ID: 214654  Cd Length: 105  Bit Score: 179.79  E-value: 2.92e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209    16 PVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPE 95
Cdd:smart00415   1 QPPPFLTKLYLLVEDPSTDKIISWSPSGKSFVIWDPEEFAKNLLPRYFKHNNFSSFVRQLNMYGFRKVDPEFQGILYNFT 80
                           90       100
                   ....*....|....*....|....*
gi 100913209    96 RDHVEFQHPSFVRGREQLLERVRRK 120
Cdd:smart00415  81 SDQWEFANPDFVRGQPELLRNIKRK 105
HSF_DNA-bind pfam00447
HSF-type DNA-binding;
20-120 1.25e-51

HSF-type DNA-binding;


Pssm-ID: 459813  Cd Length: 98  Bit Score: 170.06  E-value: 1.25e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209   20 FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQgglLRPERDHV 99
Cdd:pfam00447   1 FLRKLYRMLEDPETDDIISWSDDGDSFVILDPEEFAKEVLPKYFKHSNFSSFVRQLNMYGFHKVKDLSS---SKSMGDSW 77
                          90       100
                  ....*....|....*....|.
gi 100913209  100 EFQHPSFVRGREQLLERVRRK 120
Cdd:pfam00447  78 EFRHPNFRRGRPDLLKNIKRK 98
HSF1 COG5169
Heat shock transcription factor [Transcription];
14-195 7.78e-35

Heat shock transcription factor [Transcription];


Pssm-ID: 227497 [Multi-domain]  Cd Length: 282  Bit Score: 131.78  E-value: 7.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209  14 PSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKvVSIEQGGLLR 93
Cdd:COG5169    7 WSQPKEFVHKLYQILEEPEYYKLIQWSPDGRSFVILDPEEFTKVILPRYFKHGNFASFVRQLNKYGFHK-VSHKSGQRSY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 100913209  94 PERDHVEFQHPSFVRGREQLLERV-RRKVPALRGD-DGRWRPEDLGrllGEVQALRGVQESTEARLRELRQQNEILWREV 171
Cdd:COG5169   86 YNENVWEFGNKNFQLGMIELLKKIkRKKAPSNRVDsNNESKDAMMN---IEVENIILPQSELYNSLSSLSNVNQTLLLYL 162
                        170       180
                 ....*....|....*....|....
gi 100913209 172 VTLRQSHGQQHRVIGKLIQCLFGP 195
Cdd:COG5169  163 NELKEYNYRNLRTIDDINAMLADL 186
Rootletin pfam15035
Ciliary rootlet component, centrosome cohesion;
110-177 3.75e-03

Ciliary rootlet component, centrosome cohesion;


Pssm-ID: 464459 [Multi-domain]  Cd Length: 190  Bit Score: 38.48  E-value: 3.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 100913209  110 REQLlERVRRKVPALRgddgrwrpEDLGRLLGEVQALRGVQESTEARLRELRQ---------QNEI--LWREVVTLRQS 177
Cdd:pfam15035  98 REQL-EQASRANEALR--------EDLQKLTNDWERAREELEQKESEWRKEEEafneylsseHSRLlsLWREVVAVRRQ 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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