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Conserved domains on  [gi|115430217|ref|NP_001041730|]
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piercer of microtubule wall 1 protein isoform 1 [Homo sapiens]

Protein Classification

DUF4490 domain-containing protein( domain architecture ID 10632856)

DUF4490 domain-containing protein similar to Homo sapiens UPF0691 protein C9orf116, also known as p53-induced expression in RB-null cells protein 1 (Pierce1), which may play a role in DNA damage response

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4490 pfam14892
Domain of unknown function (DUF4490); This family of proteins is found in eukaryotes. Proteins ...
 9-106 1.72e-59

Domain of unknown function (DUF4490); This family of proteins is found in eukaryotes. Proteins in this family are typically between 101 and 220 amino acids in length. In mice, a member of this family whose expression is induced by p53 may play a role in DNA damage response.


:

Pssm-ID: 434291  Cd Length: 99  Bit Score: 178.69  E-value: 1.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430217    9 CAEPVAPKATAPPERTSDYYRVSADLPGRFNNPGWFRGYRTQKAVSVYRTSNQAYGSRAPTVHEMPKVFYPNSNKFSQQL 88
Cdd:pfam14892   2 CGEPAEPKAEEPPEKTSDYYRVSENLPARFNNPGWFKGYRGKEGNPIYRTSNQQYGSRAPTVHEMPKVFYPRSQKFSQHL 81

                          90
                  ....*....|....*...
gi 115430217   89 AAGGMFRNNTLNVYLEKS 106
Cdd:pfam14892  82 LACGMYRNNGLNTSMEKS 99
 
Name Accession Description Interval E-value
DUF4490 pfam14892
Domain of unknown function (DUF4490); This family of proteins is found in eukaryotes. Proteins ...
 9-106 1.72e-59

Domain of unknown function (DUF4490); This family of proteins is found in eukaryotes. Proteins in this family are typically between 101 and 220 amino acids in length. In mice, a member of this family whose expression is induced by p53 may play a role in DNA damage response.


Pssm-ID: 434291  Cd Length: 99  Bit Score: 178.69  E-value: 1.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430217    9 CAEPVAPKATAPPERTSDYYRVSADLPGRFNNPGWFRGYRTQKAVSVYRTSNQAYGSRAPTVHEMPKVFYPNSNKFSQQL 88
Cdd:pfam14892   2 CGEPAEPKAEEPPEKTSDYYRVSENLPARFNNPGWFKGYRGKEGNPIYRTSNQQYGSRAPTVHEMPKVFYPRSQKFSQHL 81

                          90
                  ....*....|....*...
gi 115430217   89 AAGGMFRNNTLNVYLEKS 106
Cdd:pfam14892  82 LACGMYRNNGLNTSMEKS 99
 
Name Accession Description Interval E-value
DUF4490 pfam14892
Domain of unknown function (DUF4490); This family of proteins is found in eukaryotes. Proteins ...
 9-106 1.72e-59

Domain of unknown function (DUF4490); This family of proteins is found in eukaryotes. Proteins in this family are typically between 101 and 220 amino acids in length. In mice, a member of this family whose expression is induced by p53 may play a role in DNA damage response.


Pssm-ID: 434291  Cd Length: 99  Bit Score: 178.69  E-value: 1.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430217    9 CAEPVAPKATAPPERTSDYYRVSADLPGRFNNPGWFRGYRTQKAVSVYRTSNQAYGSRAPTVHEMPKVFYPNSNKFSQQL 88
Cdd:pfam14892   2 CGEPAEPKAEEPPEKTSDYYRVSENLPARFNNPGWFKGYRGKEGNPIYRTSNQQYGSRAPTVHEMPKVFYPRSQKFSQHL 81

                          90
                  ....*....|....*...
gi 115430217   89 AAGGMFRNNTLNVYLEKS 106
Cdd:pfam14892  82 LACGMYRNNGLNTSMEKS 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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