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Conserved domains on  [gi|1812589212|ref|NP_001036096|]
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succinate dehydrogenase assembly factor 1, mitochondrial [Homo sapiens]

Protein Classification

LYR motif-containing protein( domain architecture ID 14448869)

LYR motif-containing protein plays a key role in the assembly and function of complexes I, II, and III; LYR motifs are molecular signatures of specific recipient Fe-S proteins or accessory factors that assist Fe-S cluster delivery

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_SDHAF1_LYRM8 cd20268
LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly ...
 5-63 1.23e-24

LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins; SDHAF1, also called SDH assembly factor 1, or LYR motif-containing protein 8 (LYRM8), is a LYR complex-II specific assembly factor that plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. It promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. SDHAF1 may act together with SDHAF3. It is mutated in SDH-defective infantile leukoencephalopathy. SDHAF1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380763  Cd Length: 64  Bit Score: 88.42  E-value: 1.23e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812589212   5 SRLQRQVLSLYRDLLRA-----GRGKPGAEARVRAEFRQHAGLPRSDVLRIEYLYRRGRRQLQL 63
Cdd:cd20268     1 SGLQKQVLSLYRSFLRAarskpGENRPGFRAYIRDEFRKNASIPRKDFLTIEHLLRRGQRQLEM 64
 
Name Accession Description Interval E-value
Complex1_LYR_SDHAF1_LYRM8 cd20268
LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly ...
 5-63 1.23e-24

LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins; SDHAF1, also called SDH assembly factor 1, or LYR motif-containing protein 8 (LYRM8), is a LYR complex-II specific assembly factor that plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. It promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. SDHAF1 may act together with SDHAF3. It is mutated in SDH-defective infantile leukoencephalopathy. SDHAF1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380763  Cd Length: 64  Bit Score: 88.42  E-value: 1.23e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812589212   5 SRLQRQVLSLYRDLLRA-----GRGKPGAEARVRAEFRQHAGLPRSDVLRIEYLYRRGRRQLQL 63
Cdd:cd20268     1 SGLQKQVLSLYRSFLRAarskpGENRPGFRAYIRDEFRKNASIPRKDFLTIEHLLRRGQRQLEM 64
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 9-63 1.42e-10

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 52.58  E-value: 1.42e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1812589212   9 RQVLSLYRDLLRAGRGKPG------AEARVRAEFRQHAGLprSDVLRIEYLYRRGRRQLQL 63
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPDynfreyFRRRIRDEFRKNKDL--TDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_SDHAF1_LYRM8 cd20268
LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly ...
 5-63 1.23e-24

LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins; SDHAF1, also called SDH assembly factor 1, or LYR motif-containing protein 8 (LYRM8), is a LYR complex-II specific assembly factor that plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. It promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. SDHAF1 may act together with SDHAF3. It is mutated in SDH-defective infantile leukoencephalopathy. SDHAF1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380763  Cd Length: 64  Bit Score: 88.42  E-value: 1.23e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812589212   5 SRLQRQVLSLYRDLLRA-----GRGKPGAEARVRAEFRQHAGLPRSDVLRIEYLYRRGRRQLQL 63
Cdd:cd20268     1 SGLQKQVLSLYRSFLRAarskpGENRPGFRAYIRDEFRKNASIPRKDFLTIEHLLRRGQRQLEM 64
Complex1_LYR_LYRM2 cd20262
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ...
 7-62 1.17e-10

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380757  Cd Length: 63  Bit Score: 52.92  E-value: 1.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1812589212   7 LQRQVLSLYRDLLRAGRGKPGAEAR------VRAEFRQHAGLprSDVLRIEYLYRRGRRQLQ 62
Cdd:cd20262     2 LRAQVLSLYRDILRAIRKIPDPSTRrelrdwVREEFERNRNE--TDEDAIKYLLSQGKRQLK 61
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 9-63 1.42e-10

