INO80 complex subunit B [Rattus norvegicus]
Protein Classification
PAPA-1 and zf-HIT domain-containing protein( domain architecture ID 10521558)
PAPA-1 and zf-HIT domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_IN80B | cd23021 | zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ... |
309-341 | 4.58e-15 | ||
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain. : Pssm-ID: 467793 Cd Length: 33 Bit Score: 68.07 E-value: 4.58e-15
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| PAPA-1 super family | cl04756 | PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a ... |
211-289 | 1.15e-06 | ||
PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein. The actual alignment was detected with superfamily member pfam04795: Pssm-ID: 461431 [Multi-domain] Cd Length: 78 Bit Score: 45.63 E-value: 1.15e-06
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| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_IN80B | cd23021 | zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ... |
309-341 | 4.58e-15 | ||
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain. Pssm-ID: 467793 Cd Length: 33 Bit Score: 68.07 E-value: 4.58e-15
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| PAPA-1 | pfam04795 | PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a ... |
211-289 | 1.15e-06 | ||
PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein. Pssm-ID: 461431 [Multi-domain] Cd Length: 78 Bit Score: 45.63 E-value: 1.15e-06
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| zf-HIT | pfam04438 | HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
307-338 | 3.73e-05 | ||
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor. Pssm-ID: 461310 Cd Length: 30 Bit Score: 40.31 E-value: 3.73e-05
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| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_IN80B | cd23021 | zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ... |
309-341 | 4.58e-15 | ||
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain. Pssm-ID: 467793 Cd Length: 33 Bit Score: 68.07 E-value: 4.58e-15
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| zf-HIT | cd23020 | zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ... |
310-341 | 7.98e-09 | ||
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes. Pssm-ID: 467792 Cd Length: 31 Bit Score: 50.58 E-value: 7.98e-09
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| PAPA-1 | pfam04795 | PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a ... |
211-289 | 1.15e-06 | ||
PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein. Pssm-ID: 461431 [Multi-domain] Cd Length: 78 Bit Score: 45.63 E-value: 1.15e-06
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| zf-HIT | pfam04438 | HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
307-338 | 3.73e-05 | ||
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor. Pssm-ID: 461310 Cd Length: 30 Bit Score: 40.31 E-value: 3.73e-05
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| zf-HIT_DDX59 | cd23022 | zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, ... |
309-342 | 8.43e-03 | ||
zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, also called zinc finger HIT domain-containing protein 5 (ZNHIT5), is a probable ATP-dependent RNA helicase (EC 3.6.4.13) that plays a role in nervous system development and function. It has an important role in lung cancer development through promoting DNA replication. Mutations in DDX59 implicate RNA helicase in the pathogenesis of oral-facial-digital syndrome (OFDS). DDX59 contains a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. Pssm-ID: 467794 Cd Length: 35 Bit Score: 33.75 E-value: 8.43e-03
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