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Conserved domains on  [gi|115527110|ref|NP_001070143|]
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zinc finger protein 626 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.62e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.62e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 115527110     4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-520 8.50e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 8.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 264 -------KAFMSSSTLSKHEIIHTEKKP-------YKCEECGKAFNRSSTLTTHKIIHTGEKPykcEECDKAFKYSYTLT 329
Cdd:COG5048  112 ssssnsnDNNLLSSHSLPPSSRDPQLPDllsisnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 330 THKRIHTEDKPYKCEECGKAFKYSSTLTTHKRIHTgEKPYKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYS 409
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 410 SNLTTHKKIHTGER-------PYKCEECGKAFNQSSILTTHRR--IHTGEKFYKCEE----CGKAFKCSSNLTTHKKIHT 476
Cdd:COG5048  268 ASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 115527110 477 GERPYKC--EECGKAFNQSSILTTHERIILERNSTNVKNVAKPSSG 520
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS 393
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.62e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.62e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 115527110     4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 6.92e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 6.92e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 115527110    6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 2.81e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.81e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 115527110   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFL 43
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-520 8.50e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 8.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 264 -------KAFMSSSTLSKHEIIHTEKKP-------YKCEECGKAFNRSSTLTTHKIIHTGEKPykcEECDKAFKYSYTLT 329
Cdd:COG5048  112 ssssnsnDNNLLSSHSLPPSSRDPQLPDllsisnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 330 THKRIHTEDKPYKCEECGKAFKYSSTLTTHKRIHTgEKPYKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYS 409
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 410 SNLTTHKKIHTGER-------PYKCEECGKAFNQSSILTTHRR--IHTGEKFYKCEE----CGKAFKCSSNLTTHKKIHT 476
Cdd:COG5048  268 ASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 115527110 477 GERPYKC--EECGKAFNQSSILTTHERIILERNSTNVKNVAKPSSG 520
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS 393
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 6.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.87e-05
                          10        20
                  ....*....|....*....|....*.
gi 115527110  215 SLTRHKKIHTGEKPYKCEECGKAFKH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.62e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.62e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 115527110     4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 6.92e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 6.92e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 115527110    6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 2.81e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.81e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 115527110   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFL 43
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-520 8.50e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 8.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 264 -------KAFMSSSTLSKHEIIHTEKKP-------YKCEECGKAFNRSSTLTTHKIIHTGEKPykcEECDKAFKYSYTLT 329
Cdd:COG5048  112 ssssnsnDNNLLSSHSLPPSSRDPQLPDllsisnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 330 THKRIHTEDKPYKCEECGKAFKYSSTLTTHKRIHTgEKPYKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYS 409
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 410 SNLTTHKKIHTGER-------PYKCEECGKAFNQSSILTTHRR--IHTGEKFYKCEE----CGKAFKCSSNLTTHKKIHT 476
Cdd:COG5048  268 ASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 115527110 477 GERPYKC--EECGKAFNQSSILTTHERIILERNSTNVKNVAKPSSG 520
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS 393
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-388 1.63e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 227 KPYKCEECGKAFKHSSTLTTHKR--NHTGE--KPYKCDK--CGKAFMSSSTLSKHEIIHTEKKPYKC--EECGKAFNRSS 298
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 299 T-----LTTHKIIHTGEKPYKCE--ECDKAFKYSYTLTTHKRIHTEDKP--YKCEECGKAFKYSSTLTTHKRIHTGEKPY 369
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 115527110 370 KCEECGKAFKRSSDLTTHK 388
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-495 6.10e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 338 DKPYKCEECGKAFKYSSTLTTHKR--IHTGE--KPYKCEE--CGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYSSN 411
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 412 LTT-------HKKIHTGERPYKCE--ECGKAFNQSSILTTHRRIHTGEKF--YKCEECGKAFKCSSNLTTHKKIHTGERP 480
Cdd:COG5048  367 LNNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*
gi 115527110 481 YKCEECGKAFNQSSI 495
Cdd:COG5048  447 LLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-439 1.39e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 283 KPYKCEECGKAFNRSSTLTTHK--IIHTGE--KPYKCEE--CDKAFKYSYTLTTHKRIHTEDKPYKCEEC------GKAF 350
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 351 KYSSTLTTHKRIHTGEKPYKC---EECGKAFKRSSDLTTHKIIHTGEKP--YKCEECGKAFKYSSNLTTHKKIHTGERPY 425
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....
gi 115527110 426 KCEECGKAFNQSSI 439
Cdd:COG5048  448 LCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-507 3.09e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 155 HQFPNSNGQKRGHTGKKPF--KYIECGKAFKQFSTLTTHKKIHTGGKPYKCEECGKAFNHS-CSLTRHKKIHTGEKPYKC 231
Cdd:COG5048   44 SRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLSSSSSNSNDNNLL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 232 EECGKAF--KHSSTLTTHKRNHTGEKPYKcDKCGKAFMSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTTHKIIH-- 307
Cdd:COG5048  124 SSHSLPPssRDPQLPDLLSISNLRNNPLP-GNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSen 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 308 -------------------TGEKPYKCEECDKAFKYSYTLTTHKRIHTEDKPYKCEECGKAFKYSSTLTTHKRIHTGE-- 366
Cdd:COG5048  203 splsssysipssssdqnleNSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSss 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 367 -----KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGERPYKC--EECGKA 433
Cdd:COG5048  283 ekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSK 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 434 FNQSSI------LTTHRRIHTGEKFYKCE-ECGKAFKCSSNLTTHKKIHTGERP--YKCEECGKAFNQSSILTTHERIIL 504
Cdd:COG5048  363 FSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442