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 52.58  E-value: 1.42e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1812589212   9 RQVLSLYRDLLRAGRGKPG------AEARVRAEFRQHAGLprSDVLRIEYLYRRGRRQLQL 63
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPDynfreyFRRRIRDEFRKNKDL--TDPEKIEKLLKEGKEELEE 59
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 11-63 7.80e-09

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 47.92  E-value: 7.80e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1812589212  11 VLSLYRDLLRAGRGKP------GAEARVRAEFRQHAGLprSDVLRIEYLYRRGRRQLQL 63
Cdd:cd20251     1 VLKLYRDLLRLARKGLpsrkrdALRQRIREEFRKNKNE--TDPEKIEELLAEARRGLKN 57
Complex1_LYR_1 pfam13232
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 9-65 2.65e-08

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 315815  Cd Length: 99  Bit Score: 47.78  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812589212   9 RQVLSLYRDLLRAGRGKPGAEAR------VRAEFR-------QHAGLPRSDVL--------------------------- 48
Cdd:pfam13232   1 QEKLRLYRALLKAANGFPGAEAReivaeeVRAAFRhplndslQHAELPRDDKLllgweraaaiqtyaenmywfhsrdevs 80

                          90
                  ....*....|....*....
gi 1812589212  49 -RIEYL-YRRGRRQLQLLR 65
Cdd:pfam13232  81 rEIEHHsLERDRQQIQELE 99
Complex1_LYR_MIEF1-MP cd20272
LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein ...
 9-62 1.65e-06

LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins; MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380767  Cd Length: 58  Bit Score: 41.87  E-value: 1.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1812589212   9 RQVLSLYRDLLRAGRG-----KPGAEARVRAEFRQHAGLprSDVLRIEYLYRRGRRQLQ 62
Cdd:cd20272     1 EAVLSLYRALLRYGRQlrytdKDYYRRRIRREFEKNQNL--TDPEAIEFQYEKGQKFLK 57
Complex1_LYR_LYRM4 cd20264
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ...
 10-65 3.57e-06

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380759  Cd Length: 69  Bit Score: 41.35  E-value: 3.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1812589212  10 QVLSLYRDLLRAGRGKPG------AEARVRAEFRQHAGLprSDVLRIEYLYRRGRRQLQLLR 65
Cdd:cd20264     1 QVLSLYRALLREARKFPDynfreyFLRRIRDAFRENKNL--KDPEEIKKLYEEGEEQLEVLK 60
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 11-64 1.49e-03

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 35.01  E-value: 1.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1812589212  11 VLSLYRDLLRAGRGKPGA-----EARVRAEFRQHAGLprSDVLRIEYLYRRGRRQLQLL 64
Cdd:pfam13233   1 VLSLYRALLRELRELPPNgrsygRQYLRAEFRRHKHL--TDPEEIAEFLKSWREYKELL 57
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 10-64 3.15e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 33.75  E-value: 3.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1812589212  10 QVLSLYRDLLRAGRGKPGAEAR--------VRAEFRQHAGLprSDVLRIEYLYRRGRRQLQLL 64
Cdd:cd20261     1 EVLSLYRRILRLARTWPADTEEereyilneARSLFRKNKNL--TDPEEIEEKIQEAESRLELA 61
Complex1_LYR_SDHAF3_LYRM10 cd20270
LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly ...
 11-39 5.71e-03

LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 3 (SDHAF3) and similar proteins; SDHAF3, also called SDH assembly factor 3, or LYR motif-containing protein 10 (LYRM10), plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. It promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. SDHAF3 may act together with SDHAF1. Its mutations may be associated with idiopathic SDH-associated diseases. SDHAF3 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380765  Cd Length: 56  Bit Score: 32.55  E-value: 5.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1812589212  11 VLSLYRDLLRAGRGKPgAEAR------VRAEFRQH 39
Cdd:cd20270     1 VLSLYRRILRLHRRLP-PEMRalgdqyVKDEFRRH 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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