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Conserved domains on  [gi|117938254|ref|NP_001070909|]
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bcl-2-associated transcription factor 1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THRAP3_BCLAF1 super family cl25810
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 331-574 8.38e-68

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


The actual alignment was detected with superfamily member pfam15440:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 235.83  E-value: 8.38e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  331 AKTGKFLKSPPLHKNLDAREKSTFREESPlriKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQ 410
Cdd:pfam15440 374 GDFRKEAELSSSSQHDDSREKPDVKESSP---KSVFSIKRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQ 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  411 EFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQK--ATEEHSTRQKSPEIHRRIDISPST 488
Cdd:pfam15440 451 EFRSIFEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKraAEQEEMKSNKSPEIHRRIDMSPSA 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  489 LRKHTRLAGEERVFKEENQKGDkKLRCDSADLRHDID-------RRRKERSKERGDSKGSRESSGSRKQ-EKTPKDYKEY 560
Cdd:pfam15440 531 LRKHRTLFEESKQSKESSYKEG-KVKEDPNDLRHDIErrrkerlKERDEKRFHIRDSQDSRFSSLSRERtEKFQKPHKFS 609

                         250
                  ....*....|....
gi 117938254  561 KSYKDDSKHKREQD 574
Cdd:pfam15440 610 KKNFRTSKKRRDRI 623
Btz super family cl09653
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 654-719 2.72e-03

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


The actual alignment was detected with superfamily member pfam09405:

Pssm-ID: 447763 [Multi-domain]  Cd Length: 121  Bit Score: 38.27  E-value: 2.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117938254  654 QKRPKEEEWDPEYTPKSKKYFLHDDRDDGVD-YWAKRGRGRGtfqRGRGRfNFKKSGSSPKWTHDKY 719
Cdd:pfam09405  31 EKYEKERDENPAFVPTRGAFFLHDDRFAEPAaNGFGKSKGRP---YGRRR-RLWDDASEGKWTHDLF 93
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 331-574 8.38e-68

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 235.83  E-value: 8.38e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  331 AKTGKFLKSPPLHKNLDAREKSTFREESPlriKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQ 410
Cdd:pfam15440 374 GDFRKEAELSSSSQHDDSREKPDVKESSP---KSVFSIKRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQ 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  411 EFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQK--ATEEHSTRQKSPEIHRRIDISPST 488
Cdd:pfam15440 451 EFRSIFEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKraAEQEEMKSNKSPEIHRRIDMSPSA 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  489 LRKHTRLAGEERVFKEENQKGDkKLRCDSADLRHDID-------RRRKERSKERGDSKGSRESSGSRKQ-EKTPKDYKEY 560
Cdd:pfam15440 531 LRKHRTLFEESKQSKESSYKEG-KVKEDPNDLRHDIErrrkerlKERDEKRFHIRDSQDSRFSSLSRERtEKFQKPHKFS 609

                         250
                  ....*....|....
gi 117938254  561 KSYKDDSKHKREQD 574
Cdd:pfam15440 610 KKNFRTSKKRRDRI 623
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 654-719 2.72e-03

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 38.27  E-value: 2.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117938254  654 QKRPKEEEWDPEYTPKSKKYFLHDDRDDGVD-YWAKRGRGRGtfqRGRGRfNFKKSGSSPKWTHDKY 719
Cdd:pfam09405  31 EKYEKERDENPAFVPTRGAFFLHDDRFAEPAaNGFGKSKGRP---YGRRR-RLWDDASEGKWTHDLF 93
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 331-574 8.38e-68

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 235.83  E-value: 8.38e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  331 AKTGKFLKSPPLHKNLDAREKSTFREESPlriKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQ 410
Cdd:pfam15440 374 GDFRKEAELSSSSQHDDSREKPDVKESSP---KSVFSIKRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQ 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  411 EFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQK--ATEEHSTRQKSPEIHRRIDISPST 488
Cdd:pfam15440 451 EFRSIFEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKraAEQEEMKSNKSPEIHRRIDMSPSA 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938254  489 LRKHTRLAGEERVFKEENQKGDkKLRCDSADLRHDID-------RRRKERSKERGDSKGSRESSGSRKQ-EKTPKDYKEY 560
Cdd:pfam15440 531 LRKHRTLFEESKQSKESSYKEG-KVKEDPNDLRHDIErrrkerlKERDEKRFHIRDSQDSRFSSLSRERtEKFQKPHKFS 609

                         250
                  ....*....|....
gi 117938254  561 KSYKDDSKHKREQD 574
Cdd:pfam15440 610 KKNFRTSKKRRDRI 623
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 654-719 2.72e-03

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 38.27  E-value: 2.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117938254  654 QKRPKEEEWDPEYTPKSKKYFLHDDRDDGVD-YWAKRGRGRGtfqRGRGRfNFKKSGSSPKWTHDKY 719
Cdd:pfam09405  31 EKYEKERDENPAFVPTRGAFFLHDDRFAEPAaNGFGKSKGRP---YGRRR-RLWDDASEGKWTHDLF 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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