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Conserved domains on  [gi|116812642|ref|NP_001070889|]
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spermine binding protein like precursor [Mus musculus]

Protein Classification

jacalin family lectin( domain architecture ID 10176317)

jacalin family lectin is a sugar-binding protein containing a jacalin domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 37-165 7.14e-50

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


:

Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 159.02  E-value: 7.14e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642  37 GNAAGKYFYVQGEDQGQLKGMRIFLSVFkFIKGFQLQFGNNWTDVYGSRSDNFIDFLLEDGEHVIKVEGSAVICLTSLTF 116
Cdd:cd09611    1 GSGGGKYFSDVGEGGGPITGIRVSVGNN-YIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 116812642 117 TTNKGRVATFGVRRGRYFSDTGG-SDKHLVTVNGMHAPgLCVTGMGFKWE 165
Cdd:cd09611   80 TTNKGRYLSFGKLRGRSFNATPPpSNYVLRGISGRYGG-LGIKSIGFHWG 128
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 37-165 7.14e-50

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 159.02  E-value: 7.14e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642  37 GNAAGKYFYVQGEDQGQLKGMRIFLSVFkFIKGFQLQFGNNWTDVYGSRSDNFIDFLLEDGEHVIKVEGSAVICLTSLTF 116
Cdd:cd09611    1 GSGGGKYFSDVGEGGGPITGIRVSVGNN-YIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 116812642 117 TTNKGRVATFGVRRGRYFSDTGG-SDKHLVTVNGMHAPgLCVTGMGFKWE 165
Cdd:cd09611   80 TTNKGRYLSFGKLRGRSFNATPPpSNYVLRGISGRYGG-LGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 41-164 7.90e-20

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 81.89  E-value: 7.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642    41 GKYFYVqGEDQGQLKgmRIFLSVFKFIKGFQLQFGNN---WTDVYGSRSDNFIDFLLEDGEHVIKVEGS--AVICLTSLT 115
Cdd:smart00915   1 GTEWDD-GAFDGVRK--IYVGQGGEGIKSIQFDYDKGgkvWGDEHGGKGGTGEEILLYPGEYITSVEGTydKSGVITSLT 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 116812642   116 FTTNKGRVATFGVRRGRYFSDTGGSDKHLVTVNGMHAPGLCVTGMGFKW 164
Cdd:smart00915  78 FKTNKGRTSPFGGYEGGTKFVLESKEGKKIVGFHGRSSGDGLDSLGAYF 126
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 43-164 2.63e-10

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 56.52  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642   43 YFYVQGEDQGQLKGMRIFLSV-FKFIKGFQLQF-GNNWTDVYGSRSDNFID-FLLEDG-EHVIKVEG-------SAVICL 111
Cdd:pfam01419   2 ASWDDGVYDGVRKVYVGQGGDgITYIKFEYVKGgGKVEGDEHGKKGLLGPEeFEIDYPdEYITSVEGtydkvfgSDSEVI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 116812642  112 TSLTFTTNKGRVA-TFGVRRGRYFSdTGGSDKHLVTVNGMHAPglCVTGMGFKW 164
Cdd:pfam01419  82 TSLTFKTNKGRTSpFFGTPSGTKFS-LEVKGKKIVGFHGRAGN--ALNALGAYF 132
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 37-165 7.14e-50

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 159.02  E-value: 7.14e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642  37 GNAAGKYFYVQGEDQGQLKGMRIFLSVFkFIKGFQLQFGNNWTDVYGSRSDNFIDFLLEDGEHVIKVEGSAVICLTSLTF 116
Cdd:cd09611    1 GSGGGKYFSDVGEGGGPITGIRVSVGNN-YIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 116812642 117 TTNKGRVATFGVRRGRYFSDTGG-SDKHLVTVNGMHAPgLCVTGMGFKWE 165
Cdd:cd09611   80 TTNKGRYLSFGKLRGRSFNATPPpSNYVLRGISGRYGG-LGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 41-164 7.90e-20

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 81.89  E-value: 7.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642    41 GKYFYVqGEDQGQLKgmRIFLSVFKFIKGFQLQFGNN---WTDVYGSRSDNFIDFLLEDGEHVIKVEGS--AVICLTSLT 115
Cdd:smart00915   1 GTEWDD-GAFDGVRK--IYVGQGGEGIKSIQFDYDKGgkvWGDEHGGKGGTGEEILLYPGEYITSVEGTydKSGVITSLT 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 116812642   116 FTTNKGRVATFGVRRGRYFSDTGGSDKHLVTVNGMHAPGLCVTGMGFKW 164
Cdd:smart00915  78 FKTNKGRTSPFGGYEGGTKFVLESKEGKKIVGFHGRSSGDGLDSLGAYF 126
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 43-164 2.63e-10

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 56.52  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642   43 YFYVQGEDQGQLKGMRIFLSV-FKFIKGFQLQF-GNNWTDVYGSRSDNFID-FLLEDG-EHVIKVEG-------SAVICL 111
Cdd:pfam01419   2 ASWDDGVYDGVRKVYVGQGGDgITYIKFEYVKGgGKVEGDEHGKKGLLGPEeFEIDYPdEYITSVEGtydkvfgSDSEVI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 116812642  112 TSLTFTTNKGRVA-TFGVRRGRYFSdTGGSDKHLVTVNGMHAPglCVTGMGFKW 164
Cdd:pfam01419  82 TSLTFKTNKGRTSpFFGTPSGTKFS-LEVKGKKIVGFHGRAGN--ALNALGAYF 132
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 64-135 2.41e-06

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 45.64  E-value: 2.41e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116812642  64 FKFIKGFQLqfgnNWTDVYGSRSDNFIDFLLED-GEHVIKVEG-----SAVICLTSLTFTTNKGRVATFGVRRGRYFS 135
Cdd:cd09612   30 FEYDKDGQH----VVGPWHGGGGGTPEEIVLDYpDEYITSVSGtygpvSGSNVITSLTFKTNKRTYGPFGVESGTPFS 103
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 41-140 3.30e-04

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 39.31  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812642  41 GKYFYVQGEDQGQLKGMRIFlsVFKFIKGFQLQFGNNWTDVYGSR-SDNFIDFLLEDGEHVIKVEGS-----AVICLTSL 114
Cdd:cd09302    1 GKPFSDTGGDGARLTEIRVR--SGGAVDAIRVVLRDYTDGRHGGNgGPNTSSVFLDPGEYITITSVSsgdngGGTRIDAI 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 116812642 115 TFTTNKGRVATFGVRRG----RYFSDTGGS 140
Cdd:cd09302   79 QFTTNKGRSGTYGTTSGalgtEFTVPVGGE 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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