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Conserved domains on  [gi|1519313346|ref|NP_001045|]
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sulfotransferase 1A2 isoform 1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-287 6.51e-105

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 305.81  E-value: 6.51e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKNTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 111 LALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 191 LFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREfmdhsISPFMRKGMAGDWKTTFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 1519313346 271 AQNERFDADYAKKMAGC 287
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-287 6.51e-105

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 305.81  E-value: 6.51e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKNTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 111 LALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 191 LFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREfmdhsISPFMRKGMAGDWKTTFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 1519313346 271 AQNERFDADYAKKMAGC 287
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-289 5.18e-31

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 118.48  E-value: 5.18e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346  34 FQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKVPGIPSgMETLKNTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 109 LPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHP-GTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHP 187
Cdd:PLN02164  152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 188 --VLYLFYEDMKENPKREIQKILEFVGRSLPEE-----TVDLMVEHTSFkEMKKNPMTNYTTVRREFMD--HSISPFMRK 258
Cdd:PLN02164  232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFRK 310

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1519313346 259 GMAGDWKTTFTVAQNERFDADYAKKMAGCSL 289
Cdd:PLN02164  311 GKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-287 6.51e-105

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 305.81  E-value: 6.51e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKNTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 111 LALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 191 LFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREfmdhsISPFMRKGMAGDWKTTFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 1519313346 271 AQNERFDADYAKKMAGC 287
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-289 5.18e-31

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 118.48  E-value: 5.18e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346  34 FQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKVPGIPSgMETLKNTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 109 LPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHP-GTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHP 187
Cdd:PLN02164  152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 188 --VLYLFYEDMKENPKREIQKILEFVGRSLPEE-----TVDLMVEHTSFkEMKKNPMTNYTTVRREFMD--HSISPFMRK 258
Cdd:PLN02164  232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFRK 310

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1519313346 259 GMAGDWKTTFTVAQNERFDADYAKKMAGCSL 289
Cdd:PLN02164  311 GKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
47-217 3.37e-10

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 58.07  E-value: 3.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346  47 PKSGTTWVSQILDmiyqggdlekCHRAPIFMR-----VPFLEFKVPGIPSGMETLKNTPAP-RLLKTHLP---------L 111
Cdd:pfam13469   7 PRSGTTLLHRLLA----------AHPDVRPPEetwfvIPRILALLQAWGKSLEALARVPSYaRWLCDKSPshlfhldllL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313346 112 ALLPQTlldqkvKVVYVARNAKDVAVSyyHFYHMAKVYPHPgtWESFLEKFMAGEVSYgsWYQHVQEWWELSRTHP---V 188
Cdd:pfam13469  77 KAFPDA------KFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrF 144

                         170       180
                  ....*....|....*....|....*....
gi 1519313346 189 LYLFYEDMKENPKREIQKILEFVGRSLPE 217
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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