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Conserved domains on  [gi|114796642|ref|NP_001041664|]
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regulator of chromosome condensation isoform c [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 29-389 2.16e-54

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 184.02  E-value: 2.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642  29 SHS---TEPGLVLTLGQGDVGQLGLGENVMeRKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV 105
Cdd:COG5184    8 SHScalKSDGTVWCWGDNSYGQLGDGTTTD-RSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 106 EGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDV-PVVKVASGNDHL 184
Cdd:COG5184   87 DRT--TPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 185 VMLTADGDLYTLGCGEQGQLG-------RVPELFANRGGrqglerllvpkcvmlksrgsrghvrFQDAFCGAYFTFAISH 257
Cdd:COG5184  162 CALKSDGTVWCWGANSYGQLGdgtttdrPTPVQVGGLSG-------------------------VVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 258 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSI 337
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRST 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 114796642 338 PTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184  292 PVKVPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 29-389 2.16e-54

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 184.02  E-value: 2.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642  29 SHS---TEPGLVLTLGQGDVGQLGLGENVMeRKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV 105
Cdd:COG5184    8 SHScalKSDGTVWCWGDNSYGQLGDGTTTD-RSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 106 EGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDV-PVVKVASGNDHL 184
Cdd:COG5184   87 DRT--TPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 185 VMLTADGDLYTLGCGEQGQLG-------RVPELFANRGGrqglerllvpkcvmlksrgsrghvrFQDAFCGAYFTFAISH 257
Cdd:COG5184  162 CALKSDGTVWCWGANSYGQLGdgtttdrPTPVQVGGLSG-------------------------VVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 258 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSI 337
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRST 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 114796642 338 PTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184  292 PVKVPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
363-414 4.25e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 4.25e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796642  363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGkqLENRVVLSVSSGGQHTVLL 414
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 29-389 2.16e-54

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 184.02  E-value: 2.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642  29 SHS---TEPGLVLTLGQGDVGQLGLGENVMeRKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV 105
Cdd:COG5184    8 SHScalKSDGTVWCWGDNSYGQLGDGTTTD-RSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 106 EGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDV-PVVKVASGNDHL 184
Cdd:COG5184   87 DRT--TPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 185 VMLTADGDLYTLGCGEQGQLG-------RVPELFANRGGrqglerllvpkcvmlksrgsrghvrFQDAFCGAYFTFAISH 257
Cdd:COG5184  162 CALKSDGTVWCWGANSYGQLGdgtttdrPTPVQVGGLSG-------------------------VVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 258 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSI 337
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRST 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 114796642 338 PTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184  292 PVKVPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 70-417 2.40e-52

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 178.63  E-value: 2.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642  70 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDN 149
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRS--TPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGN--NS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 150 NGVIGLLEPmKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRvpelfANRGGRqglerlLVPKCV 229
Cdd:COG5184   77 YGQLGDGTT-TDRTTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-----GTTTNR------LTPVQV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 230 MLksrgsrGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCM 309
Cdd:COG5184  145 DA------GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG----VVAVAAGGDHSCAL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 310 DSEGKAYSLGRAEYGRLGLGeGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184  215 KSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPV 293

                        330       340
                 ....*....|....*....|....*...
gi 114796642 390 EMMGkqLENrvVLSVSSGGQHTVLLVKD 417
Cdd:COG5184  294 KVPG--LSG--VVAVAAGSSHTCALLTD 317
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 28-206 1.02e-27

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 112.38  E-value: 1.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642  28 RSHS---TEPGLVLTLGQGDVGQLGLGENVmERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTS 104
Cdd:COG5184  158 GYHTcalKSDGTVWCWGANSYGQLGDGTTT-DRPTPVQVGGLSGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796642 105 VEGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGsfRDNNGVIGLLEPmKKSMVPVQVQLDVPVVKVASGNDHL 184
Cdd:COG5184  237 TDRA--TPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWG--DNSYGQLGDGTT-TDRSTPVKVPGLSGVVAVAAGSSHT 311

                        170       180
                 ....*....|....*....|..
gi 114796642 185 VMLTADGDLYTLGCGEQGQLGR 206
Cdd:COG5184  312 CALLTDGTVWCWGDNAYGQLGD 333
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
363-414 4.25e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 4.25e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796642  363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGkqLENRVVLSVSSGGQHTVLL 414
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
85-134 9.01e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.76  E-value: 9.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796642   85 SGQVYSFGCNDEGALGRDTSVegSEMVPGKVEL--QEKVVQVSAGDSHTAAL 134
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
258-309 2.26e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 52.90  E-value: 2.26e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796642  258 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstKSWVGFSGGQHHTVCM 309
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSG--NKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
35-82 2.51e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.13  E-value: 2.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 114796642   35 GLVLTLGQGDVGQLGLGENVmERKKPALVSIPED--VVQAEAGGMHTVCL 82
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
121-145 1.04e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.72  E-value: 1.04e-06
                          10        20
                  ....*....|....*....|....*
gi 114796642  121 VVQVSAGDSHTAALTDDGRVFLWGS 145
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGD 25
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
190-255 1.62e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 1.62e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114796642  190 DGDLYTLGCGEQGQLGRVPElfanrggrqglERLLVPKCVMlksrgSRGHVRFQDAFCGAYFTFAI 255
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT-----------ENVLVPQKVE-----GLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
137-187 3.94e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.96  E-value: 3.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 114796642  137 DGRVFLWGsfRDNNGVIGlLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVML 187
Cdd:pfam00415   1 DGRVYTWG--RNDYGQLG-LGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
312-355 6.07e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.19  E-value: 6.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 114796642  312 EGKAYSLGRAEYGRLGLGEGaEEKSIPTLISRLPA--VSSVACGAS 355
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGnkVVQVACGGD 45
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
347-376 3.11e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.79  E-value: 3.11e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 114796642  347 VSSVACGASVGYAVTKDGRVFAWGMGTNYQ 376
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
69-97 8.80e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 36.63  E-value: 8.80e-04
                          10        20
                  ....*....|....*....|....*....
gi 114796642   69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEG 97
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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