                 ...
gi 115527110 505 ERN 507
Cdd:COG5048  443 NHA 445
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-304 9.90e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 9.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 225 GEKPYKCE--ECGKAFKHSSTLTTHKRNhtgekpykcDKCGKAFMSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTT 302
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 115527110 303 HK 304
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-417 3.42e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 329 TTHKRIHTED-KPYKCE--ECGKAFKYSSTLTTHKrihtgekpyKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKA 405
Cdd:COG5189  337 TPSRMLKVKDgKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKR 407

                         90
                 ....*....|..
gi 115527110 406 FKYSSNLTTHKK 417
Cdd:COG5189  408 YKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-340 3.99e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.99e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115527110 267 MSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKC--EECDKAFKYSYTLTTHKRIHTEDKP 340
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 6.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.87e-05
                          10        20
                  ....*....|....*....|....*.
gi 115527110  215 SLTRHKKIHTGEKPYKCEECGKAFKH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 226-338 1.64e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 226 EKPYKCEECGKAFKHSSTLT--THKRNH--TGEKPYKCD--KCGKAFMSSSTLSKHEiihtekkpyKCEECGKAFNRSST 299
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNidTPSRMLkvKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPS 385

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 115527110 300 LTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHkRIHTED 338
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 2.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.32e-04
                          10        20
                  ....*....|....*....|....*
gi 115527110  356 LTTHKRIHTGEKPYKCEECGKAFKR 380
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-252 3.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.21e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115527110 197 GGKPYKCE--ECGKAFNHSCSLTRHKK-------------------IHTGEKPYKCEECGKAFKHSSTLTTHKRNHT 252
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 3.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 115527110  411 NLTTHKKIHTGERPYKCEECGKAFNQ 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 3.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 115527110  467 NLTTHKKIHTGERPYKCEECGKAFNQ 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 334-444 5.42e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 334 IHTEDKPYKCEECGKAFKYSSTL---TTHKRIHT-GEKPYKCE--ECGKAFKRSSDLTTHKiihtgekpyKCEECGKAFK 407
Cdd:COG5189  311 IDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLH 381

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 115527110 408 YSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHR 444
Cdd:COG5189  382 ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-396 6.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 6.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115527110 338 DKPYKCEECGKAFKYSSTLTTHKRIHTGEKPYKC--EECGKAFKRSSDLTTHKIIHTGEKP 396
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 8.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 115527110  383 DLTTHKIIHTGEKPYKCEECGKAFKY 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 8.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.81e-04
                          10        20
                  ....*....|....*....|....*
gi 115527110  300 LTTHKIIHTGEKPYKCEECDKAFKY 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 393-473 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 393 GEKPYKCE--ECGKAFKYSSNLTTHKKiHTGERPYKCEecgkafNQSSIltTHRRIHTGEKFYKCEECGKAFKCSSNLTT 470
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 115527110 471 HKK 473
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*
gi 115527110  328 LTTHKRIHTEDKPYKCEECGKAFKY 352
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-266 1.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|...
gi 115527110  244 LTTHKRNHTGEKPYKCDKCGKAF 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-212 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 115527110  188 LTTHKKIHTGGKPYKCEECGKAFNH 212
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-464 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*
gi 115527110  440 LTTHRRIHTGEKFYKCEECGKAFKC 464
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
407-510 5.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115527110 407 KYSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHRRIHTGEKFYKCEECGKAFKCS--SNLTTHKKIHTGERPYKCE 484
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNS 95

                         90       100
                 ....*....|....*....|....*.
gi 115527110 485 ECGKAFNQSSILTTHERIILERNSTN 510
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSNDNN 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-296 5.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.86e-03
                          10        20
                  ....*....|....*....|....*
gi 115527110  272 LSKHEIIHTEKKPYKCEECGKAFNR 296
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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